EA201070636A1 - Ингибирование рецептора белка, стимулирующего макрофаги (ron), и способы его лечения - Google Patents
Ингибирование рецептора белка, стимулирующего макрофаги (ron), и способы его леченияInfo
- Publication number
- EA201070636A1 EA201070636A1 EA201070636A EA201070636A EA201070636A1 EA 201070636 A1 EA201070636 A1 EA 201070636A1 EA 201070636 A EA201070636 A EA 201070636A EA 201070636 A EA201070636 A EA 201070636A EA 201070636 A1 EA201070636 A1 EA 201070636A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- ron
- treatment
- methods
- inhibition
- stimulating macrophage
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Согласно настоящему изобретению предложены антитела или фрагменты антител, включая антитела человека, специфичные в отношении рецептора к белку, стимулирующему макрофаги (MSP-R или RON), которые подавляют активацию RON. Также предложены способы ингибирования RON, в частности применение RON для лечения таких заболеваний, как рак.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98955807P | 2007-11-21 | 2007-11-21 | |
PCT/US2008/013130 WO2009070294A2 (en) | 2007-11-21 | 2008-11-21 | Inhibition of macrophage-stimulating protein receptor (ron) and methods of treatment thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201070636A1 true EA201070636A1 (ru) | 2010-10-29 |
EA018717B1 EA018717B1 (ru) | 2013-10-30 |
Family
ID=40364492
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201070636A EA018717B1 (ru) | 2007-11-21 | 2008-11-21 | Антитело или фрагмент антитела, которое связывается с белком ron человека, и его применение |
Country Status (20)
Country | Link |
---|---|
US (2) | US7947811B2 (ru) |
EP (1) | EP2222703A2 (ru) |
JP (1) | JP5324593B2 (ru) |
KR (1) | KR101227338B1 (ru) |
CN (1) | CN101868478B (ru) |
AR (1) | AR069393A1 (ru) |
AU (1) | AU2008330089B2 (ru) |
BR (1) | BRPI0820218A2 (ru) |
CA (1) | CA2706583A1 (ru) |
CL (1) | CL2008003449A1 (ru) |
EA (1) | EA018717B1 (ru) |
IL (1) | IL204743A (ru) |
MX (1) | MX2010005651A (ru) |
NZ (1) | NZ584271A (ru) |
PA (1) | PA8804901A1 (ru) |
PE (1) | PE20091713A1 (ru) |
TW (1) | TWI417106B (ru) |
UA (1) | UA99633C2 (ru) |
UY (1) | UY31478A1 (ru) |
WO (1) | WO2009070294A2 (ru) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE450615T1 (de) | 2005-07-22 | 2009-12-15 | Five Prime Therapeutics Inc | Zusammensetzungen und verfahren zur behandlung von krankheiten mit fgfr-fusionsproteinen |
EP2245066A2 (en) * | 2008-01-22 | 2010-11-03 | Biogen Idec MA Inc. | Ron antibodies and uses thereof |
EP2265270A1 (en) | 2008-02-04 | 2010-12-29 | OSI Pharmaceuticals, Inc. | 2-aminopyridine kinase inhibitors |
AR070317A1 (es) | 2008-02-06 | 2010-03-31 | Osi Pharm Inc | Furo (3,2-c) piridina y tieno (3,2-c) piridinas |
TWI480050B (zh) * | 2009-02-10 | 2015-04-11 | Daiichi Sankyo Co Ltd | 抗-mst1r抗體及其用途 |
CN105693861A (zh) * | 2009-12-29 | 2016-06-22 | 新兴产品开发西雅图有限公司 | 异二聚体结合蛋白及其应用 |
CA2804399A1 (en) | 2010-07-06 | 2012-01-12 | Aveo Pharmaceuticals, Inc. | Anti-ron antibodies |
US8481038B2 (en) | 2010-11-15 | 2013-07-09 | Five Prime Therapeutics, Inc. | Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins |
US8951972B2 (en) * | 2010-12-09 | 2015-02-10 | Five Prime Therapeutics, Inc. | FGFR1 extracellular domain combination therapies for lung cancer |
AU2012245205B2 (en) | 2011-04-21 | 2017-06-01 | The Regents Of The University Of California, A California Corporation | Compositions and methods for the treatment of neuromyelitis optica |
MX2014002289A (es) | 2011-08-26 | 2015-03-20 | Merrimack Pharmaceuticals Inc | Anticuerpos fc especificos en tandem. |
JP2015505818A (ja) | 2011-11-14 | 2015-02-26 | ファイブ プライム セラピューティックス インコーポレイテッド | 癌を治療する方法 |
CA2890305A1 (en) * | 2012-11-30 | 2014-06-05 | Genentech, Inc. | Ron compositions and methods of use thereof |
WO2014131715A1 (en) * | 2013-02-26 | 2014-09-04 | Roche Glycart Ag | Anti-mcsp antibodies |
EP2964676A1 (en) | 2013-03-06 | 2016-01-13 | Merrimack Pharmaceuticals, Inc. | Anti-c-met tandem fc bispecific antibodies |
JP6779858B2 (ja) * | 2014-07-29 | 2020-11-04 | ウェルマーカー バイオ カンパニー リミテッド | Egfr−標的製剤に対する感受性予測用の新規なバイオマーカー及びその用途 |
WO2016036172A1 (ko) * | 2014-09-03 | 2016-03-10 | 씨제이헬스케어 주식회사 | 단백질 키나제 억제제에 대한 감수성 예측용 바이오 마커 및 이의 용도 |
JP2020500834A (ja) * | 2016-08-26 | 2020-01-16 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | マクロファージ刺激タンパク質受容体(又はRON(Recepteur d′Origine Nantais))抗体及びその使用 |
CN110799211A (zh) | 2016-09-08 | 2020-02-14 | 美国德州精准药靶有限公司 | 特异性识别丛蛋白-信号素-整合素结构域的抗ron单克隆抗体的药物呈递作用及其在肿瘤治疗中的应用 |
US20220372125A1 (en) * | 2019-10-02 | 2022-11-24 | Aslan Pharmaceuticals Pte. Ltd. | Antigen Specific Binding Domains and Antibody Molecules |
WO2022060906A1 (en) * | 2020-09-15 | 2022-03-24 | Duke University | Coronavirus antibodies and uses thereof |
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US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4275149A (en) * | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
JPH02500329A (ja) | 1987-05-21 | 1990-02-08 | クリエイテイブ・バイオマリキユールズ・インコーポレーテツド | ターゲット化多機能蛋白質 |
WO1989006692A1 (en) * | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
DK0536350T3 (da) | 1991-02-22 | 2002-09-02 | American Cyanamid Co | Identifikation af et nyt humant receptor-tyrosinkinase-gen |
WO1993011236A1 (en) | 1991-12-02 | 1993-06-10 | Medical Research Council | Production of anti-self antibodies from antibody segment repertoires and displayed on phage |
AU661533B2 (en) * | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
US5861301A (en) * | 1992-02-20 | 1999-01-19 | American Cayanamid Company | Recombinant kinase insert domain containing receptor and gene encoding same |
DE69536015D1 (de) | 1995-03-30 | 2009-12-10 | Pfizer Prod Inc | Chinazolinone Derivate |
GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
WO2001090192A2 (en) * | 2000-05-24 | 2001-11-29 | Imclone Systems Incorporated | Bispecific immunoglobulin-like antigen binding proteins and method of production |
JP2004527456A (ja) | 2000-08-09 | 2004-09-09 | イムクローン システムズ インコーポレイティド | Egf受容体拮抗剤による過増殖性の疾患の治療 |
SE518548C2 (sv) | 2001-04-11 | 2002-10-22 | Sca Hygiene Prod Ab | Absorberande alster med förbättrad diskretion |
AU2002258798A1 (en) * | 2001-04-13 | 2002-10-28 | Children's Hospital Medical Center | Methods for the treatment of hepatic disorders |
WO2002102854A2 (en) | 2001-06-20 | 2002-12-27 | Morphosys Ag | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
DK1916001T3 (da) | 2002-03-04 | 2011-07-18 | Imclone Llc | KDR-specifikke humane antistoffer og anvendelser deraf |
US20040101920A1 (en) * | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
US20040185506A1 (en) * | 2003-03-21 | 2004-09-23 | Heavner George A. | Epitope mapping using nuclear magnetic resonance |
US7638605B2 (en) | 2003-05-01 | 2009-12-29 | ImClone, LLC | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
CA2566647A1 (en) * | 2004-05-13 | 2005-12-22 | Imclone Systems Incorporated | Inhibition of macrophage-stimulating protein receptor (ron) |
-
2008
- 2008-11-20 UY UY31478A patent/UY31478A1/es not_active Application Discontinuation
- 2008-11-20 AR ARP080105061A patent/AR069393A1/es not_active Application Discontinuation
- 2008-11-20 CL CL2008003449A patent/CL2008003449A1/es unknown
- 2008-11-21 PA PA20088804901A patent/PA8804901A1/es unknown
- 2008-11-21 EP EP08854059A patent/EP2222703A2/en not_active Withdrawn
- 2008-11-21 MX MX2010005651A patent/MX2010005651A/es active IP Right Grant
- 2008-11-21 JP JP2010534977A patent/JP5324593B2/ja not_active Expired - Fee Related
- 2008-11-21 UA UAA201006208A patent/UA99633C2/ru unknown
- 2008-11-21 BR BRPI0820218-4A patent/BRPI0820218A2/pt not_active IP Right Cessation
- 2008-11-21 EA EA201070636A patent/EA018717B1/ru not_active IP Right Cessation
- 2008-11-21 KR KR1020107011065A patent/KR101227338B1/ko not_active IP Right Cessation
- 2008-11-21 TW TW097145251A patent/TWI417106B/zh not_active IP Right Cessation
- 2008-11-21 CA CA2706583A patent/CA2706583A1/en not_active Abandoned
- 2008-11-21 WO PCT/US2008/013130 patent/WO2009070294A2/en active Application Filing
- 2008-11-21 US US12/313,589 patent/US7947811B2/en not_active Expired - Fee Related
- 2008-11-21 AU AU2008330089A patent/AU2008330089B2/en not_active Ceased
- 2008-11-21 CN CN2008801172313A patent/CN101868478B/zh not_active Expired - Fee Related
- 2008-11-21 NZ NZ584271A patent/NZ584271A/en not_active IP Right Cessation
- 2008-11-24 PE PE2008001959A patent/PE20091713A1/es not_active Application Discontinuation
-
2010
- 2010-03-25 IL IL204743A patent/IL204743A/en not_active IP Right Cessation
- 2010-12-14 US US12/967,241 patent/US8133489B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN101868478A (zh) | 2010-10-20 |
TW200936161A (en) | 2009-09-01 |
MX2010005651A (es) | 2010-06-11 |
IL204743A0 (en) | 2010-11-30 |
EP2222703A2 (en) | 2010-09-01 |
UA99633C2 (ru) | 2012-09-10 |
CA2706583A1 (en) | 2009-06-04 |
PE20091713A1 (es) | 2009-11-13 |
NZ584271A (en) | 2012-05-25 |
BRPI0820218A2 (pt) | 2015-06-23 |
KR101227338B1 (ko) | 2013-01-28 |
WO2009070294A2 (en) | 2009-06-04 |
TWI417106B (zh) | 2013-12-01 |
WO2009070294A3 (en) | 2009-08-20 |
AU2008330089A1 (en) | 2009-06-04 |
JP2011504176A (ja) | 2011-02-03 |
EA018717B1 (ru) | 2013-10-30 |
CL2008003449A1 (es) | 2010-02-19 |
AU2008330089B2 (en) | 2013-09-05 |
CN101868478B (zh) | 2013-11-13 |
US20110135631A1 (en) | 2011-06-09 |
AR069393A1 (es) | 2010-01-20 |
IL204743A (en) | 2013-10-31 |
US8133489B2 (en) | 2012-03-13 |
UY31478A1 (es) | 2009-07-17 |
PA8804901A1 (es) | 2009-06-23 |
US20090136510A1 (en) | 2009-05-28 |
KR20100074293A (ko) | 2010-07-01 |
US7947811B2 (en) | 2011-05-24 |
JP5324593B2 (ja) | 2013-10-23 |
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Designated state(s): AM BY KZ KG MD TJ TM |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AZ RU |