SI2173379T1 - Sestavki in postopki za zdravljenje in diagnosticiranje raka - Google Patents
Sestavki in postopki za zdravljenje in diagnosticiranje rakaInfo
- Publication number
- SI2173379T1 SI2173379T1 SI200831523T SI200831523T SI2173379T1 SI 2173379 T1 SI2173379 T1 SI 2173379T1 SI 200831523 T SI200831523 T SI 200831523T SI 200831523 T SI200831523 T SI 200831523T SI 2173379 T1 SI2173379 T1 SI 2173379T1
- Authority
- SI
- Slovenia
- Prior art keywords
- compositions
- treating
- methods
- diagnosing cancer
- diagnosing
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94761107P | 2007-07-02 | 2007-07-02 | |
| EP08779934.2A EP2173379B2 (en) | 2007-07-02 | 2008-07-02 | Compositions and methods for treating and diagnosing cancer |
| PCT/US2008/008210 WO2009005809A2 (en) | 2007-07-02 | 2008-07-02 | Compositions and methods for treating and diagnosing cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2173379T1 true SI2173379T1 (sl) | 2015-12-31 |
Family
ID=40226729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200831523T SI2173379T1 (sl) | 2007-07-02 | 2008-07-02 | Sestavki in postopki za zdravljenje in diagnosticiranje raka |
Country Status (14)
| Country | Link |
|---|---|
| US (10) | US8158758B2 (enExample) |
| EP (3) | EP3424529A1 (enExample) |
| JP (3) | JP5931336B2 (enExample) |
| AU (1) | AU2008270972B2 (enExample) |
| CA (1) | CA2691378A1 (enExample) |
| CY (1) | CY1116967T1 (enExample) |
| DK (1) | DK2173379T3 (enExample) |
| ES (2) | ES2694018T3 (enExample) |
| HR (1) | HRP20151261T1 (enExample) |
| HU (1) | HUE027154T2 (enExample) |
| PL (2) | PL3009148T3 (enExample) |
| PT (1) | PT2173379E (enExample) |
| SI (1) | SI2173379T1 (enExample) |
| WO (1) | WO2009005809A2 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005040418A2 (en) * | 2003-10-10 | 2005-05-06 | Deutsches Krebsforschungszentrum | Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (r-spondins) and/or wnt |
| JP5777281B2 (ja) | 2006-10-20 | 2015-09-09 | デウトスクフエス クレブスフオルスチュングスゼントルム ストイフトウング デス オフフエントリクヘンレクフトス | 血管新生及び脈管形成のモジュレーターとしてのrスポンジン |
| EP3424529A1 (en) | 2007-07-02 | 2019-01-09 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for treating and diagnosing cancer |
| WO2009063970A1 (ja) | 2007-11-14 | 2009-05-22 | Forerunner Pharma Research Co., Ltd. | 抗gpr49抗体を用いる癌の診断および治療 |
| WO2010016766A2 (en) * | 2008-08-08 | 2010-02-11 | Koninklijke Nederlandse Akademie Van Wetenschappen | Antibodies recognizing endogenous human lgr5 and/or lgr6 |
| WO2010019702A2 (en) | 2008-08-12 | 2010-02-18 | Oncomed Pharmaceuticals, Inc. | Ddr1-binding agents and methods of use thereof |
| WO2010033553A2 (en) * | 2008-09-16 | 2010-03-25 | University Of Florida Research Foundation Inc. | Gene expression related to preeclampsia |
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| PL2393917T3 (pl) | 2009-02-03 | 2016-12-30 | Podłoże do hodowli nabłonkowych komórek macierzystych i organoidów zawierających komórki macierzyste | |
| US8563307B2 (en) | 2009-02-24 | 2013-10-22 | James Wang | Treatment of immunosuppression-related disorders |
| ES2617281T3 (es) | 2009-10-28 | 2017-06-16 | Janssen Biotech, Inc. | Anticuerpos anti-glp-1r y sus usos |
| EP4190149A1 (en) | 2009-12-25 | 2023-06-07 | Chugai Seiyaku Kabushiki Kaisha | Method for searching and screening for target of anti-cancer agent using non-human animal model having nog established cancer cell line transplanted therein |
| US8679474B2 (en) | 2010-08-04 | 2014-03-25 | StemBios Technologies, Inc. | Somatic stem cells |
| WO2012046797A1 (ja) | 2010-10-06 | 2012-04-12 | ファーマロジカルズ・リサーチ プライベート リミテッド | 癌幹細胞集団及びその作製方法 |
| GB201106395D0 (en) | 2011-04-14 | 2011-06-01 | Hubrecht Inst | Compounds |
| US9057096B2 (en) | 2011-05-20 | 2015-06-16 | Board Of Regents Of The University Of Texas System | Regulation of Wnt/beta-catenin signaling |
| RU2014101669A (ru) | 2011-07-15 | 2015-09-20 | Онкомед Фармасьютикалс, Инк. | Агенты, связывающие белки r-спондины (rspo), и способы их применения |
| AU2013204484B2 (en) * | 2011-07-15 | 2016-05-12 | Oncomed Pharmaceuticals, Inc. | RSPO binding agents and uses thereof |
| US10018630B2 (en) | 2011-09-07 | 2018-07-10 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell isolation |
| TWI571513B (zh) | 2011-09-28 | 2017-02-21 | 幹細胞生物科技股份有限公司 | 體幹細胞及其製備方法 |
| CN109111523B (zh) | 2011-10-14 | 2022-06-07 | 诺华股份有限公司 | 用于Wnt途径相关疾病的抗体和方法 |
| EP3603671A3 (en) | 2011-10-28 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell-specific molecule |
| EP2773664A1 (en) * | 2011-11-01 | 2014-09-10 | Bionomics, Inc. | Anti-gpr49 antibodies |
| US9221907B2 (en) | 2011-11-01 | 2015-12-29 | Bionomics Inc. | Anti-GPR49 monoclonal antibodies |
| JP2014533247A (ja) | 2011-11-01 | 2014-12-11 | バイオノミクス インコーポレイテッド | 抗体および癌を治療する方法 |
| US10598653B2 (en) | 2011-11-01 | 2020-03-24 | Bionomics Inc. | Methods of blocking cancer stem cell growth |
| US9352039B2 (en) | 2012-02-09 | 2016-05-31 | The Regents Of The University Of Michigan | Method of reducing the number of EMT and MET type breast cancer stem cells |
| US20130209473A1 (en) | 2012-02-11 | 2013-08-15 | Genentech, Inc. | R-spondin translocations and methods using the same |
| AR090549A1 (es) * | 2012-03-30 | 2014-11-19 | Genentech Inc | Anticuerpos anti-lgr5 e inmunoconjugados |
| KR20150036603A (ko) | 2012-07-13 | 2015-04-07 | 온코메드 파마슈티칼스, 인크. | Rspo3 결합제 및 그의 용도 |
| US20140017721A1 (en) * | 2012-07-13 | 2014-01-16 | The Research Foundation Of State University Of New York | Spontaneously immortalized prostate cancer cell line |
| TWI687519B (zh) | 2012-12-06 | 2020-03-11 | 美商幹細胞生物科技股份有限公司 | Lgr5+體幹細胞 |
| EP2746770A1 (en) | 2012-12-21 | 2014-06-25 | Stembios Technologies, Inc. | Method for evaluating effect of action on subject based on stem celldynamics |
| CA2913924A1 (en) | 2013-05-30 | 2014-12-04 | Order-Made Medical Research Inc. | Reagent including anti-lgr6 antibodies for detection and diagnosis of cancer |
| BR112016004450A2 (pt) | 2013-09-17 | 2017-10-17 | Genentech Inc | métodos para tratar uma doença, para aumentar a eficácia de um tratamento, para adiar e/ou prevenir desenvolvimento da reincidência e/ou resistência de uma doença, para aumentar a sensibilidade a um inibidor, para estender o período de sensibilidade a um inibidor e para estender a duração de resposta a um inibidor |
| WO2015108203A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社オーダーメードメディカルリサーチ | 抗slc6a6抗体を用いたがん治療用医薬組成物 |
| SG11201607109QA (en) | 2014-02-28 | 2016-09-29 | Merus Nv | Antibodies that bind egfr and erbb3 |
| CN106459212B (zh) | 2014-02-28 | 2021-07-13 | 美勒斯公司 | 结合erbb-2和erbb-3的抗体 |
| KR102352573B1 (ko) | 2014-04-04 | 2022-01-18 | 바이오노믹스 인코포레이티드 | Lgr5에 결합하는 인간화된 항체들 |
| ES2734146T3 (es) * | 2014-05-05 | 2019-12-04 | Synexis Llc | Dispositivos para la generación de gas de peróxido de hidrógeno purificado |
| RU2016148616A (ru) | 2014-06-11 | 2018-07-18 | Дженентек, Инк. | Анти-lgr5 антитела и их применение |
| TW201628648A (zh) * | 2014-09-16 | 2016-08-16 | 安可美德藥物股份有限公司 | 纖維變性疾病之治療 |
| WO2016057629A1 (en) * | 2014-10-07 | 2016-04-14 | Duke University | Methods and therapeutics relating to human r-spondin protein and leucine-rich repeat-containing g protein-coupled receptor protein |
| MA41123A (fr) * | 2014-12-02 | 2017-10-10 | Oncomed Pharm Inc | Polythérapie pour le traitement du cancer |
| WO2017040660A1 (en) * | 2015-08-31 | 2017-03-09 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
| DK3365373T3 (da) | 2015-10-23 | 2021-04-06 | Merus Nv | Bindingsmolekyler, der hæmmer cancervækst |
| CN105274061A (zh) * | 2015-10-26 | 2016-01-27 | 无锡傲锐东源生物科技有限公司 | 抗lgr5蛋白单克隆抗体杂交瘤细胞及其产生的抗lgr5单克隆抗体和应用 |
| EP3432925A4 (en) * | 2016-03-22 | 2019-11-06 | Bionomics Limited | ADMINISTRATION OF A MONOCLONAL ANTI-LGR5 ANTIBODY |
| CN109789206A (zh) * | 2016-09-16 | 2019-05-21 | 生态有限公司 | 抗体和检查点抑制剂的组合疗法 |
| MX389083B (es) | 2016-12-01 | 2025-03-20 | Regeneron Pharma | Anticuerpos anti-pd-l1 radiomarcados para imagenes de inmuno-pet. |
| EP3600413A1 (en) | 2017-03-31 | 2020-02-05 | Merus N.V. | Erbb-2 and erbb3 binding bispecific antibodies for use in the treatment f cells that have an nrg1 fusion gene |
| AU2018271157C1 (en) | 2017-05-17 | 2021-11-18 | Merus N.V. | Combination of an ErbB-2/ErbB-3 bispecific antibody with endocrine therapy for breast cancer |
| CN118562014A (zh) | 2017-08-09 | 2024-08-30 | 美勒斯公司 | 结合EGFR和cMET的抗体 |
| GB201721615D0 (en) | 2017-12-21 | 2018-02-07 | Koninklijke Nederlandse Akademie Van Wetenschappen | Immune cell organoid co-cultures |
| WO2021123198A1 (en) * | 2019-12-19 | 2021-06-24 | Deutsches Krebsforschungszentrum | Leukemia treatment |
| WO2021247497A1 (en) * | 2020-06-03 | 2021-12-09 | Children's Hospital Medical Center | Compositions and methods comprising r-spondins for treatment of tumors |
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