DE602006020501D1 - Synthetische mecp2-sequenz für die proteinersatztherapie - Google Patents

Synthetische mecp2-sequenz für die proteinersatztherapie

Info

Publication number
DE602006020501D1
DE602006020501D1 DE602006020501T DE602006020501T DE602006020501D1 DE 602006020501 D1 DE602006020501 D1 DE 602006020501D1 DE 602006020501 T DE602006020501 T DE 602006020501T DE 602006020501 T DE602006020501 T DE 602006020501T DE 602006020501 D1 DE602006020501 D1 DE 602006020501D1
Authority
DE
Germany
Prior art keywords
protein
proteins
therapy
nucleic acid
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006020501T
Other languages
English (en)
Inventor
Franco Antonio Laccone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georg August Universitaet Goettingen
Universitaetsmedizin Goettingen Georg August Universitaet
Original Assignee
Georg August Universitaet Goettingen
Universitaetsmedizin Goettingen Georg August Universitaet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georg August Universitaet Goettingen, Universitaetsmedizin Goettingen Georg August Universitaet filed Critical Georg August Universitaet Goettingen
Publication of DE602006020501D1 publication Critical patent/DE602006020501D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
DE602006020501T 2006-04-07 2006-04-07 Synthetische mecp2-sequenz für die proteinersatztherapie Active DE602006020501D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2006/003203 WO2007115578A1 (en) 2006-04-07 2006-04-07 Synthetic mecp2 sequence for protein substitution therapy

Publications (1)

Publication Number Publication Date
DE602006020501D1 true DE602006020501D1 (de) 2011-04-14

Family

ID=36589309

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006020501T Active DE602006020501D1 (de) 2006-04-07 2006-04-07 Synthetische mecp2-sequenz für die proteinersatztherapie

Country Status (16)

Country Link
US (1) US8226930B2 (de)
EP (1) EP2010563B1 (de)
JP (1) JP5102283B2 (de)
CN (1) CN101415726B (de)
AT (1) ATE500265T1 (de)
AU (1) AU2006341726B2 (de)
CA (1) CA2647125C (de)
DE (1) DE602006020501D1 (de)
DK (1) DK2010563T3 (de)
ES (1) ES2362195T3 (de)
HK (1) HK1121468A1 (de)
HR (1) HRP20110386T1 (de)
IL (1) IL194274A (de)
PL (1) PL2010563T3 (de)
SI (1) SI2010563T1 (de)
WO (1) WO2007115578A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1398191B1 (it) * 2010-02-17 2013-02-14 Ist Superiore Sanita Uso di tossine che attivano le rho gtpasi per il trattamento e/o la prevenzione della sintomatologia associata alla sindrome di rett (rtt).
US9920317B2 (en) 2010-11-12 2018-03-20 The General Hospital Corporation Polycomb-associated non-coding RNAs
AU2011325956B2 (en) 2010-11-12 2016-07-14 The General Hospital Corporation Polycomb-associated non-coding RNAs
WO2013173598A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics, Inc. Compositions and methods for modulating atp2a2 expression
EP2850188A4 (de) 2012-05-16 2016-01-20 Rana Therapeutics Inc Zusammensetzungen und verfahren zur modulierung der expression der hämoglobin-genfamilien
CA2873794A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics Inc. Compositions and methods for modulating smn gene family expression
EA201492116A1 (ru) 2012-05-16 2015-05-29 Рана Терапьютикс, Инк. Композиции и способы для модулирования экспрессии mecp2
JP2015518713A (ja) 2012-05-16 2015-07-06 ラナ セラピューティクス インコーポレイテッド Ｕｔｒｎ発現を調節するための組成物及び方法
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
WO2014130408A1 (en) * 2013-02-20 2014-08-28 The Research Foundation For The State University Of New York Regulators of rab5 activity
CA2966044A1 (en) 2014-10-30 2016-05-06 The General Hospital Corporation Methods for modulating atrx-dependent gene repression
US10900036B2 (en) 2015-03-17 2021-01-26 The General Hospital Corporation RNA interactome of polycomb repressive complex 1 (PRC1)
TWI601821B (zh) * 2016-04-15 2017-10-11 中央研究院 治療神經發展性疾病
JP7170656B2 (ja) * 2017-03-24 2022-11-14 ザ ユニバーシティ コート オブ ザ ユニバーシティ オブ エジンバラ Ｍｅｃｐ２ベースの治療
WO2019079462A1 (en) * 2017-10-17 2019-04-25 President And Fellows Of Harvard College TRANSCRIPTION MODULATION SYSTEMS BASED ON CAS9
KR102052097B1 (ko) * 2017-11-30 2019-12-05 한국과학기술연구원 Mecp2 단백질 또는 이를 암호화하는 폴리뉴클레오티드를 포함하는 퇴행성 뇌질환 예방 또는 치료용 조성물
EP3973060A4 (de) * 2019-04-24 2023-05-10 The Trustees of The University of Pennsylvania Zur behandlung des rett-syndroms nützliche zusammensetzungen
WO2023235648A1 (en) * 2022-06-03 2023-12-07 The Regents Of The University Of California Nuclear Delivery and Transcriptional Repression with a Cell-penetrant MeCP2

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2364690A1 (en) * 1999-02-28 2000-10-19 Washington University Novel transduction molecules and methods for using same
US6709817B1 (en) * 1999-09-07 2004-03-23 Baylor College Of Medicine Method of screening Rett syndrome by detecting a mutation in MECP2
US20040126877A1 (en) * 2001-04-20 2004-07-01 Man-Wook Hur Repressors for hiv transcription and methods thereof
WO2005078099A1 (en) * 2004-02-17 2005-08-25 The Hospital For Sick Children Mecp2e1 gene

Also Published As

Publication number Publication date
HK1121468A1 (en) 2009-04-24
US8226930B2 (en) 2012-07-24
WO2007115578A1 (en) 2007-10-18
AU2006341726A1 (en) 2007-10-18
SI2010563T1 (sl) 2011-07-29
WO2007115578A8 (en) 2008-10-30
CN101415726B (zh) 2013-07-31
ES2362195T3 (es) 2011-06-29
CA2647125A1 (en) 2007-10-18
ATE500265T1 (de) 2011-03-15
AU2006341726B2 (en) 2012-09-20
DK2010563T3 (da) 2011-05-23
EP2010563B1 (de) 2011-03-02
CA2647125C (en) 2015-02-03
HRP20110386T1 (hr) 2011-08-31
US20090233856A1 (en) 2009-09-17
JP2009532045A (ja) 2009-09-10
IL194274A (en) 2011-07-31
JP5102283B2 (ja) 2012-12-19
EP2010563A1 (de) 2009-01-07
PL2010563T3 (pl) 2011-11-30
CN101415726A (zh) 2009-04-22

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