|
US3687808A
(en)
|
1969-08-14 |
1972-08-29 |
Univ Leland Stanford Junior |
Synthetic polynucleotides
|
|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4109496A
(en)
|
1977-12-20 |
1978-08-29 |
Norris Industries |
Trapped key mechanism
|
|
US4323546A
(en)
|
1978-05-22 |
1982-04-06 |
Nuc Med Inc. |
Method and composition for cancer detection in humans
|
|
US4411990A
(en)
|
1979-06-13 |
1983-10-25 |
University Patents, Inc. |
Primary bioassay of human tumor stem cells
|
|
US4873191A
(en)
|
1981-06-12 |
1989-10-10 |
Ohio University |
Genetic transformation of zygotes
|
|
US4612282A
(en)
|
1981-12-15 |
1986-09-16 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Monoclonal antibodies reactive with human breast cancer
|
|
US4670393A
(en)
|
1982-03-22 |
1987-06-02 |
Genentech, Inc. |
DNA vectors encoding a novel human growth hormone-variant protein
|
|
US5019497A
(en)
|
1984-11-09 |
1991-05-28 |
Lennart Olsson |
Human squamous lung carcinoma cell specific antigens and antibodies
|
|
US5034506A
(en)
|
1985-03-15 |
1991-07-23 |
Anti-Gene Development Group |
Uncharged morpholino-based polymers having achiral intersubunit linkages
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
US5087570A
(en)
|
1988-05-10 |
1992-02-11 |
Weissman Irving L |
Homogeneous mammalian hematopoietic stem cell composition
|
|
US4981785A
(en)
|
1988-06-06 |
1991-01-01 |
Ventrex Laboratories, Inc. |
Apparatus and method for performing immunoassays
|
|
US4968103A
(en)
|
1988-07-22 |
1990-11-06 |
Photofinish Cosmetics Inc. |
Method of making a brush
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5994617A
(en)
|
1988-09-19 |
1999-11-30 |
Hsc Research Development Corporation |
Engraftment of immune-deficient mice with human cells
|
|
US5688666A
(en)
|
1988-10-28 |
1997-11-18 |
Genentech, Inc. |
Growth hormone variants with altered binding properties
|
|
US5534617A
(en)
|
1988-10-28 |
1996-07-09 |
Genentech, Inc. |
Human growth hormone variants having greater affinity for human growth hormone receptor at site 1
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
GB8901778D0
(en)
|
1989-01-27 |
1989-03-15 |
Univ Court Of The University O |
Manipulatory technique
|
|
US6583115B1
(en)
|
1989-10-12 |
2003-06-24 |
Ohio University/Edison Biotechnology Institute |
Methods for treating acromegaly and giantism with growth hormone antagonists
|
|
US5061620A
(en)
|
1990-03-30 |
1991-10-29 |
Systemix, Inc. |
Human hematopoietic stem cell
|
|
US5614396A
(en)
|
1990-06-14 |
1997-03-25 |
Baylor College Of Medicine |
Methods for the genetic modification of endogenous genes in animal cells by homologous recombination
|
|
US5602240A
(en)
|
1990-07-27 |
1997-02-11 |
Ciba Geigy Ag. |
Backbone modified oligonucleotide analogs
|
|
US5489677A
(en)
|
1990-07-27 |
1996-02-06 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
|
|
DE69129154T2
(de)
|
1990-12-03 |
1998-08-20 |
Genentech, Inc., South San Francisco, Calif. |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
|
US5856441A
(en)
|
1991-05-03 |
1999-01-05 |
Yale University |
Serrate fragments and derivatives
|
|
IE20030749A1
(en)
|
1991-05-03 |
2003-11-12 |
Indiana University Foundation |
Human notch and delta binding domains in torporythmic proteins, and methods based thereon
|
|
IL101728A
(en)
|
1991-05-03 |
2007-08-19 |
Univ Yale |
Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
|
|
US6429186B1
(en)
|
1991-05-10 |
2002-08-06 |
Genentech, Inc. |
Ligand antagonists for treatment of breast cancer
|
|
US5539082A
(en)
|
1993-04-26 |
1996-07-23 |
Nielsen; Peter E. |
Peptide nucleic acids
|
|
US5719262A
(en)
|
1993-11-22 |
1998-02-17 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having amino acid side chains
|
|
US5714331A
(en)
|
1991-05-24 |
1998-02-03 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
US5750376A
(en)
|
1991-07-08 |
1998-05-12 |
Neurospheres Holdings Ltd. |
In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
|
|
ES2136092T3
(es)
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
|
US5753229A
(en)
|
1991-09-25 |
1998-05-19 |
Mordoh; Jose |
Monoclonal antibodies reactive with tumor proliferating cells
|
|
US6353150B1
(en)
|
1991-11-22 |
2002-03-05 |
Hsc Research And Development Limited Partnership |
Chimeric mammals with human hematopoietic cells
|
|
US6004924A
(en)
|
1991-12-11 |
1999-12-21 |
Imperial Cancer Research Technology, Ltd. |
Protein sequences of serrate gene products
|
|
US5869282A
(en)
|
1991-12-11 |
1999-02-09 |
Imperial Cancer Research Technology, Ltd. |
Nucleotide and protein sequences of the serrate gene and methods based thereon
|
|
EP0552108B1
(en)
|
1992-01-17 |
1999-11-10 |
Lakowicz, Joseph R. |
Energy transfer phase-modulation fluoro-immunoassay
|
|
US5376313A
(en)
|
1992-03-27 |
1994-12-27 |
Abbott Laboratories |
Injection molding a plastic assay cuvette having low birefringence
|
|
US5786158A
(en)
|
1992-04-30 |
1998-07-28 |
Yale University |
Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
|
|
US5589376A
(en)
|
1992-07-27 |
1996-12-31 |
California Institute Of Technology |
Mammalian neural crest stem cells
|
|
US5849553A
(en)
|
1992-07-27 |
1998-12-15 |
California Institute Of Technology |
Mammalian multipotent neural stem cells
|
|
US5654183A
(en)
|
1992-07-27 |
1997-08-05 |
California Institute Of Technology |
Genetically engineered mammalian neural crest stem cells
|
|
JPH08500245A
(ja)
|
1992-07-27 |
1996-01-16 |
カリフォルニア インスティテュート オブ テクノロジー |
哺乳動物の多能性神経幹細胞
|
|
US5928947A
(en)
|
1992-07-27 |
1999-07-27 |
California Institute Of Technology |
Mammalian multipotent neural stem cells
|
|
JP3537141B2
(ja)
|
1992-10-30 |
2004-06-14 |
ザ ゼネラル ホスピタル コーポレーション |
新種蛋白質分離のための相互作用を用いる補捉システム
|
|
GB9223084D0
(en)
|
1992-11-04 |
1992-12-16 |
Imp Cancer Res Tech |
Compounds to target cells
|
|
JP3106021B2
(ja)
|
1992-11-30 |
2000-11-06 |
キヤノン株式会社 |
パターンデータの圧縮方法及び装置と出力方法及び装置
|
|
AU6044994A
(en)
|
1993-02-19 |
1994-09-14 |
Nippon Shinyaku Co. Ltd. |
Glycerol derivative, device and pharmaceutical composition
|
|
US5643765A
(en)
|
1993-04-06 |
1997-07-01 |
University Of Rochester |
Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
|
|
US5876978A
(en)
|
1993-04-06 |
1999-03-02 |
Medical College Of Ohio |
Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
|
|
US5639606A
(en)
|
1993-04-06 |
1997-06-17 |
The University Of Rochester |
Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
|
|
US5538848A
(en)
|
1994-11-16 |
1996-07-23 |
Applied Biosystems Division, Perkin-Elmer Corp. |
Method for detecting nucleic acid amplification using self-quenching fluorescence probe
|
|
US5599677A
(en)
|
1993-12-29 |
1997-02-04 |
Abbott Laboratories |
Immunoassays for prostate specific antigen
|
|
EP0784690B1
(en)
|
1994-06-10 |
2006-08-16 |
Genvec, Inc. |
Complementary adenoviral vector systems and cell lines
|
|
US6156305A
(en)
|
1994-07-08 |
2000-12-05 |
Baxter International Inc. |
Implanted tumor cells for the prevention and treatment of cancer
|
|
US5650317A
(en)
|
1994-09-16 |
1997-07-22 |
Michigan State University |
Human breast epithelial cell type with stem cell and luminal epithelial cell characteristics
|
|
CA2203809C
(en)
|
1994-10-28 |
2008-06-03 |
James M. Wilson |
Recombinant adenovirus and methods of use thereof
|
|
US6218166B1
(en)
|
1994-12-09 |
2001-04-17 |
John Wayne Cancer Institute |
Adjuvant incorporation into antigen carrying cells: compositions and methods
|
|
US5736396A
(en)
|
1995-01-24 |
1998-04-07 |
Case Western Reserve University |
Lineage-directed induction of human mesenchymal stem cell differentiation
|
|
US5872154A
(en)
|
1995-02-24 |
1999-02-16 |
The Trustees Of The University Of Pennsylvania |
Method of reducing an immune response to a recombinant adenovirus
|
|
DE69637552D1
(de)
|
1995-03-17 |
2008-07-10 |
Wayne John Cancer Inst |
Nachweis von Brustmetastasen unter Verwendung eines Mehrfachmarker-Tests
|
|
US5707618A
(en)
|
1995-03-24 |
1998-01-13 |
Genzyme Corporation |
Adenovirus vectors for gene therapy
|
|
US5633161A
(en)
|
1995-03-29 |
1997-05-27 |
Millennium Pharmaceuticals, Inc. |
Murine gene fomy030 coding for tumor progression inhibitor
|
|
US5821108A
(en)
|
1995-04-07 |
1998-10-13 |
The Board Of Trustees Of The Leland Stanford Junior University |
Enrichment for a thymocyte subset having progenitor cell activity using c-kit as a selection marker
|
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
|
US6019978A
(en)
|
1995-06-05 |
2000-02-01 |
The Wistar Institute Of Anatomy And Biology |
Replication-defective adenovirus human type 5 recombinant as a vaccine carrier
|
|
DE69633565T3
(de)
|
1995-06-15 |
2013-01-17 |
Crucell Holland B.V. |
Verpackungssysteme für humane, menschliche adenoviren, zur verwendung in die gentherapie
|
|
US6117985A
(en)
|
1995-06-16 |
2000-09-12 |
Stemcell Technologies Inc. |
Antibody compositions for preparing enriched cell preparations
|
|
DK0861261T3
(da)
|
1995-06-28 |
2009-12-14 |
Imp Cancer Res Tech |
Nukleotid- og proteinsekvenser af hvirveldyrs-Delta-gener og fremgangsmåder baseret derpå
|
|
ATE455171T1
(de)
|
1995-09-21 |
2010-01-15 |
Genentech Inc |
Varianten des menschlichen wachstumshormons
|
|
US5780300A
(en)
|
1995-09-29 |
1998-07-14 |
Yale University |
Manipulation of non-terminally differentiated cells using the notch pathway
|
|
US5986170A
(en)
|
1995-11-13 |
1999-11-16 |
Corixa Corporation |
Murine model for human carcinoma
|
|
EP0861894B1
(en)
|
1995-11-17 |
2006-03-08 |
Asahi Kasei Kabushiki Kaisha |
Differentiation-suppressive polypeptide
|
|
CA2239957A1
(en)
|
1995-12-22 |
1997-07-03 |
Abbott Laboratories |
Fluorescence polarization immunoassay diagnostic method
|
|
US5994316A
(en)
|
1996-02-21 |
1999-11-30 |
The Immune Response Corporation |
Method of preparing polynucleotide-carrier complexes for delivery to cells
|
|
WO1999007934A1
(fr)
|
1997-08-07 |
1999-02-18 |
Kanehisa Inc. |
Procede de production d'etoffes tissees et/ou tricotees utilisant un fil de fixation de la sericine et etoffe tissee et/ou tricotee ainsi obtenue
|
|
EP0914416B1
(en)
|
1996-03-30 |
2002-06-12 |
Science Park Raf S.p.A. |
Method for the production of activated marked tumor-specific t cells and use thereof in treatment of tumors
|
|
US5753506A
(en)
|
1996-05-23 |
1998-05-19 |
Cns Stem Cell Technology, Inc. |
Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
|
|
CA2256481A1
(en)
|
1996-05-31 |
1997-12-04 |
The National American Red Cross |
Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids
|
|
US6716974B1
(en)
|
1996-05-31 |
2004-04-06 |
Maine Medical Center Research Institute |
Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids
|
|
US5885529A
(en)
|
1996-06-28 |
1999-03-23 |
Dpc Cirrus, Inc. |
Automated immunoassay analyzer
|
|
FR2751986B1
(fr)
|
1996-08-01 |
1998-12-31 |
Inst Nat Sante Rech Med |
Gene implique dans le cadasil, methode de diagnostic et application therapeutique
|
|
EP0963432A4
(en)
|
1996-08-29 |
2002-11-20 |
Univ California |
KUZ, NEW FAMILY OF METALLOPROTEASES
|
|
ATE318915T1
(de)
*
|
1996-09-24 |
2006-03-15 |
Tanox Inc |
Genfamilie von apoptose-verwandten peptiden, dadurch kodierte peptide und verfahren zu deren herstellung
|
|
ATE229810T1
(de)
|
1996-10-11 |
2003-01-15 |
Univ California |
Krebs immuntherapie unter verwendung von tumorzellen kombiniert mit lymphozytmischungen
|
|
US5994132A
(en)
|
1996-10-23 |
1999-11-30 |
University Of Michigan |
Adenovirus vectors
|
|
ES2293661T3
(es)
*
|
1996-11-27 |
2008-03-16 |
Genentech, Inc. |
Purificacion por afinidad de polipeptido en una matriz de proteinas a.
|
|
US5859535A
(en)
|
1997-02-12 |
1999-01-12 |
The United States Of America As Represented By The Secretary Of The Navy |
System for determining size and location of defects in material by use of microwave radiation
|
|
EP0965034B1
(en)
|
1997-03-07 |
2007-05-30 |
Clare Chemical Research, Inc. |
Fluorometric detection using visible light
|
|
US6080912A
(en)
|
1997-03-20 |
2000-06-27 |
Wisconsin Alumni Research Foundation |
Methods for creating transgenic animals
|
|
US5861832A
(en)
|
1997-03-27 |
1999-01-19 |
Lucent Technologies Inc. |
Analog-to-digital converter having amplifier and comparator stages
|
|
US20020137890A1
(en)
|
1997-03-31 |
2002-09-26 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
AU6952498A
(en)
|
1997-04-04 |
1998-10-30 |
Millenium Pharmaceuticals, Inc. |
Novel human delta3 compositions and therapeutic and diagnostic uses therefor
|
|
US6121045A
(en)
|
1997-04-04 |
2000-09-19 |
Millennium Biotherapeutics, Inc. |
Human Delta3 nucleic acid molecules
|
|
US20030180784A1
(en)
|
1997-04-04 |
2003-09-25 |
Millennium Pharmaceuticals, Inc. |
Novel human Delta3 compositions and therapeutic and diagnostic uses therefor
|
|
US5830730A
(en)
|
1997-05-08 |
1998-11-03 |
The Regents Of The University Of California |
Enhanced adenovirus-assisted transfection composition and method
|
|
JP4171528B2
(ja)
|
1997-05-14 |
2008-10-22 |
旭化成株式会社 |
新規な分化抑制剤
|
|
US6479255B1
(en)
*
|
1997-05-29 |
2002-11-12 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Polynucleotides encoding human FRP and fragments thereof
|
|
US6379925B1
(en)
|
1997-06-18 |
2002-04-30 |
The Trustees Of Columbia University In The City Of New York |
Angiogenic modulation by notch signal transduction
|
|
AU8162898A
(en)
|
1997-06-18 |
1999-01-04 |
Trustees Of Columbia University In The City Of New York, The |
Angiogenic modulation by notch signal transduction
|
|
US6136952A
(en)
|
1997-06-25 |
2000-10-24 |
University Of Washington |
Human jagged polypeptide, encoding nucleic acids and methods of use
|
|
EP0998565A1
(en)
|
1997-07-11 |
2000-05-10 |
Introgene B.V. |
Interleukin-3 gene therapy for cancer
|
|
US6004528A
(en)
|
1997-09-18 |
1999-12-21 |
Bergstein; Ivan |
Methods of cancer diagnosis and therapy targeted against the cancer stemline
|
|
US7361336B1
(en)
*
|
1997-09-18 |
2008-04-22 |
Ivan Bergstein |
Methods of cancer therapy targeted against a cancer stem line
|
|
US6197523B1
(en)
|
1997-11-24 |
2001-03-06 |
Robert A. Levine |
Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood
|
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
|
US6551795B1
(en)
|
1998-02-18 |
2003-04-22 |
Genome Therapeutics Corporation |
Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
|
|
US5981225A
(en)
|
1998-04-16 |
1999-11-09 |
Baylor College Of Medicine |
Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same
|
|
US20020151543A1
(en)
|
1998-05-28 |
2002-10-17 |
Sepracor Inc. |
Compositions and methods employing R (-) fluoxetine and other active ingredients
|
|
US6252050B1
(en)
*
|
1998-06-12 |
2001-06-26 |
Genentech, Inc. |
Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method
|
|
CA2337492A1
(en)
|
1998-07-27 |
2000-02-10 |
Amgen Inc. |
Delta-related polypeptides
|
|
WO2000009675A1
(en)
|
1998-08-14 |
2000-02-24 |
Aventis Pharmaceuticals Products Inc. |
Adenovirus formulations for gene therapy
|
|
EP1108047A1
(en)
|
1998-08-27 |
2001-06-20 |
Aventis Pharma S.A. |
Targeted adenovirus vectors for delivery of heterologous genes
|
|
GB9819681D0
(en)
*
|
1998-09-09 |
1998-11-04 |
Smithkline Beecham Plc |
Novel compounds
|
|
US6660843B1
(en)
*
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
DE69939327D1
(de)
|
1998-11-02 |
2008-09-25 |
Curis Inc |
Funktionelle antagonisten von hedgehog-aktivität
|
|
US6291516B1
(en)
|
1999-01-13 |
2001-09-18 |
Curis, Inc. |
Regulators of the hedgehog pathway, compositions and uses related thereto
|
|
US20030003572A1
(en)
|
1999-03-05 |
2003-01-02 |
David J. Anderson |
Isolation and enrichment of neural stem cells from uncultured tissue based on cell-surface marker expression
|
|
US20030119029A1
(en)
|
1999-04-30 |
2003-06-26 |
Regents Of The University Of Michigan |
Compositions and methods relating to novel benzodiazepine compounds and targets thereof
|
|
AU782493B2
(en)
|
1999-06-01 |
2005-08-04 |
Curis, Inc. |
Polymer conjugates of hedgehog proteins and uses
|
|
WO2001002568A2
(en)
|
1999-07-02 |
2001-01-11 |
Chiron Corporation |
Human genes and gene expression products
|
|
US6703221B1
(en)
|
1999-08-19 |
2004-03-09 |
Chiron Corporation |
Notch receptor ligands and uses thereof
|
|
CA2384713A1
(en)
|
1999-09-29 |
2001-04-05 |
Human Genome Sciences, Inc. |
Colon and colon cancer associated polynucleotides and polypeptides
|
|
AU1194501A
(en)
|
1999-10-14 |
2001-04-23 |
Wistar Institute, The |
Inhibition of tumorigenic properties of melanoma cells
|
|
US6380362B1
(en)
|
1999-12-23 |
2002-04-30 |
Genesis Research & Development Corporation Ltd. |
Polynucleotides, polypeptides expressed by the polynucleotides and methods for their use
|
|
US20040048249A1
(en)
|
2000-01-21 |
2004-03-11 |
Tang Y. Tom |
Novel nucleic acids and secreted polypeptides
|
|
AU779875B2
(en)
|
2000-01-24 |
2005-02-17 |
Merck Sharp & Dohme Limited |
Gamma-secretase inhibitors
|
|
JP5179689B2
(ja)
*
|
2000-02-11 |
2013-04-10 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
抗体ベース融合タンパク質の循環系内半減期の増強
|
|
US7115653B2
(en)
|
2000-03-30 |
2006-10-03 |
Curis, Inc. |
Small organic molecule regulators of cell proliferation
|
|
WO2001098537A2
(en)
|
2000-06-17 |
2001-12-27 |
Third Wave Technologies, Inc. |
Nucleic acid accessible hybridization sites
|
|
JP2004516812A
(ja)
|
2000-06-21 |
2004-06-10 |
インサイト・ゲノミックス・インコーポレイテッド |
受容体
|
|
US6632620B1
(en)
|
2000-06-22 |
2003-10-14 |
Andrew N. Makarovskiy |
Compositions for identification and isolation of stem cells
|
|
DE10031380A1
(de)
|
2000-06-28 |
2002-01-10 |
Merck Patent Gmbh |
Verfahren zur Übertragung von Alkyliden-Gruppen auf organischen Verbindungen
|
|
GB0016681D0
(en)
|
2000-07-06 |
2000-08-23 |
Merck Sharp & Dohme |
Therapeutic compounds
|
|
WO2002008765A2
(en)
|
2000-07-26 |
2002-01-31 |
Stanford University |
Basal cell markers in breast cancer and uses thereof
|
|
US20050089518A1
(en)
|
2001-12-07 |
2005-04-28 |
Clarke Michael F. |
Prospective identification and characterization of breast cancer stem cells
|
|
US6984522B2
(en)
|
2000-08-03 |
2006-01-10 |
Regents Of The University Of Michigan |
Isolation and use of solid tumor stem cells
|
|
US20020151487A1
(en)
|
2000-08-31 |
2002-10-17 |
Loyola University Chicago |
Method and reagents for epithelial barrier formation and treatment of malignant and benign skin disorders by modulating the notch pathway
|
|
US6689744B2
(en)
|
2000-09-22 |
2004-02-10 |
Genentech, Inc. |
Notch receptor agonists and uses
|
|
DE60138764D1
(de)
|
2000-12-13 |
2009-07-02 |
Anaphore Inc |
Methode zur identifikation und isolation von peptide die andere moleküle binden aus kombinatorische proteinbibliotheken mit einer c-typ lectin-ähnlichen domäne als gerüststruktur
|
|
US20020169300A1
(en)
*
|
2001-01-30 |
2002-11-14 |
Waterman Marian L. |
Method of detection and treatment of colon cancer by analysis of beta-catenin-sensitive isoforms of lymphoid enhancer factor-1
|
|
US7413873B2
(en)
*
|
2001-01-30 |
2008-08-19 |
The Regents Of The University Of California |
Method of detection and treatment of colon cancer
|
|
US20030064384A1
(en)
|
2001-04-02 |
2003-04-03 |
Mien-Chie Hung |
Beta-catenin is a strong and independent prognostic factor for cancer
|
|
IL142481A0
(en)
|
2001-04-05 |
2002-03-10 |
Yissum Res Dev Co |
A method for identifying consitutively active mutants of mitogen activated protein kinases (mapk) and uses thereof
|
|
JP4406206B2
(ja)
*
|
2001-04-24 |
2010-01-27 |
バイエル コーポレーション |
ヒトｔｉｍｐ−１抗体
|
|
US20030044409A1
(en)
*
|
2001-05-01 |
2003-03-06 |
Carson Dennis A. |
Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens
|
|
US7713526B2
(en)
*
|
2001-05-01 |
2010-05-11 |
The Regents Of The University Of California |
Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
|
|
AU2002308557A1
(en)
*
|
2001-05-01 |
2002-11-11 |
The Regents Of The University Of California |
Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
|
|
US7514594B2
(en)
|
2001-05-11 |
2009-04-07 |
Wyeth |
Transgenic animal model of bone mass modulation
|
|
JP2005500303A
(ja)
|
2001-06-15 |
2005-01-06 |
ジェネンテック・インコーポレーテッド |
ヒト成長ホルモンアンタゴニスト
|
|
US7171311B2
(en)
|
2001-06-18 |
2007-01-30 |
Rosetta Inpharmatics Llc |
Methods of assigning treatment to breast cancer patients
|
|
US20040023244A1
(en)
|
2001-06-21 |
2004-02-05 |
Griffin Jennifer A |
Receptors
|
|
ATE371018T1
(de)
|
2001-06-22 |
2007-09-15 |
Stemcells Inc |
Le-zellen (liver engrafting cells), assays und verwendungen davon
|
|
WO2003000893A2
(en)
|
2001-06-26 |
2003-01-03 |
Decode Genetics Ehf. |
Nucleic acids encoding g protein-coupled receptors
|
|
BR0117063A
(pt)
|
2001-07-02 |
2004-07-27 |
Sinan Tas |
Uso de ciclopamina no tratamento de carcinoma de células basais e outros tumores
|
|
CA2452152A1
(en)
|
2001-07-02 |
2002-10-10 |
Sinan Tas |
Use of cyclopamine in the treatment of psoriasis
|
|
WO2003004045A2
(en)
|
2001-07-05 |
2003-01-16 |
Xenon Genetics, Inc. |
Methods for identifying therapeutic agents for treating diseases involving wnt polypeptides and wnt receptors
|
|
WO2003053921A2
(en)
|
2001-07-18 |
2003-07-03 |
American Red Cross |
Mutant proteinase inhibitors and uses thereof
|
|
MXPA04001014A
(es)
|
2001-08-03 |
2004-05-27 |
Schering Corp |
Novedosos inhibidores de la gama secretasa.
|
|
CA2456121A1
(en)
*
|
2001-08-03 |
2003-02-20 |
Medical Research Council |
Intracellular antibodies
|
|
US7138370B2
(en)
*
|
2001-10-11 |
2006-11-21 |
Amgen Inc. |
Specific binding agents of human angiopoietin-2
|
|
JP2005526701A
(ja)
|
2001-11-14 |
2005-09-08 |
ロランティス リミテッド |
内科療法
|
|
US7053547B2
(en)
|
2001-11-29 |
2006-05-30 |
Universal Display Corporation |
Increased emission efficiency in organic light-emitting devices on high-index substrates
|
|
US20070237770A1
(en)
|
2001-11-30 |
2007-10-11 |
Albert Lai |
Novel compositions and methods in cancer
|
|
PL372144A1
(en)
*
|
2001-12-26 |
2005-07-11 |
Immunomedics, Inc. |
Methods of generating multispecific, multivalent agents from v sb h /sb and v sb l /sb domains
|
|
US6713206B2
(en)
|
2002-01-14 |
2004-03-30 |
Board Of Trustees Of University Of Illinois |
Electrochemical cells comprising laminar flow induced dynamic conducting interfaces, electronic devices comprising such cells, and methods employing same
|
|
GB0201674D0
(en)
|
2002-01-25 |
2002-03-13 |
Lorantis Ltd |
Medical treatment
|
|
US20030185829A1
(en)
|
2002-03-12 |
2003-10-02 |
Erich Koller |
Jagged 2 inhibitors for inducing apoptosis
|
|
AU2003210060B2
(en)
|
2002-03-22 |
2010-02-25 |
Aprogen, Inc. |
Humanized antibody and process for preparing same
|
|
EP1554392A4
(en)
|
2002-05-06 |
2007-08-08 |
Us Gov Health & Human Serv |
IDENTIFICATION OF NEW NEUTRALIZING HUMAN MONOCLONAL ANTIBODIES WITH WIDE CROSS-REACTIVITY USING SEQUENTIAL ANTIGEN PANNING OF PHAG DISPLAY LIBRARIES
|
|
EP1520043A4
(en)
|
2002-05-24 |
2006-10-11 |
Boehringer Ingelheim Pharma |
METHOD FOR IDENTIFYING IKK ALPHA FUNCTION AND OTHER GENES FOR THE TREATMENT OF INFLAMMATORY DISEASES
|
|
EP1534331B1
(en)
|
2002-06-21 |
2014-10-29 |
Johns Hopkins University School of Medicine |
Membrane associated tumor endothelium markers
|
|
AU2003256079A1
(en)
|
2002-08-30 |
2004-03-19 |
Japan As Represented By President Of The University Of Tokyo |
Method for treating synovial sarcoma
|
|
US7803370B2
(en)
|
2002-08-30 |
2010-09-28 |
Oncotherapy Science, Inc. |
Method for treating synovial sarcoma
|
|
US20040058217A1
(en)
|
2002-09-20 |
2004-03-25 |
Ohlsen Leroy J. |
Fuel cell systems having internal multistream laminar flow
|
|
GB0221952D0
(en)
|
2002-09-20 |
2002-10-30 |
Novartis Forschungsstiftung |
Wnt mediated ErbB1 signalling,compositions and uses related thereto
|
|
EP1549144A4
(en)
|
2002-10-04 |
2010-01-06 |
Univ California |
METHOD FOR THE TREATMENT OF CANCER BY INHIBITION OF THE WNT SIGNALING LINE
|
|
US7803783B2
(en)
|
2002-12-06 |
2010-09-28 |
The Board Of Trustees Of The Leland Stanford Junior University |
Use of WNT inhibitors to augment therapeutic index of chemotherapy
|
|
AU2003293408A1
(en)
|
2002-12-06 |
2004-06-30 |
The Board Of Trustees Of The Leland Stanford Junior University |
PROTECTION OF STEM CELLS FROM CYTOTOXIC AGENTS BY MODULATION OF Beta-CATENIN SIGNALING PATHWAYS
|
|
US20040219579A1
(en)
|
2003-02-19 |
2004-11-04 |
Natasha Aziz |
Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
|
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
US20060019256A1
(en)
|
2003-06-09 |
2006-01-26 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing cancer
|
|
JP4691626B2
(ja)
|
2003-07-11 |
2011-06-01 |
オンコセラピー・サイエンス株式会社 |
滑膜肉腫の治療方法
|
|
US20050130199A1
(en)
|
2003-09-22 |
2005-06-16 |
Regents Of The University Of California |
Mutations in WNT-frizzled signaling pathways associated with osteoarthritis
|
|
US6894522B2
(en)
|
2003-10-06 |
2005-05-17 |
International Business Machines Corporation |
Specific site backside underlaying and micromasking method for electrical characterization of semiconductor devices
|
|
WO2005116236A2
(en)
|
2004-05-14 |
2005-12-08 |
The Regents Of The University Of California |
Methods for treating cancer using anti-wnt2 monoclonal antibodies and sirna
|
|
WO2006034328A2
(en)
|
2004-09-21 |
2006-03-30 |
Rhode Island Hospital, A Lifespan-Partner |
Wnt proteins and detection and treatment of cancer
|
|
US7867705B2
(en)
|
2004-09-21 |
2011-01-11 |
Rhode Island Hospital, A Lifespan-Partner |
Frizzled proteins and detection and treatment of cancer
|
|
WO2006036175A2
(en)
|
2004-09-21 |
2006-04-06 |
Rhode Island Hospital, A Lifespan-Partner |
Wnt proteins and detection and treatment of cancer
|
|
CA2580796C
(en)
*
|
2004-09-24 |
2013-03-26 |
Amgen Inc. |
Modified fc molecules having peptides inserted in internal loop regions
|
|
DE102004050620A1
(de)
*
|
2004-10-13 |
2006-04-20 |
Eberhard-Karls-Universität Tübingen |
Monoklonaler Antikörper gegen Frizzled-Rezeptoren
|
|
WO2006055635A2
(en)
|
2004-11-15 |
2006-05-26 |
Mount Sinai School Of Medicine Of New York University |
Compositions and methods for altering wnt autocrine signaling
|
|
EP1817427B1
(en)
|
2004-11-24 |
2010-09-08 |
F. Hoffmann-La Roche AG |
Method for determining genotoxicity
|
|
US7635530B2
(en)
|
2005-03-21 |
2009-12-22 |
The Board Of Trustees Of The University Of Illinois |
Membraneless electrochemical cell and microfluidic device without pH constraint
|
|
EP1902318A1
(en)
|
2005-05-30 |
2008-03-26 |
AstraZeneca AB |
Methods for identifying fzd8 modulators and the use of such modulators for treating osteoarthritis
|
|
US20070014776A1
(en)
|
2005-06-09 |
2007-01-18 |
Gimeno Ruth E |
Identification of adiponutrin-related proteins as esterases and methods of use for the same
|
|
US20070072239A1
(en)
|
2005-09-26 |
2007-03-29 |
Wyeth |
Pharmaceutical compositions and methods of using secreted frizzled related protein
|
|
BRPI0616589A2
(pt)
|
2005-09-28 |
2011-06-28 |
Zymogenetics Inc |
polipeptìdeo, e, métodos para produzir um anticorpo para um polipeptìdeo, para reduzir ou inibir a inflamação e para tratar um mamìfero afligido com uma doença inflamatória
|
|
EP2500360B1
(en)
|
2005-10-31 |
2015-08-05 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for diagnosing and treating cancer
|
|
US7723477B2
(en)
*
|
2005-10-31 |
2010-05-25 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
|
|
DOP2006000277A
(es)
|
2005-12-12 |
2007-08-31 |
Bayer Pharmaceuticals Corp |
Anticuerpos anti mn y métodos para su utilización
|
|
AR060017A1
(es)
|
2006-01-13 |
2008-05-21 |
Novartis Ag |
Composiciones y metodos de uso para anticuerpos de dickkopf -1
|
|
WO2007092433A2
(en)
|
2006-02-06 |
2007-08-16 |
Tethys Bioscience, Inc. |
Osteoporosis associated markers and methods of use thereof
|
|
EP1982718A4
(en)
|
2006-02-09 |
2010-05-12 |
Daiichi Sankyo Co Ltd |
PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OF CANCER
|
|
GB0603683D0
(en)
*
|
2006-02-23 |
2006-04-05 |
Novartis Ag |
Organic compounds
|
|
EP2032605A2
(en)
*
|
2006-05-24 |
2009-03-11 |
Bayer Schering Pharma Aktiengesellschaft |
HIGH AFFINITY HUMAN AND HUMANIZED ANTI-alpha5ß1 INTEGRIN FUNCTION BLOCKING ANTIBODIES WITH REDUCED IMMUNOGENICITY
|
|
US8221751B2
(en)
|
2006-06-21 |
2012-07-17 |
Oncotherapy Science, Inc. |
Tumor-targeting monoclonal antibodies to FZD10 and uses thereof
|
|
TW200815469A
(en)
*
|
2006-06-23 |
2008-04-01 |
Astrazeneca Ab |
Compounds
|
|
US20080118432A1
(en)
|
2006-09-07 |
2008-05-22 |
Ivan Bergstein |
Monitoring cancer stem cells
|
|
AR062709A1
(es)
|
2006-09-08 |
2008-11-26 |
Genentech Inc |
Antagonistas del gen wnt y su uso en el diagnostico y tratamiento de trastornos mediados por el wnt
|
|
EP2074226A2
(en)
|
2006-09-19 |
2009-07-01 |
Novartis AG |
Biomarkers of target modulation, efficacy, diagnosis and/or prognosis for raf inhibitors
|
|
US20100130374A1
(en)
|
2006-09-29 |
2010-05-27 |
Annuska Maria Glas |
High-throughput diagnostic testing using arrays
|
|
CA2667894A1
(en)
|
2006-11-07 |
2008-05-15 |
Merck & Co., Inc. |
Antagonists of pcsk9
|
|
CA2668714A1
(en)
|
2006-11-14 |
2008-05-22 |
Novartis Ag |
Methods of treating, diagnosing or detecting cancer
|
|
JP5363350B2
(ja)
|
2007-03-19 |
2013-12-11 |
武田薬品工業株式会社 |
Ｍａｐｋ／ｅｒｋキナーゼ阻害剤
|
|
JP5592253B2
(ja)
|
2007-05-11 |
2014-09-17 |
バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング |
過剰増殖性疾患およびマイトジェン細胞外キナーゼ活性関連性疾患を治療するための置換フェニルアミノ−ベンゼン誘導体
|
|
EP2164850B1
(en)
|
2007-06-12 |
2016-01-13 |
Genentech, Inc. |
N-substituted azaindoles and methods of use
|
|
CN101801966A
(zh)
|
2007-07-18 |
2010-08-11 |
诺瓦提斯公司 |
双环杂芳基化合物和它们作为激酶抑制剂的用途
|
|
CN103479604B
(zh)
|
2007-07-30 |
2016-08-10 |
阿迪生物科学公司 |
作为mek抑制剂的包括多晶型物的n-(芳氨基)磺酰胺衍生物和组合物、其使用方法和制备方法
|
|
CA2694646C
(en)
|
2007-07-30 |
2017-09-05 |
Ardea Biosciences, Inc. |
Combinations of mek inhibitors and raf kinase inhibitors and uses thereof
|
|
DK2205618T3
(en)
|
2007-09-26 |
2017-02-20 |
Intrexon Corp |
SYNTHETIC 5 'NON-TRANSLATED REGIONS, EXPRESSION VECTORS AND PROCEDURES FOR INCREASING TRANSGENIC EXPRESSION
|
|
AR068767A1
(es)
*
|
2007-10-12 |
2009-12-02 |
Novartis Ag |
Anticuerpos contra esclerostina, composiciones y metodos de uso de estos anticuerpos para tratar un trastorno patologico mediado por esclerostina
|
|
AU2008324203A1
(en)
|
2007-11-05 |
2009-05-14 |
Novartis Ag |
Methods and compositions for measuring Wnt activation and for treating Wnt-related cancers
|
|
US8022057B2
(en)
|
2007-11-12 |
2011-09-20 |
Takeda Pharmaceutical Company Limited |
MAPK/ERK kinase inhibitors
|
|
US20110020368A1
(en)
|
2008-03-25 |
2011-01-27 |
Nancy Hynes |
Treating cancer by down-regulating frizzled-4 and/or frizzled-1
|
|
DE202008004821U1
(de)
|
2008-04-07 |
2008-06-12 |
Heil, Roland |
Siebdruckform
|
|
FR2936255B1
(fr)
|
2008-09-19 |
2010-10-15 |
Galderma Res & Dev |
Modulateurs de fzd2 dans le traitement de l'alopecie
|
|
EP2331136B1
(en)
|
2008-09-26 |
2018-01-10 |
OncoMed Pharmaceuticals, Inc. |
Frizzled-binding agents and uses thereof
|
|
US20130295106A1
(en)
|
2008-09-26 |
2013-11-07 |
Oncomed Pharmaceuticals, Inc. |
Frizzled-Binding Agents And Uses Thereof
|
|
EP2343080B1
(en)
|
2008-09-30 |
2017-11-08 |
Kyowa Hakko Kirin Co., Ltd. |
PHARMACEUTICAL COMPOSITION FOR TREATING BONE DISEASES WHICH COMPRISES PROTEIN COMPRISING Frizzled1, Frizzled2 OR Frizzled7 EXTRACELLULAR CYSTEINE-RICH DOMAIN AND Fc PROTEIN
|
|
US20100169025A1
(en)
|
2008-10-10 |
2010-07-01 |
Arthur William T |
Methods and gene expression signature for wnt/b-catenin signaling pathway
|
|
MA33091B1
(fr)
|
2009-03-11 |
2012-03-01 |
Ardea Biosciences Inc |
Combinaisons pharmaceutiques comprenant rdea119/bay 869766 pour le traitement de cancers specifiques
|
|
TWI535445B
(zh)
|
2010-01-12 |
2016-06-01 |
安可美德藥物股份有限公司 |
Ｗｎｔ拮抗劑及治療和篩選方法
|
|
UY33227A
(es)
|
2010-02-19 |
2011-09-30 |
Novartis Ag |
Compuestos de pirrolopirimidina como inhibidores de la cdk4/6
|
|
EP2545187B1
(en)
|
2010-03-09 |
2018-09-05 |
Dana-Farber Cancer Institute, Inc. |
Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy
|
|
CN102971337B
(zh)
|
2010-04-01 |
2016-09-21 |
昂考梅德药品有限公司 |
卷曲蛋白结合药剂及其应用
|
|
DK2585098T3
(da)
|
2010-06-28 |
2014-11-03 |
Five Prime Therapeutics Inc |
Ekstracellulære FZD8-domæner og fusionsmolekyler fraekstracellulære FZD8-domæner til anvendelse ved behandling afobesitet og obesitet-relaterede lidelser
|
|
UY33469A
(es)
|
2010-06-29 |
2012-01-31 |
Irm Llc Y Novartis Ag |
Composiciones y metodos para modular la via de señalizacion de wnt
|
|
EP3838922A1
(en)
|
2010-10-27 |
2021-06-23 |
Amgen Inc. |
Dkk1 antibodies and methods of use
|
|
JP2015536933A
(ja)
|
2012-10-23 |
2015-12-24 |
オンコメッド ファーマシューティカルズ インコーポレイテッド |
Ｗｎｔ経路結合剤を用いて神経内分泌腫瘍を処置する方法
|
|
CN105073195A
(zh)
|
2013-02-04 |
2015-11-18 |
昂科梅德制药有限公司 |
使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测
|