AR069393A1 - Inhibicion del receptor para la proteina estimulante del macrofago (ron) y metodos para el tratamiento del mismo - Google Patents

Inhibicion del receptor para la proteina estimulante del macrofago (ron) y metodos para el tratamiento del mismo

Info

Publication number
AR069393A1
AR069393A1 ARP080105061A ARP080105061A AR069393A1 AR 069393 A1 AR069393 A1 AR 069393A1 AR P080105061 A ARP080105061 A AR P080105061A AR P080105061 A ARP080105061 A AR P080105061A AR 069393 A1 AR069393 A1 AR 069393A1
Authority
AR
Argentina
Prior art keywords
ron
antibodies
stimulating protein
macrofago
inhibition
Prior art date
Application number
ARP080105061A
Other languages
English (en)
Original Assignee
Imclone Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40364492&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR069393(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Imclone Systems Inc filed Critical Imclone Systems Inc
Publication of AR069393A1 publication Critical patent/AR069393A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Anticuerpos o fragmentos del mismo, incluyendo anticuerpos humanos, específicos para el Receptor para la Proteína Estimulante del Macrofago (MSP-R o RON), que inhiben la activacion del RON. También se proporciona un método para inhibir el RON, en especial el uso de anticuerpos del RON para tratar enfermedades como el cáncer así como composiciones farmacéuticas que comprende tales anticuerpos además ácidos nucleicos que codifican anticuerpos, vectores que comprenden y células huésped.
ARP080105061A 2007-11-21 2008-11-20 Inhibicion del receptor para la proteina estimulante del macrofago (ron) y metodos para el tratamiento del mismo AR069393A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98955807P 2007-11-21 2007-11-21

Publications (1)

Publication Number Publication Date
AR069393A1 true AR069393A1 (es) 2010-01-20

Family

ID=40364492

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080105061A AR069393A1 (es) 2007-11-21 2008-11-20 Inhibicion del receptor para la proteina estimulante del macrofago (ron) y metodos para el tratamiento del mismo

Country Status (20)

Country Link
US (2) US7947811B2 (es)
EP (1) EP2222703A2 (es)
JP (1) JP5324593B2 (es)
KR (1) KR101227338B1 (es)
CN (1) CN101868478B (es)
AR (1) AR069393A1 (es)
AU (1) AU2008330089B2 (es)
BR (1) BRPI0820218A2 (es)
CA (1) CA2706583A1 (es)
CL (1) CL2008003449A1 (es)
EA (1) EA018717B1 (es)
IL (1) IL204743A (es)
MX (1) MX2010005651A (es)
NZ (1) NZ584271A (es)
PA (1) PA8804901A1 (es)
PE (1) PE20091713A1 (es)
TW (1) TWI417106B (es)
UA (1) UA99633C2 (es)
UY (1) UY31478A1 (es)
WO (1) WO2009070294A2 (es)

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Publication number Priority date Publication date Assignee Title
EP2083081A1 (en) 2005-07-22 2009-07-29 Five Prime Therapeutics, Inc. Compositions and methods of treating disease with FGFR fusion proteins
CN101977937A (zh) * 2008-01-22 2011-02-16 拜奥根Idec马萨诸塞公司 Ron抗体及其用途
EP2265270A1 (en) 2008-02-04 2010-12-29 OSI Pharmaceuticals, Inc. 2-aminopyridine kinase inhibitors
AR070317A1 (es) 2008-02-06 2010-03-31 Osi Pharm Inc Furo (3,2-c) piridina y tieno (3,2-c) piridinas
TWI480050B (zh) * 2009-02-10 2015-04-11 Daiichi Sankyo Co Ltd 抗－ｍｓｔ１ｒ抗體及其用途
AU2010343057B2 (en) * 2009-12-29 2017-02-23 Aptevo Research And Development Llc Heterodimer binding proteins and uses thereof
US8603478B2 (en) 2010-07-06 2013-12-10 Aveo Pharmaceuticals, Inc. Anti-RON antibodies
US8481038B2 (en) 2010-11-15 2013-07-09 Five Prime Therapeutics, Inc. Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins
US8951972B2 (en) * 2010-12-09 2015-02-10 Five Prime Therapeutics, Inc. FGFR1 extracellular domain combination therapies for lung cancer
CN103702682A (zh) 2011-04-21 2014-04-02 科罗拉多州立大学董事会法人团体 治疗视神经脊髓炎的组合物和方法
JP2015527869A (ja) 2011-08-26 2015-09-24 メリマック ファーマシューティカルズ インコーポレーティッド タンデムＦｃ二重特異性抗体
CN104168915A (zh) 2011-11-14 2014-11-26 戊瑞治疗有限公司 治疗癌症的方法
CN104822706A (zh) * 2012-11-30 2015-08-05 弗·哈夫曼-拉罗切有限公司 Ron组合物及其使用方法
CN104936987A (zh) * 2013-02-26 2015-09-23 罗切格利卡特公司 抗mcsp抗体
CA2902505A1 (en) 2013-03-06 2014-09-12 Merrimack Pharmaceuticals, Inc. Anti-c-met tandem fc bispecific antibodies
ES2750832T3 (es) * 2014-07-29 2020-03-27 Wellmarker Bio Co Ltd Nuevo biomarcador para predecir la sensibilidad al agente dirigido contra egfr y uso del mismo
KR101862719B1 (ko) * 2014-09-03 2018-05-31 웰마커바이오 주식회사 단백질 키나제 억제제에 대한 감수성 예측용 바이오 마커 및 이의 용도
JP2020500834A (ja) * 2016-08-26 2020-01-16 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ マクロファージ刺激タンパク質受容体（又はＲＯＮ（Ｒｅｃｅｐｔｅｕｒ ｄ′Ｏｒｉｇｉｎｅ Ｎａｎｔａｉｓ））抗体及びその使用
WO2018052789A1 (en) 2016-09-08 2018-03-22 Pcm Targetech, Llc Monoclonal antibodies specific to the plexin-semaphorin-integrin (psi) domain of ron for drug delivery and its application in cancer therapy
US20220372125A1 (en) * 2019-10-02 2022-11-24 Aslan Pharmaceuticals Pte. Ltd. Antigen Specific Binding Domains and Antibody Molecules
WO2022060906A1 (en) * 2020-09-15 2022-03-24 Duke University Coronavirus antibodies and uses thereof

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US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
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DE3856559T2 (de) 1987-05-21 2004-04-29 Micromet Ag Multifunktionelle Proteine mit vorbestimmter Zielsetzung
JP3040121B2 (ja) 1988-01-12 2000-05-08 ジェネンテク，インコーポレイテッド 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
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Also Published As

Publication number Publication date
WO2009070294A2 (en) 2009-06-04
UY31478A1 (es) 2009-07-17
WO2009070294A3 (en) 2009-08-20
CA2706583A1 (en) 2009-06-04
PA8804901A1 (es) 2009-06-23
CN101868478B (zh) 2013-11-13
US7947811B2 (en) 2011-05-24
KR101227338B1 (ko) 2013-01-28
US8133489B2 (en) 2012-03-13
AU2008330089A1 (en) 2009-06-04
US20110135631A1 (en) 2011-06-09
AU2008330089B2 (en) 2013-09-05
TWI417106B (zh) 2013-12-01
CL2008003449A1 (es) 2010-02-19
IL204743A0 (en) 2010-11-30
IL204743A (en) 2013-10-31
JP2011504176A (ja) 2011-02-03
BRPI0820218A2 (pt) 2015-06-23
EP2222703A2 (en) 2010-09-01
EA201070636A1 (ru) 2010-10-29
US20090136510A1 (en) 2009-05-28
JP5324593B2 (ja) 2013-10-23
UA99633C2 (ru) 2012-09-10
NZ584271A (en) 2012-05-25
KR20100074293A (ko) 2010-07-01
TW200936161A (en) 2009-09-01
EA018717B1 (ru) 2013-10-30
CN101868478A (zh) 2010-10-20
MX2010005651A (es) 2010-06-11
PE20091713A1 (es) 2009-11-13

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