JP2015537044A5 - - Google Patents
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- Publication number
- JP2015537044A5 JP2015537044A5 JP2015544498A JP2015544498A JP2015537044A5 JP 2015537044 A5 JP2015537044 A5 JP 2015537044A5 JP 2015544498 A JP2015544498 A JP 2015544498A JP 2015544498 A JP2015544498 A JP 2015544498A JP 2015537044 A5 JP2015537044 A5 JP 2015537044A5
- Authority
- JP
- Japan
- Prior art keywords
- ankyrin repeat
- repeat domain
- amino acid
- binding protein
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12195156.0A EP2738180A1 (en) | 2012-11-30 | 2012-11-30 | Binding proteins comprising at least two binding domains against HER2. |
| EP12195156.0 | 2012-11-30 | ||
| PCT/EP2013/075290 WO2014083208A1 (en) | 2012-11-30 | 2013-12-02 | Binding proteins comprising at least two repeat domains against her2 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015537044A JP2015537044A (ja) | 2015-12-24 |
| JP2015537044A5 true JP2015537044A5 (enExample) | 2016-12-28 |
| JP6410724B2 JP6410724B2 (ja) | 2018-10-24 |
Family
ID=47257683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015544498A Expired - Fee Related JP6410724B2 (ja) | 2012-11-30 | 2013-12-02 | 少なくとも２つの抗ｈｅｒ２反復ドメインを含む結合タンパク質 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10370414B2 (enExample) |
| EP (2) | EP2738180A1 (enExample) |
| JP (1) | JP6410724B2 (enExample) |
| KR (1) | KR102290592B1 (enExample) |
| CN (1) | CN104918959A (enExample) |
| AU (2) | AU2013351096C9 (enExample) |
| CA (1) | CA2892747C (enExample) |
| HK (1) | HK1211297A1 (enExample) |
| MX (1) | MX366223B (enExample) |
| RU (1) | RU2664464C9 (enExample) |
| WO (1) | WO2014083208A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質 |
| US9221892B2 (en) * | 2010-11-26 | 2015-12-29 | Molecular Partners Ag | Capping modules for designed ankyrin repeat proteins |
| JP2015532306A (ja) * | 2012-10-15 | 2015-11-09 | チューリッヒ大学 | 癌治療のための二重特異性ｈｅｒ２リガンド |
| JP6486908B2 (ja) | 2013-05-31 | 2019-03-20 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 肝細胞増殖因子に結合する設計アンキリン反復タンパク質 |
| MX376384B (es) | 2013-11-27 | 2025-03-07 | Zymeworks Bc Inc | Construcciones de union a antigenos biespecificas dirigidas a her2. |
| CA2968258A1 (en) | 2014-11-27 | 2016-06-02 | Zymeworks Inc. | Methods of using bispecific antigen-binding constructs targeting her2 |
| JP6738340B2 (ja) | 2015-02-06 | 2020-08-12 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | 新規なｅｇｆｒ結合タンパク質 |
| RU2769470C2 (ru) | 2015-04-02 | 2022-04-01 | Молекьюлар Партнерс Аг | Рекомбинантные связывающие белки и их применение |
| ES2916101T3 (es) | 2015-07-16 | 2022-06-28 | Navigo Proteins Gmbh | Nuevas proteínas de unión a inmunoglobulina y su uso en la purificación por afinidad |
| JP2018520675A (ja) * | 2015-07-20 | 2018-08-02 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ジユビキチン変異タンパク質をベースとした新規結合タンパク質及びその生成方法 |
| CA2991814A1 (en) * | 2015-07-20 | 2017-01-26 | Navigo Proteins Gmbh | Her2 binding proteins based on di-ubiquitin muteins |
| JP2019526526A (ja) | 2016-05-04 | 2019-09-19 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ペプチドリンカーを含む化学的部分の部位特異的カップリングのための標的化合物 |
| RU2627215C1 (ru) * | 2016-05-24 | 2017-08-03 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Нижегородский государственный университет им. Н.И. Лобачевского" | Рекомбинантный таргетный токсин, специфичный к клеткам, экспрессирующим рецептор her2 |
| DK3497117T5 (da) | 2016-08-11 | 2024-09-02 | Navigo Proteins Gmbh | Nye alkalisk stabile immunglobulin-bindende proteiner |
| CN109790206A (zh) * | 2016-09-22 | 2019-05-21 | 分子组合公司 | 重组结合蛋白及其用途 |
| CA3044682A1 (en) | 2016-12-02 | 2018-06-07 | University Of Southern California | Synthetic immune receptors and methods of use thereof |
| EP3706804B1 (en) | 2017-11-07 | 2022-02-23 | Navigo Proteins GmbH | Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer |
| MX2021014649A (es) | 2019-06-04 | 2022-01-06 | Molecular Partners Ag | Dominio de repetición de anquirina diseñado con estabilidad mejorada. |
| CA3139051A1 (en) | 2019-06-04 | 2020-12-10 | Christian REICHEN | Multispecific proteins |
| JP2022535107A (ja) * | 2019-06-04 | 2022-08-04 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 組換え４－１ｂｂ結合タンパク質及びそれらの使用 |
| EP3980045A1 (en) * | 2019-06-04 | 2022-04-13 | Molecular Partners AG | Recombinant fap binding proteins and their use |
| WO2021020846A1 (en) | 2019-07-26 | 2021-02-04 | Abl Bio Inc. | Anti-her2/anti-4-1bb bispecific antibody and use thereof |
| CN115003689A (zh) * | 2019-12-11 | 2022-09-02 | 分子合作伙伴股份公司 | 具有改变的表面残基的经设计的锚蛋白重复结构域 |
| MX2022013945A (es) | 2020-05-06 | 2023-02-14 | Molecular Partners Ag | Nuevas proteinas de union a repeticiones de anquirina y sus usos. |
| JP2023528207A (ja) * | 2020-05-14 | 2023-07-04 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 組換えｃｄ４０結合タンパク質及びそれらの使用 |
| BR112022023049A2 (pt) | 2020-05-14 | 2022-12-20 | Molecular Partners Ag | Proteínas multiespecíficas |
| CA3202358A1 (en) | 2020-12-16 | 2022-06-23 | Andreas BOSSHART | Novel slow-release prodrugs |
| EP4304731A1 (en) | 2021-03-09 | 2024-01-17 | Molecular Partners AG | Novel darpin based multi-specific t-cell engagers |
| WO2022190008A1 (en) | 2021-03-09 | 2022-09-15 | Molecular Partners Ag | Protease cleavable prodrugs |
| CA3211368A1 (en) | 2021-03-09 | 2022-09-15 | Molecular Partners Ag | Novel darpin based cd123 engagers |
| CA3211248A1 (en) | 2021-03-09 | 2022-09-15 | Nina RESCHKE | Novel darpin based cd33 engagers |
| AU2022413461A1 (en) | 2021-12-14 | 2024-06-06 | Molecular Partners Ag | Designed repeat domains with dual binding specificity and their use |
| IL318514A (en) | 2022-08-01 | 2025-03-01 | Molecular Partners Ag | Loading and using modified re-designed websites |
| WO2024038307A1 (en) | 2022-08-19 | 2024-02-22 | Novartis Ag | Dosing regimens for sars-cov-2 binding molecules |
| WO2024179981A1 (en) | 2023-02-27 | 2024-09-06 | Molecular Partners Ag | Darpins for use in reducing renal accumulation of drugs |
| WO2024251628A1 (en) | 2023-06-06 | 2024-12-12 | Molecular Partners Ag | Recombinant cd16a binding proteins and their use |
| WO2025146491A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1997891A1 (en) | 1988-09-02 | 2008-12-03 | Dyax Corporation | Generation and selection of recombinant varied binding proteins |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5348867A (en) | 1991-11-15 | 1994-09-20 | George Georgiou | Expression of proteins on bacterial surface |
| US7371376B1 (en) | 1996-10-18 | 2008-05-13 | Genentech, Inc. | Anti-ErbB2 antibodies |
| CA2196496A1 (en) | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| DE69834032T2 (de) | 1997-04-23 | 2006-12-07 | Universität Zürich | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
| ES2280131T3 (es) | 1998-12-02 | 2007-09-01 | Adnexus Therapeutics, Inc. | Fusiones de adn-proteina y utilizaciones de las mismas. |
| EP1332209B1 (en) | 2000-09-08 | 2009-11-11 | Universität Zürich | Collections of repeat proteins comprising repeat modules |
| WO2005117973A2 (en) * | 2004-05-05 | 2005-12-15 | Merrimack Pharmaceuticals, Inc. | Bispecific binding agents for modulating biological activity |
| AU2005287404B2 (en) * | 2004-07-22 | 2009-05-07 | Genentech, Inc. | HER2 antibody composition |
| AU2006268780B2 (en) | 2005-07-08 | 2011-03-24 | University Of Zurich | Phage display using cotranslational translocation of fusion polypeptides |
| EP1996937A4 (en) | 2006-03-06 | 2009-04-08 | Amunix Inc | GENETIC PACKS AND USES THEREOF |
| DE602008005596D1 (de) | 2007-06-21 | 2011-04-28 | Univ Muenchen Tech | Biologisch aktive proteine mit erhöhter in-vivo- und/oder in-vitro-stabilität |
| JP2010539915A (ja) | 2007-09-24 | 2010-12-24 | ユニバーシティ・オブ・チューリッヒ | 設計されたアルマジロリピートタンパク質 |
| CN101970490A (zh) | 2007-11-27 | 2011-02-09 | 埃博灵克斯股份有限公司 | 针对异二聚体细胞因子和/或其受体的氨基酸序列以及包括所述氨基酸序列的多肽 |
| US20100260668A1 (en) * | 2008-04-29 | 2010-10-14 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
| RU2550258C2 (ru) | 2008-11-03 | 2015-05-10 | Молекьюлар Партнерс Аг | Связывающие белки, ингибирующие взаимодействия vegf-a рецептора |
| TW201120210A (en) * | 2009-11-05 | 2011-06-16 | Hoffmann La Roche | Glycosylated repeat-motif-molecule conjugates |
| TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質 |
| US9221892B2 (en) | 2010-11-26 | 2015-12-29 | Molecular Partners Ag | Capping modules for designed ankyrin repeat proteins |
| EA201391607A1 (ru) | 2011-04-29 | 2014-04-30 | Янссен Байотек, Инк. | Связывающие il4/il13 белки с повторами и их применение |
| WO2012162418A1 (en) * | 2011-05-23 | 2012-11-29 | The University Of North Carolina At Chapel Hill | Methods and compositions for heterodimeric targeting ligands |
| RU2014150224A (ru) | 2012-06-28 | 2016-08-20 | Молекьюлар Партнерс Аг | Сконструированный белок с анкириновым повтором, связывающийся с фактором роста тромбоцитов |
| JP2015532306A (ja) | 2012-10-15 | 2015-11-09 | チューリッヒ大学 | 癌治療のための二重特異性ｈｅｒ２リガンド |
| JP6486908B2 (ja) | 2013-05-31 | 2019-03-20 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 肝細胞増殖因子に結合する設計アンキリン反復タンパク質 |
-
2012
- 2012-11-30 EP EP12195156.0A patent/EP2738180A1/en not_active Withdrawn
-
2013
- 2013-12-02 EP EP13811818.7A patent/EP2925784B1/en active Active
- 2013-12-02 MX MX2015006548A patent/MX366223B/es active IP Right Grant
- 2013-12-02 KR KR1020157017376A patent/KR102290592B1/ko not_active Expired - Fee Related
- 2013-12-02 HK HK15110090.1A patent/HK1211297A1/xx unknown
- 2013-12-02 US US14/648,611 patent/US10370414B2/en active Active
- 2013-12-02 CN CN201380062520.9A patent/CN104918959A/zh active Pending
- 2013-12-02 RU RU2015120663A patent/RU2664464C9/ru active
- 2013-12-02 JP JP2015544498A patent/JP6410724B2/ja not_active Expired - Fee Related
- 2013-12-02 AU AU2013351096A patent/AU2013351096C9/en not_active Ceased
- 2013-12-02 WO PCT/EP2013/075290 patent/WO2014083208A1/en not_active Ceased
- 2013-12-02 CA CA2892747A patent/CA2892747C/en active Active
-
2018
- 2018-11-01 AU AU2018256592A patent/AU2018256592A1/en not_active Abandoned