BR112021024231A2 - Proteínas de ligação fap recombinantes e uso da mesma - Google Patents
Proteínas de ligação fap recombinantes e uso da mesmaInfo
- Publication number
- BR112021024231A2 BR112021024231A2 BR112021024231A BR112021024231A BR112021024231A2 BR 112021024231 A2 BR112021024231 A2 BR 112021024231A2 BR 112021024231 A BR112021024231 A BR 112021024231A BR 112021024231 A BR112021024231 A BR 112021024231A BR 112021024231 A2 BR112021024231 A2 BR 112021024231A2
- Authority
- BR
- Brazil
- Prior art keywords
- binding proteins
- nucleic acids
- fap
- recombinant
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1075—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being against an enzyme
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
Abstract
proteínas de ligação fap recombinantes e uso da mesma. a presente invenção refere-se a proteínas de ligação recombinantes que compreendem um domínio de repetição de anquirina projetado com especificidade de ligação para a proteína de ativação de fibroblastos (fap). além disso, a invenção se refere a ácidos nucleicos que codificam tais proteínas de ligação, composições farmacêuticas que compreendem tais proteínas de ligação ou ácidos nucleicos, e ao uso de tais proteínas de ligação, ácidos nucleicos ou composições farmacêuticas em métodos para localizar ou liberar uma molécula biologicamente ativa em tecido que expressa fap, como tecido tumoral, e para tratar, diagnosticar ou capturar imagens de doenças, como câncer, em um mamífero, incluindo um ser humano.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19178277 | 2019-06-04 | ||
PCT/EP2020/065317 WO2020245173A1 (en) | 2019-06-04 | 2020-06-03 | Recombinant fap binding proteins and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021024231A2 true BR112021024231A2 (pt) | 2022-04-26 |
Family
ID=66857625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021024231A BR112021024231A2 (pt) | 2019-06-04 | 2020-06-03 | Proteínas de ligação fap recombinantes e uso da mesma |
Country Status (12)
Country | Link |
---|---|
US (1) | US20220242973A1 (pt) |
EP (1) | EP3980045A1 (pt) |
JP (1) | JP2022535415A (pt) |
KR (1) | KR20220016942A (pt) |
CN (1) | CN114269366A (pt) |
AU (1) | AU2020286600A1 (pt) |
BR (1) | BR112021024231A2 (pt) |
CA (1) | CA3139164A1 (pt) |
IL (1) | IL288610A (pt) |
MX (1) | MX2021014601A (pt) |
SG (1) | SG11202112925PA (pt) |
WO (1) | WO2020245173A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2022007122A (es) | 2019-12-11 | 2022-09-09 | Molecular Partners Ag | Dominios de repetición de anquirina diseñados con residuos de superficie alterados. |
CA3176845A1 (en) | 2020-05-06 | 2021-11-11 | Patrick AMSTUTZ | Novel ankyrin repeat binding proteins and their uses |
CA3176497A1 (en) | 2020-05-07 | 2021-11-11 | Fatima MECHTA-GRIGORIOU | Antxr1 as a biomarker of immunosuppressive fibroblast populations and its use for predicting response to immunotherapy |
WO2022190016A1 (en) | 2021-03-09 | 2022-09-15 | Molecular Partners Ag | Novel darpin based multi-specific t-cell engagers |
WO2024003393A1 (en) * | 2022-06-30 | 2024-01-04 | Navigo Proteins Gmbh | Fusion proteins with half life extending domains |
WO2024074706A1 (en) | 2022-10-07 | 2024-04-11 | Universität Zürich | Paracrine adenoviral delivery of biomolecules |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE448301T1 (de) | 2000-09-08 | 2009-11-15 | Univ Zuerich | Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten |
WO2009040338A1 (en) | 2007-09-24 | 2009-04-02 | University Of Zürich | Designed armadillo repeat proteins |
ES2758352T3 (es) | 2010-11-26 | 2020-05-05 | Molecular Partners Ag | Proteínas de repetición diseñadas que se une a la seroalbúmina |
AU2012249359A1 (en) * | 2011-04-29 | 2013-11-14 | Janssen Biotech, Inc. | IL4/IL13 binding repeat proteins and uses |
AU2013283296A1 (en) * | 2012-06-28 | 2015-02-05 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
EP3004152B1 (en) * | 2013-05-31 | 2020-09-30 | Molecular Partners AG | Designed ankyrin repeat proteins binding to hepatocyte growth factor |
KR102236367B1 (ko) * | 2013-07-26 | 2021-04-05 | 삼성전자주식회사 | DARPin을 포함하는 이중 특이 키메라 단백질 |
US20150126458A1 (en) * | 2013-11-05 | 2015-05-07 | Allergan, Inc. | Method of treating conditions of the eye with an anti-vegf darpin |
BR112017020986A2 (pt) * | 2015-04-02 | 2018-08-14 | Molecular Partners Ag. | proteínas de ligação recombinantes e seu uso |
WO2017210600A1 (en) * | 2016-06-03 | 2017-12-07 | The Scripps Research Institute | Compositions and methods of modulating immune response |
US10717772B2 (en) * | 2016-09-22 | 2020-07-21 | Molecular Partners Ag | Recombinant binding proteins targeting HER2 and serum albumin, and their uses |
-
2020
- 2020-06-03 MX MX2021014601A patent/MX2021014601A/es unknown
- 2020-06-03 AU AU2020286600A patent/AU2020286600A1/en active Pending
- 2020-06-03 BR BR112021024231A patent/BR112021024231A2/pt unknown
- 2020-06-03 SG SG11202112925PA patent/SG11202112925PA/en unknown
- 2020-06-03 CA CA3139164A patent/CA3139164A1/en active Pending
- 2020-06-03 US US17/596,095 patent/US20220242973A1/en active Pending
- 2020-06-03 JP JP2021571937A patent/JP2022535415A/ja active Pending
- 2020-06-03 WO PCT/EP2020/065317 patent/WO2020245173A1/en unknown
- 2020-06-03 KR KR1020227000004A patent/KR20220016942A/ko active Search and Examination
- 2020-06-03 CN CN202080055727.3A patent/CN114269366A/zh active Pending
- 2020-06-03 EP EP20728795.4A patent/EP3980045A1/en active Pending
-
2021
- 2021-12-02 IL IL288610A patent/IL288610A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2020245173A1 (en) | 2020-12-10 |
CA3139164A1 (en) | 2020-12-10 |
JP2022535415A (ja) | 2022-08-08 |
AU2020286600A1 (en) | 2021-12-23 |
KR20220016942A (ko) | 2022-02-10 |
SG11202112925PA (en) | 2021-12-30 |
CN114269366A (zh) | 2022-04-01 |
IL288610A (en) | 2022-02-01 |
US20220242973A1 (en) | 2022-08-04 |
MX2021014601A (es) | 2022-02-11 |
EP3980045A1 (en) | 2022-04-13 |
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