JP2003502283A5 - - Google Patents
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- JP2003502283A5 JP2003502283A5 JP2000612337A JP2000612337A JP2003502283A5 JP 2003502283 A5 JP2003502283 A5 JP 2003502283A5 JP 2000612337 A JP2000612337 A JP 2000612337A JP 2000612337 A JP2000612337 A JP 2000612337A JP 2003502283 A5 JP2003502283 A5 JP 2003502283A5
- Authority
- JP
- Japan
- Prior art keywords
- dendritic cells
- type lectin
- cells
- antibody
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000342 C-Type Lectins Proteins 0.000 description 31
- 102000003930 C-Type Lectins Human genes 0.000 description 31
- 210000004443 dendritic cell Anatomy 0.000 description 28
- 239000000427 antigen Substances 0.000 description 14
- 102000036639 antigens Human genes 0.000 description 14
- 108091007433 antigens Proteins 0.000 description 14
- 150000001875 compounds Chemical class 0.000 description 13
- 239000012634 fragment Substances 0.000 description 12
- 239000002523 lectin Substances 0.000 description 9
- 210000001744 T-lymphocyte Anatomy 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 102000005962 receptors Human genes 0.000 description 8
- 108020003175 receptors Proteins 0.000 description 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 7
- 235000014633 carbohydrates Nutrition 0.000 description 7
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 6
- 125000003275 alpha amino acid group Chemical group 0.000 description 6
- 239000012472 biological sample Substances 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 6
- -1 mannose carbohydrate Chemical class 0.000 description 6
- 230000028993 immune response Effects 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 108010062580 Concanavalin A Proteins 0.000 description 3
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 3
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 3
- SHZGCJCMOBCMKK-PQMKYFCFSA-N L-Fucose Natural products C[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O SHZGCJCMOBCMKK-PQMKYFCFSA-N 0.000 description 3
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 3
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 3
- 102000004856 Lectins Human genes 0.000 description 3
- 108090001090 Lectins Proteins 0.000 description 3
- 229920000057 Mannan Polymers 0.000 description 3
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 3
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 3
- 108010089814 Plant Lectins Proteins 0.000 description 3
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229930182830 galactose Natural products 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 229950006780 n-acetylglucosamine Drugs 0.000 description 3
- 239000003726 plant lectin Substances 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 150000008163 sugars Chemical class 0.000 description 3
- 208000035473 Communicable disease Diseases 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 108010052285 Membrane Proteins Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000008614 cellular interaction Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 102100037872 Intercellular adhesion molecule 2 Human genes 0.000 description 1
- 101710148794 Intercellular adhesion molecule 2 Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- WPICPWIIIBCXCV-UHFFFAOYSA-N Pradimicin A Natural products CNC1C(C)OC(OC2C3=CC(C)=C(C(=O)NC(C)C(O)=O)C(O)=C3C3=C(O)C=4C(=O)C5=CC(OC)=CC(O)=C5C(=O)C=4C=C3C2O)C(O)C1OC1OCC(O)C(O)C1O WPICPWIIIBCXCV-UHFFFAOYSA-N 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 230000006058 immune tolerance Effects 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000000816 peptidomimetic Substances 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 229930191090 pradimicin Natural products 0.000 description 1
- WPICPWIIIBCXCV-NJGWPHBESA-N pradimicin A Chemical compound O([C@@H]1[C@@H](O)[C@H](O[C@H]2C3=CC(C)=C(C(=O)N[C@H](C)C(O)=O)C(O)=C3C3=C(O)C=4C(=O)C5=CC(OC)=CC(O)=C5C(=O)C=4C=C3[C@@H]2O)O[C@H](C)[C@@H]1NC)[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O WPICPWIIIBCXCV-NJGWPHBESA-N 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19990201204 EP1046651A1 (en) | 1999-04-19 | 1999-04-19 | Composition and method for modulating dendritic cell-T interaction |
| EP99201204.7 | 1999-04-19 | ||
| US17692400P | 2000-01-20 | 2000-01-20 | |
| US60/176,924 | 2000-01-20 | ||
| PCT/NL2000/000253 WO2000063251A1 (en) | 1999-04-19 | 2000-04-19 | Composition and method for modulating dendritic cell-t cell interaction |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010176824A Division JP5363432B2 (ja) | 1999-04-19 | 2010-08-05 | 樹状細胞−ｔ細胞の相互作用を調節するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003502283A JP2003502283A (ja) | 2003-01-21 |
| JP2003502283A5 true JP2003502283A5 (enExample) | 2008-01-10 |
| JP4989820B2 JP4989820B2 (ja) | 2012-08-01 |
Family
ID=8240111
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000612337A Expired - Fee Related JP4989820B2 (ja) | 1999-04-19 | 2000-04-19 | 樹状細胞−ｔ細胞の相互作用を調節するための組成物及び方法 |
| JP2010176824A Expired - Fee Related JP5363432B2 (ja) | 1999-04-19 | 2010-08-05 | 樹状細胞−ｔ細胞の相互作用を調節するための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010176824A Expired - Fee Related JP5363432B2 (ja) | 1999-04-19 | 2010-08-05 | 樹状細胞−ｔ細胞の相互作用を調節するための組成物及び方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US7148329B1 (enExample) |
| EP (3) | EP1046651A1 (enExample) |
| JP (2) | JP4989820B2 (enExample) |
| KR (3) | KR100923340B1 (enExample) |
| AT (2) | ATE472558T1 (enExample) |
| AU (1) | AU776317B2 (enExample) |
| CA (1) | CA2330231C (enExample) |
| DE (2) | DE60039151D1 (enExample) |
| DK (2) | DK1086137T3 (enExample) |
| ES (2) | ES2346877T3 (enExample) |
| NZ (1) | NZ508723A (enExample) |
| PT (2) | PT1516881E (enExample) |
| WO (1) | WO2000063251A1 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1046651A1 (en) * | 1999-04-19 | 2000-10-25 | Koninklijke Universiteit Nijmegen | Composition and method for modulating dendritic cell-T interaction |
| US6515124B2 (en) * | 2000-02-09 | 2003-02-04 | Hoffman-La Roche Inc. | Dehydroamino acids |
| JP5007409B2 (ja) * | 2000-05-08 | 2012-08-22 | セルデックス リサーチ コーポレーション | 樹状細胞に対するヒトモノクローナル抗体 |
| US7560534B2 (en) | 2000-05-08 | 2009-07-14 | Celldex Research Corporation | Molecular conjugates comprising human monoclonal antibodies to dendritic cells |
| US20040091481A1 (en) * | 2000-12-21 | 2004-05-13 | Figdor Carl Gustav | Method for modulating the binding activity of a novel icam-3 binding receptor on sinusoidal endothelial cells in liver and lymph nodes |
| US7022323B2 (en) | 2001-06-26 | 2006-04-04 | Progenics Pharmaceuticals, Inc. | Uses of DC-SIGN and DC-SIGNR for inhibiting hepatitis C virus infection |
| US20030013081A1 (en) | 2001-06-26 | 2003-01-16 | Olson William C. | Uses of DC-SIGN and DC-SIGNR for inhibiting hepatitis C virus infection |
| ES2197826B1 (es) * | 2002-06-21 | 2005-04-01 | Consejo Superior De Investigaciones Cientificas | Compuesto terapeutico frente a la infeccion por leishmania y su uso. |
| US7541032B2 (en) | 2002-09-20 | 2009-06-02 | Stichting Katholieke Universiteit | Antigen uptake receptor for Candida albicans on dendritic cells |
| AU2003278541A1 (en) * | 2002-09-20 | 2004-04-08 | Stichting Katholieke Universiteit | Method of treating rheumatoid arthritis by interfering with expression of dc-sign by macrophages and diagnosis thereof |
| US20040146948A1 (en) * | 2002-10-18 | 2004-07-29 | Centenary Institute Of Cancer Medicine And Cell Biology | Compositions and methods for targeting antigen-presenting cells with antibody single-chain variable region fragments |
| US7427469B2 (en) | 2002-11-05 | 2008-09-23 | Institut Pasteur | Method of treating cytomegalovirus with DC-SIGN blockers |
| AU2003301804A1 (en) * | 2002-11-05 | 2004-06-07 | Institut National De La Sante Et De La Recherche Medicale | Dc-sign blockers and their use for preventing or treating viral infections. |
| EP1417965A1 (en) * | 2002-11-07 | 2004-05-12 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | C-type lectin binding molecules, identification and uses thereof |
| WO2004074432A2 (en) | 2003-01-31 | 2004-09-02 | Celldex Therapeutics, Inc. | Antibody vaccine conjugates and uses therefor |
| US9259459B2 (en) | 2003-01-31 | 2016-02-16 | Celldex Therapeutics Inc. | Antibody vaccine conjugates and uses therefor |
| AU2011211337B2 (en) * | 2003-10-16 | 2014-10-02 | Cancure Limited | Immunomodulating compositions and uses therefor |
| JP5021309B2 (ja) * | 2003-10-16 | 2012-09-05 | ステファン ジョン ラルフ | 免疫調節性組成物およびその使用方法 |
| AU2004299053B2 (en) * | 2003-12-15 | 2011-01-06 | Alexion Pharmaceuticals, Inc. | Novel anti-DC-SIGN antibodies |
| DK1761248T3 (da) | 2004-03-19 | 2012-09-03 | Rodos Biotarget Gmbh | Kulhydrat-deriverede liposomer bestemt til at målrettes mod cellulære kulhydrat-genkende-domæner af CTL/CTLD-lecitiner samt intracellulær afgivelse af terapeutisk aktive sammensætninger |
| US7884085B2 (en) * | 2004-05-12 | 2011-02-08 | Baxter International Inc. | Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes |
| EP1765294B1 (en) * | 2004-05-12 | 2008-09-24 | Baxter International Inc. | Nucleic acid microspheres, production and delivery thereof |
| EP2963118B1 (en) | 2005-06-01 | 2017-08-09 | California Institute of Technology | Method of targeted gene delivery using viral vectors |
| FR2895262B1 (fr) * | 2005-12-22 | 2009-07-17 | Lab Francais Du Fractionnement | Inhibition de la reponse immunitaire anti-fviii |
| AT503387B1 (de) * | 2006-03-27 | 2008-05-15 | Univ Wien | Pharmazeutische zusammensetzung zur vorbeugung von infektionen |
| WO2008011636A2 (en) | 2006-07-21 | 2008-01-24 | California Institute Of Technology | Targeted gene delivery for dendritic cell vaccination |
| EP2684889A3 (en) * | 2007-02-02 | 2014-03-05 | Baylor Research Institute | Multivariable antigens complexed with targeting humanized monoclonal antibody |
| TWI422594B (zh) | 2007-02-02 | 2014-01-11 | Baylor Res Inst | 經由樹狀細胞去唾液酸糖蛋白受體（ｄｃ-ａｓｇｐｒ）接合抗原呈現細胞之藥劑 |
| US8057798B2 (en) | 2007-02-02 | 2011-11-15 | Baylor Research Institute | Vaccines based on targeting antigen to DCIR expressed on antigen-presenting cells |
| WO2009026660A1 (en) | 2007-08-30 | 2009-03-05 | Walter And Eliza Hall Institute Of Medical Research | Dendritic cell marker and uses thereof |
| EP2207798A2 (en) | 2007-10-29 | 2010-07-21 | Virginia Tech Intellectual Properties, Inc. | Porcine dc-sign, icam-3 and lsectin and uses thereof |
| US8236318B2 (en) | 2007-11-07 | 2012-08-07 | Celldex Therapeutics Inc. | Antibodies that bind human dendritic and epithelial cell 205 (DEC-205) |
| EP2456786B2 (en) | 2009-07-24 | 2017-04-19 | Immune Design Corp | Lentiviral vectors pseudotyped with a sindbis virus envelope glycoprotein |
| EP2497498A4 (en) | 2009-11-05 | 2013-04-17 | Univ Osaka | THERAPEUTIC ACTIVE FOR AUTOIMMUNE DISEASES OR ALLERGIES AND METHOD FOR SCREENING AFTER THE THERAPEUTIC ACTIVE SUBSTANCE |
| JP5690132B2 (ja) | 2010-06-17 | 2015-03-25 | 株式会社マーレ フィルターシステムズ | エンジンの換気システム |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| AU2011289579B2 (en) | 2010-08-10 | 2016-11-17 | Ecole Polytechnique Federale De Lausanne | Erythrocyte-binding therapeutics |
| AU2013237900B2 (en) | 2012-03-30 | 2017-07-27 | Immune Design Corp. | Lentiviral vector particles having improved transduction efficiency for cells expressing DC- SIGN |
| US9713635B2 (en) | 2012-03-30 | 2017-07-25 | Immune Design Corp. | Materials and methods for producing improved lentiviral vector particles |
| US8323662B1 (en) | 2012-03-30 | 2012-12-04 | Immune Design Corp. | Methods useful for generating highly mannosylated pseudotyped lentiviral vector particles comprising a Vpx protein |
| MX364946B (es) * | 2012-04-04 | 2019-05-15 | Vaxform Llc | Sistema adyuvante mejorado para la administración de vacunas orales. |
| US10196614B2 (en) * | 2012-09-18 | 2019-02-05 | University Of Washington Through Its Center For Commercialization | Compositions and methods for antigen targeting to CD180 |
| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
| CA2946064C (en) | 2014-02-21 | 2023-09-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| IL300029A (en) | 2014-05-16 | 2023-03-01 | Baylor Res Institute | Methods and preparations for the treatment of autoimmune and inflammatory conditions |
| EP3318577A4 (en) | 2015-06-30 | 2019-01-23 | Osaka University | ANTIPLEXIN A1 AGONISTANTIKÖRPER |
| CN108210503A (zh) * | 2016-12-10 | 2018-06-29 | 高尚先 | 甘露糖在用于提高Treg细胞数量及其Foxp3因子表达水平的新用途 |
| EP3638296A1 (en) | 2017-06-16 | 2020-04-22 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| EP3790577A4 (en) | 2018-05-09 | 2022-04-27 | The University of Chicago | COMPOSITIONS AND METHODS RELATED TO IMMUNTOLERANCE |
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| US891992A (en) | 1907-06-27 | 1908-06-30 | Henry Hess | Method of forming conically-shaped ends upon rollers and other objects. |
| US5332567A (en) * | 1989-08-24 | 1994-07-26 | Immunomedics | Detection and treatment of infections with immunoconjugates |
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| IL102508A0 (en) * | 1991-07-16 | 1993-01-14 | Bristol Myers Squibb Co | Inhibition of non-cd4 mediated hiv infection |
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| US6084067A (en) * | 1993-07-26 | 2000-07-04 | Dana-Farber Cancer Institute | CTLA4/CD28 ligands and uses therefor |
| AUPM322393A0 (en) * | 1993-12-24 | 1994-01-27 | Austin Research Institute, The | Mucin carbohydrate compounds and their use in immunotherapy |
| WO1995032734A1 (en) | 1994-05-26 | 1995-12-07 | Innogenetics N.V. | New methods and compounds for the selective modulation of antigen-specific t-cell responsiveness |
| US5548275A (en) * | 1995-01-23 | 1996-08-20 | Shambayati; Ali | Alarm system for enclosing and protecting an area |
| US5643786A (en) | 1995-01-27 | 1997-07-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method for isolating dendritic cells |
| WO1996023882A1 (en) * | 1995-01-31 | 1996-08-08 | The Rockefeller University | IDENTIFICATION OF DEC, (DENTRITIC AND EPITHELIAL CELLS, 205 kDa), A RECEPTOR WITH C-TYPE LECTIN DOMAINS, NUCLEIC ACIDS ENCODING DEC, AND USES THEREOF |
| US5871964A (en) * | 1996-07-15 | 1999-02-16 | Incyte Pharmaceuticals, Inc. | Human C-type lectin |
| US6046158A (en) * | 1996-12-20 | 2000-04-04 | Board Of Regents The University Of Texas Systems | Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof |
| US5935813A (en) * | 1997-03-20 | 1999-08-10 | Incyte Pharmaceuticals, Inc. | Human pancreatitis-associated protein |
| AU7172198A (en) * | 1997-04-29 | 1998-11-24 | Incyte Pharmaceuticals, Inc. | Human c-type lectin |
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| US6273443B1 (en) * | 1998-06-01 | 2001-08-14 | Sunrise Medical Hhg Inc. | Universal elevating leg rest assembly |
| EP1046651A1 (en) * | 1999-04-19 | 2000-10-25 | Koninklijke Universiteit Nijmegen | Composition and method for modulating dendritic cell-T interaction |
| EP1200590B1 (en) * | 1999-08-12 | 2009-01-07 | Agensys, Inc. | C-type lectin transmembrane antigen expressed in human prostate cancer and uses thereof |
| US20040091481A1 (en) | 2000-12-21 | 2004-05-13 | Figdor Carl Gustav | Method for modulating the binding activity of a novel icam-3 binding receptor on sinusoidal endothelial cells in liver and lymph nodes |
| US20030232745A1 (en) | 2001-06-26 | 2003-12-18 | Olson William C. | Uses of DC-sign and DC-Signr for inhibiting hepatitis C virus infection |
| US7022323B2 (en) * | 2001-06-26 | 2006-04-04 | Progenics Pharmaceuticals, Inc. | Uses of DC-SIGN and DC-SIGNR for inhibiting hepatitis C virus infection |
| WO2005057996A2 (en) * | 2003-12-09 | 2005-06-23 | Synergy Microwave Corporation | User-definable thermal drift voltage control oscillator |
-
1999
- 1999-04-19 EP EP19990201204 patent/EP1046651A1/en not_active Withdrawn
-
2000
- 2000-04-19 PT PT04078220T patent/PT1516881E/pt unknown
- 2000-04-19 AU AU41526/00A patent/AU776317B2/en not_active Ceased
- 2000-04-19 KR KR1020077020353A patent/KR100923340B1/ko not_active Expired - Fee Related
- 2000-04-19 NZ NZ508723A patent/NZ508723A/en not_active IP Right Cessation
- 2000-04-19 DK DK00921181T patent/DK1086137T3/da active
- 2000-04-19 US US09/719,961 patent/US7148329B1/en not_active Expired - Fee Related
- 2000-04-19 KR KR1020007014459A patent/KR20010071530A/ko not_active Ceased
- 2000-04-19 WO PCT/NL2000/000253 patent/WO2000063251A1/en not_active Ceased
- 2000-04-19 JP JP2000612337A patent/JP4989820B2/ja not_active Expired - Fee Related
- 2000-04-19 EP EP00921181A patent/EP1086137B1/en not_active Expired - Lifetime
- 2000-04-19 PT PT00921181T patent/PT1086137E/pt unknown
- 2000-04-19 DE DE60039151T patent/DE60039151D1/de not_active Expired - Lifetime
- 2000-04-19 DE DE60044621T patent/DE60044621D1/de not_active Expired - Lifetime
- 2000-04-19 DK DK04078220.3T patent/DK1516881T3/da active
- 2000-04-19 AT AT04078220T patent/ATE472558T1/de active
- 2000-04-19 ES ES04078220T patent/ES2346877T3/es not_active Expired - Lifetime
- 2000-04-19 CA CA2330231A patent/CA2330231C/en not_active Expired - Fee Related
- 2000-04-19 ES ES00921181T patent/ES2307502T3/es not_active Expired - Lifetime
- 2000-04-19 AT AT00921181T patent/ATE398140T1/de active
- 2000-04-19 EP EP04078220A patent/EP1516881B1/en not_active Expired - Lifetime
- 2000-04-19 KR KR1020087023697A patent/KR100952883B1/ko not_active Expired - Fee Related
-
2003
- 2003-07-23 US US10/625,202 patent/US8105599B2/en not_active Expired - Fee Related
- 2003-07-23 US US10/625,204 patent/US7285642B2/en not_active Expired - Fee Related
-
2007
- 2007-10-22 US US11/977,151 patent/US8058400B2/en not_active Expired - Fee Related
-
2010
- 2010-08-05 JP JP2010176824A patent/JP5363432B2/ja not_active Expired - Fee Related
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