JP2005523681A5 - - Google Patents
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- Publication number
- JP2005523681A5 JP2005523681A5 JP2003532654A JP2003532654A JP2005523681A5 JP 2005523681 A5 JP2005523681 A5 JP 2005523681A5 JP 2003532654 A JP2003532654 A JP 2003532654A JP 2003532654 A JP2003532654 A JP 2003532654A JP 2005523681 A5 JP2005523681 A5 JP 2005523681A5
- Authority
- JP
- Japan
- Prior art keywords
- ulbp4
- protein
- seq
- polypeptide
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101001132524 Homo sapiens Retinoic acid early transcript 1E Proteins 0.000 claims 42
- 102100033964 Retinoic acid early transcript 1E Human genes 0.000 claims 42
- 108090000765 processed proteins & peptides Proteins 0.000 claims 22
- 229920001184 polypeptide Polymers 0.000 claims 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims 17
- 102000040430 polynucleotide Human genes 0.000 claims 14
- 108091033319 polynucleotide Proteins 0.000 claims 14
- 239000002157 polynucleotide Substances 0.000 claims 14
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 12
- 238000000034 method Methods 0.000 claims 10
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 8
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 150000001413 amino acids Chemical class 0.000 claims 8
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 230000002222 downregulating effect Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 238000006384 oligomerization reaction Methods 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32725201P | 2001-10-04 | 2001-10-04 | |
| PCT/US2002/031994 WO2003029436A2 (en) | 2001-10-04 | 2002-10-04 | Ul16 binding protein 4 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005523681A JP2005523681A (ja) | 2005-08-11 |
| JP2005523681A5 true JP2005523681A5 (enExample) | 2006-01-05 |
Family
ID=23275763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003532654A Pending JP2005523681A (ja) | 2001-10-04 | 2002-10-04 | Ｕｌ１６結合タンパク質４ |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7563450B2 (enExample) |
| EP (1) | EP1451333B1 (enExample) |
| JP (1) | JP2005523681A (enExample) |
| AT (1) | ATE434624T1 (enExample) |
| AU (1) | AU2002340118B2 (enExample) |
| CA (1) | CA2462790A1 (enExample) |
| DE (1) | DE60232742D1 (enExample) |
| MX (1) | MXPA04003057A (enExample) |
| PL (1) | PL373594A1 (enExample) |
| WO (1) | WO2003029436A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2483343A1 (en) * | 2002-04-22 | 2003-10-30 | Fred Hutchinson Cancer Research Center | Soluble mic polypeptides as markers for diagnosis, prognosis and treatment of cancer and autoimmune diseases or conditions |
| AU2003270063A1 (en) * | 2002-09-04 | 2004-03-29 | The Trustees Of The University Of Pennsylvania | Immune cell receptor ligand and immune cell receptor |
| US7666417B2 (en) * | 2003-04-22 | 2010-02-23 | Fred Hutchinson Cancer Research Center | Methods and compositions for treating autoimmune diseases or conditions |
| US7834155B2 (en) | 2003-07-21 | 2010-11-16 | Immunogen Inc. | CA6 antigen-specific cytotoxic conjugate and methods of using the same |
| EA014640B1 (ru) * | 2003-07-21 | 2010-12-30 | Иммьюноджен, Инк. | Антитело или его эпитоп-связывающий фрагмент, которые связываются с гликотопом са6, и способы их применения |
| US7998481B2 (en) | 2004-04-05 | 2011-08-16 | The Regents Of The University Of California | Modulation of NKG2D for treating or preventing solid organ allograft rejection |
| DE102004042894A1 (de) * | 2004-08-30 | 2006-03-02 | Eberhard-Karls-Universität Tübingen | Verwendung von Blockern der NKG2D-Rezeptor-/NKG2D-Liganden-Interaktion bei Autoimmunerkrankungen |
| MX2007006234A (es) * | 2004-11-24 | 2007-07-20 | Schering Corp | Dap10, y usos de la misma. |
| WO2011130749A2 (en) | 2010-04-16 | 2011-10-20 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Identification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector retargeting to novel non-hsv receptors |
| US20130156808A1 (en) | 2011-11-22 | 2013-06-20 | Stipan Jonjic | Vaccine comprising beta-herpesvirus |
| WO2014140904A2 (en) | 2013-03-15 | 2014-09-18 | Novelogics Biotechnology, Inc. | Antibodies to mica and micb proteins |
| DK3184641T3 (da) | 2013-10-28 | 2020-08-03 | Univ Of Pittsburgh - Of The Commonwealth System Of Higher Education | Onkolytisk hsv-vektor |
| AU2017212713B2 (en) | 2016-01-27 | 2023-01-19 | Oncorus, Inc. | Oncolytic viral vectors and uses thereof |
| MX2018015542A (es) | 2016-06-14 | 2019-10-14 | Univ Pittsburgh Commonwealth Sys Higher Education | Expresion de proteinas de ligando activadoras de nkg2d para la sensibilizacion de celulas cancerosas para el ataque por celulas inmunocitotoxicas. |
| EP3478321A4 (en) | 2016-06-30 | 2020-04-22 | Oncorus, Inc. | PSEUDOTYPIZED ONCOLYTIC VIRAL ADMINISTRATION OF THERAPEUTIC POLYPEPTIDES |
| WO2018073648A1 (en) | 2016-10-19 | 2018-04-26 | Novelogics Biotechnology, Inc. | Antibodies to mica and micb proteins |
| MX2020000993A (es) | 2017-07-26 | 2020-07-22 | Oncorus Inc | Vectores virales oncolíticos y usos de estos. |
| WO2019028336A1 (en) * | 2017-08-03 | 2019-02-07 | The Cleveland Clinic Foundation | IMPROVED PEPTIDE EXPRESSION AND ANTIBODY DETECTION OF APO-H SPECIFIC SUBJECT |
| WO2019133847A1 (en) | 2017-12-29 | 2019-07-04 | Oncorus, Inc. | Oncolytic viral delivery of therapeutic polypeptides |
| CN112285360B (zh) * | 2020-09-23 | 2023-08-22 | 台州市第一人民医院 | I-309在制备原发性干燥综合征诊断试剂或试剂盒中的应用 |
| CN119529114B (zh) * | 2024-11-29 | 2026-05-29 | 兰州大学第二医院 | 一种ulbp2特异性嵌合抗原受体、car-t细胞及其应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US22239A (en) * | 1858-12-07 | Limekiln | ||
| US4311A (en) * | 1845-12-16 | William beebe | ||
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4737462A (en) | 1982-10-19 | 1988-04-12 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β |
| US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| WO1990005183A1 (en) | 1988-10-31 | 1990-05-17 | Immunex Corporation | Interleukin-4 receptors |
| WO1991018982A1 (en) | 1990-06-05 | 1991-12-12 | Immunex Corporation | Type ii interleukin-1 receptors |
| DE4118120A1 (de) | 1991-06-03 | 1992-12-10 | Behringwerke Ag | Tetravalente bispezifische rezeptoren, ihre herstellung und verwendung |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US20030004311A1 (en) | 1997-06-18 | 2003-01-02 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US20030022239A1 (en) | 1997-06-18 | 2003-01-30 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| WO1999031241A1 (en) | 1997-12-17 | 1999-06-24 | Immunex Corporation | Cell surface glycoproteins associated with human b cell lymphomas - ulbp, dna and polypeptides |
| AU758004B2 (en) | 1997-12-17 | 2003-03-13 | Genset S.A. | Extended cDNAs for secreted proteins |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| CA2378403A1 (en) | 1999-07-26 | 2001-02-01 | Genentech, Inc. | Novel polynucleotides and method for the use thereof |
| CA2391455A1 (en) * | 1999-12-01 | 2001-06-07 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| WO2001049728A2 (en) * | 2000-01-06 | 2001-07-12 | Protegene Inc. | HUMAN PROTEINS HAVING HYDROPHOBIC DOMAINS AND DNAs ENCODING THESE PROTEINS |
| US20040219521A1 (en) * | 2000-01-21 | 2004-11-04 | Tang Y. Tom | Novel nucleic acids and polypeptides |
| EP1266014A2 (en) | 2000-03-24 | 2002-12-18 | Peter Kufer | Multifunctional polypeptides comprising a binding site to an epitope of the nkg2d receptor complex |
| US20050074754A1 (en) * | 2000-04-27 | 2005-04-07 | Shoichi Okubo | Novel protein and use thereof |
| EP1278778A2 (en) | 2000-05-03 | 2003-01-29 | Amgen Inc., | Modified peptides, comprising an fc domain, as therapeutic agents |
| WO2002068615A2 (en) | 2001-02-28 | 2002-09-06 | Fred Hutchinson Cancer Research Center, Inc. | Activation of lymphocyte populations expressing nkg2d using anti-nkg2d antibodies and ligand derivatives |
| US6821522B2 (en) * | 2001-05-31 | 2004-11-23 | The Regents Of The University Of California | Tumor Therapy |
| CA2456369A1 (en) | 2001-08-08 | 2003-02-20 | Incyte Genomics, Inc. | Proteins associated with cell growth, differentiation, and death |
| WO2003054152A2 (en) | 2001-12-10 | 2003-07-03 | Nuvelo, Inc. | Novel nucleic acids and polypeptides |
| WO2003074556A1 (fr) | 2002-03-04 | 2003-09-12 | Shanghai Genomics, Inc. | Marqueur tumoral et ses applications |
| AU2003270063A1 (en) | 2002-09-04 | 2004-03-29 | The Trustees Of The University Of Pennsylvania | Immune cell receptor ligand and immune cell receptor |
-
2002
- 2002-10-04 JP JP2003532654A patent/JP2005523681A/ja active Pending
- 2002-10-04 AT AT02778459T patent/ATE434624T1/de not_active IP Right Cessation
- 2002-10-04 PL PL02373594A patent/PL373594A1/xx unknown
- 2002-10-04 US US10/265,811 patent/US7563450B2/en not_active Expired - Fee Related
- 2002-10-04 DE DE60232742T patent/DE60232742D1/de not_active Expired - Lifetime
- 2002-10-04 CA CA002462790A patent/CA2462790A1/en not_active Abandoned
- 2002-10-04 AU AU2002340118A patent/AU2002340118B2/en not_active Ceased
- 2002-10-04 MX MXPA04003057A patent/MXPA04003057A/es unknown
- 2002-10-04 EP EP02778459A patent/EP1451333B1/en not_active Expired - Lifetime
- 2002-10-04 WO PCT/US2002/031994 patent/WO2003029436A2/en not_active Ceased
-
2009
- 2009-06-05 US US12/479,543 patent/US8129167B2/en not_active Expired - Fee Related
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