BR112012004546A8 - Terapêutica por proteínas ligantes dll4-ligantes - Google Patents

Terapêutica por proteínas ligantes dll4-ligantes

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Publication number
BR112012004546A8
BR112012004546A8 BR112012004546A BR112012004546A BR112012004546A8 BR 112012004546 A8 BR112012004546 A8 BR 112012004546A8 BR 112012004546 A BR112012004546 A BR 112012004546A BR 112012004546 A BR112012004546 A BR 112012004546A BR 112012004546 A8 BR112012004546 A8 BR 112012004546A8
Authority
BR
Brazil
Prior art keywords
dll4
proteins
linkers
angiogenesis
antibodies
Prior art date
Application number
BR112012004546A
Other languages
English (en)
Other versions
BR112012004546A2 (pt
Inventor
Benatuil Lorenzo
R Boghaert Erwin
Gu Jijie
Harris Maria
A Hickson Jonathan
Hsieh Chung-Ming
Kutskova Yuliya
Li Yingchun
Liu Zhihong
Morgan-Lappe Susan
Original Assignee
Abbott Lab
Abbvie Inc
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43035018&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012004546(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab, Abbvie Inc filed Critical Abbott Lab
Publication of BR112012004546A2 publication Critical patent/BR112012004546A2/pt
Publication of BR112012004546A8 publication Critical patent/BR112012004546A8/pt

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2857—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, orphan receptor
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
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    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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Abstract

PROTEÍNAS TERAPÊUTICAS DLL4-LIGANTES Proteínas DLL4-ligantes aperfeiçoadas são descritas, incluindo anticorpos, anticorpos CDR-enxertados, anticorpos humanos, e seus fragmentos DLL4-ligantes, proteínas que se ligam a DLL4 com alta afinidade, e proteínas DLL4-ligantes que neutralizam a atividade DLL4. As proteínas DLL4-ligantes são úteis para tratar ou prevenir cânceres, tumores e especialmente para o tratamento ou a prevenção da angiogênese tumoral, e/ou outras doenças angiogênese-dependentes tais como a neovascularização ocular, ou doenças angiogênese-independentes caracterizadas por expressão ou atividades anormais de DLL4, tais como distúrbios autoimunes, incluindo esclerose múltipla.
BR112012004546A 2009-08-29 2010-08-27 Terapêutica por proteínas ligantes dll4-ligantes BR112012004546A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23815209P 2009-08-29 2009-08-29
US26172809P 2009-11-16 2009-11-16
PCT/US2010/047006 WO2011025964A2 (en) 2009-08-29 2010-08-27 Therapeutic dll4 binding proteins

Publications (2)

Publication Number Publication Date
BR112012004546A2 BR112012004546A2 (pt) 2016-11-29
BR112012004546A8 true BR112012004546A8 (pt) 2017-12-05

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ID=43035018

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Application Number Title Priority Date Filing Date
BR112012004546A BR112012004546A8 (pt) 2009-08-29 2010-08-27 Terapêutica por proteínas ligantes dll4-ligantes

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US (5) US8623358B2 (pt)
EP (2) EP3029070A1 (pt)
JP (2) JP5903382B2 (pt)
KR (1) KR20120089659A (pt)
CN (2) CN102741288B (pt)
AR (1) AR077998A1 (pt)
AU (2) AU2010286518C1 (pt)
BR (1) BR112012004546A8 (pt)
CA (2) CA2952742A1 (pt)
CL (1) CL2012000520A1 (pt)
CO (1) CO6612215A2 (pt)
CR (1) CR20120105A (pt)
DO (1) DOP2012000052A (pt)
HK (1) HK1225743A1 (pt)
IL (1) IL218401A (pt)
MX (2) MX336152B (pt)
MY (1) MY159837A (pt)
NZ (1) NZ598524A (pt)
PE (1) PE20121647A1 (pt)
RU (1) RU2570639C2 (pt)
SG (1) SG178930A1 (pt)
TW (1) TWI465250B (pt)
UY (1) UY32869A (pt)
WO (1) WO2011025964A2 (pt)
ZA (1) ZA201201298B (pt)

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WO2007114319A1 (ja) 2006-03-31 2007-10-11 Chugai Seiyaku Kabushiki Kaisha 抗体の血中動態を制御する方法
CN101874042B9 (zh) 2007-09-26 2019-01-01 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
CA2722466A1 (en) 2008-04-29 2009-11-05 Tariq Ghayur Dual variable domain immunoglobulins and uses thereof
EP2297209A4 (en) 2008-06-03 2012-08-01 Abbott Lab IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND USES THEREOF
EP3029070A1 (en) 2009-08-29 2016-06-08 AbbVie Inc. Therapeutic dll4 binding proteins
DK2488204T3 (en) 2009-10-16 2016-06-06 Oncomed Pharm Inc Therapeutic combination and use of DLL4 antagonist antibodies and blood pressure lowering agents
JO3183B1 (ar) * 2010-01-29 2018-03-08 Regeneron Pharma طرق لمعالجة أمراض المناعة الذاتية مضادات dll4
EP3680253A3 (en) 2010-03-02 2020-09-30 AbbVie Inc. Therapeutic dll4 binding proteins
JP2013537415A (ja) 2010-08-03 2013-10-03 アッヴィ・インコーポレイテッド 二重可変ドメイン免疫グロブリンおよびその使用
AU2011293253B2 (en) 2010-08-26 2014-12-11 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
EP4303236A3 (en) 2010-11-30 2024-03-20 Chugai Seiyaku Kabushiki Kaisha Cytotoxicity-inducing therapeutic agent
US8858941B2 (en) 2011-09-23 2014-10-14 Oncomed Pharmaceuticals, Inc. VEGF/DLL4 binding agents and uses thereof
HUE033245T2 (hu) * 2011-12-19 2017-11-28 Synimmune Gmbh Bispecifikus ellenanyag molekula
CA2861610A1 (en) 2011-12-30 2013-07-04 Abbvie Inc. Dual specific binding proteins directed against il-13 and/or il-17
WO2013135748A1 (en) * 2012-03-13 2013-09-19 Universitätsklinikum Heidelberg Polypeptides binding to dll4 and uses thereof
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