JP2015537044A5 - - Google Patents
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- JP2015537044A5 JP2015537044A5 JP2015544498A JP2015544498A JP2015537044A5 JP 2015537044 A5 JP2015537044 A5 JP 2015537044A5 JP 2015544498 A JP2015544498 A JP 2015544498A JP 2015544498 A JP2015544498 A JP 2015544498A JP 2015537044 A5 JP2015537044 A5 JP 2015537044A5
- Authority
- JP
- Japan
- Prior art keywords
- ankyrin repeat
- repeat domain
- amino acid
- binding protein
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12195156.0A EP2738180A1 (en) | 2012-11-30 | 2012-11-30 | Binding proteins comprising at least two binding domains against HER2. |
| EP12195156.0 | 2012-11-30 | ||
| PCT/EP2013/075290 WO2014083208A1 (en) | 2012-11-30 | 2013-12-02 | Binding proteins comprising at least two repeat domains against her2 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015537044A JP2015537044A (ja) | 2015-12-24 |
| JP2015537044A5 true JP2015537044A5 (enExample) | 2016-12-28 |
| JP6410724B2 JP6410724B2 (ja) | 2018-10-24 |
Family
ID=47257683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015544498A Expired - Fee Related JP6410724B2 (ja) | 2012-11-30 | 2013-12-02 | 少なくとも２つの抗ｈｅｒ２反復ドメインを含む結合タンパク質 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10370414B2 (enExample) |
| EP (2) | EP2738180A1 (enExample) |
| JP (1) | JP6410724B2 (enExample) |
| KR (1) | KR102290592B1 (enExample) |
| CN (1) | CN104918959A (enExample) |
| AU (2) | AU2013351096C9 (enExample) |
| CA (1) | CA2892747C (enExample) |
| HK (1) | HK1211297A1 (enExample) |
| MX (1) | MX366223B (enExample) |
| RU (1) | RU2664464C9 (enExample) |
| WO (1) | WO2014083208A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
| CN113278077A (zh) * | 2010-11-26 | 2021-08-20 | 分子组合公司 | 设计的与血清白蛋白结合的重复蛋白 |
| CA2883264A1 (en) * | 2012-10-15 | 2014-04-24 | Universitat Zurich Prorektorat Mnw | Bispecific her2 ligands for cancer therapy |
| CN105209483B (zh) | 2013-05-31 | 2021-07-27 | 分子组合公司 | 与肝细胞生长因子结合的设计锚蛋白重复蛋白 |
| EP4570318A3 (en) | 2013-11-27 | 2025-10-15 | Zymeworks BC Inc. | Bispecific antigen-binding constructs targeting her2 |
| WO2016082044A1 (en) | 2014-11-27 | 2016-06-02 | Zymeworks Inc. | Methods of using bispecific antigen-binding constructs targeting her2 |
| EP3253785B1 (en) | 2015-02-06 | 2019-04-10 | Navigo Proteins Gmbh | Novel egfr binding proteins |
| BR112017020986A2 (pt) * | 2015-04-02 | 2018-08-14 | Molecular Partners Ag. | proteínas de ligação recombinantes e seu uso |
| CN107922483B (zh) | 2015-07-16 | 2021-07-30 | 纳维格蛋白质有限公司 | 新型免疫球蛋白结合蛋白及其在亲和纯化中的用途 |
| WO2017013136A1 (en) * | 2015-07-20 | 2017-01-26 | Scil Proteins Gmbh | Novel binding proteins based on di-ubiquitin muteins and methods for generation |
| JP6881760B2 (ja) * | 2015-07-20 | 2021-06-02 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ジユビキチン変異タンパク質に基づくＨｅｒ２結合タンパク質 |
| AU2017260274A1 (en) | 2016-05-04 | 2018-11-01 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
| RU2627215C1 (ru) * | 2016-05-24 | 2017-08-03 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Нижегородский государственный университет им. Н.И. Лобачевского" | Рекомбинантный таргетный токсин, специфичный к клеткам, экспрессирующим рецептор her2 |
| CA3030208A1 (en) | 2016-08-11 | 2018-02-15 | Navigo Proteins Gmbh | Novel alkaline stable immunoglobulin binding proteins |
| ES2953516T3 (es) | 2016-09-22 | 2023-11-14 | Molecular Partners Ag | Proteínas de unión recombinantes y su uso |
| JP7685735B2 (ja) | 2016-12-02 | 2025-05-30 | アンヘレス セラピューティクス インコーポレイテッド | 合成免疫受容体およびその使用方法 |
| US11414466B2 (en) | 2017-11-07 | 2022-08-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer |
| CA3123986A1 (en) | 2018-12-18 | 2020-06-25 | Navigo Proteins Gmbh | Novel folr1 specific binding proteins for cancer diagnosis and treatment |
| JP7611173B2 (ja) * | 2019-06-04 | 2025-01-09 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 組換えｆａｐ結合タンパク質及びそれらの使用 |
| CN114222757A (zh) * | 2019-06-04 | 2022-03-22 | 分子伴侣公司 | 重组4-1bb结合蛋白及其用途 |
| CA3138805A1 (en) * | 2019-06-04 | 2020-12-10 | Johannes Schilling | Designed ankyrin repeat domain with improved stability |
| EP3980443A1 (en) | 2019-06-04 | 2022-04-13 | Molecular Partners AG | Multispecific proteins |
| US12240913B2 (en) | 2019-07-26 | 2025-03-04 | Abl Bio Inc. | Anti-HER2/anti-4-1BB bispecific antibody and use thereof |
| BR112022011177A2 (pt) * | 2019-12-11 | 2022-09-27 | Molecular Partners Ag | Domínios de repetição de anquirina projetados com resíduos de superfície alterados |
| WO2021224686A1 (en) | 2020-05-06 | 2021-11-11 | Molecular Partners Ag | Novel ankyrin repeat binding proteins and their uses |
| WO2021229076A1 (en) * | 2020-05-14 | 2021-11-18 | Molecular Partners Ag | Recombinant cd40 binding proteins and their use |
| EP4149959A1 (en) | 2020-05-14 | 2023-03-22 | Molecular Partners AG | Multispecific proteins |
| CA3202358A1 (en) | 2020-12-16 | 2022-06-23 | Andreas BOSSHART | Novel slow-release prodrugs |
| IL305677A (en) | 2021-03-09 | 2023-11-01 | Molecular Partners Ag | Novel darpin based multi-specific t-cell engagers |
| US20240150475A1 (en) | 2021-03-09 | 2024-05-09 | Molecular Partners Ag | Novel darpin based cd123 engagers |
| JP2024509890A (ja) | 2021-03-09 | 2024-03-05 | モレキュラー パートナーズ アクチェンゲゼルシャフト | プロテアーゼ切断可能なプロドラッグ |
| JP2024508969A (ja) | 2021-03-09 | 2024-02-28 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 新規のＤＡＲＰｉｎに基づくＣＤ３３エンゲージャ |
| EP4447990A1 (en) | 2021-12-14 | 2024-10-23 | Molecular Partners AG | Designed repeat domains with dual binding specificity and their use |
| WO2024028278A1 (en) | 2022-08-01 | 2024-02-08 | Molecular Partners Ag | Charge modified designed repeat domains and their use |
| WO2024038307A1 (en) | 2022-08-19 | 2024-02-22 | Novartis Ag | Dosing regimens for sars-cov-2 binding molecules |
| EP4673159A1 (en) | 2023-02-27 | 2026-01-07 | Molecular Partners AG | Darpins for use in reducing renal accumulation of drugs |
| WO2024251628A1 (en) | 2023-06-06 | 2024-12-12 | Molecular Partners Ag | Recombinant cd16a binding proteins and their use |
| WO2025146491A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0768377A1 (en) | 1988-09-02 | 1997-04-16 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5348867A (en) | 1991-11-15 | 1994-09-20 | George Georgiou | Expression of proteins on bacterial surface |
| US7371376B1 (en) | 1996-10-18 | 2008-05-13 | Genentech, Inc. | Anti-ErbB2 antibodies |
| CA2196496A1 (en) | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| JP4086325B2 (ja) | 1997-04-23 | 2008-05-14 | プリュックテュン，アンドレアス | 標的分子と相互作用する（ポリ）ペプチドをコードする核酸分子の同定方法 |
| PT1137812E (pt) | 1998-12-02 | 2007-05-31 | Adnexus Therapeutics Inc | Fusões adn-proteína e suas utilizações |
| JP5291279B2 (ja) | 2000-09-08 | 2013-09-18 | ウニヴェルジテート・チューリッヒ | 反復モジュールを含む反復タンパク質の集合体 |
| AU2005249396B2 (en) * | 2004-05-05 | 2011-10-20 | Merrimack Pharmaceuticals, Inc. | Bispecific binding agents for modulating biological activity |
| HRP20141111T1 (hr) * | 2004-07-22 | 2015-01-02 | Genentech, Inc. | Sastav her2-protutijela |
| MX2008000345A (es) | 2005-07-08 | 2008-04-02 | Univ Zuerich | Visualizacion en fagos usando transcolocacion contraduccional de polipeptidos de fusion. |
| DK2402754T4 (da) | 2006-03-06 | 2023-08-28 | Amunix Operating Inc | Ustrukturerede rekombinante polymerer og anvendelser deraf |
| JP5351889B2 (ja) | 2007-06-21 | 2013-11-27 | テクニシェ ユニバーシタット ミュンヘン | インビボおよび／またはインビトロ安定性が増大した生物学的に活性なタンパク質 |
| CA2700391A1 (en) | 2007-09-24 | 2009-04-02 | University Of Zuerich | Designed armadillo repeat proteins |
| WO2009068631A1 (en) | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Method for obtaining polypeptide constructs comprising two or more single domain antibodies |
| US20100260668A1 (en) | 2008-04-29 | 2010-10-14 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
| MX359570B (es) | 2008-11-03 | 2018-10-01 | Molecular Partners Ag | Proteinas de union que inhiben la interaccion en el receptor de vegf-a. |
| TW201120210A (en) * | 2009-11-05 | 2011-06-16 | Hoffmann La Roche | Glycosylated repeat-motif-molecule conjugates |
| AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
| CN113278077A (zh) | 2010-11-26 | 2021-08-20 | 分子组合公司 | 设计的与血清白蛋白结合的重复蛋白 |
| WO2012149439A2 (en) | 2011-04-29 | 2012-11-01 | Janssen Biotech, Inc. | Il4/il13 binding repeat proteins and uses |
| WO2012162418A1 (en) * | 2011-05-23 | 2012-11-29 | The University Of North Carolina At Chapel Hill | Methods and compositions for heterodimeric targeting ligands |
| EP2867360B1 (en) | 2012-06-28 | 2019-05-08 | Molecular Partners AG | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
| CA2883264A1 (en) | 2012-10-15 | 2014-04-24 | Universitat Zurich Prorektorat Mnw | Bispecific her2 ligands for cancer therapy |
| CN105209483B (zh) | 2013-05-31 | 2021-07-27 | 分子组合公司 | 与肝细胞生长因子结合的设计锚蛋白重复蛋白 |
-
2012
- 2012-11-30 EP EP12195156.0A patent/EP2738180A1/en not_active Withdrawn
-
2013
- 2013-12-02 US US14/648,611 patent/US10370414B2/en active Active
- 2013-12-02 CA CA2892747A patent/CA2892747C/en active Active
- 2013-12-02 CN CN201380062520.9A patent/CN104918959A/zh active Pending
- 2013-12-02 JP JP2015544498A patent/JP6410724B2/ja not_active Expired - Fee Related
- 2013-12-02 AU AU2013351096A patent/AU2013351096C9/en not_active Ceased
- 2013-12-02 RU RU2015120663A patent/RU2664464C9/ru active
- 2013-12-02 KR KR1020157017376A patent/KR102290592B1/ko not_active Expired - Fee Related
- 2013-12-02 MX MX2015006548A patent/MX366223B/es active IP Right Grant
- 2013-12-02 WO PCT/EP2013/075290 patent/WO2014083208A1/en not_active Ceased
- 2013-12-02 EP EP13811818.7A patent/EP2925784B1/en active Active
- 2013-12-02 HK HK15110090.1A patent/HK1211297A1/xx unknown
-
2018
- 2018-11-01 AU AU2018256592A patent/AU2018256592A1/en not_active Abandoned