BR112016002753A2 - anticorpos contra o inibidor-1 de ativador de plasminogênio (pai-1) e usos dos mesmos - Google Patents
anticorpos contra o inibidor-1 de ativador de plasminogênio (pai-1) e usos dos mesmosInfo
- Publication number
- BR112016002753A2 BR112016002753A2 BR112016002753A BR112016002753A BR112016002753A2 BR 112016002753 A2 BR112016002753 A2 BR 112016002753A2 BR 112016002753 A BR112016002753 A BR 112016002753A BR 112016002753 A BR112016002753 A BR 112016002753A BR 112016002753 A2 BR112016002753 A2 BR 112016002753A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibodies
- parent
- plasminogen activator
- activator inhibitor
- specifically bind
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
a invenção refere-se a anticorpos que se ligam especifica-mente ao inibidor de ativador de plasminogênio humano de tipo 1 (pai-1). a presente invenção também refere-se a composições farma-cêuticas, bem como ácidos nucleicos que codificam os anticorpos anti-pai-1, vetores de expressão recombinantes e células hospedeiras pa-ra produção de tais anticorpos ou fragmentos dos mesmos. métodos de uso de anticorpos para modular a atividade de pai-1 ou detectar pai-1, in vitro ou in vivo, também são fornecidos. a descrição fornece ainda métodos de preparo de anticorpos que se ligam especificamente ao pai-1 no estado conformacional ativo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361865451P | 2013-08-13 | 2013-08-13 | |
EP14305757 | 2014-05-22 | ||
PCT/US2014/050896 WO2015023752A1 (en) | 2013-08-13 | 2014-08-13 | Antibodies to plasminogen activator inhibitor-1 (pai-1) and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016002753A2 true BR112016002753A2 (pt) | 2017-11-21 |
Family
ID=56194112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016002753A BR112016002753A2 (pt) | 2013-08-13 | 2014-08-13 | anticorpos contra o inibidor-1 de ativador de plasminogênio (pai-1) e usos dos mesmos |
Country Status (17)
Country | Link |
---|---|
US (4) | US9845363B2 (pt) |
JP (4) | JP6696899B2 (pt) |
KR (1) | KR20160035077A (pt) |
CN (2) | CN112142845A (pt) |
BR (1) | BR112016002753A2 (pt) |
CL (1) | CL2016000324A1 (pt) |
CR (2) | CR20190319A (pt) |
DO (1) | DOP2016000042A (pt) |
EA (1) | EA033403B1 (pt) |
ES (1) | ES2770507T3 (pt) |
HK (1) | HK1221725A1 (pt) |
MX (2) | MX2016001851A (pt) |
PE (1) | PE20160244A1 (pt) |
PH (1) | PH12016500239A1 (pt) |
SG (1) | SG10201710013RA (pt) |
TN (1) | TN2016000048A1 (pt) |
UA (1) | UA118267C2 (pt) |
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JP6682008B2 (ja) | 2015-12-18 | 2020-04-15 | タレンゲン インターナショナル リミテッドTalengen International Limited | 糖尿病性腎症を予防及び治療するための方法 |
JP6783870B2 (ja) | 2015-12-18 | 2020-11-11 | タレンゲン インターナショナル リミテッドTalengen International Limited | 心血管病を予防及び治療するための新しい方法 |
JP2019500426A (ja) | 2015-12-18 | 2019-01-10 | タレンゲン インターナショナル リミティッドTalengen International Limited | 糖尿病網膜症を予防または治療するための方法 |
WO2017101867A1 (zh) | 2015-12-18 | 2017-06-22 | 深圳瑞健生命科学研究院有限公司 | 一种预防或治疗糖尿病性神经损伤及其相关病症的方法 |
EP3556379A4 (en) | 2016-12-15 | 2020-08-19 | Talengen International Limited | METHOD AND DRUG FOR THE PREVENTION AND TREATMENT OF OBESITY |
TW202123962A (zh) * | 2016-12-15 | 2021-07-01 | 大陸商深圳瑞健生命科學研究院有限公司 | 一種預防和治療腎纖維化的方法 |
CN108210910A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 预防和治疗系统性硬化症的药物及其用途 |
WO2018107708A1 (zh) | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种促进胰岛素受体底物-2表达的方法 |
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TWI657823B (zh) * | 2016-12-15 | 2019-05-01 | 大陸商深圳瑞健生命科學研究院有限公司 | 一種預防和治療系統性硬化症的方法 |
CN108210895A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 预防动脉粥样硬化及其并发症的药物及其用途 |
CA3067890A1 (en) | 2017-06-19 | 2018-12-27 | Talengen International Limited | Method for regulating and controling glp-1/glp-1r and drug |
TW201904990A (zh) * | 2017-06-23 | 2019-02-01 | 美商波麥堤克生物治療股份有限公司 | 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療 |
CN117700548A (zh) | 2017-08-03 | 2024-03-15 | 艾利妥 | 抗cd33抗体及其使用方法 |
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CN115605219A (zh) * | 2020-02-11 | 2023-01-13 | 泰伦基国际有限公司(Hk) | 一种治疗病毒性肺炎的方法和药物 |
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CN114605550B (zh) * | 2020-12-08 | 2023-09-22 | 东莞市朋志生物科技有限公司 | 抗ca19-9的抗体、其应用和检测ca19-9的试剂盒 |
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US7981415B2 (en) | 2007-09-07 | 2011-07-19 | Cisthera, Inc. | Humanized PAI-1 antibodies |
US8410251B2 (en) * | 2008-06-20 | 2013-04-02 | National University Corporation Okayama University | Antibody against calcified globule and use of the same |
US20100254979A1 (en) * | 2009-03-06 | 2010-10-07 | Cisthera, Incorporated | Humanized PAI-1 Antibodies and Uses Thereof |
EP2566514A4 (en) * | 2010-05-03 | 2013-11-27 | Abbvie Inc | METHODS OF INHIBITING FIBROSIS WITH ANTI-PAI-1 ANTIBODIES |
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- 2014-08-13 CN CN202010898460.6A patent/CN112142845A/zh active Pending
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- 2014-08-13 MX MX2016001851A patent/MX2016001851A/es unknown
- 2014-08-13 BR BR112016002753A patent/BR112016002753A2/pt not_active Application Discontinuation
- 2014-08-13 CN CN201480055157.2A patent/CN105705520B/zh active Active
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2017
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CR20190319A (es) | 2019-08-29 |
MX2019008803A (es) | 2019-09-16 |
US20180155444A1 (en) | 2018-06-07 |
JP2023055852A (ja) | 2023-04-18 |
EA033403B1 (ru) | 2019-10-31 |
CN105705520B (zh) | 2020-09-25 |
SG10201710013RA (en) | 2018-01-30 |
ES2770507T3 (es) | 2020-07-01 |
TN2016000048A1 (en) | 2017-07-05 |
JP2021155440A (ja) | 2021-10-07 |
JP6696899B2 (ja) | 2020-05-20 |
US9845363B2 (en) | 2017-12-19 |
KR20160035077A (ko) | 2016-03-30 |
CN105705520A (zh) | 2016-06-22 |
EA201690377A1 (ru) | 2016-06-30 |
US20190359729A1 (en) | 2019-11-28 |
MX2016001851A (es) | 2016-05-16 |
HK1221725A1 (zh) | 2017-06-09 |
JP2020125333A (ja) | 2020-08-20 |
JP2016529255A (ja) | 2016-09-23 |
CN112142845A (zh) | 2020-12-29 |
US20230015181A1 (en) | 2023-01-19 |
JP7223069B2 (ja) | 2023-02-15 |
US20160200831A1 (en) | 2016-07-14 |
UA118267C2 (uk) | 2018-12-26 |
JP6907380B2 (ja) | 2021-07-21 |
CR20160117A (es) | 2016-05-20 |
DOP2016000042A (es) | 2016-04-04 |
CL2016000324A1 (es) | 2016-10-21 |
PH12016500239A1 (en) | 2016-05-16 |
PE20160244A1 (es) | 2016-05-10 |
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