KR102290592B1 - Her2에 대항하는 적어도 두 개 이상의 반복 도메인을 포함하는 결합 단백질 - Google Patents

Her2에 대항하는 적어도 두 개 이상의 반복 도메인을 포함하는 결합 단백질 Download PDF

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KR102290592B1
KR102290592B1 KR1020157017376A KR20157017376A KR102290592B1 KR 102290592 B1 KR102290592 B1 KR 102290592B1 KR 1020157017376 A KR1020157017376 A KR 1020157017376A KR 20157017376 A KR20157017376 A KR 20157017376A KR 102290592 B1 KR102290592 B1 KR 102290592B1
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KR20150091138A (ko
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윌리케 피들러
이그나시오 돌라도
하이케 스트로벨
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몰리큘라 파트너스 아게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cell Biology (AREA)
KR1020157017376A 2012-11-30 2013-12-02 Her2에 대항하는 적어도 두 개 이상의 반복 도메인을 포함하는 결합 단백질 Expired - Fee Related KR102290592B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12195156.0 2012-11-30
EP12195156.0A EP2738180A1 (en) 2012-11-30 2012-11-30 Binding proteins comprising at least two binding domains against HER2.
PCT/EP2013/075290 WO2014083208A1 (en) 2012-11-30 2013-12-02 Binding proteins comprising at least two repeat domains against her2

Publications (2)

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KR20150091138A KR20150091138A (ko) 2015-08-07
KR102290592B1 true KR102290592B1 (ko) 2021-08-19

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KR1020157017376A Expired - Fee Related KR102290592B1 (ko) 2012-11-30 2013-12-02 Her2에 대항하는 적어도 두 개 이상의 반복 도메인을 포함하는 결합 단백질

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US (1) US10370414B2 (enExample)
EP (2) EP2738180A1 (enExample)
JP (1) JP6410724B2 (enExample)
KR (1) KR102290592B1 (enExample)
CN (1) CN104918959A (enExample)
AU (2) AU2013351096C9 (enExample)
CA (1) CA2892747C (enExample)
HK (1) HK1211297A1 (enExample)
MX (1) MX366223B (enExample)
RU (1) RU2664464C9 (enExample)
WO (1) WO2014083208A1 (enExample)

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AU2018256592A1 (en) 2018-11-22
CN104918959A (zh) 2015-09-16
AU2013351096C1 (en) 2018-11-08
US10370414B2 (en) 2019-08-06
JP6410724B2 (ja) 2018-10-24
WO2014083208A9 (en) 2014-12-24
RU2664464C2 (ru) 2018-08-17
WO2014083208A1 (en) 2014-06-05
US20150299265A1 (en) 2015-10-22
EP2925784B1 (en) 2021-02-17
AU2013351096A1 (en) 2015-07-09
WO2014083208A8 (en) 2014-10-30
MX2015006548A (es) 2015-10-15
CA2892747C (en) 2022-07-19
AU2013351096C9 (en) 2019-01-31
BR112015012436A2 (pt) 2017-09-12
HK1211297A1 (zh) 2016-05-20
RU2015120663A (ru) 2017-01-10
CA2892747A1 (en) 2014-06-05
KR20150091138A (ko) 2015-08-07
MX366223B (es) 2019-07-03
EP2738180A1 (en) 2014-06-04
EP2925784A1 (en) 2015-10-07
JP2015537044A (ja) 2015-12-24
RU2664464C9 (ru) 2018-12-19
AU2013351096B2 (en) 2018-08-09

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