DK2010563T3 - Syntetisk MeCP2 sekvens til proteinsubstitutionsterapi - Google Patents
Syntetisk MeCP2 sekvens til proteinsubstitutionsterapiInfo
- Publication number
- DK2010563T3 DK2010563T3 DK06724141.4T DK06724141T DK2010563T3 DK 2010563 T3 DK2010563 T3 DK 2010563T3 DK 06724141 T DK06724141 T DK 06724141T DK 2010563 T3 DK2010563 T3 DK 2010563T3
- Authority
- DK
- Denmark
- Prior art keywords
- protein
- proteins
- nucleic acid
- relates
- substitution therapy
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 7
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 102000006890 Methyl-CpG-Binding Protein 2 Human genes 0.000 title abstract 3
- 108010072388 Methyl-CpG-Binding Protein 2 Proteins 0.000 title abstract 3
- 238000002560 therapeutic procedure Methods 0.000 title abstract 3
- 238000006467 substitution reaction Methods 0.000 title abstract 2
- 150000007523 nucleic acids Chemical group 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 208000029726 Neurodevelopmental disease Diseases 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108091005461 Nucleic proteins Proteins 0.000 abstract 1
- 208000006289 Rett Syndrome Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000026683 transduction Effects 0.000 abstract 1
- 238000010361 transduction Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2006/003203 WO2007115578A1 (en) | 2006-04-07 | 2006-04-07 | Synthetic mecp2 sequence for protein substitution therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2010563T3 true DK2010563T3 (da) | 2011-05-23 |
Family
ID=36589309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06724141.4T DK2010563T3 (da) | 2006-04-07 | 2006-04-07 | Syntetisk MeCP2 sekvens til proteinsubstitutionsterapi |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8226930B2 (da) |
| EP (1) | EP2010563B1 (da) |
| JP (1) | JP5102283B2 (da) |
| CN (1) | CN101415726B (da) |
| AT (1) | ATE500265T1 (da) |
| AU (1) | AU2006341726B2 (da) |
| CA (1) | CA2647125C (da) |
| DE (1) | DE602006020501D1 (da) |
| DK (1) | DK2010563T3 (da) |
| ES (1) | ES2362195T3 (da) |
| HR (1) | HRP20110386T1 (da) |
| IL (1) | IL194274A (da) |
| PL (1) | PL2010563T3 (da) |
| SI (1) | SI2010563T1 (da) |
| WO (1) | WO2007115578A1 (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1398191B1 (it) * | 2010-02-17 | 2013-02-14 | Ist Superiore Sanita | Uso di tossine che attivano le rho gtpasi per il trattamento e/o la prevenzione della sintomatologia associata alla sindrome di rett (rtt). |
| US9920317B2 (en) | 2010-11-12 | 2018-03-20 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
| CA2817256A1 (en) | 2010-11-12 | 2012-05-18 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
| SG11201407483YA (en) | 2012-05-16 | 2014-12-30 | Rana Therapeutics Inc | Compositions and methods for modulating smn gene family expression |
| EA201492122A1 (ru) | 2012-05-16 | 2015-10-30 | Рана Терапьютикс, Инк. | Композиции и способы для модулирования экспрессии utrn |
| EA201492116A1 (ru) | 2012-05-16 | 2015-05-29 | Рана Терапьютикс, Инк. | Композиции и способы для модулирования экспрессии mecp2 |
| BR112014028631A2 (pt) | 2012-05-16 | 2017-10-17 | Rana Therapeutics Inc | composições e métodos para modulação da expressão da família de genes da hemoglobina |
| AU2013262699A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating ATP2A2 expression |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| WO2014130408A1 (en) * | 2013-02-20 | 2014-08-28 | The Research Foundation For The State University Of New York | Regulators of rab5 activity |
| WO2016070060A1 (en) | 2014-10-30 | 2016-05-06 | The General Hospital Corporation | Methods for modulating atrx-dependent gene repression |
| WO2016149455A2 (en) | 2015-03-17 | 2016-09-22 | The General Hospital Corporation | The rna interactome of polycomb repressive complex 1 (prc1) |
| TWI601821B (zh) * | 2016-04-15 | 2017-10-11 | 中央研究院 | 治療神經發展性疾病 |
| EP3475418A4 (en) * | 2016-06-28 | 2020-03-04 | Alma Mater Studiorum -Universita' di Bologna | TATK-CDKL5 FUSION PROTEINS, COMPOSITIONS, FORMULATIONS AND THEIR USE |
| BR112019019833A2 (pt) * | 2017-03-24 | 2020-04-22 | The University Court Of The University Of Edinburgh | terapia baseada em mecp2 |
| US11629342B2 (en) | 2017-10-17 | 2023-04-18 | President And Fellows Of Harvard College | Cas9-based transcription modulation systems |
| KR102052097B1 (ko) * | 2017-11-30 | 2019-12-05 | 한국과학기술연구원 | Mecp2 단백질 또는 이를 암호화하는 폴리뉴클레오티드를 포함하는 퇴행성 뇌질환 예방 또는 치료용 조성물 |
| CA3133889A1 (en) * | 2019-04-24 | 2020-10-29 | The Trustees Of The University Of Pennsylvania | Compositions useful in treatment of rett syndrome |
| WO2023235648A1 (en) * | 2022-06-03 | 2023-12-07 | The Regents Of The University Of California | Nuclear Delivery and Transcriptional Repression with a Cell-penetrant MeCP2 |
| CN119971036A (zh) * | 2023-11-13 | 2025-05-13 | 中国科学院分子细胞科学卓越创新中心 | 核糖核酸酶RNase H修复神经元树突生长缺陷的应用和方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7497000A (en) * | 1999-02-28 | 2000-11-14 | Washington University | Novel transduction molecules and methods for using same |
| US6709817B1 (en) * | 1999-09-07 | 2004-03-23 | Baylor College Of Medicine | Method of screening Rett syndrome by detecting a mutation in MECP2 |
| WO2002085948A1 (en) * | 2001-04-20 | 2002-10-31 | Man-Wook Hur | Repressors for hiv transcription and methods thereof |
| CA2554380C (en) * | 2004-02-17 | 2015-05-19 | The Hospital For Sick Children | Mecp2e1 gene |
-
2006
- 2006-04-07 SI SI200631023T patent/SI2010563T1/sl unknown
- 2006-04-07 US US12/295,856 patent/US8226930B2/en not_active Expired - Fee Related
- 2006-04-07 EP EP06724141A patent/EP2010563B1/en not_active Expired - Lifetime
- 2006-04-07 ES ES06724141T patent/ES2362195T3/es not_active Expired - Lifetime
- 2006-04-07 CA CA2647125A patent/CA2647125C/en not_active Expired - Fee Related
- 2006-04-07 JP JP2009503417A patent/JP5102283B2/ja not_active Expired - Fee Related
- 2006-04-07 WO PCT/EP2006/003203 patent/WO2007115578A1/en not_active Ceased
- 2006-04-07 AU AU2006341726A patent/AU2006341726B2/en not_active Ceased
- 2006-04-07 CN CN2006800541487A patent/CN101415726B/zh not_active Expired - Fee Related
- 2006-04-07 DE DE602006020501T patent/DE602006020501D1/de not_active Expired - Lifetime
- 2006-04-07 PL PL06724141T patent/PL2010563T3/pl unknown
- 2006-04-07 DK DK06724141.4T patent/DK2010563T3/da active
- 2006-04-07 HR HR20110386T patent/HRP20110386T1/hr unknown
- 2006-04-07 AT AT06724141T patent/ATE500265T1/de active
-
2008
- 2008-09-22 IL IL194274A patent/IL194274A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE500265T1 (de) | 2011-03-15 |
| AU2006341726B2 (en) | 2012-09-20 |
| WO2007115578A1 (en) | 2007-10-18 |
| CN101415726A (zh) | 2009-04-22 |
| AU2006341726A1 (en) | 2007-10-18 |
| IL194274A (en) | 2011-07-31 |
| JP2009532045A (ja) | 2009-09-10 |
| WO2007115578A8 (en) | 2008-10-30 |
| DE602006020501D1 (de) | 2011-04-14 |
| US8226930B2 (en) | 2012-07-24 |
| HK1121468A1 (en) | 2009-04-24 |
| EP2010563B1 (en) | 2011-03-02 |
| EP2010563A1 (en) | 2009-01-07 |
| US20090233856A1 (en) | 2009-09-17 |
| JP5102283B2 (ja) | 2012-12-19 |
| HRP20110386T1 (hr) | 2011-08-31 |
| PL2010563T3 (pl) | 2011-11-30 |
| SI2010563T1 (sl) | 2011-07-29 |
| CA2647125A1 (en) | 2007-10-18 |
| CA2647125C (en) | 2015-02-03 |
| CN101415726B (zh) | 2013-07-31 |
| ES2362195T3 (es) | 2011-06-29 |
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