|
US4109496A
(en)
|
1977-12-20 |
1978-08-29 |
Norris Industries |
Trapped key mechanism
|
|
US4323546A
(en)
|
1978-05-22 |
1982-04-06 |
Nuc Med Inc. |
Method and composition for cancer detection in humans
|
|
US4873191A
(en)
|
1981-06-12 |
1989-10-10 |
Ohio University |
Genetic transformation of zygotes
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
US4981785A
(en)
|
1988-06-06 |
1991-01-01 |
Ventrex Laboratories, Inc. |
Apparatus and method for performing immunoassays
|
|
US4968103A
(en)
|
1988-07-22 |
1990-11-06 |
Photofinish Cosmetics Inc. |
Method of making a brush
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
GB8901778D0
(en)
|
1989-01-27 |
1989-03-15 |
Univ Court Of The University O |
Manipulatory technique
|
|
US5028205A
(en)
|
1989-12-14 |
1991-07-02 |
Ingersoll-Rand Company |
Oil scavenger system for a seal for a rotary shaft
|
|
US5614396A
(en)
|
1990-06-14 |
1997-03-25 |
Baylor College Of Medicine |
Methods for the genetic modification of endogenous genes in animal cells by homologous recombination
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
DE69127627T2
(de)
|
1990-08-29 |
1998-02-19 |
Genpharm Int |
Produktion und Nützung nicht-menschliche transgentiere zur Produktion heterologe Antikörper
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
ATE164395T1
(de)
|
1990-12-03 |
1998-04-15 |
Genentech Inc |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
ES2136092T3
(es)
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
|
DE69326967T2
(de)
|
1992-01-17 |
2000-06-15 |
Lakowicz, Joseph R. |
Phasenmodulationsenergieübertragungsfluoroimmunassay
|
|
US5376313A
(en)
|
1992-03-27 |
1994-12-27 |
Abbott Laboratories |
Injection molding a plastic assay cuvette having low birefringence
|
|
US20070124581A1
(en)
|
1992-05-17 |
2007-05-31 |
Reena Khare |
Cell adhesion and extracellular matrix proteins
|
|
WO1994010300A1
(en)
|
1992-10-30 |
1994-05-11 |
The General Hospital Corporation |
Interaction trap system for isolating novel proteins
|
|
ES2142934T3
(es)
|
1993-02-19 |
2000-05-01 |
Nippon Shinyaku Co Ltd |
Derivado del glicerol, dispositivo y composicion farmaceutica.
|
|
US5876978A
(en)
|
1993-04-06 |
1999-03-02 |
Medical College Of Ohio |
Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
|
|
US5643765A
(en)
|
1993-04-06 |
1997-07-01 |
University Of Rochester |
Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
|
|
US5639606A
(en)
|
1993-04-06 |
1997-06-17 |
The University Of Rochester |
Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
|
|
US5538848A
(en)
|
1994-11-16 |
1996-07-23 |
Applied Biosystems Division, Perkin-Elmer Corp. |
Method for detecting nucleic acid amplification using self-quenching fluorescence probe
|
|
US5599677A
(en)
|
1993-12-29 |
1997-02-04 |
Abbott Laboratories |
Immunoassays for prostate specific antigen
|
|
US5807522A
(en)
|
1994-06-17 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods for fabricating microarrays of biological samples
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
EP0874993A1
(en)
|
1995-12-22 |
1998-11-04 |
Abbott Laboratories |
Fluorescence polarization immunoassay diagnostic method
|
|
US5994316A
(en)
|
1996-02-21 |
1999-11-30 |
The Immune Response Corporation |
Method of preparing polynucleotide-carrier complexes for delivery to cells
|
|
US5885529A
(en)
|
1996-06-28 |
1999-03-23 |
Dpc Cirrus, Inc. |
Automated immunoassay analyzer
|
|
US6198107B1
(en)
|
1997-03-07 |
2001-03-06 |
Clare Chemical Research, Inc. |
Fluorometric detection using visible light
|
|
US6080912A
(en)
|
1997-03-20 |
2000-06-27 |
Wisconsin Alumni Research Foundation |
Methods for creating transgenic animals
|
|
JP2001527403A
(ja)
|
1997-04-25 |
2001-12-25 |
ジェネティックス・インスチチュート・インコーポレーテッド |
分泌蛋白およびそれらをコードするポリヌクレオチド
|
|
US6004528A
(en)
|
1997-09-18 |
1999-12-21 |
Bergstein; Ivan |
Methods of cancer diagnosis and therapy targeted against the cancer stemline
|
|
US6083616A
(en)
|
1997-09-19 |
2000-07-04 |
Seal Products, Inc. |
Nontack pressure activated adhesive
|
|
CA2304828A1
(en)
*
|
1997-09-24 |
1999-04-01 |
Merck & Co., Inc. |
G-protein coupled glycoprotein hormone receptor hg38
|
|
US20020065394A1
(en)
|
1998-03-18 |
2002-05-30 |
Kenneth Jacobs |
Secreted proteins and polynucleotides encoding them
|
|
ES2332025T3
(es)
*
|
1998-03-26 |
2010-01-22 |
The Board Of Trustees Of The Leland Stanford Junior University |
Nuevos receptores de mamiferos acoplados a la proteina g que tienen regiones extracelulares de repeticion ricas en leucina.
|
|
US6485972B1
(en)
|
1998-10-15 |
2002-11-26 |
President And Fellows Of Harvard College |
WNT signalling in reproductive organs
|
|
US20030166047A1
(en)
|
1999-05-06 |
2003-09-04 |
Millennium Pharmaceuticals, Inc. |
Lgr6 nucleic acids and uses thereof
|
|
CA2378403A1
(en)
|
1999-07-26 |
2001-02-01 |
Genentech, Inc. |
Novel polynucleotides and method for the use thereof
|
|
US6824973B2
(en)
|
2000-02-03 |
2004-11-30 |
Kirin Beer Kabushiki Kaisha |
Method of promoting stem cell proliferation or survival by contacting a cell with a stem cell factor-like polypeptide
|
|
CA2399776A1
(en)
|
2000-02-03 |
2001-08-09 |
Hyseq, Inc. |
Novel nucleic acids and polypeptides
|
|
JP4813734B2
(ja)
|
2000-03-31 |
2011-11-09 |
ザ ジェネラル ホスピタル コーポレイション |
毛の成長を調節する方法
|
|
WO2001077169A2
(en)
|
2000-04-05 |
2001-10-18 |
Kirin Beer Kabushiki Kaisha |
Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
|
|
EP1156062A1
(en)
*
|
2000-05-12 |
2001-11-21 |
GPC Biotech AG |
Immunomodulatory human MHC class II antigen-binding peptides/proteins
|
|
AU2001263006A1
(en)
|
2000-05-18 |
2001-11-26 |
Hyseq, Inc. |
Novel nucleic acids and polypeptides
|
|
US20030139341A1
(en)
|
2000-05-30 |
2003-07-24 |
Shyam Ramakrishnan |
Regulation of human lgr4-like g protein -coupled receptor
|
|
WO2003050502A2
(en)
|
2001-12-07 |
2003-06-19 |
Regents Of The University Of Michigan |
Prospective identification and characterization of breast cancer stem cells
|
|
US6984522B2
(en)
|
2000-08-03 |
2006-01-10 |
Regents Of The University Of Michigan |
Isolation and use of solid tumor stem cells
|
|
US6768004B2
(en)
|
2001-01-11 |
2004-07-27 |
Mueller Sybille |
Nucleotide sequences encoding variable regions of heavy and light chains of monoclonal antibody 1F7, an anti-idiotypic antibody reactive with anti-HIV antibodies
|
|
US20040077048A1
(en)
|
2002-01-30 |
2004-04-22 |
Warren Bridget A. |
Protein modification and maintenance molecules
|
|
US20030032034A1
(en)
|
2001-03-05 |
2003-02-13 |
Tang Y. Tom |
Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
|
|
US20100292155A1
(en)
|
2001-03-05 |
2010-11-18 |
Arca Biopharma, Inc. |
Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
|
|
US7411052B2
(en)
|
2001-03-05 |
2008-08-12 |
Nuvelo, Inc. |
Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
|
|
JP4251983B2
(ja)
|
2001-06-11 |
2009-04-08 |
協和発酵キリン株式会社 |
造血幹細胞または造血前駆細胞の増殖または生存を支持し得るポリペプチドおよびそれをコードするｄｎａ
|
|
ATE440869T1
(de)
*
|
2001-06-20 |
2009-09-15 |
Fibron Ltd |
Fgfr3 blockierende antikírper, verfahren zum screening darauf und verwendungen davon
|
|
US20030022217A1
(en)
|
2001-07-02 |
2003-01-30 |
Pe Corporation (Ny) |
Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
|
|
ATE553193T1
(de)
|
2001-08-30 |
2012-04-15 |
Arca Biopharma Inc |
Verfahren und materialien in verbindung mit stammzellen-wachstumsfaktor-ähnlichen polypeptiden und polynukleotiden
|
|
EP1434796A2
(en)
|
2001-10-03 |
2004-07-07 |
Incyte Genomics, Inc. |
Secreted proteins
|
|
US20070237770A1
(en)
|
2001-11-30 |
2007-10-11 |
Albert Lai |
Novel compositions and methods in cancer
|
|
US20040197778A1
(en)
|
2002-12-26 |
2004-10-07 |
Sagres Discovery, Inc. |
Novel compositions and methods in cancer
|
|
AU2002366951A1
(en)
|
2001-12-10 |
2003-07-09 |
Nuvelo,Inc. |
Novel nucleic acids and polypeptides
|
|
US7193069B2
(en)
|
2002-03-22 |
2007-03-20 |
Research Association For Biotechnology |
Full-length cDNA
|
|
CA2483518A1
(en)
|
2002-04-26 |
2003-11-06 |
Kirin Beer Kabushiki Kaisha |
Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell or hematopoietic progenitor cell, and dna coding for the same
|
|
EP1380644A1
(en)
|
2002-07-08 |
2004-01-14 |
Kylix B.V. |
The use of specified TCF target genes to identify drugs for the treatment of cancer, in particular colorectal cancer, in which TCF/beta-catenin/WNT signalling plays a central role
|
|
US20060205924A1
(en)
*
|
2002-12-26 |
2006-09-14 |
Marco Muda |
Spliced variants of lgr6
|
|
WO2004074436A2
(en)
|
2003-02-19 |
2004-09-02 |
Incyte Corporation |
Methods of use of a gpcr in the diagnosis and treatment of colon and lung cancer
|
|
US20050003405A1
(en)
|
2003-04-30 |
2005-01-06 |
Hua-Chien Chen |
Treatment and diagnostics of cancer
|
|
US20060019256A1
(en)
|
2003-06-09 |
2006-01-26 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing cancer
|
|
WO2005110009A2
(en)
|
2003-07-22 |
2005-11-24 |
Immunex Corporation |
COMPOSITIONS AND METHODS RELATING TO TSP-30a, b, c AND d
|
|
DE10339820A1
(de)
*
|
2003-08-22 |
2005-03-17 |
Hinzmann, Bernd, Dr. |
Verwendung von an GPR49 bindenden Substanzen zur Diagnose und Behandlung von Krebs
|
|
US9046537B2
(en)
|
2003-09-22 |
2015-06-02 |
Enzo Biochem, Inc. |
Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain
|
|
WO2005040418A2
(en)
|
2003-10-10 |
2005-05-06 |
Deutsches Krebsforschungszentrum |
Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (r-spondins) and/or wnt
|
|
WO2005040828A2
(en)
|
2003-10-24 |
2005-05-06 |
Bayer Healthcare Ag |
Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 49 (gpr49)
|
|
WO2005072419A2
(en)
|
2004-01-27 |
2005-08-11 |
Nuvelo, Inc. |
Gastrointestinal proliferative factor and uses thereof
|
|
WO2005074633A2
(en)
|
2004-02-03 |
2005-08-18 |
The Regents Of The University Of Michigan |
Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
|
|
WO2006031825A2
(en)
|
2004-09-13 |
2006-03-23 |
Macrogenics, Inc. |
Humanized antibodies against west nile virus and therapeutic and prophylactic uses thereof
|
|
CA2591665C
(en)
|
2004-12-20 |
2015-05-05 |
Crucell Holland B.V. |
Binding molecules capable of neutralizing west nile virus and uses thereof
|
|
US7439327B2
(en)
|
2005-01-18 |
2008-10-21 |
Nuvelo, Inc. |
Stem cell factor-like proteins and uses thereof
|
|
WO2006110581A2
(en)
|
2005-04-07 |
2006-10-19 |
Novartis Vaccines And Diagnostics Inc. |
Cancer-related genes
|
|
WO2007013666A2
(en)
|
2005-07-26 |
2007-02-01 |
Kirin Pharma Kabushiki Kaisha |
Anti-tumor agents comprising r-spondins
|
|
WO2007030290A2
(en)
|
2005-09-07 |
2007-03-15 |
Maine Medical Center Research |
Cristin/r-spondin ligands active in the wnt signaling pathway and methods, compositions and kits relating thereto
|
|
CA2623413A1
(en)
|
2005-10-07 |
2007-09-07 |
Nuvelo, Inc. |
Stem cell factor-like protein scfa1 and uses thereof
|
|
JP5129149B2
(ja)
|
2005-10-31 |
2013-01-23 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
癌を処置および診断するための組成物および方法
|
|
US7723477B2
(en)
|
2005-10-31 |
2010-05-25 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
|
|
GB0603683D0
(en)
*
|
2006-02-23 |
2006-04-05 |
Novartis Ag |
Organic compounds
|
|
JP4560582B2
(ja)
|
2006-06-02 |
2010-10-13 |
アベオ ファーマシューティカルズ， インコーポレイテッド |
肝細胞成長因子（ｈｇｆ）結合蛋白質
|
|
AU2007254942B2
(en)
|
2006-06-02 |
2011-10-27 |
Aveo Pharmaceuticals, Inc. |
Hepatocyte growth factor (HGF) binding proteins
|
|
PL2032166T3
(pl)
|
2006-06-13 |
2013-09-30 |
Oncomed Pharm Inc |
Kompozycje i sposoby diagnozowania i leczenia nowotworów
|
|
BRPI0714871A2
(pt)
|
2006-07-18 |
2013-05-07 |
Sanofi-Aventis |
anticorpo antagonista para o tratamento de cÂncer
|
|
JP2008044926A
(ja)
*
|
2006-08-14 |
2008-02-28 |
Trustees Of Columbia Univ In The City Of New York |
Ｗｎｔ信号伝達に関係した分泌タンパク質
|
|
PL2066694T3
(pl)
|
2006-09-29 |
2016-04-29 |
Oncomed Pharm Inc |
Kompozycje i sposoby diagnozowania i leczenia nowotworu
|
|
JP5777281B2
(ja)
|
2006-10-20 |
2015-09-09 |
デウトスクフエス クレブスフオルスチュングスゼントルム ストイフトウング デス オフフエントリクヘンレクフトス |
血管新生及び脈管形成のモジュレーターとしてのｒスポンジン
|
|
WO2008075796A1
(ja)
|
2006-12-21 |
2008-06-26 |
Kyowa Hakko Kirin Co., Ltd. |
血球回復促進剤
|
|
WO2008088524A2
(en)
*
|
2006-12-28 |
2008-07-24 |
Nuvelo, Inc. |
Thrombospondin-domain-deficient r-spondin 1 protein as gastrointestinal tract epithelial proliferation factor
|
|
KR20100044160A
(ko)
|
2007-06-12 |
2010-04-29 |
와이어쓰 엘엘씨 |
항-ｃｄ20 치료 조성물 및 방법
|
|
EP3424529A1
(en)
|
2007-07-02 |
2019-01-09 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for treating and diagnosing cancer
|
|
US20120082659A1
(en)
|
2007-10-02 |
2012-04-05 |
Hartmut Land |
Methods And Compositions Related To Synergistic Responses To Oncogenic Mutations
|
|
WO2009045443A2
(en)
|
2007-10-02 |
2009-04-09 |
The University Of Rochester |
Methods and compositions related to synergistic responses to oncogenic mutations
|
|
WO2009063970A1
(ja)
|
2007-11-14 |
2009-05-22 |
Forerunner Pharma Research Co., Ltd. |
抗gpr49抗体を用いる癌の診断および治療
|
|
EP2313435A4
(en)
|
2008-07-01 |
2012-08-08 |
Aveo Pharmaceuticals Inc |
FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) BINDING PROTEINS
|
|
WO2010016766A2
(en)
|
2008-08-08 |
2010-02-11 |
Koninklijke Nederlandse Akademie Van Wetenschappen |
Antibodies recognizing endogenous human lgr5 and/or lgr6
|
|
EP2363471B1
(en)
|
2008-10-31 |
2016-10-12 |
Toray Industries, Inc. |
Immunoassay method for human cxcl1 protein
|
|
WO2010121923A1
(en)
|
2009-04-15 |
2010-10-28 |
Deutsches Krebsforschungszentrum |
Rspondin-3 inhibition in bone disorders
|
|
US20120165270A1
(en)
|
2009-04-27 |
2012-06-28 |
Yeon Sook Choi |
Inhibition of hair follicle growth by the wnt inhibitor dkk1
|
|
WO2010129304A2
(en)
|
2009-04-27 |
2010-11-11 |
Oncomed Pharmaceuticals, Inc. |
Method for making heteromultimeric molecules
|
|
JP2012530721A
(ja)
|
2009-06-18 |
2012-12-06 |
ワイス・エルエルシー |
小モジュール免疫薬のための凍結乾燥製剤
|
|
WO2011009090A1
(en)
|
2009-07-16 |
2011-01-20 |
Xoma Technology Ltd. |
Antibodies to high molecular weight melanoma associated antigen
|
|
HUE049825T2
(hu)
|
2009-09-03 |
2020-10-28 |
Merck Sharp & Dohme |
Anti-GITR antitestek
|
|
WO2011076932A1
(en)
|
2009-12-23 |
2011-06-30 |
Deutsches Krebsforschungszentrum |
Receptors of rspo2 and rspo3
|
|
WO2011085289A1
(en)
|
2010-01-11 |
2011-07-14 |
Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University |
Production of a monoclonal antibody therapeutic against west nile virus in plants
|
|
WO2011140441A2
(en)
|
2010-05-06 |
2011-11-10 |
Children's Hospital Medical Center |
Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
|
|
EP2659005A4
(en)
|
2010-12-28 |
2016-08-24 |
Caris Mpi Inc |
MOLECULAR PROFILING OF CANCER
|
|
GB201106395D0
(en)
|
2011-04-14 |
2011-06-01 |
Hubrecht Inst |
Compounds
|
|
HUE034752T2
(en)
|
2011-04-28 |
2018-02-28 |
Sbi Biotech Co Ltd |
Antibody against human receptor protein tyrosine phosphatase
|
|
RU2014101669A
(ru)
|
2011-07-15 |
2015-09-20 |
Онкомед Фармасьютикалс, Инк. |
Агенты, связывающие белки r-спондины (rspo), и способы их применения
|
|
CN109111523B
(zh)
|
2011-10-14 |
2022-06-07 |
诺华股份有限公司 |
用于Wnt途径相关疾病的抗体和方法
|
|
EP2773664A1
(en)
|
2011-11-01 |
2014-09-10 |
Bionomics, Inc. |
Anti-gpr49 antibodies
|
|
US10598653B2
(en)
|
2011-11-01 |
2020-03-24 |
Bionomics Inc. |
Methods of blocking cancer stem cell growth
|
|
US20130209473A1
(en)
|
2012-02-11 |
2013-08-15 |
Genentech, Inc. |
R-spondin translocations and methods using the same
|
|
AR090549A1
(es)
|
2012-03-30 |
2014-11-19 |
Genentech Inc |
Anticuerpos anti-lgr5 e inmunoconjugados
|
|
KR20150036603A
(ko)
|
2012-07-13 |
2015-04-07 |
온코메드 파마슈티칼스, 인크. |
Rspo3 결합제 및 그의 용도
|
|
AU2014248568B2
(en)
|
2013-03-12 |
2017-07-13 |
Curegenix, Inc. |
Compounds for treatment of cancer
|
|
CA2913924A1
(en)
|
2013-05-30 |
2014-12-04 |
Order-Made Medical Research Inc. |
Reagent including anti-lgr6 antibodies for detection and diagnosis of cancer
|
|
TWI658052B
(zh)
|
2013-10-18 |
2019-05-01 |
美商建南德克公司 |
抗－ｒｓｐｏ抗體及使用方法
|
|
US9777052B2
(en)
|
2014-12-02 |
2017-10-03 |
The Board Of Regents Of The University Of Oklahoma |
R-spondin variants, compositions, and methods of use
|
|
MA41123A
(fr)
|
2014-12-02 |
2017-10-10 |
Oncomed Pharm Inc |
Polythérapie pour le traitement du cancer
|