JP2009509535A - タンパク様薬剤およびその使用 - Google Patents

タンパク様薬剤およびその使用 Download PDF

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JP2009509535A
JP2009509535A JP2008533574A JP2008533574A JP2009509535A JP 2009509535 A JP2009509535 A JP 2009509535A JP 2008533574 A JP2008533574 A JP 2008533574A JP 2008533574 A JP2008533574 A JP 2008533574A JP 2009509535 A JP2009509535 A JP 2009509535A
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protein
cysteine
library
scaffold
proteins
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JP2009509535A5 (enExample
Inventor
ウィレム ピー．シー． ステマー，
フォルカー シェレンバーガー，
マーティン バーダー，
マイケル ショール，
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アムニクス， インコーポレイテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Botany (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
JP2008533574A 2005-09-27 2006-09-27 タンパク様薬剤およびその使用 Withdrawn JP2009509535A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72127005P 2005-09-27 2005-09-27
US72118805P 2005-09-27 2005-09-27
US74362206P 2006-03-21 2006-03-21
PCT/US2006/037713 WO2007038619A2 (en) 2005-09-27 2006-09-27 Proteinaceous pharmaceuticals and uses thereof

Publications (2)

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JP2009509535A true JP2009509535A (ja) 2009-03-12
JP2009509535A5 JP2009509535A5 (enExample) 2009-11-12

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JP2008533574A Withdrawn JP2009509535A (ja) 2005-09-27 2006-09-27 タンパク様薬剤およびその使用

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US (2) US20070212703A1 (enExample)
EP (1) EP1929073A4 (enExample)
JP (1) JP2009509535A (enExample)
AU (1) AU2006294644A1 (enExample)
CA (1) CA2622441A1 (enExample)
SI (1) SI1996220T2 (enExample)
WO (1) WO2007038619A2 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
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JP2013505287A (ja) * 2009-09-23 2013-02-14 モロジック リミテッド ペプチドクリアリング剤
JP2016527249A (ja) * 2013-07-25 2016-09-08 ノバルティス アーゲー 合成アペリンポリペプチドのバイオコンジュゲート
JP2016527248A (ja) * 2013-07-25 2016-09-08 ノバルティス アーゲー 心不全治療用の環状アペリン誘導体
JP2016531110A (ja) * 2013-07-25 2016-10-06 ノバルティス アーゲー 心不全治療のためのジスルフィド環状ポリペプチド
JP2016532681A (ja) * 2013-07-25 2016-10-20 ノバルティス アーゲー 心不全治療用の環状ポリペプチド
JP2018533912A (ja) * 2015-09-15 2018-11-22 ジェネンテック， インコーポレイテッド シスチンノットスキャフォールドプラットフォーム
JPWO2020039984A1 (ja) * 2018-08-20 2021-08-26 国立大学法人東海国立大学機構 化合物ライブラリ

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