JP4989820B2 - 樹状細胞−t細胞の相互作用を調節するための組成物及び方法 - Google Patents

樹状細胞−t細胞の相互作用を調節するための組成物及び方法 Download PDF

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JP4989820B2
JP4989820B2 JP2000612337A JP2000612337A JP4989820B2 JP 4989820 B2 JP4989820 B2 JP 4989820B2 JP 2000612337 A JP2000612337 A JP 2000612337A JP 2000612337 A JP2000612337 A JP 2000612337A JP 4989820 B2 JP4989820 B2 JP 4989820B2
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cells
icam
cell
sign
hiv
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JP2003502283A5 (enExample
JP2003502283A (ja
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フィグドール、カール、グスタフ
ゲイイテンベーク、テウニス、ベルナルド、ヘルマン
ファン、コーイク、イベット
トレンスマ、ルード
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Radboud Universiteit Nijmegen
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P37/00Drugs for immunological or allergic disorders
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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JP2000612337A 1999-04-19 2000-04-19 樹状細胞−t細胞の相互作用を調節するための組成物及び方法 Expired - Fee Related JP4989820B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP99201204.7 1999-04-19
EP19990201204 EP1046651A1 (en) 1999-04-19 1999-04-19 Composition and method for modulating dendritic cell-T interaction
US17692400P 2000-01-20 2000-01-20
US60/176,924 2000-01-20
PCT/NL2000/000253 WO2000063251A1 (en) 1999-04-19 2000-04-19 Composition and method for modulating dendritic cell-t cell interaction

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JP2010176824A Division JP5363432B2 (ja) 1999-04-19 2010-08-05 樹状細胞−t細胞の相互作用を調節するための組成物及び方法

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JP2003502283A JP2003502283A (ja) 2003-01-21
JP2003502283A5 JP2003502283A5 (enExample) 2008-01-10
JP4989820B2 true JP4989820B2 (ja) 2012-08-01

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JP2010176824A Expired - Fee Related JP5363432B2 (ja) 1999-04-19 2010-08-05 樹状細胞−t細胞の相互作用を調節するための組成物及び方法

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EP (3) EP1046651A1 (enExample)
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KR (3) KR100952883B1 (enExample)
AT (2) ATE472558T1 (enExample)
AU (1) AU776317B2 (enExample)
CA (1) CA2330231C (enExample)
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Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1046651A1 (en) * 1999-04-19 2000-10-25 Koninklijke Universiteit Nijmegen Composition and method for modulating dendritic cell-T interaction
US6515124B2 (en) * 2000-02-09 2003-02-04 Hoffman-La Roche Inc. Dehydroamino acids
US7560534B2 (en) * 2000-05-08 2009-07-14 Celldex Research Corporation Molecular conjugates comprising human monoclonal antibodies to dendritic cells
KR100643818B1 (ko) * 2000-05-08 2006-11-10 셀덱스 쎄라퓨틱스, 인크. 수상세포에 대한 인간 모노클로날 항체
EP1339830A2 (en) * 2000-12-21 2003-09-03 Stichting Katholieke Universiteit Method for modulating the binding activity of a novel icam-3 binding receptor on sinusoidal endothelial cells in liver and lymph nodes
US20030013081A1 (en) 2001-06-26 2003-01-16 Olson William C. Uses of DC-SIGN and DC-SIGNR for inhibiting hepatitis C virus infection
US7022323B2 (en) 2001-06-26 2006-04-04 Progenics Pharmaceuticals, Inc. Uses of DC-SIGN and DC-SIGNR for inhibiting hepatitis C virus infection
ES2197826B1 (es) * 2002-06-21 2005-04-01 Consejo Superior De Investigaciones Cientificas Compuesto terapeutico frente a la infeccion por leishmania y su uso.
US7541032B2 (en) * 2002-09-20 2009-06-02 Stichting Katholieke Universiteit Antigen uptake receptor for Candida albicans on dendritic cells
US7691591B2 (en) * 2002-09-20 2010-04-06 Stichting Katholieke Universiteit Methods of identifying and isolating cells expressing DC-sign
US20040146948A1 (en) * 2002-10-18 2004-07-29 Centenary Institute Of Cancer Medicine And Cell Biology Compositions and methods for targeting antigen-presenting cells with antibody single-chain variable region fragments
US7427469B2 (en) 2002-11-05 2008-09-23 Institut Pasteur Method of treating cytomegalovirus with DC-SIGN blockers
BR0315975A (pt) * 2002-11-05 2005-09-20 Pasteur Institut Usos de uma quantidade de um modulador e de um bloqueador de dc-sign, composição farmacêutica, métodos para identificar um modulador e um bloqueador de dc-sign, bloqueador de dc-sign isolado, e, método para alvejar uma molécula objeto a uma célula que expressa um receptore de dc-sign
EP1417965A1 (en) * 2002-11-07 2004-05-12 Vereniging Voor Christelijk Wetenschappelijk Onderwijs C-type lectin binding molecules, identification and uses thereof
EP1594533B1 (en) 2003-01-31 2012-04-11 Celldex Research Corporation Antibody vaccine conjugates and uses therefor
US9259459B2 (en) 2003-01-31 2016-02-16 Celldex Therapeutics Inc. Antibody vaccine conjugates and uses therefor
AU2011211337B2 (en) * 2003-10-16 2014-10-02 Cancure Limited Immunomodulating compositions and uses therefor
EP2591786B1 (en) * 2003-10-16 2017-04-12 Cancure Limited Immunomodulating compositions and uses therefor
EP1699487A4 (en) * 2003-12-15 2009-07-08 Alexion Pharma Inc NEW ANTI-DC-SIGN ANTIBODIES
EP1761248B1 (en) 2004-03-19 2012-05-23 Rodos BioTarget GmbH Carbohydrate-derivatized liposomes for targeting cellular carbohydrate recognition domains of ctl/ctld lectins, and intracellular delivery of therapeutically active compounds
DK1765294T3 (da) * 2004-05-12 2008-11-10 Baxter Int Nukleinsyremikrokugler samt deres fremstilling og afgivelse
EP1758558B1 (en) * 2004-05-12 2013-10-16 Baxter International Inc. Oligonucleotide-containing microspheres, their use for the manufacture of a medicament for treating diabetes type 1
AU2006252406B2 (en) 2005-06-01 2012-05-17 California Institute Of Technology Method of targeted gene delivery using viral vectors
FR2895262B1 (fr) * 2005-12-22 2009-07-17 Lab Francais Du Fractionnement Inhibition de la reponse immunitaire anti-fviii
AT503387B1 (de) * 2006-03-27 2008-05-15 Univ Wien Pharmazeutische zusammensetzung zur vorbeugung von infektionen
SG173337A1 (en) 2006-07-21 2011-08-29 California Inst Of Techn Targeted gene delivery for dendritic cell vaccination
BRPI0807160A2 (pt) 2007-02-02 2018-09-25 Baylor Res Institute vacinas baseadas no direcionamento de antígeno ao dcir expresso em células apresentadoras de antígeno
TWI422594B (zh) 2007-02-02 2014-01-11 Baylor Res Inst 經由樹狀細胞去唾液酸糖蛋白受體(dc-asgpr)接合抗原呈現細胞之藥劑
ES2536900T3 (es) * 2007-02-02 2015-05-29 Baylor Research Institute Antígenos multivariables en complejo con anticuerpo monoclonal humanizado de dirección
BRPI0815848A2 (pt) 2007-08-30 2017-06-06 The Burnet Inst composto, linhagem de célula que produz anticorpo estável, composição, métodos para modular uma resposta imune em um indivíduo e para tratar e/ou prevenir uma doença, usos de um composto e/ou uma composição e de células dendríticas ou precursores das mesmas, métodos para enriquecer e detectar células dendríticas ou um subconjunto ou precursores das mesmas, polipeptídeo, polinucleotídeo vetor, célula hospedeira, planta transgênica, animal não humano transgênico, extrato, processo para preparar um composto ou um polipeptídeo, população enriquecida de células dendríticas e/ou precursores das mesmas, população de célula dendrítica expandida e/ou precursores das mesmas, métodos para identificar uma molécula que se liga a um polipeptídeo e para triar quanto a um composto que se liga a um polipeptídeo, uso de um polipeptídeo, um polinucleotídeo, um vetor, uma célula hospedeira, uma planta transgênica, um extrato, uma população de célula e/ou uma composição, método para produzir um composto, e, kit.
EP2207798A2 (en) 2007-10-29 2010-07-21 Virginia Tech Intellectual Properties, Inc. Porcine dc-sign, icam-3 and lsectin and uses thereof
BRPI0820270A2 (pt) 2007-11-07 2015-06-16 Celldex Therapeutics Inc Anticorpo monoclonal, vetor de expressão, célula, conjugado molecular, composição, uso da composição, método para detectar a presença ou ausência de dec-205 em uma amostra biológica, e, uso de um conjugado molecular.
WO2011011584A1 (en) 2009-07-24 2011-01-27 Immune Design Corp Lentiviral vectors pseudotyped with a sindbis virus envelope glycoprotein
WO2011055550A1 (ja) * 2009-11-05 2011-05-12 国立大学法人大阪大学 自己免疫疾患又はアレルギー治療剤とそのスクリーニング方法
JP5690132B2 (ja) 2010-06-17 2015-03-25 株式会社マーレ フィルターシステムズ エンジンの換気システム
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
AU2011289579B2 (en) 2010-08-10 2016-11-17 Ecole Polytechnique Federale De Lausanne Erythrocyte-binding therapeutics
EP2831095B1 (en) 2012-03-30 2018-11-28 Immune Design Corp. Lentiviral vector particles having improved transduction efficiency for cells expressing dc-sign
US8323662B1 (en) 2012-03-30 2012-12-04 Immune Design Corp. Methods useful for generating highly mannosylated pseudotyped lentiviral vector particles comprising a Vpx protein
US9713635B2 (en) 2012-03-30 2017-07-25 Immune Design Corp. Materials and methods for producing improved lentiviral vector particles
EP3549605A1 (en) * 2012-04-04 2019-10-09 Vaxform LLC Adjuvant system for oral vaccine administration
EP2897641B1 (en) * 2012-09-18 2018-07-18 University of Washington through its Center for Commercialization Compositions and methods for antigen targeting to cd180
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
LT3107563T (lt) 2014-02-21 2021-07-12 Ecole Polytechnique Fédérale De Lausanne (Epfl) Epfl-Tto Gliko-nukreipiantys terapiniai agenai
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
CN106659774A (zh) 2014-05-16 2017-05-10 贝勒研究院 用于治疗自身免疫和炎性病症的方法和组合物
US10688178B2 (en) 2015-06-30 2020-06-23 Osaka University AntiPlexin A1 agonist antibody
CN108210503A (zh) * 2016-12-10 2018-06-29 高尚先 甘露糖在用于提高Treg细胞数量及其Foxp3因子表达水平的新用途
US11253579B2 (en) 2017-06-16 2022-02-22 The University Of Chicago Compositions and methods for inducing immune tolerance
EA202092723A1 (ru) 2018-05-09 2021-04-09 Зе Юниверсити Оф Чикаго Композиции и способы, касающиеся иммунной толерантности

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US891992A (en) 1907-06-27 1908-06-30 Henry Hess Method of forming conically-shaped ends upon rollers and other objects.
US5332567A (en) * 1989-08-24 1994-07-26 Immunomedics Detection and treatment of infections with immunoconjugates
US6248332B1 (en) * 1990-10-05 2001-06-19 Medarex, Inc. Targeted immunostimulation with bispecific reagents
IE922308A1 (en) * 1991-07-16 1993-01-27 Bristol Myers Squibb Co Inhibition of non-cd4 mediated hiv infection
WO1995003234A1 (en) 1993-07-22 1995-02-02 Precision Valve Corporation Multi-directional actuation overcap
US6084067A (en) 1993-07-26 2000-07-04 Dana-Farber Cancer Institute CTLA4/CD28 ligands and uses therefor
AUPM322393A0 (en) * 1993-12-24 1994-01-27 Austin Research Institute, The Mucin carbohydrate compounds and their use in immunotherapy
AU2670995A (en) 1994-05-26 1995-12-21 Innogenetics N.V. New methods and compounds for the selective modulation of antigen-specific t-cell responsiveness
US5548275A (en) * 1995-01-23 1996-08-20 Shambayati; Ali Alarm system for enclosing and protecting an area
US5643786A (en) 1995-01-27 1997-07-01 The United States Of America As Represented By The Department Of Health And Human Services Method for isolating dendritic cells
WO1996023882A1 (en) * 1995-01-31 1996-08-08 The Rockefeller University IDENTIFICATION OF DEC, (DENTRITIC AND EPITHELIAL CELLS, 205 kDa), A RECEPTOR WITH C-TYPE LECTIN DOMAINS, NUCLEIC ACIDS ENCODING DEC, AND USES THEREOF
US5871964A (en) * 1996-07-15 1999-02-16 Incyte Pharmaceuticals, Inc. Human C-type lectin
US6046158A (en) * 1996-12-20 2000-04-04 Board Of Regents The University Of Texas Systems Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof
US5935813A (en) * 1997-03-20 1999-08-10 Incyte Pharmaceuticals, Inc. Human pancreatitis-associated protein
WO1998049306A1 (en) * 1997-04-29 1998-11-05 Incyte Pharmaceuticals, Inc. Human c-type lectin
EP0984984A2 (en) * 1997-06-03 2000-03-15 Sagami Chemical Research Center HUMAN PROTEINS HAVING TRANSMEMBRANE DOMAINS AND DNAs ENCODING THESE PROTEINS
US6273443B1 (en) * 1998-06-01 2001-08-14 Sunrise Medical Hhg Inc. Universal elevating leg rest assembly
EP1046651A1 (en) * 1999-04-19 2000-10-25 Koninklijke Universiteit Nijmegen Composition and method for modulating dendritic cell-T interaction
IL147902A0 (en) * 1999-08-12 2002-08-14 Agensys Inc C-type lectin transmembrane antigen expressed in human prostate cancer and uses thereof
EP1339830A2 (en) 2000-12-21 2003-09-03 Stichting Katholieke Universiteit Method for modulating the binding activity of a novel icam-3 binding receptor on sinusoidal endothelial cells in liver and lymph nodes
US20030232745A1 (en) 2001-06-26 2003-12-18 Olson William C. Uses of DC-sign and DC-Signr for inhibiting hepatitis C virus infection
US7022323B2 (en) * 2001-06-26 2006-04-04 Progenics Pharmaceuticals, Inc. Uses of DC-SIGN and DC-SIGNR for inhibiting hepatitis C virus infection
EP1542354B1 (en) * 2003-12-09 2021-02-03 Synergy Microwave Corporation Integrated ultra low noise microwave wideband push-push vco

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EP1046651A1 (en) 2000-10-25
KR20080098678A (ko) 2008-11-11
HK1036285A1 (en) 2001-12-28
JP5363432B2 (ja) 2013-12-11
AU776317B2 (en) 2004-09-02
US8105599B2 (en) 2012-01-31
KR100952883B1 (ko) 2010-04-16
US20050118168A1 (en) 2005-06-02
JP2003502283A (ja) 2003-01-21
DE60039151D1 (de) 2008-07-24
EP1516881B1 (en) 2010-06-30
ES2307502T3 (es) 2008-12-01
ATE398140T1 (de) 2008-07-15
EP1516881A2 (en) 2005-03-23
WO2000063251A1 (en) 2000-10-26
ATE472558T1 (de) 2010-07-15
NZ508723A (en) 2003-12-19
EP1516881A3 (en) 2005-08-31
PT1086137E (pt) 2008-09-09
CA2330231A1 (en) 2000-10-26
DK1086137T3 (da) 2008-10-27
EP1086137B1 (en) 2008-06-11
DK1516881T3 (da) 2010-09-27
ES2346877T3 (es) 2010-10-21
KR20010071530A (ko) 2001-07-28
CA2330231C (en) 2013-07-16
DE60044621D1 (de) 2010-08-12
EP1086137A1 (en) 2001-03-28
JP2010285450A (ja) 2010-12-24
KR20070094990A (ko) 2007-09-27
PT1516881E (pt) 2010-08-25
AU4152600A (en) 2000-11-02
US20080160041A1 (en) 2008-07-03
US20050220804A1 (en) 2005-10-06
KR100923340B1 (ko) 2009-10-22
US7148329B1 (en) 2006-12-12
US7285642B2 (en) 2007-10-23
US8058400B2 (en) 2011-11-15

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