BR112012029588A2 - materiais biológicas relacionados a her3. - Google Patents

materiais biológicas relacionados a her3.

Info

Publication number
BR112012029588A2
BR112012029588A2 BR112012029588A BR112012029588A BR112012029588A2 BR 112012029588 A2 BR112012029588 A2 BR 112012029588A2 BR 112012029588 A BR112012029588 A BR 112012029588A BR 112012029588 A BR112012029588 A BR 112012029588A BR 112012029588 A2 BR112012029588 A2 BR 112012029588A2
Authority
BR
Brazil
Prior art keywords
amino acid
sequences
polypeptides
nucleic acids
acid sequences
Prior art date
Application number
BR112012029588A
Other languages
English (en)
Inventor
Hock Bjoern
Knuehl Christine
Kamiel Delphina Verdonck Frank
Beste Gerald
Adi Pierrette Revets Hilde
Hofmeister Robert
Godelie Victor Cornelis Sigrid
Original Assignee
Ablynx Nv
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ablynx Nv, Merck Patent Gmbh filed Critical Ablynx Nv
Publication of BR112012029588A2 publication Critical patent/BR112012029588A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

materiais biológicos relacionados a her3 - a presente invenção refere-se a sequências de aminoácidos que são direcionadas (como definidas neste pedido) contra her3, bem como a compostos ou construtos, e em particular proteínas e polipeptídeos, que compreendem ou essencilamente consistem em uma ou mais tais sequências de aminoácidos (também referidas neste pedido como "sequências de aminoácidos da invenção", compostos da invenção, e "polipeptídeos da invenção, respectivamente). a invenção também se refere a ácidos nucleicos que codificam tais sequências de aminoácidos e poliptídeos (também referidos neste pedido como "ácidos nucleicos da invenção" ou "sequências nucleotídicas da invenção") ; a métodos para preparação de tais sequências de aminoácidos e polipeptídeos; as células hospedeiras expressando ou capaz de expressar tais sequências de aminoácidos ou poliptídeos; a composições, e em particular, composições farmacêuticas, que compreendem tais sequências de aminoácidos, polipeptídeos, ácidos nucleicos e/ou células hospedeiras; e aos usos de tais sequências de aminoácidos ou polipeptídeos, ácidos nucleicos, céululas hospedeiras e/ou composições, em particular para fins profiláticos, terapêuticos ou diagnósticos, tais como os objetivos profiláticos, terapêuticos ou diagnósticos mencionados neste pedido.
BR112012029588A 2010-05-20 2011-05-20 materiais biológicas relacionados a her3. BR112012029588A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34654810P 2010-05-20 2010-05-20
PCT/EP2011/058295 WO2011144749A1 (en) 2010-05-20 2011-05-20 Biological materials related to her3

Publications (1)

Publication Number Publication Date
BR112012029588A2 true BR112012029588A2 (pt) 2017-07-25

Family

ID=44119183

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012029588A BR112012029588A2 (pt) 2010-05-20 2011-05-20 materiais biológicas relacionados a her3.

Country Status (13)

Country Link
US (2) US9932403B2 (pt)
EP (2) EP2571901B1 (pt)
JP (1) JP6120767B2 (pt)
KR (1) KR20130080790A (pt)
CN (1) CN102906118B (pt)
AU (1) AU2011254557B2 (pt)
BR (1) BR112012029588A2 (pt)
CA (1) CA2791951C (pt)
MX (1) MX2012013490A (pt)
NZ (1) NZ603570A (pt)
RU (1) RU2012149227A (pt)
SG (1) SG185354A1 (pt)
WO (1) WO2011144749A1 (pt)

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CN102906118A (zh) 2013-01-30
WO2011144749A1 (en) 2011-11-24
US20130136748A1 (en) 2013-05-30
MX2012013490A (es) 2013-01-29
US20190023796A1 (en) 2019-01-24
AU2011254557B2 (en) 2015-09-03
JP2013529079A (ja) 2013-07-18
RU2012149227A (ru) 2014-06-27
EP2571901A1 (en) 2013-03-27
CA2791951A1 (en) 2011-11-24
US10808032B2 (en) 2020-10-20
EP2571901B1 (en) 2019-01-02
JP6120767B2 (ja) 2017-04-26
AU2011254557A1 (en) 2012-12-13
CA2791951C (en) 2019-05-14
SG185354A1 (en) 2012-12-28
NZ603570A (en) 2014-12-24
KR20130080790A (ko) 2013-07-15
EP3546483A1 (en) 2019-10-02
US9932403B2 (en) 2018-04-03

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