JP2009509535A5 - - Google Patents
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- Publication number
- JP2009509535A5 JP2009509535A5 JP2008533574A JP2008533574A JP2009509535A5 JP 2009509535 A5 JP2009509535 A5 JP 2009509535A5 JP 2008533574 A JP2008533574 A JP 2008533574A JP 2008533574 A JP2008533574 A JP 2008533574A JP 2009509535 A5 JP2009509535 A5 JP 2009509535A5
- Authority
- JP
- Japan
- Prior art keywords
- cysteine
- scaffold
- protein
- natural
- target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 235000018417 cysteine Nutrition 0.000 claims 31
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 27
- 235000018102 proteins Nutrition 0.000 claims 24
- 102000004169 proteins and genes Human genes 0.000 claims 24
- 108090000623 proteins and genes Proteins 0.000 claims 24
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 230000002068 genetic effect Effects 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 150000001945 cysteines Chemical class 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 102000007562 Serum Albumin Human genes 0.000 claims 2
- 108010071390 Serum Albumin Proteins 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 210000003743 erythrocyte Anatomy 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72118805P | 2005-09-27 | 2005-09-27 | |
| US72127005P | 2005-09-27 | 2005-09-27 | |
| US74362206P | 2006-03-21 | 2006-03-21 | |
| PCT/US2006/037713 WO2007038619A2 (en) | 2005-09-27 | 2006-09-27 | Proteinaceous pharmaceuticals and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009509535A JP2009509535A (ja) | 2009-03-12 |
| JP2009509535A5 true JP2009509535A5 (enExample) | 2009-11-12 |
Family
ID=37900430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008533574A Withdrawn JP2009509535A (ja) | 2005-09-27 | 2006-09-27 | タンパク様薬剤およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20070191272A1 (enExample) |
| EP (1) | EP1929073A4 (enExample) |
| JP (1) | JP2009509535A (enExample) |
| AU (1) | AU2006294644A1 (enExample) |
| CA (1) | CA2622441A1 (enExample) |
| SI (1) | SI1996220T2 (enExample) |
| WO (1) | WO2007038619A2 (enExample) |
Families Citing this family (124)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPR673001A0 (en) * | 2001-07-31 | 2001-08-23 | Prince Henry's Institute Of Medical Research | Pregnancy-related enzyme activity |
| JP4885729B2 (ja) * | 2003-11-20 | 2012-02-29 | サノフィ パストゥール インコーポレイテッド | 百日咳毒素を精製する方法およびそれに有用なペプチド |
| US7855279B2 (en) * | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
| US20090099031A1 (en) * | 2005-09-27 | 2009-04-16 | Stemmer Willem P | Genetic package and uses thereof |
| JP2009509535A (ja) * | 2005-09-27 | 2009-03-12 | アムニクス, インコーポレイテッド | タンパク様薬剤およびその使用 |
| US7846445B2 (en) | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
| EA200970250A1 (ru) | 2006-09-05 | 2010-02-26 | Медарекс, Инк. | Антитела к костным морфогенетическим белкам и их рецепторам и способы их применения |
| EP2486941B1 (en) | 2006-10-02 | 2017-03-15 | E. R. Squibb & Sons, L.L.C. | Human antibodies that bind CXCR4 and uses thereof |
| BRPI0717902A2 (pt) | 2006-12-01 | 2013-10-29 | Medarex Inc | "anticorpo monoclonal humano isolado, composição, conjugado anticorpo-molécula parceria, imunoconjugado, molécula de ácido nucléico isolada, vetor de expressão, célula hospedeira, método para prepar um anticorpo anti-cd22, método para inibir o desenvolvimento de uma célula tumoral que expressa cd22 e método para tratar uma doença inflamatória ou autoimuneem um indivíduo" |
| CL2007003622A1 (es) | 2006-12-13 | 2009-08-07 | Medarex Inc | Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales. |
| AU2008262384B9 (en) | 2007-06-05 | 2014-11-27 | Yale University | Inhibitors of receptor tyrosine kinases and methods of use thereof |
| CN103298935A (zh) * | 2007-08-15 | 2013-09-11 | 阿穆尼克斯公司 | 用于改善生物活性多肽性能的组合物和方法 |
| WO2009152610A1 (en) * | 2008-06-20 | 2009-12-23 | The Royal Institution For The Advancement Of Learning/Mcgill University | Interleukin-2/soluble tgf-beta type ii receptor b conjugates and methods and uses thereof |
| CA2729322C (en) | 2008-06-24 | 2020-05-26 | Technische Universitaet Muenchen | Muteins of hngal and related proteins with affinity for a given target |
| MX344076B (es) | 2008-06-30 | 2016-12-05 | Esbatech Alcon Biomed Res Unit | Polipeptidos funcionalizados. |
| EP3629022A1 (en) | 2008-07-25 | 2020-04-01 | Richard W. Wagner | Protein screening methods |
| KR101127476B1 (ko) * | 2008-08-11 | 2012-03-23 | 아주대학교산학협력단 | 크링글 도메인의 구조에 기반한 단백질 골격 라이브러리 및 그 용도 |
| AU2010207552A1 (en) | 2009-01-21 | 2011-09-01 | Oxford Biotherapeutics Ltd. | PTA089 protein |
| US20110046060A1 (en) | 2009-08-24 | 2011-02-24 | Amunix Operating, Inc., | Coagulation factor IX compositions and methods of making and using same |
| SI2393828T1 (sl) | 2009-02-03 | 2017-01-31 | Amunix Operating Inc. | Podaljšani rekombinantni polipetidi in sestavki, ki jih obsegajo |
| ME02842B (me) | 2009-03-05 | 2018-01-20 | Squibb & Sons Llc | Potpuno ljudska antitijela specifična za cadm1 |
| EP2419121B1 (en) | 2009-04-17 | 2018-07-18 | New York University | Peptides targeting tnf family receptors and antagonizing tnf action, compositions, methods and uses thereof |
| EA030182B1 (ru) | 2009-04-20 | 2018-07-31 | Оксфорд Байотерепьютикс Лтд. | Антитела, специфические для кадгерина-17 |
| AU2010258898B8 (en) * | 2009-06-08 | 2015-02-05 | Amunix Operating Inc. | Glucose-regulating polypeptides and methods of making and using same |
| IE20090514A1 (en) | 2009-07-06 | 2011-02-16 | Opsona Therapeutics Ltd | Humanised antibodies and uses therof |
| BR112012002709A2 (pt) | 2009-08-05 | 2019-04-30 | Pieris Ag | formulações de liberação controlada de muteínas de lipocalina |
| GB0916749D0 (en) * | 2009-09-23 | 2009-11-04 | Mologic Ltd | Peptide cleaning agents |
| US20120231004A1 (en) | 2009-10-13 | 2012-09-13 | Oxford Biotherapeutic Ltd. | Antibodies |
| WO2011053937A2 (en) * | 2009-10-30 | 2011-05-05 | Bayer Healthcare Llc | Antibody mimetic scaffolds |
| EP2496605A1 (en) | 2009-11-02 | 2012-09-12 | Oxford Biotherapeutics Ltd. | Ror1 as therapeutic and diagnostic target |
| EP2496944A2 (en) | 2009-11-05 | 2012-09-12 | Novartis AG | Biomarkers predictive of progression of fibrosis |
| EP3660510A3 (en) | 2009-12-07 | 2020-07-08 | Pieris Pharmaceuticals GmbH | Muteins of human lipocalin 2 (lcn2, hngal) with affinity for a given target |
| BR112012019902A2 (pt) | 2010-02-10 | 2019-09-24 | Novartis Ag | "método e compostos para o crescimento muscular" |
| WO2011103583A2 (en) * | 2010-02-22 | 2011-08-25 | University Of Chicago | Methods and compositions related to anti-angiogenic peptides |
| US8986951B2 (en) | 2010-06-08 | 2015-03-24 | Pieris Ag | Tear lipocalin in muteins binding IL-4 R alpha |
| WO2012009704A2 (en) | 2010-07-16 | 2012-01-19 | Avantgen, Inc. | Novel peptides and uses thereof |
| CA2808392C (en) | 2010-08-16 | 2020-03-10 | Pieris Pharmaceuticals Gmbh | Binding proteins for hepcidin |
| SG10201508118WA (en) | 2010-09-30 | 2015-11-27 | Agency Science Tech & Res | Methods and reagents for detection and treatment of esophageal metaplasia |
| EP2640740B1 (en) | 2010-11-15 | 2017-03-15 | Pieris Pharmaceuticals GmbH | Muteins of human lipocalin 2 with affinity for glypican-3 (gpc3) |
| DK2646552T3 (en) | 2010-12-02 | 2017-10-23 | Pieris Pharmaceuticals Gmbh | MUTEINES OF HUMAN LIPOCALIN 2 WITH AFFINITY FOR CTLA-4 |
| GB201114858D0 (en) | 2011-08-29 | 2011-10-12 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of using the same |
| ES2704007T3 (es) | 2011-05-06 | 2019-03-13 | Nexvet Australia Pty Ltd | Anticuerpos anti-factor de crecimiento nervioso y procedimientos de preparación y uso de los mismos |
| ES2905682T3 (es) | 2011-05-06 | 2022-04-11 | Zoetis Services Llc | Anticuerpos anti-factor de crecimiento nervioso y métodos de preparación y uso de los mismos |
| CN103732621B (zh) | 2011-05-06 | 2020-04-24 | 內克斯威特澳大利亚私人有限公司 | 抗神经生长因子抗体及其制备和使用方法 |
| ME02632B (me) | 2011-06-28 | 2017-06-20 | Oxford Biotherapeutics Ltd | Terapeutski i dijagnostički cilj |
| ES2640960T3 (es) | 2011-06-28 | 2017-11-07 | Oxford Biotherapeutics Ltd. | Anticuerpos para ADP-ribosil ciclasa 2 |
| WO2013074840A1 (en) | 2011-11-15 | 2013-05-23 | Allergan, Inc. | Treatment of dry age related macular degeneration |
| ES2863410T3 (es) | 2011-12-13 | 2021-10-11 | Pieris Pharmaceuticals Gmbh | Métodos para prevenir o tratar ciertos trastornos mediante la inhibición de la unión de IL-4 y/o IL-13 a sus respectivos receptores. |
| CN111548418A (zh) | 2012-02-15 | 2020-08-18 | 比奥贝拉蒂治疗公司 | 因子viii组合物及其制备和使用方法 |
| NZ628014A (en) | 2012-02-15 | 2016-09-30 | Biogen Ma Inc | Recombinant factor viii proteins |
| WO2013174783A1 (en) | 2012-05-23 | 2013-11-28 | Pieris Ag | Lipocalin muteins with binding-affinity for glypican-3 (gpc-3) and use of lipocalin muteins for target-specific delivery to cells expressing gpc-3 |
| US9347057B2 (en) * | 2012-06-12 | 2016-05-24 | The Johns Hopkins University | Methods for efficient, expansive user-defined DNA mutagenesis |
| GB201213652D0 (en) | 2012-08-01 | 2012-09-12 | Oxford Biotherapeutics Ltd | Therapeutic and diagnostic target |
| AU2013300549B2 (en) * | 2012-08-08 | 2019-04-11 | Daiichi Sankyo Company,Limited | Peptide library and use thereof |
| GB201302447D0 (en) | 2013-02-12 | 2013-03-27 | Oxford Biotherapeutics Ltd | Therapeutic and diagnostic target |
| AU2014223824B2 (en) | 2013-02-28 | 2020-02-27 | Albert Einstein College Of Medicine, Inc. | Tuberculosis biomarkers and uses thereof |
| EP2968490A1 (en) | 2013-03-14 | 2016-01-20 | Daiichi Sankyo Co., Ltd. | Novel binding proteins for pcsk9 |
| RS62633B1 (sr) | 2013-03-15 | 2021-12-31 | Protagonist Therapeutics Inc | Analozi hepcidina i njihove primene |
| CA2891557A1 (en) | 2013-03-26 | 2014-05-22 | Pieris Ag | Novel specific-binding polypeptides and uses thereof |
| PE20160991A1 (es) * | 2013-07-25 | 2016-10-15 | Novartis Ag | Bioconjugados de polipeptidos de apelina sintetica |
| US9908919B2 (en) * | 2013-07-25 | 2018-03-06 | Novartis Ag | Cyclic apelin derivatives for the treatment of heart failure |
| US9683018B2 (en) * | 2013-07-25 | 2017-06-20 | Novartis Ag | Disulfide cyclic polypeptides for the treatment of heart failure |
| TW201536814A (zh) * | 2013-07-25 | 2015-10-01 | Novartis Ag | 用於治療心臟衰竭之合成環狀多肽 |
| AR097102A1 (es) | 2013-08-02 | 2016-02-17 | Pfizer | Anticuerpo anti-cxcr4 y conjugados de anticuerpo y fármaco |
| US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
| US11559580B1 (en) | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
| WO2015104406A2 (en) | 2014-01-13 | 2015-07-16 | Pieris Ag | Multi-specific polypeptide useful for localized tumor immunomodulation |
| SI3143037T1 (sl) | 2014-05-16 | 2021-11-30 | Protagonist Therapeutics, Inc. | Antagonisti integrin alpha4beta7 tioeterskih peptidov |
| SG10201912019WA (en) | 2014-05-22 | 2020-02-27 | Pieris Pharmaceuticals Gmbh | Novel specific-binding polypeptides and uses thereof |
| CN107206254B (zh) | 2014-07-17 | 2021-08-24 | 领导医疗有限公司 | 白细胞介素-23受体的口服肽抑制剂以及其治疗炎症性肠病的用途 |
| AU2016212087B2 (en) | 2015-01-28 | 2019-11-07 | Pieris Pharmaceuticals Gmbh | Novel proteins specific for angiogenesis |
| BR112017017530A2 (pt) | 2015-02-18 | 2018-04-17 | Sanofi | proteínas específicas para pioverdina e pioquelina |
| GB201506869D0 (en) | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
| GB201506870D0 (en) | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
| AU2016258977C1 (en) | 2015-05-04 | 2022-07-14 | Pieris Pharmaceuticals Gmbh | Anti-cancer fusion polypeptide |
| RU2736312C2 (ru) | 2015-05-04 | 2020-11-13 | ПИЕРИС ФАРМАСЬЮТИКАЛС ГмбХ | Белки, специфичные в отношении cd137 |
| US10273275B2 (en) | 2015-05-18 | 2019-04-30 | Pieris Pharmaceuticals Gmbh | Muteins of human lipocalin 2 with affinity for glypican-3 (GPC3) and methods of use thereof |
| AU2016262845B2 (en) | 2015-05-18 | 2020-07-23 | Pieris Pharmaceuticals Gmbh | Anti-cancer fusion polypeptide |
| EP3115371A1 (en) | 2015-07-07 | 2017-01-11 | Sanofi | Fusion molecules |
| KR20180029238A (ko) | 2015-07-15 | 2018-03-20 | 피어이스 파마슈티컬즈 게엠베하 | Lag-3에 특이적인 신규 단백질 |
| AU2016301303B2 (en) | 2015-08-03 | 2021-10-07 | Bioverativ Therapeutics Inc. | Factor IX fusion proteins and methods of making and using same |
| TWI799366B (zh) * | 2015-09-15 | 2023-04-21 | 美商建南德克公司 | 胱胺酸結骨架平臺 |
| EA035586B1 (ru) | 2015-11-30 | 2020-07-10 | Пиерис Острелиа Пти Лтд. | Новые антиангиогенные слитые белки |
| TW201725212A (zh) | 2015-12-10 | 2017-07-16 | 第一三共股份有限公司 | 特異性於降鈣素基因相關胜肽的新穎蛋白 |
| US20170209553A1 (en) | 2016-01-22 | 2017-07-27 | Transderm, Inc. | Delivery of botulinum with microneedle arrays |
| US20190264197A1 (en) * | 2016-07-27 | 2019-08-29 | Protagonist Therapeutics, Inc. | Disulfide-rich peptide libraries and methods of use thereof |
| CN106220713B (zh) * | 2016-08-08 | 2017-09-01 | 大连医科大学 | 一种蝎毒耐热合成肽及其用途 |
| WO2018087108A1 (en) | 2016-11-09 | 2018-05-17 | Pieris Pharmaceuticals Gmbh | Proteins specific for cd137 |
| WO2018102743A1 (en) | 2016-12-02 | 2018-06-07 | Bioverativ Therapeutics Inc. | Methods of treating hemophilic arthropathy using chimeric clotting factors |
| WO2018134274A1 (en) | 2017-01-18 | 2018-07-26 | Pieris Pharmaceuticals Gmbh | Lipocalin muteins with binding affinity for lag-3 |
| WO2018158398A1 (en) | 2017-03-02 | 2018-09-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antibodies having specificity to nectin-4 and uses thereof |
| CN111417656A (zh) | 2017-08-23 | 2020-07-14 | 西卡肿瘤解决方案有限公司 | 细胞膜穿透缀合物 |
| EP4501952A3 (en) | 2018-02-08 | 2025-04-16 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
| JP7763589B2 (ja) | 2018-05-18 | 2025-11-04 | バイオベラティブ セラピューティクス インコーポレイテッド | 血友病aを処置する方法 |
| EP3820883A4 (en) | 2018-07-12 | 2022-04-20 | Protagonist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| HRP20230590T2 (hr) | 2018-07-31 | 2024-02-16 | Pieris Pharmaceuticals Gmbh | Novi fuzijski protein specifičan za cd137 i pd-l1 |
| WO2020039984A1 (ja) * | 2018-08-20 | 2020-02-27 | 国立大学法人名古屋大学 | 化合物ライブラリ |
| EP3626265A1 (en) | 2018-09-21 | 2020-03-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-human cd45rc antibodies and uses thereof |
| EP3898658A1 (en) * | 2018-12-21 | 2021-10-27 | Vib Vzw | Fusion protein with a toxin and scaffold protein |
| JP7476219B2 (ja) | 2019-02-26 | 2024-04-30 | ピエリス ファーマシューティカルズ ゲーエムベーハー | Cd137およびgpc3に特異的な新規融合タンパク質 |
| GB201902648D0 (en) * | 2019-02-27 | 2019-04-10 | Cyca Oncosolutions Ltd | Cell membrane penetrating conjugates |
| GB201903233D0 (en) | 2019-03-08 | 2019-04-24 | Oxford Genetics Ltd | Method of selecting for antibodies |
| AU2020235455A1 (en) | 2019-03-08 | 2021-10-28 | Oxford Genetics Limited | Method of selecting for antibodies |
| WO2021116119A1 (en) | 2019-12-09 | 2021-06-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antibodies having specificity to her4 and uses thereof |
| SI4090670T1 (sl) | 2020-01-15 | 2025-08-29 | Janssen Biotech, Inc. | Peptidni zaviralci receptorja interlevkina-23 in njihova uporaba za zdravljenje vnetnih bolezni |
| EP4090669A4 (en) | 2020-01-15 | 2024-11-20 | Janssen Biotech, Inc. | PEPTIDE INHIBITORS OF THE INTERLEUKIN-23 RECEPTOR AND THEIR USE IN TREATING INFLAMMATORY DISEASES |
| KR20230004510A (ko) | 2020-03-20 | 2023-01-06 | 인썸(인스티튜트 내셔날 드 라 싼테 에 드 라 리셰르셰메디칼르) | 인간 cd45rc에 특이적인 키메라 항원 수용체 및 이의 용도 |
| EP3882257A1 (en) * | 2020-03-20 | 2021-09-22 | Ospedale San Raffaele S.r.l. | Ngr conjugates and uses thereof |
| CN115551553A (zh) | 2020-05-12 | 2022-12-30 | Inserm(法国国家健康医学研究院) | 治疗皮肤t细胞淋巴瘤和tfh起源淋巴瘤的新方法 |
| JP2023527908A (ja) | 2020-06-05 | 2023-06-30 | ピエリス ファーマシューティカルズ ゲーエムベーハー | 4-1bbをターゲティングする多量体免疫調節物質 |
| WO2022043686A1 (en) * | 2020-08-25 | 2022-03-03 | Thrombosis Research Institute | Vaccine |
| IL316550A (en) | 2020-11-20 | 2024-12-01 | Janssen Pharmaceutica Nv | Compositions of interleukin-23 receptor peptide inhibitors |
| EP4320141A1 (en) | 2021-04-08 | 2024-02-14 | Pieris Pharmaceuticals GmbH | Novel lipocalin muteins specific for connective tissue growth factor (ctgf) |
| WO2022243341A1 (en) | 2021-05-18 | 2022-11-24 | Pieris Pharmaceuticals Gmbh | Lipocalin muteins with binding affinity for ox40 |
| IL310061A (en) | 2021-07-14 | 2024-03-01 | Janssen Biotech Inc | Peptide inhibitors linked to fatty residues of the interleukin-23 receptor |
| WO2023170296A1 (en) | 2022-03-11 | 2023-09-14 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Nucleic acid system to specifically reprogram b and t cells and uses thereof |
| EP4584291A1 (en) | 2022-09-08 | 2025-07-16 | Institut National de la Santé et de la Recherche Médicale | Antibodies having specificity to ltbp2 and uses thereof |
| TW202428603A (zh) | 2022-09-21 | 2024-07-16 | 美商思進公司 | 新穎的cd137及cd228特異性融合蛋白 |
| CN115851703B (zh) * | 2023-01-04 | 2024-07-26 | 厦门大学 | 定向二硫键多元环肽库构建及配体筛选方法 |
| WO2025085727A1 (en) * | 2023-10-18 | 2025-04-24 | Bandarian Vahe | Papb as a bimoiety-dependent thioether installation tool |
| WO2025175123A1 (en) | 2024-02-16 | 2025-08-21 | Seagen Inc. | Methods of treating cancer using fusion proteins specific for cd137 and cd228 |
| WO2025224297A1 (en) | 2024-04-26 | 2025-10-30 | Institut National de la Santé et de la Recherche Médicale | Antibodies having specificity to tgfbi and uses thereof |
| WO2025242732A1 (en) | 2024-05-21 | 2025-11-27 | Institut National de la Santé et de la Recherche Médicale | Pan antibodies against sars-cov-2 spike protein and uses thereof for therapeutical purposes |
| WO2025257181A1 (en) | 2024-06-11 | 2025-12-18 | Institut National de la Santé et de la Recherche Médicale | Antibodies targeting trans-active response dna-binding protein-43 (tdp-43) |
Family Cites Families (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3992518A (en) * | 1974-10-24 | 1976-11-16 | G. D. Searle & Co. | Method for making a microsealed delivery device |
| GB1478759A (en) * | 1974-11-18 | 1977-07-06 | Alza Corp | Process for forming outlet passageways in pills using a laser |
| US4284444A (en) * | 1977-08-01 | 1981-08-18 | Herculite Protective Fabrics Corporation | Activated polymer materials and process for making same |
| US4200984A (en) * | 1979-03-12 | 1980-05-06 | Fink Ray D | Detachable tool combining bracket and method |
| US4398908A (en) * | 1980-11-28 | 1983-08-16 | Siposs George G | Insulin delivery system |
| US4435173A (en) * | 1982-03-05 | 1984-03-06 | Delta Medical Industries | Variable rate syringe pump for insulin delivery |
| US4542025A (en) * | 1982-07-29 | 1985-09-17 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
| US5916588A (en) * | 1984-04-12 | 1999-06-29 | The Liposome Company, Inc. | Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use |
| US5231112A (en) * | 1984-04-12 | 1993-07-27 | The Liposome Company, Inc. | Compositions containing tris salt of cholesterol hemisuccinate and antifungal |
| ATE59302T1 (de) * | 1984-07-24 | 1991-01-15 | Key Pharma | Klebende schicht zur transdermalen freigabe. |
| US4684479A (en) * | 1985-08-14 | 1987-08-04 | Arrigo Joseph S D | Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures |
| US6759057B1 (en) * | 1986-06-12 | 2004-07-06 | The Liposome Company, Inc. | Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs |
| IE60901B1 (en) * | 1986-08-21 | 1994-08-24 | Vestar Inc | Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics |
| US4933185A (en) * | 1986-09-24 | 1990-06-12 | Massachusetts Institute Of Technology | System for controlled release of biologically active compounds |
| US6024983A (en) * | 1986-10-24 | 2000-02-15 | Southern Research Institute | Composition for delivering bioactive agents for immune response and its preparation |
| US6406713B1 (en) * | 1987-03-05 | 2002-06-18 | The Liposome Company, Inc. | Methods of preparing low-toxicity drug-lipid complexes |
| US4897268A (en) * | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| US4976696A (en) * | 1987-08-10 | 1990-12-11 | Becton, Dickinson And Company | Syringe pump and the like for delivering medication |
| US4861800A (en) * | 1987-08-18 | 1989-08-29 | Buyske Donald A | Method for administering the drug deprenyl so as to minimize the danger of side effects |
| AU598958B2 (en) * | 1987-11-12 | 1990-07-05 | Vestar, Inc. | Improved amphotericin b liposome preparation |
| US5270176A (en) * | 1987-11-20 | 1993-12-14 | Hoechst Aktiengesellschaft | Method for the selective cleavage of fusion proteins with lysostaphin |
| JP2717808B2 (ja) * | 1988-08-10 | 1998-02-25 | テルモ株式会社 | シリンジポンプ |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5017378A (en) * | 1989-05-01 | 1991-05-21 | The University Of Virginia Alumni Patents Foundation | Intraorgan injection of biologically active compounds contained in slow-release microcapsules or microspheres |
| ES2084698T5 (es) * | 1989-05-04 | 2005-03-01 | Southern Research Institute | Procedimiento de encapsulacion. |
| US5599907A (en) * | 1989-05-10 | 1997-02-04 | Somatogen, Inc. | Production and use of multimeric hemoglobins |
| US5298022A (en) * | 1989-05-29 | 1994-03-29 | Amplifon Spa | Wearable artificial pancreas |
| FR2647677B1 (fr) * | 1989-05-31 | 1991-09-27 | Roussel Uclaf | Nouvelles micro-proteines, procede de preparation et application a titre de medicaments de ces nouvelles micro-proteines |
| US7413537B2 (en) * | 1989-09-01 | 2008-08-19 | Dyax Corp. | Directed evolution of disulfide-bonded micro-proteins |
| US5492534A (en) * | 1990-04-02 | 1996-02-20 | Pharmetrix Corporation | Controlled release portable pump |
| US5318540A (en) * | 1990-04-02 | 1994-06-07 | Pharmetrix Corporation | Controlled release infusion device |
| US5176502A (en) * | 1990-04-25 | 1993-01-05 | Becton, Dickinson And Company | Syringe pump and the like for delivering medication |
| US6517859B1 (en) * | 1990-05-16 | 2003-02-11 | Southern Research Institute | Microcapsules for administration of neuroactive agents |
| US5215680A (en) * | 1990-07-10 | 1993-06-01 | Cavitation-Control Technology, Inc. | Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles |
| US5573776A (en) * | 1992-12-02 | 1996-11-12 | Alza Corporation | Oral osmotic device with hydrogel driving member |
| US5554730A (en) * | 1993-03-09 | 1996-09-10 | Middlesex Sciences, Inc. | Method and kit for making a polysaccharide-protein conjugate |
| US5981719A (en) * | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
| US6090925A (en) * | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
| CA2157793C (en) * | 1993-03-09 | 1999-07-13 | James E. Woiszwillo | Macromolecular microparticles and methods of production |
| US20020042079A1 (en) * | 1994-02-01 | 2002-04-11 | Sanford M. Simon | Methods and agents for measuring and controlling multidrug resistance |
| US5660848A (en) * | 1994-11-02 | 1997-08-26 | The Population Council, Center For Biomedical Research | Subdermally implantable device |
| GB9526733D0 (en) * | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
| PT929293E (pt) * | 1996-08-23 | 2004-03-31 | Sequus Pharm Inc | Lipossomas contendo um composto de cisplatina |
| JP2001503396A (ja) * | 1996-10-11 | 2001-03-13 | アルザ コーポレイション | 治療用リポソーム組成物および方法 |
| US6056973A (en) * | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| HUP0000522A3 (en) * | 1996-10-15 | 2000-10-30 | Transave Inc Monmouth Junction | N-acyl phoshpatidylethanolamine-mediated liposomal drug delivery |
| JP4863534B2 (ja) * | 1996-10-25 | 2012-01-25 | スパーナス ファーマシューティカルズ インコーポレイテッド | 可溶形態浸透用量送達システム |
| US6361796B1 (en) * | 1996-10-25 | 2002-03-26 | Shire Laboratories, Inc. | Soluble form osmotic dose delivery system |
| US6395302B1 (en) * | 1996-11-19 | 2002-05-28 | Octoplus B.V. | Method for the preparation of microspheres which contain colloidal systems |
| EP0842657A1 (en) * | 1996-11-19 | 1998-05-20 | OctoPlus B.V. | Microspheres for controlled release and processes to prepare these microspheres |
| US6294170B1 (en) * | 1997-08-08 | 2001-09-25 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| DE19747261A1 (de) * | 1997-10-25 | 1999-04-29 | Bayer Ag | Osmotisches Arzneimittelfreisetzungssystem |
| EP1563866B1 (en) * | 1998-02-05 | 2007-10-03 | Biosense Webster, Inc. | Intracardiac drug delivery |
| US20050260605A1 (en) * | 1998-02-11 | 2005-11-24 | Maxygen, Inc. | Targeting of genetic vaccine vectors |
| US7090976B2 (en) * | 1999-11-10 | 2006-08-15 | Rigel Pharmaceuticals, Inc. | Methods and compositions comprising Renilla GFP |
| US6329186B1 (en) * | 1998-12-07 | 2001-12-11 | Novozymes A/S | Glucoamylases with N-terminal extensions |
| US6713086B2 (en) * | 1998-12-18 | 2004-03-30 | Abbott Laboratories | Controlled release formulation of divalproex sodium |
| US6715485B1 (en) * | 1999-03-03 | 2004-04-06 | Optinose As | Nasal delivery device |
| US6183770B1 (en) * | 1999-04-15 | 2001-02-06 | Acutek International | Carrier patch for the delivery of agents to the skin |
| US6743211B1 (en) * | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| US6458387B1 (en) * | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
| US20050287153A1 (en) * | 2002-06-28 | 2005-12-29 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
| US6352721B1 (en) * | 2000-01-14 | 2002-03-05 | Osmotica Corp. | Combined diffusion/osmotic pumping drug delivery system |
| JP2003530838A (ja) * | 2000-04-12 | 2003-10-21 | ヒューマン ゲノム サイエンシズ インコーポレイテッド | アルブミン融合タンパク質 |
| KR100867392B1 (ko) * | 2000-08-15 | 2008-11-06 | 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 | 마이크로입자 |
| DE10053224A1 (de) * | 2000-10-26 | 2002-05-08 | Univ Goettingen Georg August | Verfahren zur Exposition von Peptiden und Polypeptiden auf der Zelloberfläche von Bakterien |
| US20030049689A1 (en) * | 2000-12-14 | 2003-03-13 | Cynthia Edwards | Multifunctional polypeptides |
| IN190699B (enExample) * | 2001-02-02 | 2003-08-16 | Sun Pharmaceutical Ind Ltd | |
| US20020169125A1 (en) * | 2001-03-21 | 2002-11-14 | Cell Therapeutics, Inc. | Recombinant production of polyanionic polymers and uses thereof |
| US20050048512A1 (en) * | 2001-04-26 | 2005-03-03 | Avidia Research Institute | Combinatorial libraries of monomer domains |
| WO2002087621A1 (en) * | 2001-04-30 | 2002-11-07 | Shire Laboratories Inc. | Pharmaceutical composition including ace/nep inhibitors and bioavailability enhancers |
| US6838093B2 (en) * | 2001-06-01 | 2005-01-04 | Shire Laboratories, Inc. | System for osmotic delivery of pharmaceutically active agents |
| KR100407467B1 (ko) * | 2001-07-12 | 2003-11-28 | 최수봉 | 리모컨 방식의 인슐린 자동주사기 |
| CA2469477A1 (en) * | 2001-12-07 | 2003-06-12 | Toolgen, Inc. | Phenotypic screen of chimeric proteins |
| US6945952B2 (en) * | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
| JP4644663B2 (ja) * | 2003-06-03 | 2011-03-02 | セル ジェネシス インコーポレイテッド | ペプチド開裂部位を用いた単一ベクターからの組換えポリペプチドの高められた発現のための構成と方法 |
| NZ548513A (en) * | 2004-01-14 | 2010-05-28 | Univ Ohio | Methods of producing peptides/proteins in plants and peptides/proteins produced thereby |
| EP1729795B1 (en) * | 2004-02-09 | 2016-02-03 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| CN101103045B (zh) * | 2004-09-24 | 2015-11-25 | 安姆根有限公司 | 修饰的Fc分子 |
| US7846445B2 (en) * | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
| US20090099031A1 (en) * | 2005-09-27 | 2009-04-16 | Stemmer Willem P | Genetic package and uses thereof |
| US7855279B2 (en) * | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
| JP2009509535A (ja) * | 2005-09-27 | 2009-03-12 | アムニクス, インコーポレイテッド | タンパク様薬剤およびその使用 |
| CN103298935A (zh) * | 2007-08-15 | 2013-09-11 | 阿穆尼克斯公司 | 用于改善生物活性多肽性能的组合物和方法 |
-
2006
- 2006-09-27 JP JP2008533574A patent/JP2009509535A/ja not_active Withdrawn
- 2006-09-27 US US11/528,927 patent/US20070191272A1/en not_active Abandoned
- 2006-09-27 US US11/528,950 patent/US20070212703A1/en not_active Abandoned
- 2006-09-27 CA CA002622441A patent/CA2622441A1/en not_active Abandoned
- 2006-09-27 WO PCT/US2006/037713 patent/WO2007038619A2/en not_active Ceased
- 2006-09-27 EP EP06804210A patent/EP1929073A4/en not_active Withdrawn
- 2006-09-27 AU AU2006294644A patent/AU2006294644A1/en not_active Abandoned
-
2007
- 2007-03-06 SI SI200731247T patent/SI1996220T2/sl unknown
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