JP2015537044A5 - - Google Patents
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- JP2015537044A5 JP2015537044A5 JP2015544498A JP2015544498A JP2015537044A5 JP 2015537044 A5 JP2015537044 A5 JP 2015537044A5 JP 2015544498 A JP2015544498 A JP 2015544498A JP 2015544498 A JP2015544498 A JP 2015544498A JP 2015537044 A5 JP2015537044 A5 JP 2015537044A5
- Authority
- JP
- Japan
- Prior art keywords
- ankyrin repeat
- repeat domain
- amino acid
- binding protein
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12195156.0A EP2738180A1 (en) | 2012-11-30 | 2012-11-30 | Binding proteins comprising at least two binding domains against HER2. |
| EP12195156.0 | 2012-11-30 | ||
| PCT/EP2013/075290 WO2014083208A1 (en) | 2012-11-30 | 2013-12-02 | Binding proteins comprising at least two repeat domains against her2 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015537044A JP2015537044A (ja) | 2015-12-24 |
| JP2015537044A5 true JP2015537044A5 (enExample) | 2016-12-28 |
| JP6410724B2 JP6410724B2 (ja) | 2018-10-24 |
Family
ID=47257683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015544498A Expired - Fee Related JP6410724B2 (ja) | 2012-11-30 | 2013-12-02 | 少なくとも２つの抗ｈｅｒ２反復ドメインを含む結合タンパク質 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10370414B2 (enExample) |
| EP (2) | EP2738180A1 (enExample) |
| JP (1) | JP6410724B2 (enExample) |
| KR (1) | KR102290592B1 (enExample) |
| CN (1) | CN104918959A (enExample) |
| AU (2) | AU2013351096C9 (enExample) |
| CA (1) | CA2892747C (enExample) |
| HK (1) | HK1211297A1 (enExample) |
| MX (1) | MX366223B (enExample) |
| RU (1) | RU2664464C9 (enExample) |
| WO (1) | WO2014083208A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質 |
| EP3514169B1 (en) * | 2010-11-26 | 2024-03-06 | Molecular Partners AG | Designed repeat proteins binding to serum albumin |
| EP2906591A1 (en) * | 2012-10-15 | 2015-08-19 | Universität Zürich | Bispecific her2 ligands for cancer therapy |
| US11453708B2 (en) | 2013-05-31 | 2022-09-27 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to hepatocyte growth factor |
| LT3074424T (lt) | 2013-11-27 | 2025-05-26 | Zymeworks Bc Inc. | Bispecifiniai antigeną surišantys konstruktai, nukreipti į her2 |
| FI3223848T3 (fi) | 2014-11-27 | 2025-02-28 | Zymeworks Bc Inc | Menetelmiä käyttää bispesifisiä antigeenia sitovia rakenteita, jotka kohdistuvat her2:een |
| EP3253785B1 (en) | 2015-02-06 | 2019-04-10 | Navigo Proteins Gmbh | Novel egfr binding proteins |
| US9458211B1 (en) | 2015-04-02 | 2016-10-04 | Molecular Partners Ag | Recombinant proteins that simultaneously bind HGF, VEGF-A and serum albumin, comprising ankyrin repeat domains |
| DK3322721T3 (da) | 2015-07-16 | 2022-03-14 | Navigo Proteins Gmbh | Nye immunglobulin-bindende proteiner og deres anvendelse i affinitetsoprensning |
| JP2018520675A (ja) | 2015-07-20 | 2018-08-02 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ジユビキチン変異タンパク質をベースとした新規結合タンパク質及びその生成方法 |
| CN107849147B (zh) * | 2015-07-20 | 2021-09-17 | 纳维格蛋白质有限公司 | 基于二泛素突变蛋白的Her2结合蛋白 |
| AU2017260274A1 (en) | 2016-05-04 | 2018-11-01 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
| RU2627215C1 (ru) * | 2016-05-24 | 2017-08-03 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Нижегородский государственный университет им. Н.И. Лобачевского" | Рекомбинантный таргетный токсин, специфичный к клеткам, экспрессирующим рецептор her2 |
| US11230576B2 (en) | 2016-08-11 | 2022-01-25 | Navigo Proteins Gmbh | Alkaline stable immunoglobulin-binding proteins |
| MY196882A (en) | 2016-09-22 | 2023-05-08 | Molecular Partners Ag | Recombinant binding proteins and their use |
| CN110352068A (zh) | 2016-12-02 | 2019-10-18 | 南加利福尼亚大学 | 合成的免疫受体及其使用方法 |
| WO2019091918A1 (en) | 2017-11-07 | 2019-05-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer |
| KR20210104106A (ko) | 2018-12-18 | 2021-08-24 | 나피고 프로타인스 게엠베하 | 암 진단 및 치료를 위한 신규 folr1 특이적 결합 단백질 |
| CA3139164A1 (en) | 2019-06-04 | 2020-12-10 | Molecular Partners Ag | Recombinant fap binding proteins and their use |
| KR20220016944A (ko) | 2019-06-04 | 2022-02-10 | 몰리큘라 파트너스 아게 | 개선된 안정성을 갖는 설계된 안키린 반복 도메인 |
| EP3980452A1 (en) * | 2019-06-04 | 2022-04-13 | Molecular Partners AG | Recombinant 4-1bb binding proteins and their use |
| JP2022535564A (ja) | 2019-06-04 | 2022-08-09 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 多選択性タンパク質 |
| CN118638240A (zh) | 2019-07-26 | 2024-09-13 | 柳韩洋行 | 抗her2/抗4-1bb双特异性抗体及其用途 |
| AU2020402581A1 (en) | 2019-12-11 | 2022-06-23 | Molecular Partners Ag | Designed ankyrin repeat domains with altered surface residues |
| MX2022013945A (es) | 2020-05-06 | 2023-02-14 | Molecular Partners Ag | Nuevas proteinas de union a repeticiones de anquirina y sus usos. |
| AU2021271131A1 (en) * | 2020-05-14 | 2022-12-15 | Molecular Partners Ag | Recombinant CD40 binding proteins and their use |
| IL298168A (en) | 2020-05-14 | 2023-01-01 | Molecular Partners Ag | Multispecific proteins |
| US20240108746A1 (en) | 2020-12-16 | 2024-04-04 | Molecular Partners Ag | Novel slow-release prodrugs |
| CA3211368A1 (en) | 2021-03-09 | 2022-09-15 | Molecular Partners Ag | Novel darpin based cd123 engagers |
| WO2022190016A1 (en) | 2021-03-09 | 2022-09-15 | Molecular Partners Ag | Novel darpin based multi-specific t-cell engagers |
| US20240317852A1 (en) | 2021-03-09 | 2024-09-26 | Molecular Partners Ag | Novel darpin based cd33 engagers |
| EP4305063A1 (en) | 2021-03-09 | 2024-01-17 | Molecular Partners AG | Protease cleavable prodrugs |
| WO2023110983A1 (en) | 2021-12-14 | 2023-06-22 | Molecular Partners Ag | Designed repeat domains with dual binding specificity and their use |
| CA3262553A1 (en) * | 2022-08-01 | 2024-02-08 | Molecular Partners Ag | REHEARSAL AREAS DESIGNED WITH MODIFIED CHARGES AND THEIR USE |
| WO2024038307A1 (en) | 2022-08-19 | 2024-02-22 | Novartis Ag | Dosing regimens for sars-cov-2 binding molecules |
| EP4673159A1 (en) | 2023-02-27 | 2026-01-07 | Molecular Partners AG | Darpins for use in reducing renal accumulation of drugs |
| WO2024251628A1 (en) | 2023-06-06 | 2024-12-12 | Molecular Partners Ag | Recombinant cd16a binding proteins and their use |
| WO2025146491A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68927933T2 (de) | 1988-09-02 | 1997-08-14 | Dyax Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5348867A (en) | 1991-11-15 | 1994-09-20 | George Georgiou | Expression of proteins on bacterial surface |
| US7371376B1 (en) | 1996-10-18 | 2008-05-13 | Genentech, Inc. | Anti-ErbB2 antibodies |
| CA2196496A1 (en) | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| DE69834032T2 (de) | 1997-04-23 | 2006-12-07 | Universität Zürich | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
| CA2350417C (en) | 1998-12-02 | 2010-02-09 | Bristol-Myers Squibb Company | Dna-protein fusions and uses thereof |
| EP1332209B1 (en) | 2000-09-08 | 2009-11-11 | Universität Zürich | Collections of repeat proteins comprising repeat modules |
| AU2005249396B2 (en) * | 2004-05-05 | 2011-10-20 | Merrimack Pharmaceuticals, Inc. | Bispecific binding agents for modulating biological activity |
| UA90480C2 (uk) * | 2004-07-22 | 2010-05-11 | Джэнэнтэк, Инк. | Фармацевтична композиція, що має протипухлинну активність, яка включає антитіло до her2 |
| KR101268939B1 (ko) | 2005-07-08 | 2013-05-30 | 유니버시티 오브 취리히 | 융합 폴리펩티드의 공번역 전좌를 사용한 파아지디스플레이 |
| CA2644712C (en) | 2006-03-06 | 2016-09-13 | Amunix, Inc. | Unstructured recombinant polymers and uses thereof |
| US8563521B2 (en) | 2007-06-21 | 2013-10-22 | Technische Universitat Munchen | Biological active proteins having increased in vivo and/or in vitro stability |
| CA2700391A1 (en) | 2007-09-24 | 2009-04-02 | University Of Zuerich | Designed armadillo repeat proteins |
| CA2706425A1 (en) | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Method for obtaining polypeptide constructs comprising two or more single domain antibodies |
| US20100260668A1 (en) * | 2008-04-29 | 2010-10-14 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
| NZ592591A (en) | 2008-11-03 | 2012-04-27 | Molecular Partners Ag | Binding proteins comprising ankyrin repeast domains that inhibit the vegf-a receptor interaction |
| TW201120210A (en) * | 2009-11-05 | 2011-06-16 | Hoffmann La Roche | Glycosylated repeat-motif-molecule conjugates |
| TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質 |
| EP3514169B1 (en) | 2010-11-26 | 2024-03-06 | Molecular Partners AG | Designed repeat proteins binding to serum albumin |
| WO2012149439A2 (en) | 2011-04-29 | 2012-11-01 | Janssen Biotech, Inc. | Il4/il13 binding repeat proteins and uses |
| WO2012162418A1 (en) * | 2011-05-23 | 2012-11-29 | The University Of North Carolina At Chapel Hill | Methods and compositions for heterodimeric targeting ligands |
| SG11201408196RA (en) | 2012-06-28 | 2015-03-30 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
| EP2906591A1 (en) | 2012-10-15 | 2015-08-19 | Universität Zürich | Bispecific her2 ligands for cancer therapy |
| US11453708B2 (en) | 2013-05-31 | 2022-09-27 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to hepatocyte growth factor |
-
2012
- 2012-11-30 EP EP12195156.0A patent/EP2738180A1/en not_active Withdrawn
-
2013
- 2013-12-02 KR KR1020157017376A patent/KR102290592B1/ko not_active Expired - Fee Related
- 2013-12-02 AU AU2013351096A patent/AU2013351096C9/en not_active Ceased
- 2013-12-02 WO PCT/EP2013/075290 patent/WO2014083208A1/en not_active Ceased
- 2013-12-02 CN CN201380062520.9A patent/CN104918959A/zh active Pending
- 2013-12-02 HK HK15110090.1A patent/HK1211297A1/xx unknown
- 2013-12-02 US US14/648,611 patent/US10370414B2/en active Active
- 2013-12-02 CA CA2892747A patent/CA2892747C/en active Active
- 2013-12-02 EP EP13811818.7A patent/EP2925784B1/en active Active
- 2013-12-02 RU RU2015120663A patent/RU2664464C9/ru active
- 2013-12-02 JP JP2015544498A patent/JP6410724B2/ja not_active Expired - Fee Related
- 2013-12-02 MX MX2015006548A patent/MX366223B/es active IP Right Grant
-
2018
- 2018-11-01 AU AU2018256592A patent/AU2018256592A1/en not_active Abandoned