ATE500265T1 - Synthetische mecp2-sequenz für die proteinersatztherapie - Google Patents
Synthetische mecp2-sequenz für die proteinersatztherapieInfo
- Publication number
- ATE500265T1 ATE500265T1 AT06724141T AT06724141T ATE500265T1 AT E500265 T1 ATE500265 T1 AT E500265T1 AT 06724141 T AT06724141 T AT 06724141T AT 06724141 T AT06724141 T AT 06724141T AT E500265 T1 ATE500265 T1 AT E500265T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- proteins
- nucleic acid
- relates
- replacement therapy
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 7
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 101150083522 MECP2 gene Proteins 0.000 title 1
- 102100039124 Methyl-CpG-binding protein 2 Human genes 0.000 title 1
- 238000009256 replacement therapy Methods 0.000 title 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 4
- 102000006890 Methyl-CpG-Binding Protein 2 Human genes 0.000 abstract 2
- 108010072388 Methyl-CpG-Binding Protein 2 Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 208000029726 Neurodevelopmental disease Diseases 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108091005461 Nucleic proteins Proteins 0.000 abstract 1
- 208000006289 Rett Syndrome Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 230000026683 transduction Effects 0.000 abstract 1
- 238000010361 transduction Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2006/003203 WO2007115578A1 (en) | 2006-04-07 | 2006-04-07 | Synthetic mecp2 sequence for protein substitution therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE500265T1 true ATE500265T1 (de) | 2011-03-15 |
Family
ID=36589309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06724141T ATE500265T1 (de) | 2006-04-07 | 2006-04-07 | Synthetische mecp2-sequenz für die proteinersatztherapie |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8226930B2 (de) |
| EP (1) | EP2010563B1 (de) |
| JP (1) | JP5102283B2 (de) |
| CN (1) | CN101415726B (de) |
| AT (1) | ATE500265T1 (de) |
| AU (1) | AU2006341726B2 (de) |
| CA (1) | CA2647125C (de) |
| DE (1) | DE602006020501D1 (de) |
| DK (1) | DK2010563T3 (de) |
| ES (1) | ES2362195T3 (de) |
| HR (1) | HRP20110386T1 (de) |
| IL (1) | IL194274A (de) |
| PL (1) | PL2010563T3 (de) |
| SI (1) | SI2010563T1 (de) |
| WO (1) | WO2007115578A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1398191B1 (it) * | 2010-02-17 | 2013-02-14 | Ist Superiore Sanita | Uso di tossine che attivano le rho gtpasi per il trattamento e/o la prevenzione della sintomatologia associata alla sindrome di rett (rtt). |
| AU2011325956B2 (en) | 2010-11-12 | 2016-07-14 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
| US9920317B2 (en) | 2010-11-12 | 2018-03-20 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
| AU2013262709A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating MECP2 expression |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| BR112014028644A2 (pt) | 2012-05-16 | 2017-08-15 | Rana Therapeutics Inc | Composições e métodos para modulação da expressão de atp2a2 |
| BR112014028634A2 (pt) | 2012-05-16 | 2017-06-27 | Rana Therapeutics Inc | composições e métodos para modulação da expressão de utrn |
| CA2873769A1 (en) | 2012-05-16 | 2013-11-21 | Rana Therapeutics Inc. | Compositions and methods for modulating hemoglobin gene family expression |
| SG11201407483YA (en) | 2012-05-16 | 2014-12-30 | Rana Therapeutics Inc | Compositions and methods for modulating smn gene family expression |
| WO2014130408A1 (en) * | 2013-02-20 | 2014-08-28 | The Research Foundation For The State University Of New York | Regulators of rab5 activity |
| WO2016070060A1 (en) | 2014-10-30 | 2016-05-06 | The General Hospital Corporation | Methods for modulating atrx-dependent gene repression |
| EP3271460A4 (de) | 2015-03-17 | 2019-03-13 | The General Hospital Corporation | Rna-interaktom des polycomb-repressiven komplexes 1 (prc1) |
| TWI601821B (zh) * | 2016-04-15 | 2017-10-11 | 中央研究院 | 治療神經發展性疾病 |
| US20210268072A1 (en) * | 2016-06-28 | 2021-09-02 | Alma Mater Studiorum - Universitá Di Bologna | TATk-CDKL5 Fusion Proteins, Compositions, Formulations, and Use Thereof |
| BR112019019833A2 (pt) * | 2017-03-24 | 2020-04-22 | The University Court Of The University Of Edinburgh | terapia baseada em mecp2 |
| WO2019079462A1 (en) * | 2017-10-17 | 2019-04-25 | President And Fellows Of Harvard College | TRANSCRIPTION MODULATION SYSTEMS BASED ON CAS9 |
| KR102052097B1 (ko) * | 2017-11-30 | 2019-12-05 | 한국과학기술연구원 | Mecp2 단백질 또는 이를 암호화하는 폴리뉴클레오티드를 포함하는 퇴행성 뇌질환 예방 또는 치료용 조성물 |
| SG11202111279QA (en) * | 2019-04-24 | 2021-11-29 | Univ Pennsylvania | Compositions useful in treatment of rett syndrome |
| WO2023235648A1 (en) * | 2022-06-03 | 2023-12-07 | The Regents Of The University Of California | Nuclear Delivery and Transcriptional Repression with a Cell-penetrant MeCP2 |
| CN119971036A (zh) * | 2023-11-13 | 2025-05-13 | 中国科学院分子细胞科学卓越创新中心 | 核糖核酸酶RNase H修复神经元树突生长缺陷的应用和方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1157275A4 (de) * | 1999-02-28 | 2003-01-15 | Univ Washington | Neue transduktionsmoleküle und verfahren zum benutzen derselben |
| US6709817B1 (en) | 1999-09-07 | 2004-03-23 | Baylor College Of Medicine | Method of screening Rett syndrome by detecting a mutation in MECP2 |
| US20040126877A1 (en) * | 2001-04-20 | 2004-07-01 | Man-Wook Hur | Repressors for hiv transcription and methods thereof |
| JP5830213B2 (ja) | 2004-02-17 | 2015-12-09 | ザ ホスピタル フォー シック チルドレン | Ｍｅｃｐ２ｅ１遺伝子 |
-
2006
- 2006-04-07 WO PCT/EP2006/003203 patent/WO2007115578A1/en not_active Ceased
- 2006-04-07 DE DE602006020501T patent/DE602006020501D1/de active Active
- 2006-04-07 EP EP06724141A patent/EP2010563B1/de active Active
- 2006-04-07 AT AT06724141T patent/ATE500265T1/de active
- 2006-04-07 JP JP2009503417A patent/JP5102283B2/ja not_active Expired - Fee Related
- 2006-04-07 CN CN2006800541487A patent/CN101415726B/zh not_active Expired - Fee Related
- 2006-04-07 ES ES06724141T patent/ES2362195T3/es active Active
- 2006-04-07 AU AU2006341726A patent/AU2006341726B2/en not_active Ceased
- 2006-04-07 DK DK06724141.4T patent/DK2010563T3/da active
- 2006-04-07 SI SI200631023T patent/SI2010563T1/sl unknown
- 2006-04-07 US US12/295,856 patent/US8226930B2/en not_active Expired - Fee Related
- 2006-04-07 HR HR20110386T patent/HRP20110386T1/hr unknown
- 2006-04-07 CA CA2647125A patent/CA2647125C/en not_active Expired - Fee Related
- 2006-04-07 PL PL06724141T patent/PL2010563T3/pl unknown
-
2008
- 2008-09-22 IL IL194274A patent/IL194274A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20110386T1 (hr) | 2011-08-31 |
| CA2647125C (en) | 2015-02-03 |
| WO2007115578A8 (en) | 2008-10-30 |
| HK1121468A1 (en) | 2009-04-24 |
| EP2010563A1 (de) | 2009-01-07 |
| AU2006341726A1 (en) | 2007-10-18 |
| AU2006341726B2 (en) | 2012-09-20 |
| CA2647125A1 (en) | 2007-10-18 |
| DK2010563T3 (da) | 2011-05-23 |
| WO2007115578A1 (en) | 2007-10-18 |
| PL2010563T3 (pl) | 2011-11-30 |
| SI2010563T1 (sl) | 2011-07-29 |
| DE602006020501D1 (de) | 2011-04-14 |
| US20090233856A1 (en) | 2009-09-17 |
| EP2010563B1 (de) | 2011-03-02 |
| IL194274A (en) | 2011-07-31 |
| CN101415726A (zh) | 2009-04-22 |
| CN101415726B (zh) | 2013-07-31 |
| ES2362195T3 (es) | 2011-06-29 |
| JP5102283B2 (ja) | 2012-12-19 |
| US8226930B2 (en) | 2012-07-24 |
| JP2009532045A (ja) | 2009-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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