SG10201710013RA - Antibodies to plasminogen activator inhibitor-1 (pai-1) and uses thereof - Google Patents

Antibodies to plasminogen activator inhibitor-1 (pai-1) and uses thereof

Info

Publication number
SG10201710013RA
SG10201710013RA SG10201710013RA SG10201710013RA SG10201710013RA SG 10201710013R A SG10201710013R A SG 10201710013RA SG 10201710013R A SG10201710013R A SG 10201710013RA SG 10201710013R A SG10201710013R A SG 10201710013RA SG 10201710013R A SG10201710013R A SG 10201710013RA
Authority
SG
Singapore
Prior art keywords
pai
antibodies
plasminogen activator
activator inhibitor
inhibitor
Prior art date
Application number
SG10201710013RA
Inventor
Alla Pritsker
Patrick Grailhe
Alexey Rak
Magali Mathieu
Christopher Ryan Morgan
Nicolas Baurin
Bruno Poirier
Cyril Daveu
Francis Duffieux
Han Li
Dorothea KOMINOS
Philip Janiak
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of SG10201710013RA publication Critical patent/SG10201710013RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
SG10201710013RA 2013-08-13 2014-08-13 Antibodies to plasminogen activator inhibitor-1 (pai-1) and uses thereof SG10201710013RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361865451P 2013-08-13 2013-08-13
EP14305757 2014-05-22

Publications (1)

Publication Number Publication Date
SG10201710013RA true SG10201710013RA (en) 2018-01-30

Family

ID=56194112

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201710013RA SG10201710013RA (en) 2013-08-13 2014-08-13 Antibodies to plasminogen activator inhibitor-1 (pai-1) and uses thereof

Country Status (17)

Country Link
US (4) US9845363B2 (en)
JP (4) JP6696899B2 (en)
KR (1) KR20160035077A (en)
CN (2) CN105705520B (en)
BR (1) BR112016002753A2 (en)
CL (1) CL2016000324A1 (en)
CR (2) CR20190319A (en)
DO (1) DOP2016000042A (en)
EA (1) EA033403B1 (en)
ES (1) ES2770507T3 (en)
HK (1) HK1221725A1 (en)
MX (2) MX2016001851A (en)
PE (1) PE20160244A1 (en)
PH (1) PH12016500239A1 (en)
SG (1) SG10201710013RA (en)
TN (1) TN2016000048A1 (en)
UA (1) UA118267C2 (en)

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CN110191718A (en) * 2016-12-15 2019-08-30 泰伦基国际有限公司 A method of preventing and treating histoorgan fibrosis
WO2018108161A1 (en) 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 Method and drug for preventing and treating obesity
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CN114605550B (en) * 2020-12-08 2023-09-22 东莞市朋志生物科技有限公司 Antibodies against CA19-9, uses thereof and kit for detecting CA19-9
CN114686442B (en) * 2020-12-31 2023-11-07 广州万孚生物技术股份有限公司 Hybridoma cell strain and application thereof
CN114686441B (en) * 2020-12-31 2023-11-03 广州万孚生物技术股份有限公司 Hybridoma cell strain capable of secreting tPAI-C monoclonal antibody and application thereof

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Also Published As

Publication number Publication date
US20230015181A1 (en) 2023-01-19
BR112016002753A2 (en) 2017-11-21
JP2020125333A (en) 2020-08-20
JP6696899B2 (en) 2020-05-20
PH12016500239A1 (en) 2016-05-16
JP2016529255A (en) 2016-09-23
US20190359729A1 (en) 2019-11-28
EA201690377A1 (en) 2016-06-30
JP2023055852A (en) 2023-04-18
JP7223069B2 (en) 2023-02-15
JP2021155440A (en) 2021-10-07
ES2770507T3 (en) 2020-07-01
HK1221725A1 (en) 2017-06-09
MX2019008803A (en) 2019-09-16
CR20160117A (en) 2016-05-20
US20180155444A1 (en) 2018-06-07
JP6907380B2 (en) 2021-07-21
US20160200831A1 (en) 2016-07-14
CL2016000324A1 (en) 2016-10-21
CR20190319A (en) 2019-08-29
MX2016001851A (en) 2016-05-16
US9845363B2 (en) 2017-12-19
TN2016000048A1 (en) 2017-07-05
PE20160244A1 (en) 2016-05-10
UA118267C2 (en) 2018-12-26
DOP2016000042A (en) 2016-04-04
CN112142845A (en) 2020-12-29
KR20160035077A (en) 2016-03-30
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CN105705520B (en) 2020-09-25
CN105705520A (en) 2016-06-22

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