PL220113B1 - Variant of parent polypeptide comprising the Fc region, polypeptide comprising a variant of the Fc region with altered binding affinity of Fc gamma receptor (FcγR), a polypeptide comprising the variant of Fc region with altered binding affinity of neonatal Fc receptor (FcRn), a composition, isolated nucleic acid, vector, host cell, method for preparing the polypeptide variant, the use of the polypeptide variant and method for preparing a the Fc region variant - Google Patents

Variant of parent polypeptide comprising the Fc region, polypeptide comprising a variant of the Fc region with altered binding affinity of Fc gamma receptor (FcγR), a polypeptide comprising the variant of Fc region with altered binding affinity of neonatal Fc receptor (FcRn), a composition, isolated nucleic acid, vector, host cell, method for preparing the polypeptide variant, the use of the polypeptide variant and method for preparing a the Fc region variant

Info

Publication number
PL220113B1
PL220113B1 PL394232A PL39423200A PL220113B1 PL 220113 B1 PL220113 B1 PL 220113B1 PL 394232 A PL394232 A PL 394232A PL 39423200 A PL39423200 A PL 39423200A PL 220113 B1 PL220113 B1 PL 220113B1
Authority
PL
Poland
Prior art keywords
variant
polypeptide
fc region
fc
preparing
Prior art date
Application number
PL394232A
Other languages
Unknown language (xx)
Other versions
PL394232A1 (en
Inventor
Leonard G. Presta
Original Assignee
Genentech Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US11602399P priority Critical
Application filed by Genentech Inc. filed Critical Genentech Inc.
Publication of PL394232A1 publication Critical patent/PL394232A1/en
Publication of PL220113B1 publication Critical patent/PL220113B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734Complement-dependent cytotoxicity [CDC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
PL394232A 1999-01-15 2000-01-14 Variant of parent polypeptide comprising the Fc region, polypeptide comprising a variant of the Fc region with altered binding affinity of Fc gamma receptor (FcγR), a polypeptide comprising the variant of Fc region with altered binding affinity of neonatal Fc receptor (FcRn), a composition, isolated nucleic acid, vector, host cell, method for preparing the polypeptide variant, the use of the polypeptide variant and method for preparing a the Fc region variant PL220113B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11602399P true 1999-01-15 1999-01-15

Publications (2)

Publication Number Publication Date
PL394232A1 PL394232A1 (en) 2011-07-04
PL220113B1 true PL220113B1 (en) 2015-08-31

Family

ID=22364785

Family Applications (3)

Application Number Title Priority Date Filing Date
PL388183A PL209786B1 (en) 1999-01-15 2000-01-14 Variant of mother polypeptide containing Fc region, polypeptide containing variant of Fc region with altered affinity of Fc gamma receptor binding (Fc R), polypeptide containing variant of Fc region with altered affinity of Fc gamma neonatal receptor binding (Fc Rn), composition, isolated nucleic acid, vector, host cell, method for obtaining polypeptide variant, the use thereof and method for obtaining region Fc variant
PL394232A PL220113B1 (en) 1999-01-15 2000-01-14 Variant of parent polypeptide comprising the Fc region, polypeptide comprising a variant of the Fc region with altered binding affinity of Fc gamma receptor (FcγR), a polypeptide comprising the variant of Fc region with altered binding affinity of neonatal Fc receptor (FcRn), a composition, isolated nucleic acid, vector, host cell, method for preparing the polypeptide variant, the use of the polypeptide variant and method for preparing a the Fc region variant
PL349770A PL209392B1 (en) 1999-01-15 2000-01-14 Polypeptide variants with altered effector function

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL388183A PL209786B1 (en) 1999-01-15 2000-01-14 Variant of mother polypeptide containing Fc region, polypeptide containing variant of Fc region with altered affinity of Fc gamma receptor binding (Fc R), polypeptide containing variant of Fc region with altered affinity of Fc gamma neonatal receptor binding (Fc Rn), composition, isolated nucleic acid, vector, host cell, method for obtaining polypeptide variant, the use thereof and method for obtaining region Fc variant

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL349770A PL209392B1 (en) 1999-01-15 2000-01-14 Polypeptide variants with altered effector function

Country Status (17)

Country Link
US (4) US7371826B2 (en)
EP (4) EP2364997A3 (en)
JP (4) JP2003512019A (en)
KR (4) KR101077001B1 (en)
CN (2) CN1763097B (en)
AU (2) AU778683B2 (en)
BR (1) BR0008758A (en)
CA (1) CA2359067C (en)
ES (1) ES2694002T3 (en)
HK (1) HK1090066A1 (en)
HU (2) HU230769B1 (en)
IL (5) IL144056D0 (en)
MX (2) MXPA01007170A (en)
NZ (1) NZ539776A (en)
PL (3) PL209786B1 (en)
WO (1) WO2000042072A2 (en)
ZA (1) ZA200105484B (en)

Families Citing this family (967)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6528624B1 (en) 1998-04-02 2003-03-04 Genentech, Inc. Polypeptide variants
US7183387B1 (en) 1999-01-15 2007-02-27 Genentech, Inc. Polypeptide variants with altered effector function
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
ES2694002T3 (en) 1999-01-15 2018-12-17 Genentech, Inc. Polypeptide comprising an Fc region of variant human IgG1
EP1637160A3 (en) 1999-05-07 2006-05-03 Genentech, Inc. Treatment of autoimmune diseases with antagonists which bind to B cell surface markers
PT1355919E (en) 2000-12-12 2011-03-02 Medimmune Llc Molecules with extended half-lives, compositions and uses thereof
US7658921B2 (en) 2000-12-12 2010-02-09 Medimmune, Llc Molecules with extended half-lives, compositions and uses thereof
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
JP4524074B2 (en) * 2001-03-09 2010-08-11 アーナソン, バリー ジー. Polymeric immunoglobulin fusion proteins targeting low affinity Fcγ receptors
US20110045005A1 (en) 2001-10-19 2011-02-24 Craig Crowley Compositions and methods for the treatment of tumor of hematopoietic origin
HU0600342A3 (en) * 2001-10-25 2011-03-28 Genentech Inc Glycoprotein compositions
US20040002587A1 (en) * 2002-02-20 2004-01-01 Watkins Jeffry D. Fc region variants
US8084582B2 (en) 2003-03-03 2011-12-27 Xencor, Inc. Optimized anti-CD20 monoclonal antibodies having Fc variants
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US9051373B2 (en) 2003-05-02 2015-06-09 Xencor, Inc. Optimized Fc variants
US9714282B2 (en) 2003-09-26 2017-07-25 Xencor, Inc. Optimized Fc variants and methods for their generation
US7662925B2 (en) 2002-03-01 2010-02-16 Xencor, Inc. Optimized Fc variants and methods for their generation
US20090010920A1 (en) 2003-03-03 2009-01-08 Xencor, Inc. Fc Variants Having Decreased Affinity for FcyRIIb
US8188231B2 (en) 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
US8388955B2 (en) 2003-03-03 2013-03-05 Xencor, Inc. Fc variants
WO2003101485A1 (en) 2002-05-30 2003-12-11 Macrogenics, Inc. Cd16a binding proteins and use for the treatment of immune disorders
US7132100B2 (en) 2002-06-14 2006-11-07 Medimmune, Inc. Stabilized liquid anti-RSV antibody formulations
US8968730B2 (en) 2002-08-14 2015-03-03 Macrogenics Inc. FcγRIIB specific antibodies and methods of use thereof
US7425620B2 (en) * 2002-08-14 2008-09-16 Scott Koenig FcγRIIB-specific antibodies and methods of use thereof
US8946387B2 (en) 2002-08-14 2015-02-03 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
US8101720B2 (en) * 2004-10-21 2012-01-24 Xencor, Inc. Immunoglobulin insertions, deletions and substitutions
CA2624189A1 (en) 2005-10-03 2007-04-12 Xencor, Inc. Fc variants with optimized fc receptor binding properties
CA2766627A1 (en) * 2003-05-02 2004-11-18 Xencor, Inc. Optimized fc variants and methods for their generation
WO2006105338A2 (en) * 2005-03-31 2006-10-05 Xencor, Inc. Fc VARIANTS WITH OPTIMIZED PROPERTIES
DK2345671T3 (en) 2002-09-27 2016-02-15 Xencor Inc Optimized Fc variants and methods for their formation
US20040132101A1 (en) * 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
DK1562972T3 (en) 2002-10-15 2010-12-06 Facet Biotech Corp Modification of FcRn binding affinities or serum half-lives for antibodies by mutagenesis
JP4685764B2 (en) * 2003-04-10 2011-05-18 アボット バイオセラピューティクス コーポレイション Modification of antibody FcRn binding affinity or serum half-life by mutagenesis
US7361740B2 (en) 2002-10-15 2008-04-22 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
US7365168B2 (en) 2002-10-15 2008-04-29 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
AT470675T (en) 2002-12-16 2010-06-15 Genentech Inc Immunoglobulin variants and its uses
JP2006524039A (en) * 2003-01-09 2006-10-26 マクロジェニクス,インコーポレーテッド Identification and production of antibody containing mutant Fc region and use thereof
CN101189028B (en) * 2004-07-12 2013-05-29 马克罗基因公司 Identification and engineering of antibodies with variant Fc regions and methods of using the same
US7960512B2 (en) 2003-01-09 2011-06-14 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
AU2011265460B2 (en) * 2003-01-09 2014-07-17 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
AU2004204817C1 (en) 2003-01-13 2011-01-20 Macrogenics, Inc. Soluble FcyR fusion proteins and methods of use thereof
DK1613350T3 (en) 2003-04-09 2009-06-22 Genentech Inc Treatment of autoimmune disease in a patient with an inadequate response to a TNF-alpha inhibitor
TWI353991B (en) * 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
AR044388A1 (en) 2003-05-20 2005-09-07 Applied Molecular Evolution CD20 binding molecules
ES2538469T3 (en) 2003-06-05 2015-06-22 Genentech, Inc. Combination therapy for B cell disorders
CA2532547A1 (en) 2003-07-24 2005-02-03 Innate Pharma Methods and compositions for increasing the efficiency of therapeutic antibodies using nk cell potentiating compounds
US20050106667A1 (en) 2003-08-01 2005-05-19 Genentech, Inc Binding polypeptides with restricted diversity sequences
WO2005018572A2 (en) 2003-08-22 2005-03-03 Biogen Idec Ma Inc. Improved antibodies having altered effector function and methods for making the same
WO2005037867A1 (en) 2003-10-15 2005-04-28 Pdl Biopharma, Inc. ALTERATION OF Fc-FUSION PROTEIN SERUM HALF-LIVES BY MUTAGENESIS OF POSITIONS 250, 314 AND/OR 428 OF THE HEAVY CHAIN CONSTANT REGION OF IG
GB0324368D0 (en) * 2003-10-17 2003-11-19 Univ Cambridge Tech Polypeptides including modified constant regions
CN104829719A (en) 2003-11-05 2015-08-12 罗氏格黎卡特股份公司 CD20 antibodies with increased FC receptor binding affinity and effector function
WO2005063815A2 (en) * 2003-11-12 2005-07-14 Biogen Idec Ma Inc. Fcϝ receptor-binding polypeptide variants and methods related thereto
AU2004290070A1 (en) 2003-11-12 2005-05-26 Biogen Idec Ma Inc. Neonatal Fc receptor (FcRn)-binding polypeptide variants, dimeric Fc binding proteins and methods related thereto
EP1684790A4 (en) * 2003-11-18 2008-04-30 Iconic Therapeutics Inc Homogeneous preparations of chimeric proteins
EP2221315A1 (en) 2003-12-04 2010-08-25 Xencor, Inc. Methods of generating variant proteins with increased host string content and compositions thereof
CA2546054C (en) 2003-12-10 2014-05-13 Medarex, Inc. Interferon alpha antibodies and their uses
PT1691837E (en) 2003-12-10 2012-08-27 Medarex Inc Ip-10 antibodies and their uses
EP1706424B1 (en) 2004-01-12 2009-07-22 Applied Molecular Evolution Fc region variants
SG172616A1 (en) * 2004-04-13 2011-07-28 Hoffmann La Roche Anti-p-selectin antibodies
EP1761563A4 (en) 2004-05-10 2008-05-14 Macrogenics Inc HUMANIZED Fc gamma RIIB SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF
KR100545720B1 (en) 2004-05-31 2006-01-24 메덱스젠 주식회사 Glycosylated Immunoglobulin and Immunoadhesin comprising the same
KR20150092374A (en) 2004-06-04 2015-08-12 제넨테크, 인크. Method for treating multiple sclerosis
EP1781705B1 (en) 2004-06-21 2014-10-08 Medarex, L.L.C. Interferon alpha receptor i antibodies and their uses
EP1919950A1 (en) * 2004-07-15 2008-05-14 Xencor, Inc. Optimized fc variants
EP1791563A4 (en) 2004-07-26 2009-07-08 Biogen Idec Inc Anti-cd154 antibodies
DK1776384T3 (en) 2004-08-04 2013-09-02 Mentrik Biotech Llc VARIANT Fc REGIONS
US20060040325A1 (en) 2004-08-16 2006-02-23 Medimmune, Inc. Integrin antagonists with enhanced antibody dependent cell-mediated cytoxicity activity
WO2006031370A2 (en) * 2004-08-19 2006-03-23 Genentech, Inc. Polypeptide variants with altered effector function
WO2006041680A2 (en) 2004-10-05 2006-04-20 Genentech, Inc. Method for treating vasculitis
JO3000B1 (en) 2004-10-20 2016-09-05 Genentech Inc Antibody Formulations.
CA2587766A1 (en) * 2004-11-10 2007-03-01 Macrogenics, Inc. Engineering fc antibody regions to confer effector function
US8546543B2 (en) 2004-11-12 2013-10-01 Xencor, Inc. Fc variants that extend antibody half-life
US8367805B2 (en) * 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
EP2332985A3 (en) 2004-11-12 2012-01-25 Xencor, Inc. Fc variants with altered binding to FcRn
US20070135620A1 (en) * 2004-11-12 2007-06-14 Xencor, Inc. Fc variants with altered binding to FcRn
US8802820B2 (en) 2004-11-12 2014-08-12 Xencor, Inc. Fc variants with altered binding to FcRn
KR20070107687A (en) * 2004-12-31 2007-11-07 바이오젠 아이덱 엠에이 인크. Polypeptides that bind br3 and uses thereof
US8029783B2 (en) * 2005-02-02 2011-10-04 Genentech, Inc. DR5 antibodies and articles of manufacture containing same
EP2548575A1 (en) 2005-02-15 2013-01-23 Duke University Anti-CD19 antibodies that mediate ADCC for use in treating autoimmune diseases
US8444973B2 (en) 2005-02-15 2013-05-21 Duke University Anti-CD19 antibodies and uses in B cell disorders
CA2596133C (en) 2005-02-23 2016-11-15 Genentech, Inc. Extending time to disease progression or survival in cancer patients
NZ586780A (en) 2005-03-23 2012-02-24 Genmab As Antibodies against CD38 for treatment of multiple myeloma
WO2006105062A2 (en) * 2005-03-29 2006-10-05 Verenium Corporation Altered antibody fc regions and uses thereof
US9284375B2 (en) 2005-04-15 2016-03-15 Macrogenics, Inc. Covalent diabodies and uses thereof
US9963510B2 (en) 2005-04-15 2018-05-08 Macrogenics, Inc. Covalent diabodies and uses thereof
AU2006236439B2 (en) 2005-04-15 2012-05-03 Macrogenics, Inc. Covalent diabodies and uses thereof
PE20061324A1 (en) 2005-04-29 2007-01-15 Centocor Inc anti-IL-6 antibodies, compositions, methods and uses
AU2006244445B2 (en) 2005-05-05 2013-04-18 Duke University Anti-CD19 antibody therapy for autoimmune disease
CA2970873A1 (en) 2005-05-09 2006-11-16 E. R. Squibb & Sons, L.L.C. Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
CA2608835A1 (en) 2005-05-20 2006-11-30 Genentech, Inc. Pretreatment of a biological sample from an autoimmune disease subject
US20070110757A1 (en) 2005-06-23 2007-05-17 Ziping Wei Antibody formulations having optimized aggregation and fragmentation profiles
ES2410406T3 (en) 2005-06-30 2013-07-01 Janssen Biotech, Inc. Anti-IL-23 antibodies, compositions, procedures and uses
HUE026039T2 (en) 2005-07-01 2016-05-30 Squibb & Sons Llc Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
EP1910836B1 (en) * 2005-07-21 2014-11-26 Genmab A/S Potency assays for antibody drug substance binding to an fc receptor
CA2616395C (en) 2005-07-25 2016-10-04 Trubion Pharmaceuticals B-cell reduction using cd37-specific and cd20-specific binding molecules
EP2415483A1 (en) 2005-07-25 2012-02-08 Emergent Product Development Seattle, LLC Single dose use of cd20-specific binding molecules
JP5105485B2 (en) 2005-08-10 2012-12-26 マクロジェニクス,インコーポレーテッド Identification and engineering modification of antibodies having mutant Fc region and methods of use thereof
WO2007031875A2 (en) 2005-08-26 2007-03-22 Glycart Biotechnology Ag Modified antigen binding molecules with altered cell signaling activity
WO2007044616A2 (en) 2005-10-06 2007-04-19 Xencor, Inc. Optimized anti-cd30 antibodies
NZ567124A (en) 2005-10-21 2011-08-26 Novartis Ag Human antibodies against Interleukin-13 and therapeutic uses to treat asthma
KR20170002684A (en) 2005-11-04 2017-01-06 제넨테크, 인크. Use of complement pathway inhibitors to treat ocular diseases
ES2577292T3 (en) 2005-11-07 2016-07-14 Genentech, Inc. Binding polypeptides with diversified VH / VL hypervariable sequences and consensus
EP1957099B1 (en) 2005-11-07 2015-03-25 The Rockefeller University Reagents, methods and systems for selecting a cytotoxic antibody or variant thereof
MY149159A (en) 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
AU2006318539B2 (en) 2005-11-23 2012-09-13 Genentech, Inc. Methods and compositions related to B cell assays
CN105859886A (en) 2005-12-02 2016-08-17 健泰科生物技术公司 Compositions and methods associated with antibodies that bind to IL-22 and IL-22R
WO2007094842A2 (en) 2005-12-02 2007-08-23 Genentech, Inc. Binding polypeptides and uses thereof
EA017491B1 (en) 2005-12-08 2012-12-28 Медарекс, Инк. Human monoclonal antibodies to fucosyl-gm1 and methods for using anti-fucosyl-gm1 antibodies
KR20080080651A (en) 2005-12-20 2008-09-04 아라나 테라퓨틱스 리미티드 Anti-inflammatory dab
UA101301C2 (en) 2005-12-29 2013-03-25 Сентокор, Инк. Isolated il-23pl9 antibody and use thereof
CA2638785C (en) 2006-01-05 2017-02-21 Genentech, Inc. Anti-ephb4 antibodies and methods using same
BRPI0706935A2 (en) 2006-01-20 2011-04-19 Genentech Inc anti-ephrine b2 antibodies isolated, vector, host cell, anti-ephrine b2 antibody preparation method, anti-ephrine b2 immunoconjugate preparation method, ephrine b2 detection method, dysfunction diagnostic method, composition, inhibition method of angiogenesis and use of anti-ephrine b2 antibody
MX2008009792A (en) 2006-02-01 2008-09-01 Arana Therapeutics Ltd Domain antibody construct.
EP1999148B8 (en) 2006-03-06 2014-03-05 Medlmmune, LLC Humanized anti-cd22 antibodies and their use in treatment of oncology, transplantation and autoimmune disease
AR059851A1 (en) 2006-03-16 2008-04-30 Genentech Inc Egfl7 antibodies and methods of use
MX2008011905A (en) 2006-03-21 2008-09-30 Genentech Inc Combinatorial therapies.
US20100080794A1 (en) * 2006-04-14 2010-04-01 Takashi Tsuji Mutant polypeptide having effector function
ES2444010T3 (en) 2006-05-30 2014-02-21 Genentech, Inc. Antibodies and immunoconjugates and uses thereof
WO2008060705A2 (en) 2006-06-06 2008-05-22 Genentech, Inc. Anti-dll4 antibodies and methods using same
RU2487888C2 (en) 2006-06-12 2013-07-20 ЭМЕРДЖЕНТ ПРОДАКТ ДИВЕЛОПМЕНТ СИЭТЛ, ЭлЭлСи Single-chain multivalent binding proteins with effector function
WO2008002933A2 (en) 2006-06-26 2008-01-03 Macrogenics, Inc. Combination of fcgammariib antibodies and cd20-specific antibodies and methods of use thereof
ES2599319T3 (en) 2006-06-26 2017-02-01 Macrogenics, Inc. Fc RIIB specific antibodies and their methods of use
EP2046833B9 (en) 2006-07-14 2014-02-19 AC Immune S.A. Humanized antibody against amyloid beta
WO2008011081A2 (en) 2006-07-19 2008-01-24 The Trustees Of The University Of Pennsylvania Wsx-1/p28 as a target for anti-inflammatory responses
RS53263B (en) 2006-08-14 2014-08-29 Xencor Inc. Optimized antibodies that target cd19
CA2662350A1 (en) 2006-09-05 2008-03-13 Medarex, Inc. Antibodies to bone morphogenic proteins and receptors therefor and methods for their use
ES2383710T3 (en) 2006-09-08 2012-06-25 Medimmune, Llc Humanized anti-CD19 antibodies and their use in the treatment of tumors, transplants and autoimmune diseases
JP2010503407A (en) 2006-09-12 2010-02-04 ジェネンテック・インコーポレーテッドGenentech,Inc. Methods and compositions for diagnosis and treatment of cancer
EP2083017A4 (en) 2006-09-14 2011-01-12 Med & Biological Lab Co Ltd Antibody having enhanced adcc activity and method for production thereof
AU2007299843B2 (en) 2006-09-18 2012-03-08 Xencor, Inc Optimized antibodies that target HM1.24
ES2553553T3 (en) 2006-10-02 2015-12-10 E. R. Squibb & Sons, L.L.C. Human antibodies that bind to CXCR4 and their uses
RU2486201C2 (en) * 2006-10-12 2013-06-27 Дженентек, Инк. Lymphotoxin alpha antibodies
WO2008048545A2 (en) * 2006-10-16 2008-04-24 Medimmune, Llc. Molecules with reduced half-lives, compositions and uses thereof
WO2008060814A2 (en) 2006-10-19 2008-05-22 Merck & Co., Inc. ANTI-IL-13Rα1 ANTIBODIES AND THEIR USES THEREOF
CN101588816B (en) 2006-10-19 2013-06-19 Csl有限公司 High affinity antibody antagonists of interleukin-13 receptor alpha 1
EP2845866B1 (en) 2006-10-27 2017-05-03 Genentech, Inc. Antibodies and immunoconjugates and uses therefor
US8618248B2 (en) 2006-10-31 2013-12-31 President And Fellows Of Harvard College Phosphopeptide compositions and anti-phosphopeptide antibody compositions and methods of detecting phosphorylated peptides
TWI391401B (en) 2006-11-02 2013-04-01 Genentech Inc Humanized anti-factor d antibodies and uses thereof
EP2097447A4 (en) 2006-11-15 2010-12-29 Medarex Inc Human monoclonal antibodies to btla and methods of use
WO2008067547A2 (en) 2006-11-30 2008-06-05 Research Development Foundation Improved immunoglobulin libraries
TWI447124B (en) 2006-12-01 2014-08-01 Medarex Llc Human antibodies that bind cd22 and uses thereof
US20080127996A1 (en) * 2006-12-04 2008-06-05 Weinhold Dennis G Method and apparatus to remediate an acid and/or liquid spill
WO2008140603A2 (en) 2006-12-08 2008-11-20 Macrogenics, Inc. METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING
CL2007003622A1 (en) 2006-12-13 2009-08-07 Medarex Inc Human monoclonal antibody anti-CD19; composition comprising; and method of inhibiting the growth of tumor cells.
NZ578354A (en) 2006-12-14 2012-01-12 Medarex Inc Antibody-partner molecule conjugates that bind cd70 and uses thereof
JP2010513566A (en) 2006-12-19 2010-04-30 ジェネンテック, インコーポレイテッド Treatment of early stage tumors with VEGF-specific antagonists for adjuvant and neoadjuvant therapy
US20110236374A1 (en) 2007-01-24 2011-09-29 Kyowa Hakko Kirin Co., Ltd. Genetically recombinant antibody composition capable of binding specifically to ganglioside gm2
US7994290B2 (en) 2007-01-24 2011-08-09 Kyowa Hakko Kirin Co., Ltd Effector function enhanced recombinant antibody composition
MX2009008430A (en) 2007-02-09 2009-10-28 Genentech Inc Anti-robo4 antibodies and uses therefor.
MX2009008981A (en) 2007-03-02 2009-09-02 Genentech Inc Predicting response to a her inhibitor.
CN101641115B (en) 2007-03-08 2013-04-24 卡罗拜奥斯制药公司 Epha3 antibodies for the treatment of solid tumors
WO2008118356A2 (en) 2007-03-22 2008-10-02 Biogen Idec Ma Inc. Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof
WO2008118324A2 (en) 2007-03-26 2008-10-02 Macrogenics, Inc. Composition and method of treating cancer with an anti-uroplakin ib antibody
TWI570135B (en) 2007-04-27 2017-02-11 建南德克公司 Potent, stable and non-immunosuppressive anti-cd4 antibodies
DK2155789T3 (en) * 2007-05-01 2013-10-21 Res Dev Foundation Immunoglobulin Fc libraries
EP2737907A3 (en) 2007-05-07 2014-11-05 MedImmune, LLC Anti-icos antibodies and their use in treatment of oncology, transplantation and autoimmune disease
WO2008141197A1 (en) * 2007-05-10 2008-11-20 Sea Lane Biotechnologies, Llc Chain reaction creating oligomers from repeat units of binding molecules
ES2441189T3 (en) 2007-05-14 2014-02-03 Novimmune Sa Fc receptor binding polypeptides with modified effector functions
WO2008150494A1 (en) 2007-05-30 2008-12-11 Xencor, Inc. Methods and compositions for inhibiting cd32b expressing cells
JP6071165B2 (en) * 2007-05-31 2017-02-01 ゲンマブ エー/エス Stable IgG4 antibody
EP1997830A1 (en) 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV specific binding molecules and means for producing them
PE20090321A1 (en) 2007-06-04 2009-04-20 Genentech Inc Anti-notch1 nrr, preparation method and pharmaceutical composition
SI2171090T1 (en) 2007-06-08 2013-07-31 Genentech, Inc. Gene expression markers of tumor resistance to her2 inhibitor treatment
US8048420B2 (en) 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
CL2008001741A1 (en) * 2007-06-12 2008-11-21 Genentech Inc Humanized antibody or chimeric or fragment thereof which specifically bind at least one epitope in the beta-amyloid protein; nucleic acid molecule encoding it; composition comprising; and their use to treat diseases associated with amyloid plaque formation.
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
WO2008157379A2 (en) 2007-06-21 2008-12-24 Macrogenics, Inc. Covalent diabodies and uses thereof
CA2692392A1 (en) * 2007-06-29 2009-01-08 Centocor Ortho Biotech Inc. Anti- mcp-1 antibodies, compositions, methods and uses
TR201802088T4 (en) 2007-07-09 2018-03-21 Genentech Inc prevent the reduction of disulfide bonds during the recombinant production of the polypeptides.
WO2009009103A2 (en) * 2007-07-10 2009-01-15 Medimmune, Llc CRYSTALS AND STRUCTURE OF HUMAN IgG Fc VARIANT
MX2010008437A (en) 2008-01-31 2010-11-25 Genentech Inc Anti-cd79b antibodies and immunoconjugates and methods of use.
EP2474557B1 (en) 2007-07-16 2014-08-20 Genentech, Inc. Anti-CD79b antibodies and immunoconjugates and methods of use
CA2692819A1 (en) 2007-07-16 2009-01-22 Genentech, Inc. Humanized anti-cd79b antibodies and immunoconjugates and methods of use
WO2009018386A1 (en) 2007-07-31 2009-02-05 Medimmune, Llc Multispecific epitope binding proteins and uses thereof
LT2769729T (en) 2007-09-04 2019-05-10 Compugen Ltd. Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
PL2202245T3 (en) 2007-09-26 2017-02-28 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substitution in cdr
US9403902B2 (en) 2007-10-05 2016-08-02 Ac Immune S.A. Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody
EP2205632B1 (en) * 2007-10-05 2016-11-16 Genentech, Inc. Use of anti-amyloid beta antibody in ocular diseases
TWI489993B (en) 2007-10-12 2015-07-01 Novartis Ag Compositions and methods of use for antibodies against sclerostin
WO2009052293A1 (en) 2007-10-16 2009-04-23 Zymogenetics, Inc. Combination of blys inhibition and anti-cd 20 agents for treatment of autoimmune disease
US20120047586A9 (en) 2007-10-24 2012-02-23 Otsuka Chemical Co., Ltd Polypeptide having enhanced effector function
EP2209491B1 (en) 2007-11-02 2015-10-28 Novartis AG Molecules and methods for modulating low-density-lipoprotein receptor-related protein 6 (lrp6)
EP3360567A1 (en) 2007-11-07 2018-08-15 Genentech, Inc. Amp for use in treating microbial disorders
TWI580694B (en) 2007-11-30 2017-05-01 建南德克公司 Anti-vegf antibodies
CA2708854C (en) 2007-12-14 2017-11-28 Novo Nordisk A/S Antibodies against human nkg2d and uses thereof
WO2009117030A2 (en) 2007-12-19 2009-09-24 Macrogenics, Inc. Improved compositions for the prevention and treatment of smallpox
CN104788563A (en) 2007-12-21 2015-07-22 米迪缪尼有限公司 Binding members for interleukin-4 receptor alpha (Il-4Ra) - 173
BRPI0821604A2 (en) * 2007-12-26 2015-06-23 Xencor Inc Fc variants with connection changed to fcrn
EP2077281A1 (en) 2008-01-02 2009-07-08 Bergen Teknologioverforing AS Anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome
US7914785B2 (en) 2008-01-02 2011-03-29 Bergen Teknologieverforing As B-cell depleting agents, like anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome
AU2009205995B2 (en) 2008-01-18 2014-04-03 Medimmune, Llc Cysteine engineered antibodies for site-specific conjugation
TWI472339B (en) 2008-01-30 2015-02-11 Genentech Inc Composition comprising antibody that binds to domain ii of her2 and acidic variants thereof
DK2240203T3 (en) 2008-02-05 2014-05-05 Pfizer Alfa5-beta1 antibodies and their uses
PL2250279T3 (en) 2008-02-08 2016-11-30 Anti-ifnar1 antibodies with reduced fc ligand affinity
CN102232113A (en) * 2008-03-31 2011-11-02 健泰科生物技术公司 Compositions and methods for treating and diagnosing asthma
CA2720365C (en) 2008-04-02 2019-01-15 Macrogenics, Inc. Bcr-complex-specific antibodies and methods of using same
EP2247304B1 (en) 2008-04-02 2016-05-25 MacroGenics, Inc. Her2/neu-specific antibodies and methods of using same
WO2009125825A1 (en) 2008-04-11 2009-10-15 中外製薬株式会社 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
PL2132228T3 (en) 2008-04-11 2012-01-31 Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
CR20170001A (en) 2008-04-28 2017-08-10 Genentech Inc Humanized anti factor d
MX2010011955A (en) * 2008-04-29 2011-01-21 Abbott Lab Dual variable domain immunoglobulins and uses thereof.
KR20110016959A (en) 2008-06-03 2011-02-18 아보트 러보러터리즈 Dual variable domain immunoglobulins and uses thereof
EP3002299A1 (en) 2008-06-03 2016-04-06 AbbVie Inc. Dual variable domain immunoglobulins and uses thereof
WO2010033279A2 (en) 2008-06-04 2010-03-25 Macrogenics, Inc. Antibodies with altered binding to fcrn and methods of using same
MX2010014574A (en) 2008-07-08 2011-04-27 Abbott Lab Prostaglandin e2 dual variable domain immunoglobulins and uses thereof.
TW201016233A (en) * 2008-07-15 2010-05-01 Genentech Inc Methods of treating autoimmune diseases using CD4 antibodies
MX2011001371A (en) 2008-08-05 2011-06-16 Novartis Ag Compositions and methods for antibodies targeting complement protein c5.
AR072999A1 (en) 2008-08-11 2010-10-06 Medarex Inc human antibodies that bind to the gene 3 of lymphocyte activation (LAG-3) and uses these
TW201438738A (en) 2008-09-16 2014-10-16 Genentech Inc Methods for treating progressive multiple sclerosis
AU2009294415B2 (en) 2008-09-19 2015-09-24 Medimmune Llc Antibodies directed to DLL4 and uses thereof
SG10201605250SA (en) * 2008-10-14 2016-08-30 Genentech Inc Immunoglobulin variants and uses thereof
US8298533B2 (en) 2008-11-07 2012-10-30 Medimmune Limited Antibodies to IL-1R1
ES2719496T3 (en) 2008-11-12 2019-07-10 Medimmune Llc Antibody formulation
WO2010059969A2 (en) 2008-11-22 2010-05-27 Genentech, Inc. Anti-angiogenesis therapy for the treatment of breast cancer
CN102300874B (en) 2008-12-08 2015-08-05 卡姆普根有限公司 Tmem154 polypeptides and polynucleotides and their use as pharmaceutical and biological products to produce a target for drug
WO2010068722A1 (en) 2008-12-12 2010-06-17 Medimmune, Llc Crystals and structure of a human igg fc variant with enhanced fcrn binding
HUE043084T2 (en) 2008-12-19 2019-08-28 Macrogenics Inc Covalent diabodies and uses thereof
WO2010075249A2 (en) 2008-12-22 2010-07-01 Genentech, Inc. A method for treating rheumatoid arthritis with b-cell antagonists
US20120114667A1 (en) 2008-12-23 2012-05-10 Medimmune Limited TARGETED BINDING AGENTS DIRECTED TO a5BETA1 AND USES THEREOF
JP2012514458A (en) 2008-12-31 2012-06-28 バイオジェン・アイデック・エムエイ・インコーポレイテッド Anti-lymphotoxin antibody
WO2011028228A1 (en) 2009-08-24 2011-03-10 Amunix Operating Inc. Coagulation factor vii compositions and methods of making and using same
US9238878B2 (en) 2009-02-17 2016-01-19 Redwood Bioscience, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
WO2010095031A2 (en) 2009-02-23 2010-08-26 Glenmark Pharmaceuticals S.A. Humanized antibodies that bind to cd19 and their uses
UA102891C2 (en) 2009-03-05 2013-08-27 Медарекс, Інк. Fully human antibodies specific to cadm1
EP2403879A1 (en) 2009-03-06 2012-01-11 Kalobios Pharmaceuticals, Inc. Treatment of leukemias and chronic myeloproliferative diseases with antibodies to epha3
BRPI1009460A2 (en) 2009-03-16 2016-03-01 Cephalon Australia Pty Ltd antibody binding domain, antibody, use of a binding domain or antibody, method for detecting the presence of cancer cells in a sample.
TWI461211B (en) 2009-03-20 2014-11-21 Genentech Inc Anti-her antibodies
EP2233500A1 (en) * 2009-03-20 2010-09-29 LFB Biotechnologies Optimized Fc variants
CA2756197A1 (en) * 2009-03-24 2010-09-30 Bayer Healthcare Llc Factor viii variants and methods of use
AU2010229479B2 (en) 2009-03-25 2013-03-28 Genentech, Inc. Novel anti-alpha5beta1 antibodies and uses thereof
KR101830024B1 (en) 2009-03-25 2018-02-19 제넨테크, 인크. Anti-fgfr3 antibodies and methods using same
CA2759942A1 (en) 2009-04-27 2010-10-07 Novartis Ag Composition and methods of use for therapeutic antibodies specific for the il-12 receptore betai subunit
PE20121397A1 (en) 2009-04-20 2012-10-23 Oxford Biotherapeutics Ltd antibodies specific for cadherin-17
WO2010124113A1 (en) 2009-04-23 2010-10-28 Infinity Pharmaceuticals, Inc. Anti-fatty acid amide hydrolase-2 antibodies and uses thereof
NZ595235A (en) 2009-04-27 2013-06-28 Novartis Ag Compositions and methods for increasing muscle growth
KR20140014382A (en) * 2009-05-01 2014-02-06 애브비 인코포레이티드 Dual variable domain immunoglobulins and uses thereof
NZ597611A (en) 2009-06-18 2014-03-28 Pfizer Anti notch-1 antibodies
RU2012101999A (en) 2009-06-22 2013-07-27 МЕДИММЬЮН, ЭлЭлСи Fc RECOMBINED SITES FOR SITE-SPECIFIC CONJUGATION
CA2766065A1 (en) * 2009-06-30 2011-01-20 Research Development Foundation Immunoglobulin fc polypeptides
BR112012000735A2 (en) 2009-07-13 2016-11-16 Genentech Inc "compound methods, kits and sets"
WO2011014457A1 (en) 2009-07-27 2011-02-03 Genentech, Inc. Combination treatments
CN102498129B (en) 2009-07-31 2016-03-02 霍夫曼-拉罗奇有限公司 Use bv8 antagonist or g-csf antagonist inhibits tumor metastasis
MX2012001417A (en) 2009-07-31 2012-07-03 Organon Nv Fully human antibodies to btla.
AU2010282733B2 (en) 2009-08-11 2016-07-14 Genentech, Inc. Production of proteins in glutamine-free cell culture media
BR112012003077A2 (en) 2009-08-14 2019-09-24 Genentech Inc biological goods to monitor patient response to vegf antagonists
AU2010284446A1 (en) 2009-08-15 2012-03-08 Genentech, Inc. Anti-angiogenesis therapy for the treatment of previously treated breast cancer
WO2011021146A1 (en) 2009-08-20 2011-02-24 Pfizer Inc. Osteopontin antibodies
GB0914691D0 (en) * 2009-08-21 2009-09-30 Lonza Biologics Plc Immunoglobulin variants
US9321823B2 (en) 2009-09-02 2016-04-26 Genentech, Inc. Mutant smoothened and methods of using the same
US8728730B2 (en) 2009-09-03 2014-05-20 Genentech, Inc. Methods for treating, diagnosing, and monitoring rheumatoid arthritis
WO2011029823A1 (en) 2009-09-09 2011-03-17 Novartis Ag Monoclonal antibody reactive with cd63 when expressed at the surface of degranulated mast cells
BR112012005315A2 (en) 2009-09-11 2016-03-22 Genentech Inc method for identifying a patient likely to respond to an anticancer agent, method for identifying a patient who has an increased likelihood of metastasis, method for monitoring the effectiveness of anticancer therapy, and method for dose optimization of a anticancer agent
EP2478114B1 (en) 2009-09-17 2014-12-17 F.Hoffmann-La Roche Ag Diagnostic methods for lung cancer
US8568726B2 (en) 2009-10-06 2013-10-29 Medimmune Limited RSV specific binding molecule
RU2583298C2 (en) 2009-10-07 2016-05-10 Макродженикс, Инк. POLYPEPTIDES CONTAINING Fc-SECTION THAT DISPLAY INCREASED EFFECTOR FUNCTION OWING TO VARYING FUCOSYLATION LEVEL AND THEIR APPLICATIONS
EP2470569A1 (en) 2009-10-13 2012-07-04 Oxford Biotherapeutics Ltd. Antibodies against epha10
WO2011053465A1 (en) 2009-10-14 2011-05-05 Kalobios Pharmaceuticals, Inc. Antibodies to epha3
AR078651A1 (en) * 2009-10-15 2011-11-23 Abbott Lab Immunoglobulins Dual variable domain and uses thereof
NZ599337A (en) 2009-10-22 2013-05-31 Genentech Inc Anti-hepsin antibodies and methods using same
BR112012007523A2 (en) 2009-10-23 2017-06-20 Amgen British Columbia anti-gcc antibody molecules and related compositions and methods
WO2011056497A1 (en) 2009-10-26 2011-05-12 Genentech, Inc. Activin receptor type iib compositions and methods of use
WO2011056502A1 (en) 2009-10-26 2011-05-12 Genentech, Inc. Bone morphogenetic protein receptor type ii compositions and methods of use
WO2011056494A1 (en) 2009-10-26 2011-05-12 Genentech, Inc. Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations
UY32979A (en) 2009-10-28 2011-02-28 Abbott Lab Immunoglobulins Dual variable domain and uses thereof
CA2779615A1 (en) 2009-11-02 2011-05-05 University Of Washington Therapeutic nuclease compositions and methods
US8637019B2 (en) 2009-11-04 2014-01-28 Merck Sharp & Dohme Corp. Engineered anti-TSLP antibody
CA2778552A1 (en) 2009-11-05 2011-05-12 Cephalon Australia Pty Ltd Treatment of cancer involving mutated kras or braf genes
JP6173690B2 (en) 2009-11-05 2017-08-02 ジェネンテック, インコーポレイテッド Methods and compositions for secretion of heterologous polypeptides
WO2011060015A1 (en) 2009-11-11 2011-05-19 Genentech, Inc. Methods and compositions for detecting target proteins
WO2011066389A1 (en) 2009-11-24 2011-06-03 Medimmmune, Limited Targeted binding agents against b7-h1
EP2506871B1 (en) * 2009-11-30 2016-10-19 Janssen Biotech, Inc. ANTIBODY Fc MUTANTS WITH ABLATED EFFECTOR FUNCTIONS
WO2011067711A2 (en) 2009-12-01 2011-06-09 Compugen Ltd Novel heparanase splice variant
JP2013512674A (en) 2009-12-02 2013-04-18 アクセルロン ファーマ, インコーポレイテッド Compositions and methods for increasing the serum half-life of an Fc fusion protein
WO2011071577A1 (en) 2009-12-11 2011-06-16 Genentech, Inc. Anti-vegf-c antibodies and methods using same
JP2013514795A (en) 2009-12-22 2013-05-02 ノバルティス アーゲー Tetravalent CD47 antibody constant region fusion protein for use in therapy
NZ600826A (en) 2009-12-23 2014-09-26 Genentech Inc Anti-bv8 antibodies and uses thereof
US8362210B2 (en) 2010-01-19 2013-01-29 Xencor, Inc. Antibody variants with enhanced complement activity
BR112012020102A2 (en) 2010-02-10 2016-11-29 Immunogen Inc cd20 antibodies and uses thereof.
US20120296403A1 (en) 2010-02-10 2012-11-22 Novartis Ag Methods and compounds for muscle growth
EP2536748B1 (en) 2010-02-18 2014-08-20 Genentech, Inc. Neuregulin antagonists and use thereof in treating cancer
CA3027824A1 (en) * 2010-02-23 2011-09-01 Sanofi Anti-alpha2 integrin antibodies and their uses
EP3064509A3 (en) 2010-02-23 2016-11-02 F. Hoffmann-La Roche AG Anti-angiogenesis therapy for the treatment of ovarian cancer
US9260529B2 (en) 2010-02-24 2016-02-16 The University Of Washington Through Its Center For Commercialization Molecules that bind CD180, compositions and methods of use
AU2011222012C1 (en) 2010-03-02 2015-02-26 Kyowa Kirin Co., Ltd. Modified antibody composition
US8802091B2 (en) 2010-03-04 2014-08-12 Macrogenics, Inc. Antibodies reactive with B7-H3 and uses thereof
NZ705128A (en) 2010-03-04 2015-04-24 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
AU2011232514A1 (en) 2010-03-24 2012-08-30 Genentech, Inc. Anti-LRP6 antibodies
JP2013528357A (en) 2010-03-29 2013-07-11 ザイムワークス,インコーポレイテッド Antibody with enhanced or suppressed effector function
TWI667257B (en) 2010-03-30 2019-08-01 中外製藥股份有限公司 Antibodies with modified affinity to fcrn that promote antigen clearance
WO2012133782A1 (en) 2011-03-30 2012-10-04 中外製薬株式会社 Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity
CN103237811A (en) 2010-05-06 2013-08-07 诺瓦提斯公司 Compositions and methods of use for therapeutic low density lipoprotein-related protein 6 (LPR6) multivalent antibodies
CA2798432A1 (en) 2010-05-06 2011-11-10 Novartis Ag Compositions and methods of use for therapeutic low density lipoprotein -related protein 6 (lrp6) antibodies
WO2011146568A1 (en) 2010-05-19 2011-11-24 Genentech, Inc. Predicting response to a her inhibitor
WO2011147834A1 (en) 2010-05-26 2011-12-01 Roche Glycart Ag Antibodies against cd19 and uses thereof
WO2011153224A2 (en) 2010-06-02 2011-12-08 Genentech, Inc. Diagnostic methods and compositions for treatment of cancer
WO2011153243A2 (en) 2010-06-02 2011-12-08 Genentech, Inc. Anti-angiogenesis therapy for treating gastric cancer
KR20130098165A (en) 2010-06-03 2013-09-04 제넨테크, 인크. Immuno-pet imaging of antibodies and immunoconjugates and uses therefor
EP3098240A3 (en) 2010-06-18 2017-04-05 F. Hoffmann-La Roche AG Anti-axl antibodies and methods of use
ES2719624T3 (en) 2010-09-23 2019-07-11 Prec Biologics Inc Peptidomimetics of colon and pancreas cancer
US20130189268A1 (en) 2010-06-22 2013-07-25 Precision Biologics, Inc. Colon and pancreas cancer specific antigens and antibodies
WO2011161119A1 (en) 2010-06-22 2011-12-29 F. Hoffmann-La Roche Ag Antibodies against insulin-like growth factor i receptor and uses thereof
WO2011161189A1 (en) 2010-06-24 2011-12-29 F. Hoffmann-La Roche Ag Anti-hepsin antibodies and methods of use
CA2804280A1 (en) 2010-07-09 2012-01-12 Biogen Idec Hemophilia Inc. Chimeric clotting factors
SG186983A1 (en) 2010-07-09 2013-02-28 Genentech Inc Anti-neuropilin antibodies and methods of use
WO2012010550A1 (en) 2010-07-19 2012-01-26 F. Hoffmann-La Roche Ag Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy
RU2013104039A (en) 2010-07-19 2014-08-27 Ф. Хоффманн-Ля Рош Аг Method for identification of a patient with an increased probability of answer to anti-cancer therapy
WO2012010582A1 (en) 2010-07-21 2012-01-26 Roche Glycart Ag Anti-cxcr5 antibodies and methods of use
CN106432495A (en) 2010-07-22 2017-02-22 加利福尼亚大学董事会 Anti-tumor antigen antibodies and methods of use
US20130022551A1 (en) 2011-07-22 2013-01-24 Trustees Of Boston University DEspR ANTAGONISTS AND AGONISTS AS THERAPEUTICS
US20130177500A1 (en) 2010-07-23 2013-07-11 Trustee Of Boston University Anti-despr inhibitors as therapeutics for inhibition of pathological angiogenesis and tumor cell invasiveness and for molecular imaging and targeted delivery
ES2701405T3 (en) 2010-07-29 2019-02-22 Eleven Biotherapeutics Inc Agonists and antagonists of the type I receptor of chimeric IL-1
EP2598882B1 (en) 2010-07-30 2017-07-26 AC Immune S.A. Safe and functional humanized antibodies for use in treating an amyloidosis
MX339622B (en) 2010-08-02 2016-06-02 Macrogenics Inc Covalent diabodies and uses thereof.
BR112013002578A2 (en) 2010-08-03 2019-05-14 Abbvie Inc immunoglobulins dual variable domain and uses the same
RU2013106216A (en) 2010-08-03 2014-09-10 Ф. Хоффманн-Ля Рош Аг BIOMARKERS OF CHRONIC Lymphocytic Leukemia
BR112013002532A2 (en) 2010-08-05 2016-05-31 Hoffmann La Roche anti-mhc antibody anti-viral cytokine fusion protein
WO2012019061A2 (en) 2010-08-05 2012-02-09 Stem Centrx, Inc. Novel effectors and methods of use
TW201209063A (en) 2010-08-13 2012-03-01 Roche Glycart Ag Anti-tenascin-C A2 antibodies and methods of use
US20130177555A1 (en) 2010-08-13 2013-07-11 Medimmune Limited Monomeric Polypeptides Comprising Variant FC Regions And Methods Of Use
EA201300239A1 (en) 2010-08-13 2013-08-30 Роше Гликарт Аг Antibodies to fap and methods of their application
WO2012022734A2 (en) 2010-08-16 2012-02-23 Medimmune Limited Anti-icam-1 antibodies and methods of use
RS55930B1 (en) 2010-08-20 2017-09-29 Novartis Ag Antibodies for epidermal growth factor receptor 3 (her3)
TW201215405A (en) 2010-08-25 2012-04-16 Hoffmann La Roche Antibodies against IL-18R1 and uses thereof
BR112013004581A2 (en) 2010-08-26 2017-06-27 Abbvie Inc dual variable domain immunoglobulins and their uses
JP2013539468A (en) 2010-08-27 2013-10-24 ステム セントリックス, インコーポレイテッド Notum protein modulators and methods of use
CA2808236A1 (en) 2010-08-31 2012-03-08 Genentech, Inc. Biomarkers and methods of treatment
UY33578A (en) 2010-08-31 2012-03-30 Sanofi Sa COMPLEX peptide or peptide that binds to integrin (alpha) AND METHODS AND USES INVOLVING THE SAME
EP2611928B1 (en) 2010-09-03 2016-04-27 Academia Sinica Anti-c-met antibody and methods of use thereof
SA4398B1 (en) 2011-02-18 2015-10-09 ستيم سينتركس، انك. Novel modulators and methods of use
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
WO2012031273A2 (en) 2010-09-03 2012-03-08 Stem Centrx, Inc. Novel modulators and methods of use
WO2012032080A1 (en) 2010-09-07 2012-03-15 F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H Stabilised human fc
US8999335B2 (en) 2010-09-17 2015-04-07 Compugen Ltd. Compositions and methods for treatment of drug resistant multiple myeloma
LT2621531T (en) 2010-09-27 2017-04-10 Morphosys Ag Anti-cd38 antibody and lenalidomide or bortezomib for the treatment of multiple myeloma and nhl
US8481680B2 (en) 2010-10-05 2013-07-09 Genentech, Inc. Mutant smoothened and methods of using the same
CN103154037A (en) 2010-10-05 2013-06-12 诺瓦提斯公司 Anti-IL 12 Rbeta 1 antibodies and their use in treating autoimmune and inflammatory disorders
KR101920250B1 (en) 2010-10-13 2018-11-20 얀센 바이오테크 인코포레이티드 Human oncostatin m antibodies and methods of use
NZ610091A (en) * 2010-10-20 2015-02-27 Oxford Biotherapeutics Ltd Antibodies
CN108341868A (en) 2010-11-05 2018-07-31 酵活有限公司 There is the antibody design of the stabilization heterodimeric of mutation in Fc structural domains
CN103476793A (en) 2010-11-08 2013-12-25 基因技术公司 Subcutaneously administered anti-IL-6 receptor antibody
ES2607086T3 (en) 2010-11-10 2017-03-29 F. Hoffmann-La Roche Ag Methods and compositions for immunotherapy of neuronal diseases
CA2818814A1 (en) 2010-11-23 2012-05-31 Alder Biopharmaceuticals, Inc. Anti-il-6 antibodies for the treatment of anemia
NZ610464A (en) 2010-11-23 2015-02-27 Glaxo Group Ltd Antigen binding proteins to oncostatin m (osm)
EP2643351A1 (en) 2010-11-24 2013-10-02 Glaxo Group Limited Multispecific antigen binding proteins targeting hgf
SG10201609301QA (en) 2011-11-30 2016-12-29 Chugai Pharmaceutical Co Ltd Drug containing carrier into cell for forming immune complex
WO2012073992A1 (en) 2010-11-30 2012-06-07 中外製薬株式会社 Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
AU2011336716B2 (en) 2010-11-30 2016-01-21 Genentech, Inc. Low affinity blood brain barrier receptor antibodies and uses therefor
AR084208A1 (en) 2010-12-08 2013-05-02 Stem Centrx Inc Modulators of ephrin ligand to (FENa) and methods for use
BR112013015122A2 (en) 2010-12-15 2017-05-30 Wyeth Llc anti-notch1 antibodies
CA3040095A1 (en) 2010-12-16 2012-06-21 Genentech, Inc. Diagnosis and treatments relating to th2 inhibition
TWI589589B (en) 2010-12-20 2017-07-01 建南德克公司 Anti-mesothelin antibodies and immunoconjugates
WO2012088313A1 (en) 2010-12-22 2012-06-28 Genentech, Inc. Anti-pcsk9 antibodies and methods of use
EP2654780B1 (en) * 2010-12-23 2017-02-01 Janssen Biotech, Inc. Active protease-resistant antibody fc mutants
WO2012092539A2 (en) 2010-12-31 2012-07-05 Takeda Pharmaceutical Company Limited Antibodies to dll4 and uses thereof
CN102128937B (en) * 2010-12-31 2014-05-28 江苏华冠生物技术股份有限公司 Evaluating and monitoring method for effect of desensitization therapy, detection kit of allergen specificity IgG4 antibody and preparation method thereof
KR20140016262A (en) 2011-01-14 2014-02-07 레드우드 바이오사이언스 인코포레이티드 Aldehyde-tagged immunoglobulin polypeptides and method of use thereof
JP6228014B2 (en) 2011-02-07 2017-11-08 リサーチ ディベロップメント ファウンデーション Engineered immunoglobulin Fc polypeptides
CN103492565A (en) 2011-02-25 2014-01-01 中外制药株式会社 FcgRIIb-specific Fc antibody
SG10201805584YA (en) 2012-02-24 2018-08-30 Chugai Pharmaceutical Co Ltd ANTIGEN-BINDING MOLECULE FOR PROMOTING DISAPPEARANCE OF ANTIGEN VIA FcγRIIB
RU2014117505A (en) 2011-09-30 2015-11-10 Чугаи Сейяку Кабусики Кайся Antigen-binding molecule for acceleration of removal of antigens
EP2680884B1 (en) 2011-02-28 2018-01-17 F.Hoffmann-La Roche Ag Biological markers and methods for predicting response to b-cell antagonists
MX354359B (en) * 2011-03-29 2018-02-28 Roche Glycart Ag Antibody fc variants.
TW201817745A (en) 2011-09-30 2018-05-16 日商中外製藥股份有限公司 Therapeutic antigen-binding molecule with a FcRn-binding domain that promotes antigen clearance
MX2013011130A (en) 2011-03-31 2013-10-30 Genentech Inc Methods of administering beta7 integrin antagonists.
RU2013143358A (en) 2011-04-07 2015-05-20 Дженентек, Инк. Anti-fgfr4 antibodies and ways of their application
SI2697257T1 (en) 2011-04-13 2017-02-28 Bristol-Myers Squibb Company Fc fusion proteins comprising novel linkers or arrangements
AU2012241373B2 (en) 2011-04-15 2016-06-09 Compugen Ltd. Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer
RS57324B1 (en) 2011-04-20 2018-08-31 Medimmune Llc Antibodies and other molecules that bind b7-h1 and pd-1
WO2013101771A2 (en) 2011-12-30 2013-07-04 Genentech, Inc. Compositions and method for treating autoimmune diseases
GB201107170D0 (en) 2011-04-28 2011-06-15 Clark Michael Binding molecules with biased recognition
WO2012146630A1 (en) 2011-04-29 2012-11-01 F. Hoffmann-La Roche Ag N-terminal acylated polypeptides, methods for their production and uses thereof
MX351953B (en) 2011-04-29 2017-11-06 Univ Washington Therapeutic nuclease compositions and methods.
ES2567276T3 (en) 2011-05-12 2016-04-21 Genentech, Inc. LC-MS / MS method of monitoring multiple reactions to detect therapeutic antibodies in animal samples using frame-changing peptides
PT2707391T (en) 2011-05-13 2018-02-06 Inserm Institut National De La Santa© Et De La Rech Ma©Dicale Antibodies against her3
JP5836481B2 (en) 2011-05-16 2015-12-24 ジェネンテック, インコーポレイテッド FGFR1 agonist and method of use
EP2714733B1 (en) 2011-05-21 2019-01-23 MacroGenics, Inc. Cd3-binding molecules capable of binding to human and non-human cd3
NZ618016A (en) 2011-05-21 2015-05-29 Macrogenics Inc Deimmunized serum-binding domains and their use for extending serum half-life
EP2714738B1 (en) 2011-05-24 2018-10-10 Zyngenia, Inc. Multivalent and monovalent multispecific complexes and their uses
EP2714732A4 (en) 2011-05-25 2014-12-10 Merck Sharp & Dohme METHOD FOR PREPARING Fc-CONTAINING POLYPEPTIDES HAVING IMPROVED PROPERTIES
WO2012170740A2 (en) 2011-06-07 2012-12-13 University Of Hawaii Biomarker of asbestos exposure and mesothelioma
US9561274B2 (en) 2011-06-07 2017-02-07 University Of Hawaii Treatment and prevention of cancer with HMGB1 antagonists
AU2012267484B2 (en) 2011-06-10 2017-03-23 Bioverativ Therapeutics Inc. Pro-coagulant compounds and methods of use thereof
WO2012172495A1 (en) 2011-06-14 2012-12-20 Novartis Ag Compositions and methods for antibodies targeting tem8
JP5984919B2 (en) 2011-06-15 2016-09-06 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Anti-human EPO receptor antibody and method of use
CN103635490A (en) 2011-06-16 2014-03-12 诺瓦提斯公司 Soluble proteins for use as therapeutics
CN110229235A (en) 2011-06-22 2019-09-13 霍夫曼-拉罗奇有限公司 Target cell is removed by the HIV-specific cytotoxic T lymphocytes in circulation using the compound comprising MHC I class
WO2012175691A1 (en) 2011-06-22 2012-12-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-axl antibodies and uses thereof
EP2723377B1 (en) 2011-06-22 2018-06-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-axl antibodies and uses thereof
EP2537864B1 (en) * 2011-06-24 2019-08-07 Laboratoire Français du Fractionnement et des Biotechnologies Fc variants with reduced effector functions
MX347424B (en) 2011-06-28 2017-04-26 Oxford Biotherapeutics Ltd Antibodies to adp-ribosyl cyclase 2.
EP2728002A4 (en) 2011-06-30 2015-03-25 Chugai Pharmaceutical Co Ltd Heterodimerized polypeptide
RU2013155695A (en) 2011-06-30 2015-08-10 Дженентек, Инк. Antibodies against c-met
AU2012277376B2 (en) 2011-06-30 2016-11-24 Compugen Ltd. Polypeptides and uses thereof for treatment of autoimmune disorders and infection
EP2726099B1 (en) 2011-07-01 2018-07-25 Novartis AG Method for treating metabolic disorders
SG10201605703TA (en) 2012-07-06 2016-09-29 Genmab B V Dimeric protein with triple mutations
CN104220093A (en) * 2011-07-06 2014-12-17 根马布私人有限公司 Antibody variants and uses thereof
WO2013012733A1 (en) 2011-07-15 2013-01-24 Biogen Idec Ma Inc. Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
US9238689B2 (en) 2011-07-15 2016-01-19 Morpho Sys AG Antibodies that are cross-reactive for macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT)
GB201112429D0 (en) 2011-07-19 2011-08-31 Glaxo Group Ltd Antigen-binding proteins with increased FcRn binding
JP5987057B2 (en) 2011-07-27 2016-09-06 グラクソ グループ リミテッドGlaxo Group Limited Anti-VEGF single variable domain fused with FC domain
AU2012296613B2 (en) 2011-08-15 2016-05-12 Amplimmune, Inc. Anti-B7-H4 antibodies and their uses
EP2744824A1 (en) 2011-08-17 2014-06-25 F.Hoffmann-La Roche Ag Neuregulin antibodies and uses thereof
BR112014003599A2 (en) 2011-08-17 2018-04-17 Genentech Inc tumor angiogenesis inhibition method, tumor growth suppression method and tumor treatment method
US9309306B2 (en) 2011-08-23 2016-04-12 Roche Glycart Ag Anti-MCSP antibodies
US9790268B2 (en) 2012-09-12 2017-10-17 Genzyme Corporation Fc containing polypeptides with altered glycosylation and reduced effector function
US20130108641A1 (en) 2011-09-14 2013-05-02 Sanofi Anti-gitr antibodies
KR20140068062A (en) 2011-09-15 2014-06-05 제넨테크, 인크. Methods of promoting differentiation
BR112014006419A2 (en) 2011-09-19 2018-08-07 Genentech Inc Methods to Treat a Cancer Patient, Kit and Article
US20150050269A1 (en) 2011-09-30 2015-02-19 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
JP6352634B2 (en) * 2011-09-30 2018-07-04 中外製薬株式会社 Antigen-binding molecules that induce immune responses to target antigens
EP2765192A4 (en) 2011-10-05 2015-04-15 Chugai Pharmaceutical Co Ltd Antigen-binding molecule for promoting clearance from plasma of antigen comprising saccharide chain receptor-binding domain
BR112014008212A2 (en) 2011-10-05 2017-06-13 Genentech Inc method for treating a liver condition, hepatic differentiation induction method, and abnormal bile duct proliferation reduction method
JP2014530816A (en) 2011-10-14 2014-11-20 ノバルティスアーゲー Antibodies and methods for Wnt pathway related diseases
NZ623346A (en) 2011-10-14 2016-09-30 Genentech Inc Anti-htra1 antibodies and methods of use
CN103998027A (en) 2011-10-15 2014-08-20 霍夫曼-拉罗奇有限公司 Methods of using SCD1 antagonists for cancer therapy
WO2013059531A1 (en) 2011-10-20 2013-04-25 Genentech, Inc. Anti-gcgr antibodies and uses thereof
EP2776051A4 (en) 2011-10-28 2015-06-17 Hoffmann La Roche Therapeutic combinations and methods of treating melanoma
EP2773664A1 (en) 2011-11-01 2014-09-10 Bionomics, Inc. Anti-gpr49 antibodies
CA2853951A1 (en) 2011-11-01 2013-05-10 Bionomics, Inc. Antibodies and methods of treating cancer
EP2773373B1 (en) 2011-11-01 2018-08-22 Bionomics, Inc. Methods of blocking cancer stem cell growth
WO2013067060A1 (en) 2011-11-01 2013-05-10 Bionomics, Inc. Anti-gpr49 antibodies
BR112014010580A2 (en) 2011-11-04 2017-05-02 Zymeworks Inc stable heterodimeric antibody design with fc domain mutations
EP2776061B1 (en) 2011-11-07 2019-08-14 MedImmune, LLC Multispecific and multivalent binding proteins and uses thereof
CA2854477A1 (en) 2011-11-21 2013-05-30 Genentech, Inc. Purification of anti-c-met antibodies
AU2012340623A1 (en) 2011-11-23 2014-07-17 Igenica Biotherapeutics, Inc. Anti-CD98 antibodies and methods of use thereof
WO2013085972A1 (en) 2011-12-05 2013-06-13 X-Body, Inc. Pdgf receptor beta binding polypeptides
SG11201402739YA (en) 2011-12-05 2014-06-27 Novartis Ag Antibodies for epidermal growth factor receptor 3 (her3) directed to domain ii of her3
AU2012349735B2 (en) 2011-12-05 2016-05-19 Novartis Ag Antibodies for epidermal growth factor receptor 3 (HER3)
WO2013083497A1 (en) 2011-12-06 2013-06-13 F. Hoffmann-La Roche Ag Antibody formulation
WO2013101509A2 (en) 2011-12-15 2013-07-04 Alternative Innovative Technologies Llc Hsp70 fusion protein conjugates and uses thereof
AU2012355415B2 (en) 2011-12-20 2017-07-06 Medimmune, Llc Modified polypeptides for bispecific antibody scaffolds
MX2014007665A (en) 2011-12-21 2015-03-05 Novartis Ag Compositions and methods for antibodies targeting factor p.
AR089434A1 (en) 2011-12-23 2014-08-20 Genentech Inc Process for preparing formulations with high protein concentration
ES2721882T3 (en) 2011-12-23 2019-08-06 Pfizer Constant regions of genetically engineered antibody for site-specific conjugation and procedures and uses thereof
TWI593705B (en) 2011-12-28 2017-08-01 Chugai Pharmaceutical Co Ltd Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient
BR112014015851A2 (en) 2011-12-30 2019-09-24 Abbvie Inc double specific binding proteins directed against il-13 and / or il-17
CN104411717A (en) 2012-01-09 2015-03-11 斯克利普斯研究所 Humanized antibodies with ultralong CDR3S
CA2863224A1 (en) 2012-01-09 2013-07-18 The Scripps Research Institute Ultralong complementarity determining regions and uses thereof
EP3505179A1 (en) 2012-01-12 2019-07-03 Bioverativ Therapeutics Inc. Chimeric factor viii polypeptides and uses thereof
MX356802B (en) 2012-01-13 2018-06-13 Genentech Inc Biological markers for identifying patients for treatment with vegf antagonists.
AU2013209707A1 (en) 2012-01-18 2014-07-24 Genentech, Inc. Anti-LRP5 antibodies and methods of use
KR20140119114A (en) 2012-01-18 2014-10-08 제넨테크, 인크. Methods of using fgf19 modulators
CN104185681A (en) 2012-02-01 2014-12-03 卡姆普根有限公司 C10RF32 antibodies, and uses thereof for treatment of cancer
SG11201404703WA (en) 2012-02-11 2014-09-26 Genentech Inc R-spondin translocations and methods using the same
KR20190094480A (en) 2012-02-15 2019-08-13 바이오버라티브 테라퓨틱스 인크. Recombinant factor viii proteins
ES2676031T3 (en) 2012-02-15 2018-07-16 F. Hoffmann-La Roche Ag Affinity chromatography based on the Fc receptor
WO2013122617A1 (en) 2012-02-15 2013-08-22 Amunix Operating Inc. Factor viii compositions and methods of making and using same
JP6089047B2 (en) 2012-02-24 2017-03-01 アッヴィ・ステムセントルクス・エル・エル・シー DLL3 modulator and method of use
AU2013240261A1 (en) 2012-03-27 2014-09-18 Genentech, Inc. Diagnosis and treatments relating to HER3 inhibitors
EA201491784A1 (en) 2012-03-28 2015-02-27 Санофи Antibodies Against Ligand Recorder B1 Bradykinin
WO2013147153A1 (en) 2012-03-29 2013-10-03 株式会社未来創薬研究所 Anti-lamp5 antibody and utilization thereof
US20150056190A1 (en) 2012-03-30 2015-02-26 Genentech, Inc. Diagnostic methods and compositions for treatment of cancer
AR090549A1 (en) 2012-03-30 2014-11-19 Genentech Inc Antibodies and immunoconjugates LGR5
SG11201406347TA (en) 2012-04-05 2014-11-27 Ac Immune Sa Humanized tau antibody
US9156915B2 (en) 2012-04-26 2015-10-13 Thomas Jefferson University Anti-GCC antibody molecules
KR20150006000A (en) 2012-05-01 2015-01-15 제넨테크, 인크. Anti-pmel17 antibodies and immunoconjugates
WO2013166290A1 (en) 2012-05-04 2013-11-07 Abbvie Biotherapeutics Inc. P21 biomarker assay
EP2847216A1 (en) 2012-05-07 2015-03-18 Sanofi Methods for preventing biofilm formation
WO2013170191A1 (en) 2012-05-11 2013-11-14 Genentech, Inc. Methods of using antagonists of nad biosynthesis from nicotinamide
TR201810930T4 (en) 2012-05-18 2018-08-27 Genentech Inc High concentrations of monoclonal antibody formulations.
SG11201407669QA (en) 2012-05-21 2014-12-30 Genentech Inc Methods for improving safety of blood-brain barrier transport
US9695454B2 (en) 2012-05-23 2017-07-04 Glykos Finland Oy Production of fucosylated glycoproteins
WO2013175276A1 (en) 2012-05-23 2013-11-28 Argen-X B.V Il-6 binding molecules
RU2625771C2 (en) 2012-05-23 2017-07-18 Дженентек, Инк. Therapeutics selection method
WO2013177386A1 (en) 2012-05-24 2013-11-28 Abbvie Biotherapeutics Inc. Biomarkers for predicting response to tweak receptor (tweakr) agonist therapy
RU2014154067A (en) 2012-05-30 2016-07-20 Чугаи Сейяку Кабусики Кайся Target-specific antigen-binding molecule
WO2013180201A1 (en) 2012-05-30 2013-12-05 中外製薬株式会社 Antigen-binding molecule for eliminating aggregated antigens
ES2703540T3 (en) 2012-06-04 2019-03-11 Novartis Ag Site-specific marking methods and molecules produced in this way
CN104520330A (en) 2012-06-08 2015-04-15 格兰马克药品股份有限公司 Humanized anti-TrkA antibodies with amino acid substitutions
EP2858659A4 (en) 2012-06-08 2016-09-28 Biogen Ma Inc Procoagulant compounds
CN104427995A (en) 2012-06-08 2015-03-18 比奥根艾迪克Ma公司 Chimeric clotting factors
JPWO2013187495A1 (en) * 2012-06-14 2016-02-08 中外製薬株式会社 Antigen binding molecules comprising modified Fc regions
MX2014014830A (en) 2012-06-15 2015-05-11 Genentech Inc Anti-pcsk9 antibodies, formulations, dosing, and methods of use.
US20140051834A1 (en) * 2012-06-21 2014-02-20 Hoffmann-La Roche, Inc. Incretin Receptor Ligand Polypeptide Fc-Region Fusion Polypeptides And Conjugates With Altered Fc-Effector Function
WO2014004586A1 (en) 2012-06-25 2014-01-03 Zymeworks Inc. Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells
UY34887A (en) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Optimization of antibodies that bind to the gene of T cell activation 3 (LAG-3) and their uses
MX358281B (en) 2012-07-04 2018-08-13 Hoffmann La Roche Covalently linked antigen-antibody conjugates.
EP2870180A1 (en) 2012-07-04 2015-05-13 F. Hoffmann-La Roche AG Anti-biotin antibodies and methods of use
DK2869837T3 (en) 2012-07-04 2016-09-26 F Hoffmann-La Roche Ag Anti-theophylline antibodies and methods of use
CA2877009A1 (en) 2012-07-05 2014-01-09 Devin TESAR Expression and secretion system
WO2014008480A2 (en) 2012-07-06 2014-01-09 Biogen Idec Ma Inc. Cell line expressing single chain factor viii polypeptides and uses thereof
BR112015000437A2 (en) 2012-07-09 2017-06-27 Genentech Inc immunoconjugates, pharmaceutical formulation, methods of treating and inhibiting cell proliferation
CN104428007B (en) 2012-07-09 2018-03-16 基因泰克公司 Immunoconjugates comprising anti-CD22 antibody
KR20150027829A (en) 2012-07-09 2015-03-12 제넨테크, 인크. Immunoconjucates comprising anti-CD22 antibodies
US20140030282A1 (en) 2012-07-09 2014-01-30 Genentech, Inc. Anti-cd79b antibodies and immunoconjugates
SG10201701037WA (en) 2012-07-11 2017-03-30 Amunix Operating Inc Factor viii complex with xten and von willebrand factor protein, and uses thereof
ES2690312T3 (en) 2012-07-13 2018-11-20 Roche Glycart Ag Bispecific anti-VEGF / anti-ANG-2 antibodies and their use in the treatment of ocular vascular diseases
NZ701974A (en) 2012-07-18 2018-03-23 Glycotope Gmbh Novel therapeutic treatments with anti-her2 antibodies having a low fucosylation
MX360620B (en) 2012-07-25 2018-11-09 Celldex Therapeutics Inc Anti-kit antibodies and uses thereof.
WO2014029752A1 (en) 2012-08-22 2014-02-27 Glaxo Group Limited Anti lrp6 antibodies
JPWO2014030750A1 (en) 2012-08-24 2016-08-08 中外製薬株式会社 Mouse FcγRII specific Fc antibody
WO2014030728A1 (en) 2012-08-24 2014-02-27 中外製薬株式会社 Fcγriib-specific fc region variant
WO2014033074A1 (en) 2012-08-29 2014-03-06 F. Hoffmann-La Roche Ag Blood brain barrier shuttle
US9376489B2 (en) 2012-09-07 2016-06-28 Novartis Ag IL-18 binding molecules
WO2014059028A1 (en) 2012-10-09 2014-04-17 Igenica, Inc. Anti-c16orf54 antibodies and methods of use thereof
KR20190107184A (en) 2012-11-01 2019-09-18 애브비 인코포레이티드 Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof
MA38165A1 (en) 2012-11-08 2018-07-31 Hoffmann La Roche binding proteins HER3 antigen-binding hairpin beta HER3
SG11201503245PA (en) 2012-11-09 2015-05-28 Pfizer Platelet-derived growth factor b specific antibodies and compositions and uses thereof
UA116999C2 (en) 2012-11-13 2018-06-11 Дженентек, Інк. Anti-hemagglutinin antibodies and methods of use
EP2733153A1 (en) 2012-11-15 2014-05-21 INSERM (Institut National de la Santé et de la Recherche Medicale) Methods for the preparation of immunoconjugates and uses thereof
US9914785B2 (en) 2012-11-28 2018-03-13 Zymeworks Inc. Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
EP2925779A1 (en) 2012-11-30 2015-10-07 Institut Pasteur Use of anti-fcyri and/or anti-fcyriia antibodies for treating arthritis, inflammation, thrombocytopenia and allergic shock
WO2014084859A1 (en) 2012-11-30 2014-06-05 Novartis Ag Molecules and methods for modulating tmem16a activities
EA201591010A1 (en) 2012-12-05 2015-10-30 Новартис Аг Compositions and methods for taring antibodies on epo
CN105452295A (en) 2012-12-10 2016-03-30 比奥根Ma公司 Anti-blood dendritic cell antigen 2 antibodies and uses thereof
EP2934576A1 (en) 2012-12-19 2015-10-28 The Johns Hopkins University Anti-human b7-h4 antibodies and their uses
TW201436805A (en) 2012-12-21 2014-10-01 Chugai Pharmaceutical Co Ltd Gpc3-targeted therapeutic agent for administration to patients for whom gpc3-targeted therapeutic agent therapy is effective
CA2896091C (en) 2012-12-21 2018-06-19 Amplimmune, Inc. Anti-h7cr antibodies
CN105102618B (en) 2012-12-27 2018-04-17 中外制药株式会社 heterodimerization polypeptide
CA2896723A1 (en) 2012-12-28 2014-07-03 Precision Biologics, Inc. Humanized monoclonal antibodies and methods of use for the diagnosis and treatment of colon and pancreas cancer
CN105102067A (en) 2013-01-02 2015-11-25 格兰马克药品股份有限公司 Antibodies that bind to tl1a and their uses
WO2014107739A1 (en) 2013-01-07 2014-07-10 Eleven Biotherapeutics, Inc. Antibodies against pcsk9
AU2013372331A1 (en) 2013-01-10 2015-07-23 Genmab B.V. Human IgG1 Fc region variants and uses thereof
WO2014116749A1 (en) 2013-01-23 2014-07-31 Genentech, Inc. Anti-hcv antibodies and methods of using thereof
BR112015017619A2 (en) 2013-01-24 2017-11-21 Glaxosmithkline Ip Dev Ltd liquid formulation, use of a formulation, and kit
TW201835108A (en) 2013-02-01 2018-10-01 美商再生元醫藥公司 Antibodies comprising chimeric constant domains
EP2762496A1 (en) 2013-02-05 2014-08-06 EngMab AG Method for the selection of antibodies against BCMA
CN104968683A (en) 2013-02-05 2015-10-07 英格玛布股份公司 Method for the selection of antibodies against bcma
AU2014214751B2 (en) 2013-02-08 2017-06-01 Novartis Ag Specific sites for modifying antibodies to make immunoconjugates
AU2014213599C1 (en) 2013-02-08 2017-09-07 Novartis Ag Anti-IL-17A antibodies and their use in treating autoimmune and inflammatory disorders
WO2014124258A2 (en) 2013-02-08 2014-08-14 Irm Llc Specific sites for modifying antibodies to make immunoconjugates
EP3161001A2 (en) 2014-06-25 2017-05-03 Novartis AG Antibodies specific for il-17a fused to hyaluronan binding peptide tags
WO2014126884A1 (en) 2013-02-12 2014-08-21 Bristol-Myers Squibb Company High ph protein refolding methods
EP2956468A1 (en) 2013-02-12 2015-12-23 Bristol-Myers Squibb Company Tangential flow filtration based protein refolding methods
DK2956482T3 (en) 2013-02-14 2017-10-16 Innate Pharma TREATMENT OF PERFECT T cell lymphoma
EP2956477A4 (en) 2013-02-15 2016-12-28 Biogen Ma Inc Optimized factor viii gene
CA2899241A1 (en) 2013-02-20 2014-08-28 Innate Pharma A compound that specifically binds to kir3dl2 for use in the treatment of peripheral t cell lymphoma
ES2731681T3 (en) 2013-02-22 2019-11-18 Abbvie Stemcentrx Llc Anti-DLL3 and PBD antibody conjugates and uses thereof
WO2014128235A1 (en) 2013-02-22 2014-08-28 F. Hoffmann-La Roche Ag Methods of treating cancer and preventing drug resistance
MX2015010776A (en) 2013-02-25 2015-11-26 Genentech Inc Methods and compositions for detecting and treating drug resistant akt mutant.
WO2014131715A1 (en) 2013-02-26 2014-09-04 Roche Glycart Ag Anti-mcsp antibodies
US9487587B2 (en) 2013-03-05 2016-11-08 Macrogenics, Inc. Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
BR112015021423A2 (en) 2013-03-06 2017-07-18 Genentech Inc cancer treatment methods, egfr antagonist-resistant cancer cells, cancer cells, methods of increasing the sensitivity and effectiveness of cancer treatment, and methods of delaying, treating cancer patients and extending
US9701753B2 (en) 2013-03-11 2017-07-11 Genzyme Corporation Hyperglycosylated binding polypeptides
US9498532B2 (en) 2013-03-13 2016-11-22 Novartis Ag Antibody drug conjugates
US9562099B2 (en) 2013-03-14 2017-02-07 Genentech, Inc. Anti-B7-H4 antibodies and immunoconjugates
JP2016516046A (en) 2013-03-14 2016-06-02 ジェネンテック, インコーポレイテッド Methods for treating cancer and methods for preventing cancer drug resistance
WO2014159239A2 (en) 2013-03-14 2014-10-02 Novartis Ag Antibodies against notch 3
AU2014244286B2 (en) 2013-03-14 2018-11-08 Duke University Bispecific molecules that are immunoreactive with immune effector cells that express an activating receptor
JP6436965B2 (en) 2013-03-14 2018-12-12 ジェネンテック, インコーポレイテッド Anti-B7-H4 antibody and immunoconjugate
RU2015138576A (en) 2013-03-14 2017-04-19 Дженентек, Инк. Combinations of the combination of the mek inhibitor with the connection of the her3 / egfr inhibitor and methods of application
WO2014151680A1 (en) 2013-03-15 2014-09-25 Biogen Idec Ma Inc. Treatment and prevention of acute kidney injury using anti-alpha v beta 5 antibodies
WO2014150877A2 (en) 2013-03-15 2014-09-25 Ac Immune S.A. Anti-tau antibodies and methods of use
CA2907181A1 (en) 2013-03-15 2014-09-18 Viktor Roschke Multivalent and monovalent multispecific complexes and their uses
DK2968495T3 (en) 2013-03-15 2019-10-14 Daniel J Capon Hybrid immunoglobulin containing a non-peptid-bro
BR112015021521A2 (en) 2013-03-15 2017-10-10 Genentech Inc anti-crth2 antibodies and methods for their use
HUE039291T2 (en) 2013-03-15 2018-12-28 Hoffmann La Roche Il-22 polypeptides and il-22 fc fusion proteins and methods of use
TWI658051B (en) 2013-03-15 2019-05-01 葛蘭素史密斯克藍智慧財產發展有限公司 Antigen binding proteins
WO2014144466A1 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anti-alpha v beta 6 antibodies and uses thereof
JP2016514676A (en) 2013-03-15 2016-05-23 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung Tetravalent bispecific antibody
FR3003171B1 (en) * 2013-03-15 2015-04-10 Lab Francais Du Fractionnement Novel medicaments comprising an enhanced antibody composition in majority load enforcement
US10035860B2 (en) 2013-03-15 2018-07-31 Biogen Ma Inc. Anti-alpha V beta 6 antibodies and uses thereof
WO2014151006A2 (en) 2013-03-15 2014-09-25 Genentech, Inc. Biomarkers and methods of treating pd-1 and pd-l1 related conditions
RU2015143437A (en) 2013-03-15 2017-04-27 Дженентек, Инк. Methods for treating cancer and preventing resistance to medicines for treating cancer
CA2903772A1 (en) 2013-03-15 2014-09-25 Novartis Ag Antibody drug conjugates
US9587235B2 (en) 2013-03-15 2017-03-07 Atyr Pharma, Inc. Histidyl-tRNA synthetase-Fc conjugates
MX2015011075A (en) 2013-03-15 2015-10-29 Dana Farber Cancer Inst Inc Therapeutic peptides.
MA38495A1 (en) 2013-03-15 2017-08-31 Genentech Inc Compositions and methods for the diagnosis and treatment of liver cancers
EP2970459A2 (en) 2013-03-15 2016-01-20 AbbVie Inc. Dual specific binding proteins directed against il-1beta and il-17
CA2904095A1 (en) 2013-03-27 2014-10-02 Genentech, Inc. Use of biomarkers for assessing treatment of gastrointestinal inflammatory disorders with beta7 integrin antagonists
AU2014257650A1 (en) 2013-04-22 2015-11-12 Glycotope Gmbh Anti-cancer treatments with anti-EGFR antibodies having a low fucosylation
AU2013388126B2 (en) 2013-04-29 2019-03-07 Teva Pharmaceuticals Australia Pty Ltd. Anti-CD38 antibodies and fusions to attenuated interferon alpha-2b
US9963515B2 (en) 2013-04-29 2018-05-08 Teva Pharmaceuticals Australia Pty Ltd. Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B
AU2014261630B2 (en) 2013-04-29 2019-05-09 F. Hoffmann-La Roche Ag Human FcRn-binding modified antibodies and methods of use
CA2922704A1 (en) 2013-05-24 2014-11-27 Neil R. Cashman Cell senescence markers as diagnostic and therapeutic targets
SG10201709715RA (en) 2013-05-24 2017-12-28 Medimmune Llc Anti-b7-h5 antibodies and their uses
US9562101B2 (en) 2013-06-21 2017-02-07 Novartis Ag Lectin-like oxidized LDL receptor 1 antibodies and methods of use
AR096601A1 (en) 2013-06-21 2016-01-20 Novartis Ag Antibodies receptor 1 ldl similar oxidized lectin and methods of use
AU2014299916A1 (en) 2013-06-24 2015-12-24 Chugai Seiyaku Kabushiki Kaisha Therapeutic agent comprising humanized anti-Epiregulin antibody as active ingredient for non-small-cell lung carcinoma excluding adenocarcinoma
US20160168231A1 (en) 2013-07-18 2016-06-16 Fabrus, Inc. Antibodies with ultralong complementarity determining regions
WO2015010100A2 (en) 2013-07-18 2015-01-22 Fabrus, Inc. Humanized antibodies with ultralong complementarity determining regions
AU2014306105B2 (en) 2013-08-09 2019-05-23 Macrogenics, Inc. Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79B and uses thereof
BR112016002845A2 (en) 2013-08-12 2017-09-12 Genentech Inc compositions and methods for treating complement-associated conditions
EA033403B1 (en) 2013-08-13 2019-10-31 Sanofi Sa Antibodies to plasminogen activator inhibitor-1 (pai-1) and uses thereof
US20160199454A1 (en) 2013-08-14 2016-07-14 Biogen Ma Inc. Factor viii-xten fusions and uses thereof
BR112016002198A2 (en) 2013-08-14 2017-09-12 Novartis Ag Methods of treating sporadic inclusion body myositis
EP2840091A1 (en) 2013-08-23 2015-02-25 MacroGenics, Inc. Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof
EP2839842A1 (en) 2013-08-23 2015-02-25 MacroGenics, Inc. Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof
US20150093399A1 (en) 2013-08-28 2015-04-02 Bioasis Technologies, Inc. Cns-targeted conjugates having modified fc regions and methods of use thereof
BR112016004245A2 (en) 2013-08-28 2017-10-17 Stemcentrx Inc sez6 modulators and methods of use
CA2924172A1 (en) 2013-09-13 2015-03-19 Beigene, Ltd. Anti-pd1 antibodies and their use as therapeutics and diagnostics
RU2016109247A (en) 2013-09-17 2017-10-19 Дженентек, Инк. Ways of application of antibodies to lgr5
MX2016003616A (en) 2013-09-27 2016-07-21 Chugai Pharmaceutical Co Ltd Method for producing polypeptide heteromultimer.
WO2015050959A1 (en) 2013-10-01 2015-04-09 Yale University Anti-kit antibodies and methods of use thereof
MX2016004573A (en) 2013-10-11 2016-07-21 Genentech Inc Nsp4 inhibitors and methods of use.
CA2922912A1 (en) 2013-10-11 2015-04-16 F. Hoffmann-La Roche Ag Multispecific domain exchanged common variable light chain antibodies
US20150147333A1 (en) 2013-10-18 2015-05-28 Genentech, Inc. Anti-rspo antibodies and methods of use
MX2016005159A (en) 2013-10-23 2016-07-05 Genentech Inc Methods of diagnosing and treating eosinophilic disorders.
EP3063275B1 (en) 2013-10-31 2019-09-25 Resolve Therapeutics, LLC Therapeutic nuclease-albumin fusions and methods
AU2014346792A1 (en) 2013-11-06 2016-06-02 Abbvie Stemcentrx Llc Novel anti-claudin antibodies and methods of use
MX2016005854A (en) 2013-11-07 2017-07-28 Inserm (Institut Nat De La Santé Et De La Rech Médicale) Neuregulin allosteric anti-her3 antibody.
CN105940107A (en) 2013-11-11 2016-09-14 中外制药株式会社 Antigen-binding molecule containing modified antibody variable region
US9683998B2 (en) 2013-11-13 2017-06-20 Pfizer Inc. Tumor necrosis factor-like ligand 1A specific antibodies and compositions and uses thereof
AU2014351996A1 (en) 2013-11-21 2016-03-24 F. Hoffmann-La Roche Ag Anti-alpha-synuclein antibodies and methods of use
CN105980557A (en) 2013-12-04 2016-09-28 中外制药株式会社 Antigen-binding molecules, the antigen-binding activity of which varies according to the concentration of compounds, and libraries of said molecules
CA2932767A1 (en) 2013-12-06 2015-06-11 Dana-Farber Cancer Institute, Inc. Therapeutic peptides
US9546215B2 (en) 2013-12-09 2017-01-17 Allakos Inc. Anti-Siglec-8 antibodies and methods of use thereof
EP3080611B1 (en) 2013-12-13 2018-11-14 The General Hospital Corporation Soluble high molecular weight (hmw) tau species and applications thereof
EA201691214A1 (en) 2013-12-13 2016-12-30 Дженентек, Инк. Antibodies to cd33 and immunoconjugates
SG11201604875PA (en) 2013-12-17 2016-07-28 Genentech Inc Methods of treating cancer using pd-1 axis binding antagonists and an anti-cd20 antibody
CA2931812A1 (en) 2013-12-17 2015-06-25 Genentech, Inc. Methods of treating cancers using pd-1 axis binding antagonists and taxanes
CA2934028A1 (en) 2013-12-17 2015-06-25 Genentech, Inc. Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
US10174124B2 (en) 2013-12-17 2019-01-08 Genentech, Inc. Anti-CD3 antibodies and methods of use
PE20161032A1 (en) 2013-12-20 2016-10-19 F Hoffmann-La Roche Ag Anti-tau (ps422) Humanized and methods of use
CN106103476A (en) 2013-12-24 2016-11-09 阿尔金-X有限公司 FcRn antagonist and using method
EP3089758A1 (en) 2014-01-03 2016-11-09 F.Hoffmann-La Roche Ag Covalently linked helicar-anti-helicar antibody conjugates and uses thereof
CA2933384A1 (en) 2014-01-03 2015-07-09 F. Hoffmann-La Roche Ag Bispecific anti-hapten/anti-blood brain barrier receptor antibodies, complexes thereof and their use as blood brain barrier shuttles
CN105873616A (en) 2014-01-03 2016-08-17 豪夫迈·罗氏有限公司 Covalently linked polypeptide toxin-antibody conjugates
BR112016015589A2 (en) 2014-01-06 2017-10-31 Hoffmann La Roche monovalent transit modules for the blood-brain barrier
WO2015107026A1 (en) 2014-01-15 2015-07-23 F. Hoffmann-La Roche Ag Fc-region variants with modified fcrn- and maintained protein a-binding properties
WO2015109212A1 (en) 2014-01-17 2015-07-23 Pfizer Inc. Anti-il-2 antibodies and compositions and uses thereof
MX2016009515A (en) 2014-01-24 2016-10-26 Genentech Inc Methods of using anti-steap1 antibodies and immunoconjugates.
JP2017506072A (en) 2014-02-04 2017-03-02 ジェネンテック, インコーポレイテッド Smoothing variants and methods of use thereof
JP2017511793A (en) 2014-02-08 2017-04-27 ジェネンテック, インコーポレイテッド Alzheimer's disease treatment method
MX2016010237A (en) 2014-02-08 2017-04-27 Genentech Inc Methods of treating alzheimer's disease.
LT3105253T (en) 2014-02-12 2018-09-10 F. Hoffmann-La Roche Ag Anti-jagged1 antibodies and methods of use
SG11201606714TA (en) 2014-02-14 2016-09-29 Andrew S Chi Improved methods for the treatment of vascularizing cancers
CA2937556A1 (en) 2014-02-21 2015-08-27 Genentech, Inc. Anti-il-13/il-17 bispecific antibodies and uses thereof
US9732154B2 (en) * 2014-02-28 2017-08-15 Janssen Biotech, Inc. Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
CA2939931A1 (en) 2014-02-28 2015-09-03 Allakos Inc. Methods and compositions for treating siglec-8 associated diseases
NZ711451A (en) 2014-03-07 2016-05-27 Alexion Pharma Inc Anti-c5 antibodies having improved pharmacokinetics
EA201691827A1 (en) 2014-03-12 2017-01-30 Новартис Аг Specific plots for modification of antibodies with the purpose of obtaining immunoconjugates
SG11201607519VA (en) 2014-03-14 2016-10-28 Genentech Inc Methods and compositions for secretion of heterologous polypeptides
AU2015229009B2 (en) 2014-03-14 2019-08-22 Dana-Farber Cancer Institute, Inc. Vaccine compositions and methods for restoring NKG2D pathway function against cancers
JP2017511152A (en) 2014-03-21 2017-04-20 エックス−ボディ インコーポレイテッド Bispecific antigen binding polypeptide
WO2015140591A1 (en) 2014-03-21 2015-09-24 Nordlandssykehuset Hf Anti-cd14 antibodies and uses thereof
CN107002119A (en) 2014-03-24 2017-08-01 豪夫迈·罗氏有限公司 Treatment of cancer and the former and associating that HGF is expressed using C MET antagonists
CA2943834A1 (en) 2014-03-31 2015-10-08 Genentech, Inc. Combination therapy comprising anti-angiogenesis agents and ox40 binding agonists
WO2015153513A1 (en) 2014-03-31 2015-10-08 Genentech, Inc. Anti-ox40 antibodies and methods of use
JP2017512479A (en) 2014-04-04 2017-05-25 バイオノミクス インコーポレイテッド Humanized antibody that binds to LGR5
US10160812B2 (en) 2014-04-11 2018-12-25 Medimmune, Llc Bispecific HER2 antibodies
EP3134439B1 (en) 2014-04-21 2018-12-26 Millennium Pharmaceuticals, Inc. Anti-psyk antibody molecules and use of same for syk-targeted therapy
TW201622746A (en) 2014-04-24 2016-07-01 Novartis Ag Improve or accelerate hip fracture surgery method of Rehab
WO2015164615A1 (en) 2014-04-24 2015-10-29 University Of Oslo Anti-gluten antibodies and uses thereof
AU2015253042A1 (en) 2014-05-01 2016-10-20 Genentech, Inc. Anti-factor D antibody variants and uses thereof
CN106536562A (en) 2014-05-01 2017-03-22 泰华制药澳大利亚公司 Combination of lenalidomide or pomalidomide and CD38 antibody-attenuated interferon-alpha constructs, and the use thereof
JPWO2015174439A1 (en) * 2014-05-13 2017-04-20 中外製薬株式会社 T cell redirect antigen binding molecule for cells having immunosuppressive function
BR112016027222A2 (en) 2014-05-22 2018-01-30 Genentech Inc isolated antibodies, isolated nucleic acid, host cell, method of producing an antibody, immunoconjugate, pharmaceutical formulation, methods of treating an individual with cancer, inhibiting cell proliferation, detecting human gpc3 and detecting a cancer
CN106661622A (en) 2014-05-23 2017-05-10 豪夫迈·罗氏有限公司 MIT biomarkers and methods using the same
CA2949998A1 (en) 2014-05-28 2015-12-03 Agenus Inc. Anti-gitr antibodies and methods of use thereof
CA2950572A1 (en) 2014-05-29 2015-12-03 Macrogenics, Inc. Tri-specific binding molecules that specifically bind to multiple cancer antigens and methods of use thereof
CN106459203A (en) 2014-06-06 2017-02-22 百时美施贵宝公司 Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof
JP2017526618A (en) 2014-06-11 2017-09-14 ジェネンテック, インコーポレイテッド Anti-LgR5 antibody and use thereof
WO2015191986A1 (en) 2014-06-13 2015-12-17 Genentech, Inc. Methods of treating and preventing cancer drug resistance
AR100978A1 (en) 2014-06-26 2016-11-16 F Hoffmann-La Roche Ag SHUTTLE BRAIN OF ANTI-Tau Humanized Antibody (pS422) AND USES THEREOF
EP3313876A2 (en) 2015-06-23 2018-05-02 Innate Pharma Multispecific antigen binding proteins
EP3313881A1 (en) 2015-06-23 2018-05-02 Innate Pharma Multispecific nk engager proteins
EP3166974A1 (en) 2014-07-11 2017-05-17 Genentech, Inc. Anti-pd-l1 antibodies and diagnostic uses thereof
BR112017000130A2 (en) 2014-07-11 2018-01-09 Genentech Inc method for mitigating toxicity associated with notch pathway inhibition and cancer treatment method
US8986691B1 (en) 2014-07-15 2015-03-24 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
US8980273B1 (en) 2014-07-15 2015-03-17 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
WO2016014688A2 (en) 2014-07-22 2016-01-28 Junzhuan Qiu Anti-pd-1 antibodies
WO2016020791A1 (en) 2014-08-05 2016-02-11 Novartis Ag Ckit antibody drug conjugates
AU2015301126A1 (en) 2014-08-05 2017-02-23 Cb Therapeutics, Inc. Anti-PD-L1 antibodies
WO2016020882A2 (en) 2014-08-07 2016-02-11 Novartis Ag Angiopoetin-like 4 (angptl4) antibodies and methods of use
CR20170040A (en) 2014-08-07 2017-04-28 Novartis Ag anti angiopoietin like protein 4 antibodies and methods of use
US9982045B2 (en) 2014-08-12 2018-05-29 Novartis Ag Anti-CDH6 antibody drug conjugates
EP3182999A1 (en) 2014-08-19 2017-06-28 Merck Sharp & Dohme Corp. Anti-lag3 antibodies and antigen-binding fragments
EA201790413A1 (en) 2014-08-19 2017-08-31 Мерк Шарп И Доум Корп. Antibodies against tigit
WO2016030488A1 (en) 2014-08-27 2016-03-03 Innate Pharma Treatment of celiac disease
TW201617368A (en) 2014-09-05 2016-05-16 Stemcentrx Inc Novel antibodies and methods of use of anti-mfi2
FR3025515B1 (en) 2014-09-05 2016-09-09 Lab Francais Du Fractionnement Process for purifying monoclonal antibody
JP2017534256A (en) 2014-09-12 2017-11-24 ジェネンテック, インコーポレイテッド ANTI-CLL-1 antibody and immune complex
US10059768B2 (en) 2014-09-12 2018-08-28 Genentech, Inc. Anti-B7-H4 antibodies and immunoconjugates
AU2015314826A1 (en) 2014-09-12 2017-03-02 Genentech, Inc. Cysteine engineered antibodies and conjugates
BR112017004953A2 (en) 2014-09-17 2017-12-05 Genentech Inc immunoconjugate, pharmaceutical formulation, method of treatment and method of inhibiting cell proliferation
US20180022780A1 (en) 2014-09-26 2018-01-25 Bayer Pharma Aktiengesellschaft Stabilization adrenomedullin derivatives and use thereof
WO2016056812A1 (en) * 2014-10-06 2016-04-14 Genexine, Inc. Human igg4 fc polypeptide variant
US20170306038A1 (en) 2014-10-08 2017-10-26 Jennifer Brogdon Compositions and methods of use for augmented immune response and cancer therapy
AU2015330869A1 (en) 2014-10-09 2017-05-25 Genzyme Corporation Glycoengineered antibody drug conjugates
WO2016061286A2 (en) 2014-10-14 2016-04-21 Halozyme, Inc. Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same
US9732148B2 (en) 2014-10-16 2017-08-15 Genentech, Inc. Anti-α-synuclein antibodies and methods of use
JP2017537069A (en) 2014-10-23 2017-12-14 イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. Treatment of cancer with anti-NKG2A agent
EP3215850B1 (en) 2014-11-03 2019-07-03 F. Hoffmann-La Roche AG Assays for detecting t cell immune subsets and methods of use thereof
CN107108740A (en) 2014-11-05 2017-08-29 豪夫迈·罗氏有限公司 Anti- FGFR2/3 antibody and its application method
JP2018500008A (en) 2014-11-05 2018-01-11 ジェネンテック, インコーポレイテッド Method for producing double-chain protein in bacteria
BR112017009262A2 (en) 2014-11-05 2018-03-06 Genentech Inc Two-chain protein production methods in bacteria
WO2016073157A1 (en) 2014-11-06 2016-05-12 Genentech, Inc. Anti-ang2 antibodies and methods of use thereof
RU2017119428A3 (en) 2014-11-06 2019-10-25
BR112017009398A2 (en) 2014-11-10 2018-05-15 Medimmune Ltd cd73-specific binding molecules and their uses
AU2015346460A1 (en) 2014-11-10 2017-03-23 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
CN107105632A (en) 2014-11-10 2017-08-29 豪夫迈·罗氏有限公司 Nephrosis animal model and its therapeutic agent
PE20170912A1 (en) 2014-11-14 2017-07-12 Novartis Ag Conjugates of the antibody-drug
SG11201703605QA (en) 2014-11-17 2017-06-29 Genentech Inc Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
WO2016081640A1 (en) 2014-11-19 2016-05-26 Genentech, Inc. Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use
JP2018503357A (en) 2014-11-19 2018-02-08 ジェネンテック, インコーポレイテッド Anti-transferrin receptor antibody and method of use thereof
CN107108745A (en) 2014-11-19 2017-08-29 基因泰克公司 Anti- BACE1 antibody is used for the purposes of neural disease immunotherapy with it
RU2017120688A3 (en) 2014-11-19 2019-07-17
BR112017010110A2 (en) 2014-11-21 2018-01-30 Squibb Bristol Myers Co antibodies to cd73 and uses thereof
US9605080B2 (en) 2014-11-21 2017-03-28 Bristol-Myers Squibb Company Antibodies against CD73
US9382321B2 (en) * 2014-11-26 2016-07-05 Adventis Health System/Sunbelt, Inc. Effector-deficient anti-CD32A antibodies
AR102918A1 (en) 2014-12-05 2017-04-05 Genentech Inc Anti-CD79b antibodies and methods of use
JP2018505911A (en) 2014-12-05 2018-03-01 イミュネクスト,インコーポレーテッド Identification of VSIG8 as a putative VISTA receptor and its use to produce a VISTA / VSIG8 modulator
EP3229836B1 (en) 2014-12-09 2019-11-13 Institut National de la Sante et de la Recherche Medicale (INSERM) Human monoclonal antibodies against axl
EP3230317A2 (en) 2014-12-10 2017-10-18 Hoffmann-La Roche AG Blood brain barrier receptor antibodies and methods of use
WO2016094881A2 (en) 2014-12-11 2016-06-16 Abbvie Inc. Lrp-8 binding proteins
UY36449A (en) 2014-12-19 2016-07-29 Novartis Ag Compositions and methods for antibodies directed to BMP6
EP3233912A1 (en) 2014-12-19 2017-10-25 Regenesance B.V. Antibodies that bind human c6 and uses thereof
PE20171111A1 (en) 2014-12-19 2017-08-07 Chugai Pharmaceutical Co Ltd Myostatin antibodies, polypeptides comprising variant Fc regions, and methods of use
WO2016117346A1 (en) 2015-01-22 2016-07-28 Chugai Seiyaku Kabushiki Kaisha A combination of two or more anti-c5 antibodies and methods of use
WO2016123329A2 (en) 2015-01-28 2016-08-04 Genentech, Inc. Gene expression markers and treatment of multiple sclerosis
CA2975875A1 (en) 2015-02-04 2016-08-11 Genentech, Inc. Mutant smoothened and methods of using the same
CA2974547A1 (en) 2015-02-05 2016-08-11 Chugai Seiyaku Kabushiki Kaisha Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof
WO2016130516A1 (en) 2015-02-09 2016-08-18 Research Development Foundation Engineered immunoglobulin fc polypeptides displaying improved complement activation
US20170088607A1 (en) 2015-02-19 2017-03-30 Compugen Ltd. Pvrig polypeptides and methods of treatment
KR20170137067A (en) 2015-02-19 2017-12-12 컴퓨젠 엘티디. Anti-PVRIG antibody and methods of use
WO2016135041A1 (en) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Fusion proteins and antibodies comprising thereof for promoting apoptosis
WO2016138207A1 (en) 2015-02-26 2016-09-01 Genentech, Inc. Integrin beta7 antagonists and methods of treating crohn's disease
KR20170131463A (en) 2015-03-09 2017-11-29 아르제넥스 비브이비에이 Methods of Reducing Serum Levels of Fc-Containing Agents Using FcRn Antagonists
AR103935A1 (en) 2015-03-16 2017-06-14 Genentech Inc You methods of detection and quantification of IL-13 and their uses in the diagnosis and treatment of diseases associated with th-2
WO2016146833A1 (en) 2015-03-19 2016-09-22 F. Hoffmann-La Roche Ag Biomarkers for nad(+)-diphthamide adp ribosyltransferase resistance
FR3034420A1 (en) 2015-03-31 2016-10-07 Lab Francais Du Fractionnement Anti-cd303 monoclonal antibodies
AR104368A1 (en) 2015-04-03 2017-07-19 Lilly Co Eli Bispecific anti-CD20 / anti-BAFF
MX2017012352A (en) 2015-04-03 2018-01-26 Eureka Therapeutics Inc Constructs targeting afp peptide/mhc complexes and uses thereof.
EP3283508A2 (en) 2015-04-17 2018-02-21 Alpine Immune Sciences, Inc. Immunomodulatory proteins with tunable affinities
WO2016172551A2 (en) 2015-04-24 2016-10-27 Genentech, Inc. Methods of identifying bacteria comprising binding polypeptides
WO2016179003A1 (en) 2015-05-01 2016-11-10 Genentech, Inc. Masked anti-cd3 antibodies and methods of use
JP2018520993A (en) 2015-05-07 2018-08-02 アジェナス インコーポレイテッド Anti-OX40 antibody and method of use thereof
WO2016188911A1 (en) 2015-05-22 2016-12-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Human monoclonal antibodies fragments inhibiting both the cath-d catalytic activity and its binding to the lrp1 receptor
AU2016271111A1 (en) 2015-05-29 2017-12-07 Bristol-Myers Squibb Company Antibodies against OX40 and uses thereof
WO2016196343A1 (en) 2015-05-29 2016-12-08 Genentech, Inc. Humanized anti-ebola virus glycoprotein antibodies and methods of use
MX2017014735A (en) 2015-05-29 2018-03-23 Genentech Inc Pd-l1 promoter methylation in cancer.
CA2984003A1 (en) 2015-05-29 2016-12-08 Genentech, Inc. Therapeutic and diagnostic methods for cancer
JP2018527882A (en) 2015-05-30 2018-09-27 モレキュラー テンプレーツ,インク.Molecular Templates, Inc. Deimmunized Shiga toxin A subunit scaffold and cell targeting molecule comprising the same
WO2016196679A1 (en) 2015-06-02 2016-12-08 Genentech, Inc. Compositions and methods for using anti-il-34 antibodies to treat neurological diseases
BR112017021484A2 (en) 2015-06-05 2018-07-03 Novartis Ag antibodies targeting bone morphogenetic protein 9 (bmp9) and methods for them
AR104875A1 (en) 2015-06-05 2017-08-23 Genentech Inc Anti-tau antibodies and methods of use
US20160355597A1 (en) 2015-06-08 2016-12-08 Genentech, Inc. Methods of treating cancer using anti-ox40 antibodies
EP3303397A1 (en) 2015-06-08 2018-04-11 H. Hoffnabb-La Roche Ag Methods of treating cancer using anti-ox40 antibodies and pd-1 axis binding antagonists
TW201709934A (en) 2015-06-15 2017-03-16 建南德克公司 Antibodies and immunoconjugates
TW201710286A (en) 2015-06-15 2017-03-16 艾伯維有限公司 Binding proteins against VEGF, PDGF, and/or their receptors
US20160368994A1 (en) 2015-06-16 2016-12-22 Genentech, Inc. Anti-cll-1 antibodies and methods of use
WO2016204966A1 (en) 2015-06-16 2016-12-22 Genentech, Inc. Anti-cd3 antibodies and methods of use
CA2986928A1 (en) 2015-06-16 2016-12-22 Genentech, Inc. Humanized and affinity matured antibodies to fcrh5 and methods of use
WO2016205531A2 (en) 2015-06-17 2016-12-22 Genentech, Inc. Anti-her2 antibodies and methods of use
EP3310813A1 (en) 2015-06-17 2018-04-25 Novartis AG Antibody drug conjugates
JP2018522851A (en) 2015-06-17 2018-08-16 ジェネンテック, インコーポレイテッド Method for treating locally advanced or metastatic breast cancer using PD-1 axis binding antagonist and taxane
UY36751A (en) 2015-06-26 2017-01-31 Novartis Ag Xi factor antibodies and methods of use
CA2990214A1 (en) 2015-06-29 2017-01-05 Spring Bioscience Corporation Materials and methods for performing histochemical assays for human pro-epiregulin and amphiregulin
US20170029520A1 (en) 2015-06-29 2017-02-02 Genentech, Inc. Compositions and methods for use in organ transplantation
EP3322733A1 (en) 2015-07-13 2018-05-23 Compugen Ltd. Hide1 compositions and methods
EA201890296A1 (en) 2015-07-30 2018-08-31 Макродженикс, Инк. PD-1-binding molecules and methods of their application
EP3331914A1 (en) 2015-08-03 2018-06-13 Novartis AG Methods of treating fgf21-associated disorders
WO2017040342A1 (en) 2015-08-28 2017-03-09 Genentech, Inc. Anti-hypusine antibodies and uses thereof
AU2016317915A1 (en) 2015-09-01 2018-03-01 Agenus Inc. Anti-PD-1 antibodies and methods of use thereof
UY36889A (en) 2015-09-09 2017-04-28 Novartis Ag Binding molecules thymic stromal lymphopoietin (TSLP) and methods of using the molecules
WO2017046746A1 (en) 2015-09-15 2017-03-23 Acerta Pharma B.V. Therapeutic combinations of a btk inhibitor and a gitr binding molecule, a 4-1bb agonist, or an ox40 agonist
US9862760B2 (en) 2015-09-16 2018-01-09 Novartis Ag Polyomavirus neutralizing antibodies
TWI621628B (en) 2015-09-18 2018-04-21 日商中外製藥股份有限公司 Il-8-binding antibodies and uses thereof
TW201722990A (en) 2015-09-18 2017-07-01 希佛隆公司 Antibodies that specifically bind to TL1A
AU2016328357A1 (en) 2015-09-22 2018-03-01 Spring Bioscience Corporation Anti-OX40 antibodies and diagnostic uses thereof
EP3353203A2 (en) 2015-09-23 2018-08-01 H. Hoffnabb-La Roche Ag Optimized variants of anti-vegf antibodies
AU2016326738A1 (en) 2015-09-24 2018-04-12 Abvitro Llc HIV antibody compositions and methods of use
KR20180054824A (en) 2015-09-29 2018-05-24 셀진 코포레이션 PD-1 binding protein and method of use thereof
JP2018535662A (en) 2015-10-02 2018-12-06 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Bispecific antibody to costimulatory TNF receptor
JP2018537951A (en) 2015-10-02 2018-12-27 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Anti-PD1 antibody and method of use
AR106235A1 (en) 2015-10-02 2017-12-27 Genentech Inc Conjugates of antibody-drug and methods of use pirrolobenzodiazepina
EP3150636A1 (en) 2015-10-02 2017-04-05 F. Hoffmann-La Roche AG Tetravalent multispecific antibodies
CA2992853A1 (en) 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Bispecific antibodies specific for pd1 and tim3
CA2997801A1 (en) 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Bispecific anti-human cd20/human transferrin receptor antibodies and methods of use
AR106189A1 (en) 2015-10-02 2017-12-20 F Hoffmann-La Roche Ag Bispecific antibodies against human Ab AND human transferrin receptor and methods of use
CN108431038A (en) 2015-10-06 2018-08-21 豪夫迈·罗氏有限公司 The method for treating multiple sclerosis
EP3359568A1 (en) 2015-10-07 2018-08-15 H. Hoffnabb-La Roche Ag Bispecific antibodies with tetravalency for a costimulatory tnf receptor
JP2018537416A (en) 2015-10-16 2018-12-20 ジェネンテック, インコーポレイテッド Constrained disulfide drug conjugate
WO2017066714A1 (en) 2015-10-16 2017-04-20 Compugen Ltd. Anti-vsig1 antibodies and drug conjugates
WO2017068511A1 (en) 2015-10-20 2017-04-27 Genentech, Inc. Calicheamicin-antibody-drug conjugates and methods of use
WO2017070561A1 (en) 2015-10-23 2017-04-27 Pfizer Inc. Anti-il-2 antibodies and compositions and uses thereof
PE20181347A1 (en) 2015-10-29 2018-08-22 Novartis Ag Antibody conjugates comprising a receptor agonist type toll
MX2018005036A (en) 2015-10-29 2018-08-01 Hoffmann La Roche Anti-variant fc-region antibodies and methods of use.
EP3184547A1 (en) 2015-10-29 2017-06-28 F. Hoffmann-La Roche AG Anti-tpbg antibodies and methods of use
EA201891048A1 (en) 2015-10-29 2018-10-31 Мерк Шарп И Доум Корп. Antibody, neutralizing respiratory-synctial human virus
US10407510B2 (en) 2015-10-30 2019-09-10 Genentech, Inc. Anti-factor D antibodies and conjugates
EP3368579A1 (en) 2015-10-30 2018-09-05 H. Hoffnabb-La Roche Ag Hinge modified antibody fragments and methods of making
CN108602884A (en) 2015-11-08 2018-09-28 豪夫迈·罗氏有限公司 The method for screening multi-specificity antibody
CA3005855A1 (en) 2015-11-19 2017-05-26 Bristol-Myers Squibb Company Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof
WO2017095875A1 (en) 2015-11-30 2017-06-08 Bristol-Myers Squibb Company Anti human ip-10 antibodies and their uses
EP3383911A1 (en) 2015-12-02 2018-10-10 STCube & Co. Inc. Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof
EP3383891A1 (en) 2015-12-04 2018-10-10 Novartis AG Antibody cytokine engrafted compositions and methods of use for immunoregulation
JP2019506844A (en) 2015-12-18 2019-03-14 ノバルティス アーゲー Antibodies targeting CD32b and methods of use thereof
WO2017127764A1 (en) 2016-01-20 2017-07-27 Genentech, Inc. High dose treatments for alzheimer's disease
JP2019506166A (en) 2016-02-01 2019-03-07 バイオベラティブ セラピューティクス インコーポレイテッド Optimized factor VIII gene
JP2019509721A (en) 2016-02-04 2019-04-11 キュリス,インコーポレイテッド Mutant smoothened and method of using the same
MX2018010021A (en) 2016-02-17 2018-11-09 Novartis Ag Tgfbeta 2 antibodies.
AU2017225854A1 (en) 2016-02-29 2018-09-13 Foundation Medicine, Inc. Therapeutic and diagnostic methods for cancer
MX2018010473A (en) 2016-03-04 2018-09-28 Squibb Bristol Myers Co Combination therapy with anti-cd73 antibodies.
JP2019517993A (en) 2016-03-15 2019-06-27 イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. Anti-MICA antibody
EP3430054A1 (en) 2016-03-15 2019-01-23 Chugai Seiyaku Kabushiki Kaisha Methods of treating cancers using pd-1 axis binding antagonists and anti-gpc3 antibodies
WO2017161173A1 (en) 2016-03-16 2017-09-21 Merrimack Pharmaceuticals, Inc. Engineered trail for cancer therapy
WO2017162678A1 (en) 2016-03-22 2017-09-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Humanized anti-claudin-1 antibodies and uses thereof
EP3433621A1 (en) 2016-03-25 2019-01-30 H. Hoffnabb-La Roche Ag Multiplexed total antibody and antibody-conjugated drug quantification assay
KR20180128471A (en) 2016-03-29 2018-12-03 얀센 바이오테크 인코포레이티드 Treatment of psoriasis with increased dosing intervals of anti-IL12 and / or anti-IL23 antibodies
WO2017180864A1 (en) 2016-04-14 2017-10-19 Genentech, Inc. Anti-rspo3 antibodies and methods of use
JP2019521641A (en) 2016-04-15 2019-08-08 ジェネンテック, インコーポレイテッド Methods for monitoring and treating cancer
CA3019199A1 (en) 2016-04-15 2017-10-19 Alpine Immune Sciences, Inc. Icos ligand variant immunomodulatory proteins and uses thereof
EP3443000A2 (en) 2016-04-15 2019-02-20 Alpine Immune Sciences, Inc. Cd80 variant immunomodulatory proteins and uses thereof
CN109154027A (en) 2016-04-15 2019-01-04 豪夫迈·罗氏有限公司 For monitoring and the method for the treatment of cancer
US20190135908A1 (en) 2016-04-27 2019-05-09 Hong Chen Antibodies against growth differentiation factor 15 and uses thereof
CN109071635A (en) 2016-05-02 2018-12-21 豪夫迈·罗氏有限公司 Contorsbody- single-stranded target conjugate
CN109476742A (en) 2016-05-09 2019-03-15 百时美施贵宝公司 TL1A antibody and application thereof
EP3455252A1 (en) 2016-05-11 2019-03-20 H. Hoffnabb-La Roche Ag Modified anti-tenascin antibodies and methods of use
EP3458101A1 (en) 2016-05-20 2019-03-27 H. Hoffnabb-La Roche Ag Protac antibody conjugates and methods of use
TW201802121A (en) 2016-05-25 2018-01-16 諾華公司 Reversal binding agents for anti-factor XI/XIa antibodies and uses thereof
US20170370906A1 (en) 2016-05-27 2017-12-28 Genentech, Inc. Bioanalytical analysis of site-specific antibody drug conjugates
KR20190021224A (en) 2016-05-27 2019-03-05 아게누스 인코포레이티드 Anti-TIM-3 antibodies and methods of use thereof
US20170348422A1 (en) 2016-06-06 2017-12-07 Genentech, Inc. Silvestrol antibody-drug conjugates and methods of use
CA3027651A1 (en) 2016-06-15 2017-12-21 Novartis Ag Methods for treating disease using inhibitors of bone morphogenetic protein 6 (bmp6)
WO2017223405A1 (en) 2016-06-24 2017-12-28 Genentech, Inc. Anti-polyubiquitin multispecific antibodies
WO2018005954A2 (en) 2016-07-01 2018-01-04 Resolve Therapeutics, Llc Optimized binuclease fusions and methods
EP3478717A1 (en) 2016-07-04 2019-05-08 H. Hoffnabb-La Roche Ag Novel antibody format
WO2018013818A2 (en) 2016-07-14 2018-01-18 Bristol-Myers Squibb Company Antibodies against tim3 and uses thereof
US20190330318A1 (en) 2016-07-25 2019-10-31 Biogen Ma Inc. Anti-hspa5 (grp78) antibodies and uses thereof
CA3032120A1 (en) 2016-07-28 2018-02-01 Alpine Immune Sciences, Inc. Cd155 variant immunomodulatory proteins and uses thereof
WO2018022945A1 (en) 2016-07-28 2018-02-01 Alpine Immune Sciences, Inc. Cd112 variant immunomodulatory proteins and uses thereof
NL2017267B1 (en) 2016-07-29 2018-02-01 Aduro Biotech Holdings Europe B V Anti-pd-1 antibodies
CA3027018A1 (en) 2016-07-29 2018-02-01 Chugai Seiyaku Kabushiki Kaisha Bispecific antibody exhibiting increased alternative fviii-cofactor-function activity
CN109661406A (en) 2016-07-29 2019-04-19 国家医疗保健研究所 The antibody and application thereof of target tumor associated macrophages
NL2017270B1 (en) 2016-08-02 2018-02-09 Aduro Biotech Holdings Europe B V New anti-hCTLA-4 antibodies
KR20190035863A (en) 2016-08-05 2019-04-03 알라코스 인크. Anti-Siglec-7 Antibody for Cancer Treatment
JP2019531268A (en) 2016-08-08 2019-10-31 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Cancer treatment and diagnostic methods
EP3496763A1 (en) 2016-08-11 2019-06-19 Genentech, Inc. Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof
CA3032331A1 (en) 2016-08-17 2018-02-22 Compugen Ltd. Anti-tigit antibodies, anti-pvrig antibodies and combinations thereof
WO2018044970A1 (en) 2016-08-31 2018-03-08 University Of Rochester Human monoclonal antibodies to human endogenous retrovirus k envelope (herv-k) and uses thereof
WO2018045379A1 (en) 2016-09-02 2018-03-08 Dana-Farber Cancer Institute, Inc. Composition and methods of treating b cell disorders
WO2018053032A1 (en) 2016-09-13 2018-03-22 Humanigen, Inc. Epha3 antibodies for the treatment of pulmonary fibrosis
WO2018050878A1 (en) 2016-09-19 2018-03-22 F. Hoffmann-La Roche Ag Complement factor based affinity chromatography
TW201815415A (en) 2016-09-23 2018-05-01 美商建南德克公司 Uses of IL-13 antagonists for treating atopic dermatitis
CR20190140A (en) 2016-09-26 2019-05-17 Merck Sharp & Dohme Anti-cd27 antibodies
WO2018065501A1 (en) 2016-10-05 2018-04-12 F. Hoffmann-La Roche Ag Methods for preparing antibody drug conjugates
AU2017339517A1 (en) 2016-10-06 2019-04-18 Foundation Medicine, Inc. Therapeutic and diagnostic methods for cancer
AU2017343621A1 (en) 2016-10-11 2019-04-11 Agenus Inc. Anti-LAG-3 antibodies and methods of use thereof
WO2018073363A1 (en) 2016-10-21 2018-04-26 Innate Pharma Treatment with anti-kir3dl2 agents
EP3532091A2 (en) 2016-10-29 2019-09-04 H. Hoffnabb-La Roche Ag Anti-mic antibidies and methods of use
TW201831690A (en) 2016-10-31 2018-09-01 美商艾歐凡斯生物治療公司 Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion
US20190263920A1 (en) 2016-11-02 2019-08-29 Engmab Sarl Bispecific antibody against bcma and cd3 and an immunological drug for combined use in treating multiple myeloma
WO2018087720A1 (en) 2016-11-14 2018-05-17 Novartis Ag Compositions, methods, and therapeutic uses related to fusogenic protein minion
AU2017361081A1 (en) 2016-11-15 2019-05-23 Genentech, Inc. Dosing for treatment with anti-CD20/anti-CD3 bispecific antibodies
TW201829463A (en) 2016-11-18 2018-08-16 瑞士商赫孚孟拉羅股份公司 Anti-hla-g antibodies and use thereof
BR112019010128A2 (en) 2016-11-19 2019-10-08 Potenza Therapeutics Inc anti-gitr antigen binding proteins and methods of use thereof
AU2017361887B2 (en) 2016-11-21 2019-08-15 Cureab Gmbh Anti-GP73 antibodies and immunoconjugates
WO2018098363A2 (en) 2016-11-23 2018-05-31 Bioverativ Therapeutics Inc. Bispecific antibodies binding to coagulation factor ix and coagulation factor x
WO2018102743A1 (en) 2016-12-02 2018-06-07 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
EP3548063A1 (en) 2016-12-02 2019-10-09 Bioverativ Therapeutics Inc. Methods of inducing immune tolerance to clotting factors
WO2018104893A1 (en) 2016-12-06 2018-06-14 Glaxosmithkline Intellectual Property Development Limited Alpha4-beta7 antibodies with incrased fcrn binding and/or half-life
AU2017373944A1 (en) 2016-12-07 2019-06-20 Agenus Inc. Anti-CTLA-4 antibodies and methods of use thereof
KR20190091274A (en) 2016-12-07 2019-08-05 제넨테크, 인크. Anti-tau antibodies and methods of using the same
TW201827466A (en) 2016-12-07 2018-08-01 美商建南德克公司 Anti-tau antibodies and methods of use
AU2017373945A1 (en) 2016-12-07 2019-06-20 Agenus Inc. Antibodies and methods of use thereof
AU2017375946A1 (en) 2016-12-12 2019-06-20 Genentech, Inc. Methods of treating cancer using anti-PD-l1 antibodies and antiandrogens
WO2018115960A1 (en) 2016-12-19 2018-06-28 Mosaic Biomedicals, S.L. Antibodies against lif and uses thereof
CN110088135A (en) 2016-12-20 2019-08-02 豪夫迈·罗氏有限公司 The combination treatment of anti-CD20/ AntiCD3 McAb bispecific antibody and 4-1BB (CD137) agonist
CN110325550A (en) 2016-12-23 2019-10-11 诺华股份有限公司 Factor XI, plasma thromboplastin antecedent antibody and application method
EP3559032A1 (en) 2016-12-23 2019-10-30 Innate Pharma Heterodimeric antigen binding proteins
TW201829466A (en) 2016-12-23 2018-08-16 美商潛能醫療有限公司 Anti-neuropilin antigen-binding proteins and methods of use thereof
CN110461873A (en) 2017-01-03 2019-11-15 豪夫迈·罗氏有限公司 Bispecific antigen binding molecules comprising anti-4-1BB clone 20H4.9
TW201825515A (en) 2017-01-04 2018-07-16 美商伊繆諾金公司 Met antibodies and immunoconjugates and uses thereof
EP3565586A1 (en) 2017-01-06 2019-11-13 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof
AU2018205234A1 (en) 2017-01-06 2019-07-04 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes (TILs) with tumor necrosis factor receptor superfamily (TNFRSF) agonists and therapeutic combinations of TILs and TNFRSF agonists
TWI658834B (en) 2017-01-31 2019-05-11 日商中外製藥股份有限公司 A pharmaceutical composition for use in the treatment or prevention of a c5-related disease and a method for treating or preventing a c5-related disease
TW201835103A (en) 2017-02-08 2018-10-01 瑞士商諾華公司 Fgf21 mimetic antibodies and uses thereof
CR20190387A (en) 2017-02-10 2019-09-25 Genentech Inc Anti-tryptase antibodies, compositions thereof, and uses thereof
WO2018151821A1 (en) 2017-02-17 2018-08-23 Bristol-Myers Squibb Company Antibodies to alpha-synuclein and uses thereof
CA3054928A1 (en) 2017-02-28 2018-09-07 Bristol-Myers Squibb Company Use of anti-ctla-4 antibodies with enhanced adcc to enhance immune response to a vaccine
TW201837467A (en) 2017-03-01 2018-10-16 美商建南德克公司 Diagnostic and therapeutic methods for cancer
WO2018158398A1 (en) 2017-03-02 2018-09-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity to nectin-4 and uses thereof
CA3053804A1 (en) 2017-03-16 2018-09-20 Alpine Immune Sciences, Inc. Pd-l1 variant immunomodulatory proteins and uses thereof
CA3053812A1 (en) 2017-03-16 2018-09-20 Alpine Immune Sciences, Inc. Pd-l2 variant immunomodulatory proteins and uses thereof
AU2018235838A1 (en) 2017-03-16 2019-09-05 Alpine Immune Sciences, Inc. CD80 variant immunomodulatory proteins and uses thereof
SG11201908650PA (en) 2017-03-22 2019-10-30 Genentech Inc Optimized antibody compositions for treatment of ocular disorders
CA3054837A1 (en) 2017-03-24 2018-09-27 Novartis Ag Methods for preventing and treating heart disease
WO2018183175A1 (en) 2017-03-28 2018-10-04 Genentech, Inc. Methods of treating neurodegenerative diseases
WO2018178055A1 (en) 2017-03-29 2018-10-04 F. Hoffmann-La Roche Ag Bispecific antigen binding molecule for a costimulatory tnf receptor
WO2018178076A1 (en) 2017-03-29 2018-10-04 F. Hoffmann-La Roche Ag Bispecific antigen binding molecule for a costimulatory tnf receptor
AU2018243665A1 (en) 2017-03-30 2019-09-26 Potenza Therapeutics, Inc. Anti-TIGIT antigen-binding proteins and methods of use thereof
WO2018185618A1 (en) 2017-04-03 2018-10-11 Novartis Ag Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment
AU2018247796A1 (en) 2017-04-04 2019-08-29 F. Hoffmann-La Roche Ag Novel bispecific antigen binding molecules capable of specific binding to CD40 and to FAP
CA3053360A1 (en) 2017-04-05 2018-10-11 F. Hoffmann-La Roche Ag Anti-lag3 antibodies
TW201841941A (en) 2017-04-05 2018-12-01 瑞士商赫孚孟拉羅股份公司 Bispecific antibodies specifically binding to pd1 and lag3
TW201839014A (en) 2017-04-07 2018-11-01 美商默沙東藥廠 Anti-ilt4 antibodies and antigen-binding fragments
TW201841942A (en) 2017-04-13 2018-12-01 美商艾吉納斯公司 Anti-CD137 antibodies and methods of use thereof
CA3058282A1 (en) 2017-04-14 2018-10-18 Gamamabs Pharma Amhrii-binding compounds for preventing or treating cancers
WO2018189381A1 (en) 2017-04-14 2018-10-18 Gamamabs Pharma Amhrii-binding compounds for preventing or treating lung cancers
CA3058478A1 (en) 2017-04-14 2018-10-18 Genentech, Inc. Diagnostic and therapeutic methods for cancer
WO2018195472A1 (en) 2017-04-21 2018-10-25 Genentech, Inc. Use of klk5 antagonists for treatment of a disease
CA3059468A1 (en) 2017-04-27 2018-11-01 Tesaro, Inc. Antibody agents directed against lymphocyte activation gene-3 (lag-3) and uses thereof
AR111651A1 (en) 2017-04-28 2019-08-07 Novartis Ag Antibody Conjugates comprising receptor agonists toll-like and combination therapies
US20180355040A1 (en) 2017-05-01 2018-12-13 Agenus Inc. Anti-tigit antibodies and methods of use thereof
TW201904578A (en) 2017-05-10 2019-02-01 美商艾歐凡斯生物治療公司 Liquid tumors derived from the tumor infiltrating lymphocytes and amplification of the amplified therapeutic use of tumor infiltrating lymphocytes
WO2019103857A1 (en) 2017-11-22 2019-05-31 Iovance Biotherapeutics, Inc. Expansion of peripheral blood lymphocytes (pbls) from peripheral blood
WO2018213097A1 (en) 2017-05-15 2018-11-22 University Of Rochester Broadly neutralizing anti-influenza monoclonal antibody and uses thereof
UY37738A (en) 2017-05-24 2019-01-02 Novartis Ag Proteins grafted antibody-cytokine and methods of use for immune related disorders
WO2018215937A1 (en) 2017-05-24 2018-11-29 Novartis Ag Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer
WO2018215938A1 (en) 2017-05-24 2018-11-29 Novartis Ag Antibody-cytokine engrafted proteins and methods of use
WO2018215936A1 (en) 2017-05-24 2018-11-29 Novartis Ag Antibody-cytokine engrafted proteins and methods of use in the treatment of cancer
WO2018218056A1 (en) 2017-05-25 2018-11-29 Birstol-Myers Squibb Company Antibodies comprising modified heavy constant regions
WO2018222689A1 (en) 2017-05-31 2018-12-06 Stcube & Co., Inc. Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof
WO2018222685A1 (en) 2017-05-31 2018-12-06 Stcube & Co., Inc. Methods of treating cancer using antibodies and molecules that immunospecifically bind to btn1a1
WO2018220446A1 (en) 2017-06-01 2018-12-06 Compugen Ltd. Triple combination antibody therapies
WO2018226671A1 (en) 2017-06-06 2018-12-13 Stcube & Co., Inc. Methods of treating cancer using antibodies and molecules that bind to btn1a1 or btn1a1-ligands
UY37758A (en) 2017-06-12 2019-01-31 Novartis Ag Method for making bispecific antibodies, bispecific antibodies and therapeutic use of such antibodies
WO2018229715A1 (en) 2017-06-16 2018-12-20 Novartis Ag Compositions comprising anti-cd32b antibodies and methods of use thereof
WO2018229706A1 (en) 2017-06-16 2018-12-20 Novartis Ag Combination therapy for the treatment of cancer
WO2018237097A1 (en) 2017-06-20 2018-12-27 Amgen Inc. Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists
WO2018237335A1 (en) 2017-06-23 2018-12-27 VelosBio Inc. Ror1 antibody immunoconjugates
WO2019003104A1 (en) 2017-06-28 2019-01-03 Novartis Ag Methods for preventing and treating urinary incontinence
WO2019018757A1 (en) 2017-07-21 2019-01-24 Genentech, Inc. Therapeutic and diagnostic methods for cancer
CN107748262A (en) * 2017-07-26 2018-03-02 东曜药业有限公司 A kind of ELISA detection method of Fc γ RIIIA acceptors
CN107748253A (en) * 2017-07-26 2018-03-02 东曜药业有限公司 A kind of ELISA detection method of Fc γ RI acceptors
CN107748258A (en) * 2017-07-26 2018-03-02 东曜药业有限公司 A kind of ELISA detection method of Fc γ RII acceptors
WO2019023347A1 (en) 2017-07-26 2019-01-31 Forty Seven, Inc. Anti-sirp-alpha antibodies and related methods
CN107748259A (en) * 2017-07-26 2018-03-02 东曜药业有限公司 A kind of ELISA detection method of FcRn acceptors
TW201920255A (en) 2017-08-09 2019-06-01 美商生物化學醫療公司 Nucleic acid molecules and uses thereof
WO2019033043A2 (en) 2017-08-11 2019-02-14 Genentech, Inc. Anti-cd8 antibodies and uses thereof
US20190194293A1 (en) 2017-08-22 2019-06-27 Sanabio, Llc Soluble interferon receptors and uses thereof
WO2019040780A1 (en) 2017-08-25 2019-02-28 Five Prime Therapeutics Inc. B7-h4 antibodies and methods of use thereof
EP3456736A1 (en) 2017-09-19 2019-03-20 Tillotts Pharma Ag Antibody variants
EP3456737A1 (en) 2017-09-19 2019-03-20 Tillotts Pharma Ag Antibody variants
WO2019059411A1 (en) 2017-09-20 2019-03-28 Chugai Seiyaku Kabushiki Kaisha Dosage regimen for combination therapy using pd-1 axis binding antagonists and gpc3 targeting agent
WO2019074983A1 (en) 2017-10-10 2019-04-18 Alpine Immune Sciences, Inc. Ctla-4 variant immunomodulatory proteins and uses thereof
US20190144549A1 (en) 2017-10-10 2019-05-16 Tilos Therapeutics, Inc. Anti-lap antibodies and uses thereof
TW201925223A (en) 2017-10-18 2019-07-01 美商艾爾潘免疫科學有限公司 Variant ICOS ligand immunomodulatory proteins and related compositions and methods
WO2019077092A1 (en) 2017-10-20 2019-04-25 F. Hoffmann-La Roche Ag Method for generating multispecific antibodies from monospecific antibodies
WO2019081983A1 (en) 2017-10-25 2019-05-02 Novartis Ag Antibodies targeting cd32b and methods of use thereof
WO2019086362A1 (en) 2017-10-30 2019-05-09 F. Hoffmann-La Roche Ag Method for in vivo generation of multispecific antibodies from monospecific antibodies
WO2019090263A1 (en) 2017-11-06 2019-05-09 Genentech, Inc. Diagnostic and therapeutic methods for cancer
WO2019101695A1 (en) 2017-11-21 2019-05-31 Innate Pharma Multispecific antigen binding proteins
WO2019102353A1 (en) 2017-11-22 2019-05-31 Novartis Ag Reversal binding agents for anti-factor xi/xia antibodies and uses thereof
WO2019106578A2 (en) 2017-12-01 2019-06-06 Novartis Ag Polyomavirus neutralizing antibodies
US20190194277A1 (en) 2017-12-08 2019-06-27 Argenx Bvba Use of fcrn antagonists for treatment of generalized myasthenia gravis
WO2019118873A2 (en) 2017-12-15 2019-06-20 Iovance Biotherapeutics, Inc. Systems and methods for determining the beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof and beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof
EP3498293A1 (en) 2017-12-15 2019-06-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Treatment of monogenic diseases with an anti-cd45rc antibody
WO2019126536A1 (en) 2017-12-20 2019-06-27 Alexion Pharmaceuticals Inc. Humanized anti-cd200 antibodies and uses thereof
WO2019126133A1 (en) 2017-12-20 2019-06-27 Alexion Pharmaceuticals, Inc. Liquid formulations of anti-cd200 antibodies
EP3502140A1 (en) 2017-12-21 2019-06-26 F. Hoffmann-La Roche AG Combination therapy of tumor targeted icos agonists with t-cell bispecific molecules
US20190211098A1 (en) 2017-12-22 2019-07-11 Genentech, Inc. Use of pilra binding agents for treatment of a disease
FR3076294A1 (en) 2017-12-29 2019-07-05 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Process for purifying antibodies from raw milk
WO2019129679A1 (en) 2017-12-29 2019-07-04 F. Hoffmann-La Roche Ag Method for improving vegf-receptor blocking selectivity of an anti-vegf antibody
WO2019136179A1 (en) 2018-01-03 2019-07-11 Alpine Immune Sciences, Inc. Multi-domain immunomodulatory proteins and methods of use thereof
WO2019134981A1 (en) 2018-01-05 2019-07-11 Ac Immune Sa Misfolded tdp-43 binding molecules
WO2019140229A1 (en) 2018-01-12 2019-07-18 Bristol-Myers Squibb Company Antibodies against tim3 and uses thereof
WO2019143636A1 (en) 2018-01-16 2019-07-25 Lakepharma, Inc. Bispecific antibody that binds cd3 and another target
WO2019148020A1 (en) 2018-01-26 2019-08-01 Genentech, Inc. Compositions and methods of use
WO2019148026A1 (en) 2018-01-26 2019-08-01 Genentech, Inc. Il-22 fc fusion proteins and methods of use
US20190263934A1 (en) * 2018-01-26 2019-08-29 Genzyme Corporation Fc variants with enhanced binding to fcrn and prolonged half-life
WO2019148412A1 (en) 2018-02-01 2019-08-08 Merck Sharp & Dohme Corp. Anti-pd-1/lag3 bispecific antibodies
WO2019152692A1 (en) 2018-02-01 2019-08-08 Bioverativ Therapeutics, Inc. Use of lentiviral vectors expressing factor viii
US20190270814A1 (en) 2018-02-08 2019-09-05 Genentech, Inc. Bispecific antigen-binding molecules and methods of use
WO2019157358A1 (en) 2018-02-09 2019-08-15 Genentech, Inc. Therapeutic and diagnostic methods for mast cell-mediated inflammatory diseases
WO2019160829A1 (en) 2018-02-13 2019-08-22 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes (tils) with adenosine a2a receptor antagonists and therapeutic combinations of tils and adenosine a2a receptor antagonists
WO2019158645A1 (en) 2018-02-14 2019-08-22 Abba Therapeutics Ag Anti-human pd-l2 antibodies
WO2019165140A1 (en) 2018-02-21 2019-08-29 Genentech, Inc. DOSING FOR TREATMENT WITH IL-22 Fc FUSION PROTEINS
WO2019165434A1 (en) 2018-02-26 2019-08-29 Genentech, Inc. Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
WO2019169229A1 (en) 2018-03-01 2019-09-06 Nextcure, Inc. Klrg1 binding compositions and methods of use thereof
NL2020520B1 (en) 2018-03-02 2019-09-12 Labo Bio Medical Invest B V Multispecific binding molecules for the prevention, treatment and diagnosis of neurodegenerative disorders
WO2019175071A1 (en) 2018-03-13 2019-09-19 F. Hoffmann-La Roche Ag Therapeutic combination of 4-1 bb agonists with anti-cd20 antibodies
WO2019178316A1 (en) 2018-03-14 2019-09-19 Genentech, Inc. Anti-klk5 antibodies and methods of use
WO2019183040A1 (en) 2018-03-21 2019-09-26 Five Prime Therapeutics, Inc. ANTIBODIES BINDING TO VISTA AT ACIDIC pH
US20190300592A1 (en) 2018-03-28 2019-10-03 Bristol-Myers Squibb Company Interleukin-2/interleukin-2 receptor alpha fusion proteins and methods of use
WO2019191552A1 (en) 2018-03-29 2019-10-03 Genentech, Inc. Modulating lactogenic activity in mammalian cells
US20190300608A1 (en) 2018-04-02 2019-10-03 Bristol-Myers Squibb Company Anti-trem-1 antibodies and uses thereof
WO2019195514A1 (en) 2018-04-04 2019-10-10 Genentech, Inc. Methods for detecting and quantifying fgf21
EP3552631A1 (en) 2018-04-10 2019-10-16 Inatherys Antibody-drug conjugates and their uses for the treatment of cancer
WO2019197903A1 (en) 2018-04-12 2019-10-17 Mosaic Biomedicals Slu Combination of lif inhibitors and pd-1 axis inhibitors for use in treating cancer
WO2019202041A1 (en) 2018-04-18 2019-10-24 F. Hoffmann-La Roche Ag Multispecific antibodies and use thereof
WO2019202040A1 (en) 2018-04-18 2019-10-24 F. Hoffmann-La Roche Ag Anti-hla-g antibodies and use thereof
WO2019213384A1 (en) 2018-05-03 2019-11-07 University Of Rochester Anti-influenza neuraminidase monoclonal antibodies and uses thereof

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4318980A (en) 1978-04-10 1982-03-09 Miles Laboratories, Inc. Heterogenous specific binding assay employing a cycling reactant as label
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
FR2413974B1 (en) 1978-01-06 1982-12-03 David Bernard
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4490473A (en) * 1983-03-28 1984-12-25 Panab Labeled antibodies and methods
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DD266710A3 (en) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Process for the biotechnical production of alkaline phosphatase
US4752601A (en) * 1983-08-12 1988-06-21 Immunetech Pharmaceuticals Method of blocking immune complex binding to immunoglobulin FC receptors
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5091178A (en) 1986-02-21 1992-02-25 Oncogen Tumor therapy with biologically active anti-tumor antibodies
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US5985599A (en) * 1986-05-29 1999-11-16 The Austin Research Institute FC receptor for immunoglobulin
JP3101690B2 (en) 1987-03-18 2000-10-23 エス・ビィ・2・インコーポレイテッド Denaturation antibody, or improvements relating modified antibody
US5204244A (en) * 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5576184A (en) * 1988-09-06 1996-11-19 Xoma Corporation Production of chimeric mouse-human antibodies with specificity to human tumor antigens
AT135397T (en) 1988-09-23 1996-03-15 Cetus Oncology Corp Cell culture medium for enhanced cell growth, to increase the longevity and expression of products
FR2646437B1 (en) 1989-04-28 1991-08-30 Transgene Sa New DNA sequences, their application as a sequence encoding a signal peptide for secretion of mature proteins by recombinant yeast expression cassettes, transformed yeasts and method of preparation of proteins corresponding
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
EP0739904A1 (en) 1989-06-29 1996-10-30 Medarex, Inc. Bispecific reagents for aids therapy
GB8916400D0 (en) * 1989-07-18 1989-09-06 Dynal As Modified igg3
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
US5364930A (en) * 1990-10-16 1994-11-15 Northwestern University Synthetic C1q peptide fragments
US5419904A (en) * 1990-11-05 1995-05-30 The Regents Of The University Of California Human B-lymphoblastoid cell line secreting anti-ganglioside antibody
JPH06507398A (en) 1991-05-14 1994-08-25
US6136310A (en) * 1991-07-25 2000-10-24 Idec Pharmaceuticals Corporation Recombinant anti-CD4 antibodies for human therapy
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
GB9206422D0 (en) * 1992-03-24 1992-05-06 Bolt Sarah L Antibody preparation
EP0640094A1 (en) * 1992-04-24 1995-03-01 Board Of Regents The University Of Texas System Recombinant production of immunoglobulin-like domains in prokaryotic cells
DE69308573T2 (en) 1992-08-17 1997-08-07 Genentech Inc bispecific immunoadhesine
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
MD1367C2 (en) 1992-11-13 2000-11-30 Idec Pharmaceuticals Corporation Methods of B-cells lymphoma treatment, anti-CD20 antibodies, hybridoma
US5885573A (en) * 1993-06-01 1999-03-23 Arch Development Corporation Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
US6491916B1 (en) * 1994-06-01 2002-12-10 Tolerance Therapeutics, Inc. Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies
AU691811B2 (en) 1993-06-16 1998-05-28 Celltech Therapeutics Limited Antibodies
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5730977A (en) * 1995-08-21 1998-03-24 Mitsui Toatsu Chemicals, Inc. Anti-VEGF human monoclonal antibody
US6750334B1 (en) 1996-02-02 2004-06-15 Repligen Corporation CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
WO1997034631A1 (en) 1996-03-18 1997-09-25 Board Of Regents, The University Of Texas System Immunoglobin-like domains with increased half lives
US5834597A (en) * 1996-05-20 1998-11-10 Protein Design Labs, Inc. Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
WO1998023289A1 (en) * 1996-11-27 1998-06-04 The General Hospital Corporation MODULATION OF IgG BINDING TO FcRn
US6277375B1 (en) * 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
DE19721700C1 (en) 1997-05-23 1998-11-19 Deutsches Krebsforsch Mutated OKT3 antibody
AT296315T (en) * 1997-06-24 2005-06-15 Genentech Inc Galactosylated glycoprotein containing compositions and method for the production thereof
CZ20003099A3 (en) 1998-02-25 2002-04-17 Lexigen Pharmaceuticals Corporation Enhancing the circulating half-life of antibody-based fusion proteins
DK1068241T3 (en) * 1998-04-02 2008-02-04 Genentech Inc Antibody variants and fragments thereof
US6242195B1 (en) * 1998-04-02 2001-06-05 Genentech, Inc. Methods for determining binding of an analyte to a receptor
US6528624B1 (en) * 1998-04-02 2003-03-04 Genentech, Inc. Polypeptide variants
US6194551B1 (en) * 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
JP2002522063A (en) 1998-08-17 2002-07-23 アブジェニックス インコーポレイテッド Generation of modified molecules having increased serum half-life
ES2694002T3 (en) 1999-01-15 2018-12-17 Genentech, Inc. Polypeptide comprising an Fc region of variant human IgG1
US7183387B1 (en) * 1999-01-15 2007-02-27 Genentech, Inc. Polypeptide variants with altered effector function
US6737056B1 (en) * 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US6676927B1 (en) * 1999-01-20 2004-01-13 The Rockefeller University Animal model and methods for its use in the selection of cytotoxic antibodies
DE60122286T2 (en) 2000-02-11 2007-08-02 Merck Patent Gmbh Increasing the circulatory half-time of antibody-based fusion proteins
EP2264072A1 (en) * 2000-04-13 2010-12-22 The Rockefeller University Enhancement of antibody-mediated cytotoxicity.
PT1355919E (en) * 2000-12-12 2011-03-02 Medimmune Llc Molecules with extended half-lives, compositions and uses thereof
US20040002587A1 (en) * 2002-02-20 2004-01-01 Watkins Jeffry D. Fc region variants
US20060062727A1 (en) 2002-07-09 2006-03-23 Philips Heidi S Compositions and methods for the diagnosis and treatment of tumor
DK2345671T3 (en) 2002-09-27 2016-02-15 Xencor Inc Optimized Fc variants and methods for their formation
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
DK1562972T3 (en) 2002-10-15 2010-12-06 Facet Biotech Corp Modification of FcRn binding affinities or serum half-lives for antibodies by mutagenesis
US7608260B2 (en) * 2003-01-06 2009-10-27 Medimmune, Llc Stabilized immunoglobulins
JP2006524039A (en) 2003-01-09 2006-10-26 マクロジェニクス,インコーポレーテッド Identification and production of antibody containing mutant Fc region and use thereof
WO2005037867A1 (en) 2003-10-15 2005-04-28 Pdl Biopharma, Inc. ALTERATION OF Fc-FUSION PROTEIN SERUM HALF-LIVES BY MUTAGENESIS OF POSITIONS 250, 314 AND/OR 428 OF THE HEAVY CHAIN CONSTANT REGION OF IG
WO2006031370A2 (en) * 2004-08-19 2006-03-23 Genentech, Inc. Polypeptide variants with altered effector function
DOP2006000029A (en) * 2005-02-07 2006-08-15 Genentech Inc Antibody variants and use thereof. (Variants of an antibody and uses thereof)

Also Published As

Publication number Publication date
AU2850500A (en) 2000-08-01
AU2008229968A1 (en) 2008-11-06
US20080274506A1 (en) 2008-11-06
KR101155191B1 (en) 2012-06-13
KR20100045527A (en) 2010-05-03
CN1763097A (en) 2006-04-26
EP1141024A2 (en) 2001-10-10
CN1343221A (en) 2002-04-03
IL144056D0 (en) 2002-04-21
US20060194290A1 (en) 2006-08-31
HU230769B1 (en) 2018-03-28
CN1237076C (en) 2006-01-18
US7785791B2 (en) 2010-08-31
JP2016136951A (en) 2016-08-04
EP2364997A2 (en) 2011-09-14
HU0104865A2 (en) 2002-04-29
NZ539776A (en) 2006-12-22
IL223047D0 (en) 2012-12-31
AU2008229968B2 (en) 2012-08-09
PL209392B1 (en) 2011-08-31
HU1500355A2 (en) 2002-04-29
WO2000042072A2 (en) 2000-07-20
CN1763097B (en) 2011-04-13
KR100940380B1 (en) 2010-02-02
IL223048D0 (en) 2012-12-31
US7790858B2 (en) 2010-09-07
ES2694002T3 (en) 2018-12-17
JP6312092B2 (en) 2018-04-18
US20080274105A1 (en) 2008-11-06
ZA200105484B (en) 2002-07-29
CA2359067A1 (en) 2000-07-20
HK1090066A1 (en) 2011-12-09
BR0008758A (en) 2001-12-04
JP2013166770A (en) 2013-08-29
PL394232A1 (en) 2011-07-04
JP2010227116A (en) 2010-10-14
PL209786B1 (en) 2011-10-31
WO2000042072A3 (en) 2000-11-30
JP5335735B2 (en) 2013-11-06
KR20090078369A (en) 2009-07-17
EP1141024B1 (en) 2018-08-08
IL144056A (en) 2014-04-30
EP2364997A3 (en) 2012-07-04
IL223048A (en) 2016-09-29
EP2366713A2 (en) 2011-09-21
KR20080090572A (en) 2008-10-08
US7371826B2 (en) 2008-05-13
AU778683B2 (en) 2004-12-16
JP2003512019A (en) 2003-04-02
EP2386574A2 (en) 2011-11-16
MXPA01007170A (en) 2002-07-30
CA2359067C (en) 2017-03-14
IL222149A (en) 2018-11-29
KR101077001B1 (en) 2011-10-26
MX353234B (en) 2018-01-08
HU0104865A3 (en) 2004-07-28
US20060194291A1 (en) 2006-08-31
JP6230257B2 (en) 2017-11-15
PL349770A1 (en) 2002-09-09
EP2366713A3 (en) 2012-06-27
EP2386574A3 (en) 2012-06-27
KR20060067983A (en) 2006-06-20
IL223047A (en) 2016-10-31

Similar Documents

Publication Publication Date Title
DK0724642T3 (en) Nucleic acid vector, composition containing such vector and vaccine for immunization against hepatitis
AU692968B2 (en) Recombinant dna molecules and expression vectors for erythropoietin
AU751324C (en) Solid-phase nucleic acid isolation
DE69535467D1 (en) Factor of pigmented epithel (pedf) characterization, genomic organization and sequence of the pedf gene
DE69739539D1 (en) Nucleic acid coding for the gai gene of arabidopsis thaliana
WO1999006550B1 (en) 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN PROSTATE
CA2243088A1 (en) Humanized green fluorescent protein genes and methods
CA2365446A1 (en) Polypeptides having alkaline alpha-amylase activity and nucleic acids encoding same
MXPA01013174A (en) Compositions and methods for increasing cholesterol efflux and raising hdl using atp binding cassette transporter protein abc1.
NO324506B1 (en) OB fusion protein, nucleic acid, vector, host cell, process feed for the production of the protein, pharmaceutical composition and use of the protein as a therapeutic composition.
GR3015537T3 (en) Recombinant DNA methods, vectors and host cells.
WO2003052056A3 (en) Egviii endoglucanase and nucleic acids encoding the same
EP1686134A3 (en) Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU7945682A (en) Rennin from recombinant dna
GB2347930B (en) IGF-1 receptor interacting proteins (IIPs), genes coding therefor and uses thereof
AU4349597A (en) Isolated nucleic acid molecule encoding cancer associated antigen, the antigen itself, and uses thereof
PL191251B1 (en) Method for integrating genes at specific sites of mammalian cell genome via honologous recombination and vectors for accomplishing the same
EP1198250B8 (en) Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
EP0360257A3 (en) Rna catalyst for cleaving specific rna sequences
AU8147294A (en) Recombinant viruses coding for thymidine kinase in gene therapy
GB9509392D0 (en) Recombinant prrsv proteins,diagnostic kits and vaccines containing such recombinant prrsv proteins
NZ204302A (en) Recombinant dna method for preparation of polypeptides,using the yeast kluyveromyces as host
IL122403D0 (en) Recombinant dna vector comprising aav nucleic acid sequences
NZ582315A (en) Fusion constructs and use of same to produce antibodies with increased Fc receptor binding affinity and effector function
HU9701341A3 (en) Modified thermostable dns polymerase, process for producing thereof, nucleic acid codind the enzyme, vector containing the nucleic acid, a composition containing thereof