|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4002531A
(en)
|
1976-01-22 |
1977-01-11 |
Pierce Chemical Company |
Modifying enzymes with polyethylene glycol and product produced thereby
|
|
USRE30985E
(en)
|
1978-01-01 |
1982-06-29 |
|
Serum-free cell culture media
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
US4419446A
(en)
|
1980-12-31 |
1983-12-06 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant DNA process utilizing a papilloma virus DNA as a vector
|
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4601978A
(en)
|
1982-11-24 |
1986-07-22 |
The Regents Of The University Of California |
Mammalian metallothionein promoter system
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
EP0206448B1
(en)
|
1985-06-19 |
1990-11-14 |
Ajinomoto Co., Inc. |
Hemoglobin combined with a poly(alkylene oxide)
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
US5770697A
(en)
|
1986-11-04 |
1998-06-23 |
Protein Polymer Technologies, Inc. |
Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
|
|
US6018030A
(en)
|
1986-11-04 |
2000-01-25 |
Protein Polymer Technologies, Inc. |
Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
|
|
US5641648A
(en)
|
1986-11-04 |
1997-06-24 |
Protein Polymer Technologies, Inc. |
Methods for preparing synthetic repetitive DNA
|
|
US5514581A
(en)
|
1986-11-04 |
1996-05-07 |
Protein Polymer Technologies, Inc. |
Functional recombinantly prepared synthetic protein polymer
|
|
US4863457A
(en)
|
1986-11-24 |
1989-09-05 |
Lee David A |
Drug delivery device
|
|
US4997652A
(en)
|
1987-12-22 |
1991-03-05 |
Visionex |
Biodegradable ocular implants
|
|
DE68925971T2
(de)
|
1988-09-23 |
1996-09-05 |
Cetus Oncology Corp |
Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
|
|
FR2646437B1
(fr)
|
1989-04-28 |
1991-08-30 |
Transgene Sa |
Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
|
|
US5164188A
(en)
|
1989-11-22 |
1992-11-17 |
Visionex, Inc. |
Biodegradable ocular implants
|
|
US5766897A
(en)
|
1990-06-21 |
1998-06-16 |
Incyte Pharmaceuticals, Inc. |
Cysteine-pegylated proteins
|
|
AU8498091A
(en)
|
1990-08-02 |
1992-03-02 |
Regents Of The University Of Colorado, The |
Systematic polypeptide evolution by reverse translation
|
|
JP3051145B2
(ja)
|
1990-08-28 |
2000-06-12 |
住友製薬株式会社 |
新規なポリエチレングリコール誘導体修飾ペプチド
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
KR0185215B1
(ko)
|
1990-11-30 |
1999-05-01 |
요시다 쇼오지 |
서방성 안구삽입용 약제
|
|
US5773574A
(en)
|
1990-12-03 |
1998-06-30 |
The Scripps Research Institute |
Polypeptides for promoting cell attachment
|
|
US5235041A
(en)
|
1990-12-28 |
1993-08-10 |
Protein Polymer Technologies, Inc. |
Purification of structurally ordered recombinant protein polymers
|
|
JPH04108827U
(ja)
|
1991-03-04 |
1992-09-21 |
カシオ計算機株式会社 |
電子機器におけるスライドスイツチ構造
|
|
US5792742A
(en)
|
1991-06-14 |
1998-08-11 |
New York University |
Fibrin-binding peptide fragments of fibronectin
|
|
US5281698A
(en)
|
1991-07-23 |
1994-01-25 |
Cetus Oncology Corporation |
Preparation of an activated polymer ester for protein conjugation
|
|
AU2313392A
(en)
|
1991-08-01 |
1993-03-02 |
University Research Corporation |
Systematic polypeptide evolution by reverse translation
|
|
AU673190B2
(en)
|
1992-07-13 |
1996-10-31 |
Bionebraska, Inc. |
Method for modification of recombinant polypeptides
|
|
US5382657A
(en)
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
|
NZ258392A
(en)
|
1992-11-13 |
1997-09-22 |
Idec Pharma Corp |
Chimeric and radiolabelled antibodies to the b lymphocyte cellsurface antigen bp35 (cd-20) and their use in the treatment of b cell lymphona
|
|
WO1994017097A1
(en)
|
1993-01-19 |
1994-08-04 |
Regents Of The University Of Minnesota |
Synthetic fibronectin fragments as inhibitors of retroviral infections
|
|
PT654256E
(pt)
|
1993-02-26 |
2000-12-29 |
Santen Pharmaceutical Co Ltd |
Rolha de esclerotica biodegradavel
|
|
WO1995011922A1
(en)
|
1993-10-29 |
1995-05-04 |
Affymax Technologies N.V. |
In vitro peptide and antibody display libraries
|
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
|
US5443505A
(en)
|
1993-11-15 |
1995-08-22 |
Oculex Pharmaceuticals, Inc. |
Biocompatible ocular implants
|
|
US5516522A
(en)
|
1994-03-14 |
1996-05-14 |
Board Of Supervisors Of Louisiana State University |
Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US5559000A
(en)
|
1995-01-18 |
1996-09-24 |
The Scripps Research Institute |
Encoded reaction cassette
|
|
US6369116B1
(en)
|
1995-06-02 |
2002-04-09 |
Oculex Pharmaceuticals, Inc. |
Composition and method for treating glaucoma
|
|
US5869079A
(en)
|
1995-06-02 |
1999-02-09 |
Oculex Pharmaceuticals, Inc. |
Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
|
|
DE19646372C1
(de)
|
1995-11-11 |
1997-06-19 |
Evotec Biosystems Gmbh |
Genotyp und Phänotyp koppelnde Verbindung
|
|
JP3556050B2
(ja)
|
1996-06-24 |
2004-08-18 |
株式会社大井製作所 |
ドアクロージャ
|
|
GB9618960D0
(en)
|
1996-09-11 |
1996-10-23 |
Medical Science Sys Inc |
Proteases
|
|
US5922676A
(en)
|
1996-09-20 |
1999-07-13 |
The Burnham Institute |
Methods of inhibiting cancer by using superfibronectin
|
|
DE69730157T2
(de)
|
1996-10-17 |
2005-07-28 |
Mitsubishi Chemical Corp. |
Molekül, welches genotyp und phänotyp zusammenführt und dessen anwendungen
|
|
WO1998031794A1
(fr)
|
1997-01-17 |
1998-07-23 |
Toa Gosei Co., Ltd. |
Polypeptide liant le facteur vegf
|
|
EP1712623B1
(en)
|
1997-01-21 |
2011-10-19 |
The General Hospital Corporation |
Selection of proteins using RNA-protein fusions
|
|
US6261804B1
(en)
|
1997-01-21 |
2001-07-17 |
The General Hospital Corporation |
Selection of proteins using RNA-protein fusions
|
|
CA2288992C
(en)
|
1997-04-30 |
2012-06-12 |
Enzon, Inc. |
Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof
|
|
EP0985039B1
(en)
|
1997-06-12 |
2008-02-20 |
Novartis International Pharmaceutical Ltd. |
Artificial antibody polypeptides
|
|
US6159722A
(en)
|
1997-12-03 |
2000-12-12 |
Boehringer Mannheim Gmbh |
Chimeric serine proteases
|
|
JP2002510505A
(ja)
|
1998-04-03 |
2002-04-09 |
フィロス インク. |
位置特定可能な蛋白質アレイ
|
|
US20030045681A1
(en)
|
1998-05-11 |
2003-03-06 |
Anthony J. Zelano |
Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis
|
|
US6818418B1
(en)
|
1998-12-10 |
2004-11-16 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US7115396B2
(en)
|
1998-12-10 |
2006-10-03 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
GB9827228D0
(en)
|
1998-12-10 |
1999-02-03 |
Univ Nottingham |
Cancer detection method and reagents
|
|
DE69941267D1
(de)
|
1998-12-10 |
2009-09-24 |
Bristol Myers Squibb Co |
Proteingerüste für antikörper-nachahmer und andere bindende proteine
|
|
US6342221B1
(en)
|
1999-04-28 |
2002-01-29 |
Board Of Regents, The University Of Texas System |
Antibody conjugate compositions for selectively inhibiting VEGF
|
|
ATE551352T1
(de)
|
1999-07-27 |
2012-04-15 |
Bristol Myers Squibb Co |
Peptidakzeptorbindungsverfahren
|
|
AU4445601A
(en)
|
2000-03-31 |
2001-10-08 |
Centre National De La Recherche Scientifique-Cnrs |
Peptides blocking vascular endothelial growth factor (vegf)-mediated angiogenesis, polynucleotides encoding said peptides and methods of use thereof
|
|
US20030104520A1
(en)
|
2000-06-15 |
2003-06-05 |
Ellington Andrew D. |
Regulatable, catalytically active nucleic acids
|
|
ES2564161T3
(es)
|
2000-07-11 |
2016-03-18 |
Research Corporation Technologies, Inc |
Polipéptidos de anticuerpos artificiales
|
|
EP2295450B1
(en)
|
2000-09-29 |
2015-01-28 |
Merck Sharp & Dohme Corp. |
Pegylated interleukin-10
|
|
EP2141243A3
(en)
|
2000-10-16 |
2010-01-27 |
Brystol-Myers Squibb Company |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US7598352B2
(en)
|
2000-11-17 |
2009-10-06 |
University Of Rochester |
Method of identifying polypeptide monobodies which bind to target proteins and use thereof
|
|
ATE306951T1
(de)
|
2000-11-29 |
2005-11-15 |
Allergan Inc |
Verhinderung von transplantatabstossung im auge
|
|
US6509027B2
(en)
|
2001-02-12 |
2003-01-21 |
Supergen, Inc. |
Injectable pharmaceutical composition comprising coated particles of camptothecin
|
|
EP1572718A4
(en)
|
2001-04-04 |
2006-03-15 |
Univ Rochester |
ALPHA NU BETA-3 INTEGRIN BINDING POLYPEPTIDE ANTIBODY AND THEIR USE
|
|
AU2002256371B2
(en)
|
2001-04-26 |
2008-01-10 |
Amgen Mountain View Inc. |
Combinatorial libraries of monomer domains
|
|
WO2003022858A2
(de)
|
2001-09-11 |
2003-03-20 |
Nascacell Gmbh |
Verfahren zum screenen von inhibitoren für die protein-protein-wechselwirkung sowie ribozyme hierzu
|
|
US20080193445A1
(en)
|
2002-01-18 |
2008-08-14 |
Liliane Goetsch |
Novel anti-IGF-IR antibodies and uses thereof
|
|
DK1478339T3
(da)
|
2002-02-22 |
2008-08-25 |
Schering Corp |
Farmaceutiske formuleringer af antineoplastiske midler, specielt temozolomid, fremgangsmåder til fremstilling og anvendelse heraf
|
|
AU2003213687A1
(en)
|
2002-03-04 |
2003-09-22 |
Imclone Systems Incorporated |
Human antibodies specific to kdr and uses thereof
|
|
WO2003104418A2
(en)
|
2002-06-06 |
2003-12-18 |
Research Corporation Technologies, Inc. |
Reconstituted polypeptides
|
|
ES2466716T3
(es)
|
2002-11-08 |
2014-06-11 |
Ablynx N.V. |
Anticuerpos de un solo dominio estabilizados
|
|
CA2524305C
(en)
|
2003-05-01 |
2015-12-08 |
Imclone Systems Incorporated |
Fully human antibodies directed against the human insulin-like growth factor-1 receptor
|
|
US7053701B2
(en)
|
2003-11-04 |
2006-05-30 |
Vice Michael W |
Power amplifier output stage with multiple power states and improved efficiency
|
|
US7610783B2
(en)
|
2003-11-17 |
2009-11-03 |
Telezygology Inc. |
Fasteners and other assemblies
|
|
BRPI0417302A
(pt)
|
2003-12-05 |
2007-03-06 |
Compound Therapeutics Inc |
inibidores de receptores de fator de crescimento endotelial vascular do tipo 2
|
|
US20080220049A1
(en)
|
2003-12-05 |
2008-09-11 |
Adnexus, A Bristol-Myers Squibb R&D Company |
Compositions and methods for intraocular delivery of fibronectin scaffold domain proteins
|
|
ES2567634T3
(es)
|
2004-02-09 |
2016-04-25 |
Human Genome Sciences, Inc. |
Proteínas de fusión de albúmina
|
|
US20060182783A1
(en)
|
2004-04-30 |
2006-08-17 |
Allergan, Inc. |
Sustained release intraocular drug delivery systems
|
|
US20070059336A1
(en)
|
2004-04-30 |
2007-03-15 |
Allergan, Inc. |
Anti-angiogenic sustained release intraocular implants and related methods
|
|
WO2005110374A1
(en)
|
2004-04-30 |
2005-11-24 |
Allergan, Inc. |
Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component
|
|
US20050244469A1
(en)
|
2004-04-30 |
2005-11-03 |
Allergan, Inc. |
Extended therapeutic effect ocular implant treatments
|
|
JP2008512352A
(ja)
|
2004-07-17 |
2008-04-24 |
イムクローン システムズ インコーポレイティド |
新規な四価の二重特異性抗体
|
|
US7597884B2
(en)
|
2004-08-09 |
2009-10-06 |
Alios Biopharma, Inc. |
Hyperglycosylated polypeptide variants and methods of use
|
|
US20060210604A1
(en)
|
2004-10-04 |
2006-09-21 |
Eric Dadey |
Ocular delivery of polymeric delivery formulations
|
|
EP1838307A1
(en)
|
2004-12-02 |
2007-10-03 |
Schering Corporation |
Methods of using temozolomide formulation intrathecally in the treatment of cancers
|
|
BRPI0519897A2
(pt)
|
2005-02-23 |
2009-08-18 |
Merrimack Pharmaceuticals Inc |
método para modular a atividade ou atividades biológicas de moléculas alvo em uma célula alvo, agente de ligação biespecìfico, composição, uso de um agente de ligação biespecìfico, e, kit
|
|
FR2888850B1
(fr)
|
2005-07-22 |
2013-01-11 |
Pf Medicament |
Nouveaux anticorps anti-igf-ir et leurs applications
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
US20070072933A1
(en)
|
2005-09-26 |
2007-03-29 |
Peyman Gholam A |
Delivery of an ocular agent
|
|
JP2009511020A
(ja)
|
2005-10-07 |
2009-03-19 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
改変チトクロームp450酵素をコードする核酸およびその使用法
|
|
CA2602577C
(en)
|
2005-10-18 |
2015-03-31 |
Allergan, Inc. |
Ocular therapy using glucocorticoid derivatives selectively penetrating posterior segment tissues
|
|
WO2007053807A2
(en)
|
2005-10-31 |
2007-05-10 |
Wisconsin Alumni Research Foundation |
Calcitriol for treating intraocular diseases associated with angiogenesis
|
|
JP2009514540A
(ja)
|
2005-11-09 |
2009-04-09 |
バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト |
機能−阻止抗−ed−b−フィブロネクチン抗体(private)の同定及び特徴化
|
|
AU2006318449B2
(en)
|
2005-11-23 |
2012-07-05 |
Acceleron Pharma Inc. |
Activin-actRIIa antagonists and uses for promoting bone growth
|
|
AU2007293169A1
(en)
|
2006-02-02 |
2008-03-13 |
Allergan, Inc. |
Compositions and methods for the treatment of ophthalmic disease
|
|
CA2638841A1
(en)
|
2006-02-24 |
2007-08-30 |
Chiesi Farmaceutici S.P.A. |
Anti-amyloid immunogenic compositions, methods and uses
|
|
WO2007121894A2
(en)
|
2006-04-21 |
2007-11-01 |
Transgene S.A. |
Hpv-18-based papillomavirus vaccine
|
|
US20070269422A1
(en)
|
2006-05-17 |
2007-11-22 |
Ablynx N.V. |
Serum albumin binding proteins with long half-lives
|
|
BRPI0714728A2
(pt)
|
2006-08-04 |
2013-05-14 |
Astrazeneca Ab |
agente de ligaÇço alvejado, anticorpo, composiÇço, linhagem de cÉlula isolada molÉcula de Ácido nucleico isolada, vetor, cÉlula hospedeira, mÉtodos para produzir um agente de ligaÇço alvejado, para isolar um anticorpo ou porÇço de ligaÇço de antÍgeno do mesmo, para fabricar um anticorpo monoclonal humano, para tratar, prevenir ou aliviar os sintomas de um distérbio, para inibir a proliferaÇço de uma cÉlula cancerosa, para inibir uma atividade de erbb2 em uma cÉlula que expressa erbb2, e para modular uma atividade de erbb2 em uma cÉlula que expressa erbb2, e, animal transgÊnico nço humano ou planta transgÊnica
|
|
US7882645B2
(en)
|
2006-08-07 |
2011-02-08 |
Boring Colette R |
System and method for making an applique
|
|
WO2008031098A1
(en)
|
2006-09-09 |
2008-03-13 |
The University Of Chicago |
Binary amino acid libraries for fibronectin type iii polypeptide monobodies
|
|
CA2666507A1
(en)
|
2006-10-16 |
2008-04-24 |
The Arizona Board Of Regents, A Body Corporate Of The State Of Arizona A Cting For And On Behalf Of Arizona State University |
Synthetic antibodies
|
|
WO2008066752A2
(en)
|
2006-11-22 |
2008-06-05 |
Adnexus, A Bristol-Myers Squibb R & D Company |
Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir
|
|
US8476243B2
(en)
*
|
2006-12-29 |
2013-07-02 |
Transderm, Inc. |
Methods and compositions for treating keratin hyperproliferative disorders
|
|
ATE516814T1
(de)
|
2007-02-02 |
2011-08-15 |
Bristol Myers Squibb Co |
10fn3 domain zur behandlung von krankheiten begleitet von unerwünschter angiogenese
|
|
EP2129397B1
(en)
|
2007-03-02 |
2018-10-31 |
Amgen, Inc. |
Methods and compositions for treating tumor diseases
|
|
US11078262B2
(en)
|
2007-04-30 |
2021-08-03 |
Allergan, Inc. |
High viscosity macromolecular compositions for treating ocular conditions
|
|
CA2687141C
(en)
*
|
2007-05-22 |
2014-04-01 |
Amgen Inc. |
Compositions and methods for producing bioactive fusion proteins
|
|
US8470966B2
(en)
|
2007-08-10 |
2013-06-25 |
Protelica, Inc. |
Universal fibronectin type III binding-domain libraries
|
|
EP2222846B1
(en)
|
2007-08-10 |
2017-05-03 |
Protelix, Inc. |
Universal fibronectin type iii binding-domain libraries
|
|
US8680019B2
(en)
|
2007-08-10 |
2014-03-25 |
Protelica, Inc. |
Universal fibronectin Type III binding-domain libraries
|
|
WO2009025806A2
(en)
|
2007-08-20 |
2009-02-26 |
Adnexus, A Bristol-Myers Squibb R & D Company |
Use of vegfr-2 inhibitors for treating metastatic cancer
|
|
CA2971794C
(en)
|
2007-10-04 |
2020-03-24 |
Zymogenetics, Inc. |
B7 family member zb7h6 and related compositions and methods
|
|
JP2011501951A
(ja)
|
2007-10-31 |
2011-01-20 |
メディミューン,エルエルシー |
タンパク質足場
|
|
WO2009073115A1
(en)
|
2007-11-28 |
2009-06-11 |
Bristol-Myers Squibb Company |
Combination vegfr2 therapy with mtor inhibitors
|
|
AU2008345674A1
(en)
|
2007-12-19 |
2009-07-09 |
Centocor, Ortho Biotech Inc. |
Alternative scaffold protein fusions phage display via fusion to pIX of M13 phage
|
|
KR20100111283A
(ko)
|
2007-12-27 |
2010-10-14 |
노파르티스 아게 |
개선된 피브로넥틴계 결합 분자 및 그들의 용도
|
|
KR20100128291A
(ko)
|
2008-02-14 |
2010-12-07 |
브리스톨-마이어스 스큅 컴퍼니 |
Egfr에 결합하는 조작된 단백질을 기초로 하는 표적화된 치료제
|
|
EP3173424A1
(en)
|
2008-05-02 |
2017-05-31 |
Novartis Ag |
Improved fibronectin-based binding molecules and uses thereof
|
|
PE20091931A1
(es)
|
2008-05-22 |
2009-12-31 |
Bristol Myers Squibb Co |
Proteinas de dominio de armazon basadas en fibronectina multivalentes
|
|
PL2356269T3
(pl)
|
2008-10-31 |
2016-12-30 |
|
Kompozycje białek rusztowania oparte na domenie fibronektyny typu III, sposoby i zastosowania
|
|
US8415291B2
(en)
|
2008-10-31 |
2013-04-09 |
Centocor Ortho Biotech Inc. |
Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses
|
|
TWI496582B
(zh)
|
2008-11-24 |
2015-08-21 |
必治妥美雅史谷比公司 |
雙重專一性之egfr/igfir結合分子
|
|
MX2011006483A
(es)
|
2008-12-16 |
2011-07-13 |
Novartis Ag |
Sistemas de despliegue en levadura.
|
|
WO2010093771A1
(en)
|
2009-02-11 |
2010-08-19 |
Bristol-Myers Squibb Company |
Combination vegfr2 therapy with temozolomide
|
|
JP5873335B2
(ja)
|
2009-02-12 |
2016-03-01 |
ヤンセン バイオテツク,インコーポレーテツド |
フィブロネクチンiii型ドメインに基づくスカフォールド組成物、方法及び使用
|
|
US8067201B2
(en)
|
2009-04-17 |
2011-11-29 |
Bristol-Myers Squibb Company |
Methods for protein refolding
|
|
WO2011020033A2
(en)
|
2009-08-13 |
2011-02-17 |
Massachusetts Institute Of Technology |
Engineered proteins including mutant fibronectin domains
|
|
US9139825B2
(en)
|
2009-10-30 |
2015-09-22 |
Novartis Ag |
Universal fibronectin type III bottom-side binding domain libraries
|
|
WO2011051466A1
(en)
|
2009-11-02 |
2011-05-05 |
Novartis Ag |
Anti-idiotypic fibronectin-based binding molecules and uses thereof
|
|
US20110123545A1
(en)
|
2009-11-24 |
2011-05-26 |
Bristol-Myers Squibb Company |
Combination of vegfr2 and igf1r inhibitors for the treatment of proliferative diseases
|
|
WO2011092233A1
(en)
|
2010-01-29 |
2011-08-04 |
Novartis Ag |
Yeast mating to produce high-affinity combinations of fibronectin-based binders
|
|
US8961977B2
(en)
|
2010-02-12 |
2015-02-24 |
University Of Rochester |
Antigenic mimics of discontinuous epitopes of pathogen recognized by broadly neutralizing antibodies
|
|
EA201270713A1
(ru)
|
2010-02-18 |
2013-01-30 |
Бристол-Майерс Сквибб Компани |
Белки на основе фибронектина с каркасными доменами, которые связывают ил-23
|
|
CN102906112B
(zh)
|
2010-04-13 |
2016-12-07 |
米迪缪尼有限公司 |
Trail r2-特异性多聚体支架
|
|
EP2558491B1
(en)
*
|
2010-04-13 |
2018-07-04 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold domain proteins that bind pcsk9
|
|
US8569227B2
(en)
|
2010-04-30 |
2013-10-29 |
Janssen Biotech, Inc. |
Stabilized fibronectin domain compositions, methods and uses
|
|
TW201138808A
(en)
|
2010-05-03 |
2011-11-16 |
Bristol Myers Squibb Co |
Serum albumin binding molecules
|
|
WO2011150133A2
(en)
|
2010-05-26 |
2011-12-01 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold proteins having improved stability
|
|
KR20130136443A
(ko)
|
2010-07-30 |
2013-12-12 |
노파르티스 아게 |
피브로넥틴 크레이들 분자 및 그의 라이브러리
|
|
US9260496B2
(en)
|
2010-12-22 |
2016-02-16 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold domain proteins that bind IL-23
|
|
EP3144320B9
(en)
|
2011-04-13 |
2018-08-22 |
Bristol-Myers Squibb Company |
Fc fusion proteins comprising novel linkers or arrangements
|
|
EP3318880B1
(en)
|
2011-05-17 |
2020-12-16 |
Bristol-Myers Squibb Company |
Improved methods for the selection of binding proteins
|
|
EP2709669A1
(en)
|
2011-05-17 |
2014-03-26 |
Bristol-Myers Squibb Company |
Methods for maintaining pegylation of polypeptides
|
|
BR112014007469B1
(pt)
|
2011-09-27 |
2022-06-14 |
Janssen Biotech, Inc |
Método de fabricação de uma biblioteca de domínios de módulo de fibronectina tipo iii (fn3), biblioteca e método para obter um arcabouço de proteína
|
|
NZ628446A
(en)
*
|
2012-09-13 |
2017-06-30 |
Bristol Myers Squibb Co |
Fibronectin based scaffold domain proteins that bind to myostatin
|