|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4002531A
(en)
|
1976-01-22 |
1977-01-11 |
Pierce Chemical Company |
Modifying enzymes with polyethylene glycol and product produced thereby
|
|
USRE30985E
(en)
|
1978-01-01 |
1982-06-29 |
|
Serum-free cell culture media
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
US4419446A
(en)
|
1980-12-31 |
1983-12-06 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant DNA process utilizing a papilloma virus DNA as a vector
|
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4601978A
(en)
|
1982-11-24 |
1986-07-22 |
The Regents Of The University Of California |
Mammalian metallothionein promoter system
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
EP0206448B1
(en)
|
1985-06-19 |
1990-11-14 |
Ajinomoto Co., Inc. |
Hemoglobin combined with a poly(alkylene oxide)
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
US5514581A
(en)
|
1986-11-04 |
1996-05-07 |
Protein Polymer Technologies, Inc. |
Functional recombinantly prepared synthetic protein polymer
|
|
US5641648A
(en)
|
1986-11-04 |
1997-06-24 |
Protein Polymer Technologies, Inc. |
Methods for preparing synthetic repetitive DNA
|
|
US5770697A
(en)
|
1986-11-04 |
1998-06-23 |
Protein Polymer Technologies, Inc. |
Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
|
|
US6018030A
(en)
|
1986-11-04 |
2000-01-25 |
Protein Polymer Technologies, Inc. |
Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
|
|
US4863457A
(en)
|
1986-11-24 |
1989-09-05 |
Lee David A |
Drug delivery device
|
|
US4997652A
(en)
|
1987-12-22 |
1991-03-05 |
Visionex |
Biodegradable ocular implants
|
|
EP0435911B1
(en)
|
1988-09-23 |
1996-03-13 |
Cetus Oncology Corporation |
Cell culture medium for enhanced cell growth, culture longevity and product expression
|
|
FR2646437B1
(fr)
|
1989-04-28 |
1991-08-30 |
Transgene Sa |
Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
|
|
US5164188A
(en)
|
1989-11-22 |
1992-11-17 |
Visionex, Inc. |
Biodegradable ocular implants
|
|
US5766897A
(en)
|
1990-06-21 |
1998-06-16 |
Incyte Pharmaceuticals, Inc. |
Cysteine-pegylated proteins
|
|
WO1992002536A1
(en)
|
1990-08-02 |
1992-02-20 |
The Regents Of The University Of Colorado |
Systematic polypeptide evolution by reverse translation
|
|
JP3051145B2
(ja)
|
1990-08-28 |
2000-06-12 |
住友製薬株式会社 |
新規なポリエチレングリコール誘導体修飾ペプチド
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
KR0185215B1
(ko)
|
1990-11-30 |
1999-05-01 |
요시다 쇼오지 |
서방성 안구삽입용 약제
|
|
US5773574A
(en)
|
1990-12-03 |
1998-06-30 |
The Scripps Research Institute |
Polypeptides for promoting cell attachment
|
|
US5235041A
(en)
|
1990-12-28 |
1993-08-10 |
Protein Polymer Technologies, Inc. |
Purification of structurally ordered recombinant protein polymers
|
|
JPH04108827U
(ja)
|
1991-03-04 |
1992-09-21 |
カシオ計算機株式会社 |
電子機器におけるスライドスイツチ構造
|
|
US5792742A
(en)
|
1991-06-14 |
1998-08-11 |
New York University |
Fibrin-binding peptide fragments of fibronectin
|
|
US5281698A
(en)
|
1991-07-23 |
1994-01-25 |
Cetus Oncology Corporation |
Preparation of an activated polymer ester for protein conjugation
|
|
AU2313392A
(en)
|
1991-08-01 |
1993-03-02 |
University Research Corporation |
Systematic polypeptide evolution by reverse translation
|
|
NZ255041A
(en)
|
1992-07-13 |
1996-11-26 |
Bionebraska Inc |
Preparation of a recombinant single copy polypeptide or portion thereof modified with a terminal alpha amino carbon reactive group and reactive side chain groups involving biologically added protective groups
|
|
US5382657A
(en)
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
|
PT752248E
(pt)
|
1992-11-13 |
2001-01-31 |
Idec Pharma Corp |
Aplicacao terapeutica de anticorpos quimericos e marcados radioactivamente contra antigenios de diferenciacao restrita de linfocitos b humanos para o tratamento do linfoma de celulas b
|
|
WO1994017097A1
(en)
|
1993-01-19 |
1994-08-04 |
Regents Of The University Of Minnesota |
Synthetic fibronectin fragments as inhibitors of retroviral infections
|
|
EP0654256B1
(en)
|
1993-02-26 |
2000-08-02 |
Santen Pharmaceutical Co., Ltd. |
Biodegradable sclera plug
|
|
AU8124694A
(en)
|
1993-10-29 |
1995-05-22 |
Affymax Technologies N.V. |
In vitro peptide and antibody display libraries
|
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
|
US5443505A
(en)
|
1993-11-15 |
1995-08-22 |
Oculex Pharmaceuticals, Inc. |
Biocompatible ocular implants
|
|
US5516522A
(en)
|
1994-03-14 |
1996-05-14 |
Board Of Supervisors Of Louisiana State University |
Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US5559000A
(en)
|
1995-01-18 |
1996-09-24 |
The Scripps Research Institute |
Encoded reaction cassette
|
|
US6369116B1
(en)
|
1995-06-02 |
2002-04-09 |
Oculex Pharmaceuticals, Inc. |
Composition and method for treating glaucoma
|
|
US5869079A
(en)
|
1995-06-02 |
1999-02-09 |
Oculex Pharmaceuticals, Inc. |
Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
|
|
DE19646372C1
(de)
|
1995-11-11 |
1997-06-19 |
Evotec Biosystems Gmbh |
Genotyp und Phänotyp koppelnde Verbindung
|
|
JP3556050B2
(ja)
|
1996-06-24 |
2004-08-18 |
株式会社大井製作所 |
ドアクロージャ
|
|
GB9618960D0
(en)
|
1996-09-11 |
1996-10-23 |
Medical Science Sys Inc |
Proteases
|
|
US5922676A
(en)
|
1996-09-20 |
1999-07-13 |
The Burnham Institute |
Methods of inhibiting cancer by using superfibronectin
|
|
JP3683282B2
(ja)
|
1996-10-17 |
2005-08-17 |
三菱化学株式会社 |
遺伝子型と表現型の対応付け分子及びその利用
|
|
US6348333B1
(en)
|
1997-01-17 |
2002-02-19 |
Toa Gosei Co., Ltd. |
VEGF-binding KDR polypeptide
|
|
DE69835143T2
(de)
|
1997-01-21 |
2007-06-06 |
The General Hospital Corp., Boston |
Selektion von proteinen mittels rns-protein fusionen
|
|
US6261804B1
(en)
|
1997-01-21 |
2001-07-17 |
The General Hospital Corporation |
Selection of proteins using RNA-protein fusions
|
|
CA2288994C
(en)
|
1997-04-30 |
2011-07-05 |
Enzon, Inc. |
Polyalkylene oxide-modified single chain polypeptides
|
|
EP1958962A3
(en)
|
1997-06-12 |
2013-05-01 |
Novartis International Pharmaceutical Ltd. |
Artificial antibody polypeptides
|
|
US6159722A
(en)
|
1997-12-03 |
2000-12-12 |
Boehringer Mannheim Gmbh |
Chimeric serine proteases
|
|
WO1999051773A1
(en)
|
1998-04-03 |
1999-10-14 |
Phylos, Inc. |
Addressable protein arrays
|
|
US20030045681A1
(en)
|
1998-05-11 |
2003-03-06 |
Anthony J. Zelano |
Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis
|
|
AU775076B2
(en)
|
1998-12-10 |
2004-07-15 |
Bristol-Myers Squibb Company |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US6818418B1
(en)
|
1998-12-10 |
2004-11-16 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US7115396B2
(en)
|
1998-12-10 |
2006-10-03 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
GB9827228D0
(en)
|
1998-12-10 |
1999-02-03 |
Univ Nottingham |
Cancer detection method and reagents
|
|
MXPA01010891A
(es)
|
1999-04-28 |
2002-11-07 |
Univ Texas |
Composiciones y metodos para el tratamiento contra el cancer mediante la inhibicion selectiva del factor de crecimiento endotelial vascular (vegf).
|
|
CA2377468C
(en)
|
1999-07-27 |
2010-04-20 |
Phylos, Inc. |
Peptide acceptor ligation methods
|
|
US20050019826A1
(en)
|
2000-03-31 |
2005-01-27 |
Roselyne Tournaire |
Peptides blocking vascular endothelial growth factor(vegf)-mediated angiogenesis, polynucleotides encoding said pepetides and methods of use thereof
|
|
AU2001268481A1
(en)
|
2000-06-15 |
2001-12-24 |
Board Of Regents, The University Of Texas System |
Regulatable, catalytically active nucleic acids
|
|
WO2002004523A2
(en)
|
2000-07-11 |
2002-01-17 |
Research Corporation Technologies, Inc. |
Artificial antibody polypeptides
|
|
ES2367891T3
(es)
|
2000-09-29 |
2011-11-10 |
Schering Corporation |
Interleucina-10 pegilada.
|
|
WO2002032925A2
(en)
|
2000-10-16 |
2002-04-25 |
Phylos, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US7598352B2
(en)
|
2000-11-17 |
2009-10-06 |
University Of Rochester |
Method of identifying polypeptide monobodies which bind to target proteins and use thereof
|
|
ATE306951T1
(de)
|
2000-11-29 |
2005-11-15 |
Allergan Inc |
Verhinderung von transplantatabstossung im auge
|
|
US6509027B2
(en)
|
2001-02-12 |
2003-01-21 |
Supergen, Inc. |
Injectable pharmaceutical composition comprising coated particles of camptothecin
|
|
US7556925B2
(en)
|
2001-04-04 |
2009-07-07 |
University Of Rochester |
ανβ3 integrin-binding polypeptide monobodies and their use
|
|
DK1390535T3
(da)
|
2001-04-26 |
2010-12-06 |
Amgen Mountain View Inc |
Kombinatoriske biblioteker af monomer-domæner
|
|
WO2003022858A2
(de)
|
2001-09-11 |
2003-03-20 |
Nascacell Gmbh |
Verfahren zum screenen von inhibitoren für die protein-protein-wechselwirkung sowie ribozyme hierzu
|
|
US20080193445A1
(en)
|
2002-01-18 |
2008-08-14 |
Liliane Goetsch |
Novel anti-IGF-IR antibodies and uses thereof
|
|
CN101172104B
(zh)
|
2002-02-22 |
2013-04-03 |
默沙东公司 |
抗肿瘤剂,特别是替莫唑胺的药物制剂,其制备方法和用途
|
|
JP2005526506A
(ja)
|
2002-03-04 |
2005-09-08 |
イムクローン システムズ インコーポレイティド |
Kdrに特異的なヒト抗体及びその利用
|
|
WO2003104418A2
(en)
|
2002-06-06 |
2003-12-18 |
Research Corporation Technologies, Inc. |
Reconstituted polypeptides
|
|
PT2316852E
(pt)
|
2002-11-08 |
2014-06-23 |
Ablynx Nv |
Anticorpos de domínio único estáveis
|
|
JP2007535895A
(ja)
|
2003-05-01 |
2007-12-13 |
イムクローン システムズ インコーポレイティド |
ヒトインシュリン様成長因子−1受容体に対する完全ヒト抗体
|
|
US7053701B2
(en)
|
2003-11-04 |
2006-05-30 |
Vice Michael W |
Power amplifier output stage with multiple power states and improved efficiency
|
|
CN104132043B
(zh)
|
2003-11-17 |
2017-04-12 |
远程接合技术公司 |
固定器和其他组件
|
|
US20080220049A1
(en)
|
2003-12-05 |
2008-09-11 |
Adnexus, A Bristol-Myers Squibb R&D Company |
Compositions and methods for intraocular delivery of fibronectin scaffold domain proteins
|
|
BRPI0417302A
(pt)
|
2003-12-05 |
2007-03-06 |
Compound Therapeutics Inc |
inibidores de receptores de fator de crescimento endotelial vascular do tipo 2
|
|
EP1729795B1
(en)
|
2004-02-09 |
2016-02-03 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
US20060182783A1
(en)
|
2004-04-30 |
2006-08-17 |
Allergan, Inc. |
Sustained release intraocular drug delivery systems
|
|
US20050244469A1
(en)
|
2004-04-30 |
2005-11-03 |
Allergan, Inc. |
Extended therapeutic effect ocular implant treatments
|
|
US20070059336A1
(en)
|
2004-04-30 |
2007-03-15 |
Allergan, Inc. |
Anti-angiogenic sustained release intraocular implants and related methods
|
|
WO2005110374A1
(en)
|
2004-04-30 |
2005-11-24 |
Allergan, Inc. |
Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component
|
|
WO2006020258A2
(en)
|
2004-07-17 |
2006-02-23 |
Imclone Systems Incorporated |
Novel tetravalent bispecific antibody
|
|
US7597884B2
(en)
|
2004-08-09 |
2009-10-06 |
Alios Biopharma, Inc. |
Hyperglycosylated polypeptide variants and methods of use
|
|
MX2007003789A
(es)
|
2004-10-04 |
2007-07-20 |
Qlt Usa Inc |
Suministro ocular de formulaciones polimericas para suministro.
|
|
EP1838307A1
(en)
|
2004-12-02 |
2007-10-03 |
Schering Corporation |
Methods of using temozolomide formulation intrathecally in the treatment of cancers
|
|
WO2006091209A2
(en)
|
2005-02-23 |
2006-08-31 |
Merrimack Pharmaceuticals, Inc. |
Bispecific binding agents for modulating biological activity
|
|
FR2888850B1
(fr)
|
2005-07-22 |
2013-01-11 |
Pf Medicament |
Nouveaux anticorps anti-igf-ir et leurs applications
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
US20070072933A1
(en)
|
2005-09-26 |
2007-03-29 |
Peyman Gholam A |
Delivery of an ocular agent
|
|
US8097438B2
(en)
|
2005-10-07 |
2012-01-17 |
The Regents Of The University Of California |
Nucleic acids encoding modified cytochrome P450 enzymes and methods of use thereof
|
|
MX2007012061A
(es)
|
2005-10-18 |
2007-12-13 |
Allergan Inc |
Terapia ocular que usa derivados glucocorticoides que penetran selectivamente los tejidos del segmento posterior.
|
|
US20070099879A1
(en)
|
2005-10-31 |
2007-05-03 |
Wisconsin Alumni Research Foundation (Warf) |
Method of using calcitriol for treating intraocular diseases associated with angiogenesis
|
|
DE502005009389D1
(de)
|
2005-11-09 |
2010-05-20 |
Morphosys Ag |
Identifizierung und charakterisierung von funktionsblockierenden anti-ed-b-fibronektin antikörpern
|
|
MX2008006626A
(es)
|
2005-11-23 |
2008-09-24 |
Acceleron Pharma Inc |
Antagonistas de activin-actriia y usos para promover el crecimiento de huesos.
|
|
EP2397148A3
(en)
|
2006-02-02 |
2012-04-25 |
Allergan, Inc. |
Compositions and methods for the treatment of ophthalmic disease
|
|
CN101384279B
(zh)
|
2006-02-24 |
2012-02-22 |
奇斯药制品公司 |
抗淀粉样蛋白免疫原性组合物、方法和用途
|
|
BRPI0710242A2
(pt)
|
2006-04-21 |
2011-08-09 |
Transgene Sa |
uso de uma composição
|
|
US20070269422A1
(en)
|
2006-05-17 |
2007-11-22 |
Ablynx N.V. |
Serum albumin binding proteins with long half-lives
|
|
ES2613957T3
(es)
|
2006-08-04 |
2017-05-29 |
Medimmune Limited |
Anticuerpos contra ERBB2
|
|
US7882645B2
(en)
|
2006-08-07 |
2011-02-08 |
Boring Colette R |
System and method for making an applique
|
|
WO2008031098A1
(en)
|
2006-09-09 |
2008-03-13 |
The University Of Chicago |
Binary amino acid libraries for fibronectin type iii polypeptide monobodies
|
|
CA2666507A1
(en)
|
2006-10-16 |
2008-04-24 |
The Arizona Board Of Regents, A Body Corporate Of The State Of Arizona A Cting For And On Behalf Of Arizona State University |
Synthetic antibodies
|
|
CA2670471A1
(en)
|
2006-11-22 |
2008-06-05 |
Adnexus, A Bristol-Myers Squibb R&D Company (A Delaware Corporation) |
Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir
|
|
US8476243B2
(en)
*
|
2006-12-29 |
2013-07-02 |
Transderm, Inc. |
Methods and compositions for treating keratin hyperproliferative disorders
|
|
WO2008097497A2
(en)
|
2007-02-02 |
2008-08-14 |
Adnexus, A Bristol-Myers Squibb R & D Company |
Vegf pathway blockade
|
|
MX2009009379A
(es)
|
2007-03-02 |
2009-09-14 |
Amgen Inc |
Metodos y composiciones para tratar enfermedades tumorales.
|
|
US11078262B2
(en)
|
2007-04-30 |
2021-08-03 |
Allergan, Inc. |
High viscosity macromolecular compositions for treating ocular conditions
|
|
EP2738257A1
(en)
*
|
2007-05-22 |
2014-06-04 |
Amgen Inc. |
Compositions and methods for producing bioactive fusion proteins
|
|
US20090176654A1
(en)
|
2007-08-10 |
2009-07-09 |
Protelix, Inc. |
Universal fibronectin type III binding-domain libraries
|
|
US8470966B2
(en)
|
2007-08-10 |
2013-06-25 |
Protelica, Inc. |
Universal fibronectin type III binding-domain libraries
|
|
US8680019B2
(en)
|
2007-08-10 |
2014-03-25 |
Protelica, Inc. |
Universal fibronectin Type III binding-domain libraries
|
|
US20100285000A1
(en)
|
2007-08-20 |
2010-11-11 |
Bristol-Myers Squibb Company |
Use of vegfr-2 inhibitors for treating metastatic cancer
|
|
EA201000343A1
(ru)
|
2007-10-04 |
2011-10-31 |
Займодженетикс, Инк. |
ЧЛЕН СЕМЕЙСТВА B7, zB7H6 И РОДСТВЕННЫЕ КОМПОЗИЦИИ И СПОСОБЫ
|
|
CN101932720A
(zh)
|
2007-10-31 |
2010-12-29 |
米迪缪尼有限公司 |
蛋白质支架
|
|
EP2217274A1
(en)
|
2007-11-28 |
2010-08-18 |
Bristol-Myers Squibb Company |
Combination vegfr2 therapy with mtor inhibitors
|
|
AU2008345674A1
(en)
|
2007-12-19 |
2009-07-09 |
Centocor, Ortho Biotech Inc. |
Alternative scaffold protein fusions phage display via fusion to pIX of M13 phage
|
|
CA2710835A1
(en)
|
2007-12-27 |
2009-07-09 |
Novartis Ag |
Improved fibronectin-based binding molecules and their use
|
|
JP2011517314A
(ja)
|
2008-02-14 |
2011-06-02 |
ブリストル−マイヤーズ スクイブ カンパニー |
Egfrに結合する操作されたタンパク質に基づく標的化された治療薬
|
|
WO2009133208A1
(en)
*
|
2008-05-02 |
2009-11-05 |
Novartis Ag |
Improved fibronectin-based binding molecules and uses thereof
|
|
CN102099373A
(zh)
|
2008-05-22 |
2011-06-15 |
百时美施贵宝公司 |
基于纤连蛋白的多价支架结构域蛋白
|
|
RS55218B1
(sr)
|
2008-10-31 |
2017-02-28 |
Janssen Biotech Inc |
Kompozicije fibronektin tip iii skalno baziranih domena, metode i upotrebe
|
|
US8415291B2
(en)
|
2008-10-31 |
2013-04-09 |
Centocor Ortho Biotech Inc. |
Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses
|
|
TWI496582B
(zh)
*
|
2008-11-24 |
2015-08-21 |
必治妥美雅史谷比公司 |
雙重專一性之egfr/igfir結合分子
|
|
WO2010069913A1
(en)
|
2008-12-16 |
2010-06-24 |
Novartis Ag |
Yeast display systems
|
|
EP2396000A1
(en)
|
2009-02-11 |
2011-12-21 |
Bristol-Myers Squibb Company |
Combination vegfr2 therapy with temozolomide
|
|
MX2011008566A
(es)
|
2009-02-12 |
2011-11-29 |
Janssen Biotech Inc |
Composiciones supercontigo basadas en el dominio de fibronectina tipo iii, metodos y usos.
|
|
US8067201B2
(en)
|
2009-04-17 |
2011-11-29 |
Bristol-Myers Squibb Company |
Methods for protein refolding
|
|
US20120270797A1
(en)
|
2009-08-13 |
2012-10-25 |
Massachusetts Institute Of Technology |
Engineered proteins including mutant fibronectin domains
|
|
WO2011051333A1
(en)
|
2009-10-30 |
2011-05-05 |
Novartis Ag |
Universal fibronectin type iii bottom-side binding domain libraries
|
|
WO2011051466A1
(en)
|
2009-11-02 |
2011-05-05 |
Novartis Ag |
Anti-idiotypic fibronectin-based binding molecules and uses thereof
|
|
US20110123545A1
(en)
|
2009-11-24 |
2011-05-26 |
Bristol-Myers Squibb Company |
Combination of vegfr2 and igf1r inhibitors for the treatment of proliferative diseases
|
|
WO2011092233A1
(en)
|
2010-01-29 |
2011-08-04 |
Novartis Ag |
Yeast mating to produce high-affinity combinations of fibronectin-based binders
|
|
CA2788972A1
(en)
|
2010-02-12 |
2011-08-18 |
University Of Rochester |
Antigenic mimics of discontinuous epitopes of pathogen recognized by broadly neutralizing antibodies
|
|
US8927693B2
(en)
|
2010-02-18 |
2015-01-06 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold domain proteins that bind IL-23
|
|
JP2013523179A
(ja)
|
2010-04-13 |
2013-06-17 |
メディミューン,エルエルシー |
フィブロネクチンタイプiiiドメインに基づく多量体足場
|
|
UY33331A
(es)
*
|
2010-04-13 |
2011-10-31 |
Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware |
Proteinas de dominio de armazon basadas en fibronectina que se unen a pcsk9
|
|
RU2767543C2
(ru)
|
2010-04-30 |
2022-03-17 |
Янссен Байотек, Инк. |
Композиции на основе стабилизированных фибронектиновых доменов, способы и области их применения
|
|
TW201138808A
(en)
|
2010-05-03 |
2011-11-16 |
Bristol Myers Squibb Co |
Serum albumin binding molecules
|
|
EP2576615B1
(en)
|
2010-05-26 |
2016-03-30 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold proteins having improved stability
|
|
JP6092773B2
(ja)
|
2010-07-30 |
2017-03-08 |
ノバルティス アーゲー |
フィブロネクチンクレードル分子及びそのライブラリ
|
|
JP2014504587A
(ja)
|
2010-12-22 |
2014-02-24 |
ブリストル−マイヤーズ スクイブ カンパニー |
Il−23に結合するフィブロネクチンをベースとするスカフォールドドメインタンパク質
|
|
US9469676B2
(en)
|
2011-04-13 |
2016-10-18 |
Bristol-Myers Squibb Company |
Fc fusion proteins comprising novel linkers or arrangements
|
|
ES2848531T3
(es)
|
2011-05-17 |
2021-08-10 |
Bristol Myers Squibb Co |
Métodos mejorados para la selección de proteínas de unión
|
|
US20140187488A1
(en)
|
2011-05-17 |
2014-07-03 |
Bristol-Myers Squibb Company |
Methods for maintaining pegylation of polypeptides
|
|
US9200273B2
(en)
|
2011-09-27 |
2015-12-01 |
Janssen Biotech, Inc. |
Fibronectin type III repeat based protein scaffolds with alternative binding surfaces
|
|
PL3564258T3
(pl)
*
|
2012-09-13 |
2021-10-25 |
Bristol-Myers Squibb Company |
Oparte na fibronektynie białka z domeną rusztowania, które wiążą się z miostatyną
|