CY1111454T1 - Παραγωγα φαινυλο-πυραζολιου ως συνδετες υποδοχεα μη στεροειδων γλυκοκορτικοειδων - Google Patents
Παραγωγα φαινυλο-πυραζολιου ως συνδετες υποδοχεα μη στεροειδων γλυκοκορτικοειδωνInfo
- Publication number
- CY1111454T1 CY1111454T1 CY20111100112T CY111100112T CY1111454T1 CY 1111454 T1 CY1111454 T1 CY 1111454T1 CY 20111100112 T CY20111100112 T CY 20111100112T CY 111100112 T CY111100112 T CY 111100112T CY 1111454 T1 CY1111454 T1 CY 1111454T1
- Authority
- CY
- Cyprus
- Prior art keywords
- phynyl
- glycocorticoids
- pyrazoli
- steroid
- connectors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Η παρούσα εφεύρεση παρέχει ενώσεις του τύπου (I): μια μέθοδο παρασκευής τους, φαρμακευτικές συνθέσεις που περιέχουν τις ενώσεις και την παρασκευή των αναφερόμενων ενώσεων, ενδιάμεσες ενώσεις και τη χρήση των ενώσεων για την παρασκευή ενός φαρμάκου για θεραπευτική αντιμετώπιση, και ιδιαίτερα για τη θεραπεία φλεγμονής, αλλεργίας και/ή αυτοάνοσων καταστάσεων.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0611587.7A GB0611587D0 (en) | 2006-06-12 | 2006-06-12 | Novel compounds |
GB0625457A GB0625457D0 (en) | 2006-12-20 | 2006-12-20 | Novel compounds |
GB0710217A GB0710217D0 (en) | 2007-05-29 | 2007-05-29 | Novel compounds |
EP07765362A EP2029549B1 (en) | 2006-06-12 | 2007-06-11 | Phenyl-pyrazole derivatives as non-steroidal glucocoricoid receptor ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1111454T1 true CY1111454T1 (el) | 2015-08-05 |
Family
ID=38659745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100112T CY1111454T1 (el) | 2006-06-12 | 2011-02-02 | Παραγωγα φαινυλο-πυραζολιου ως συνδετες υποδοχεα μη στεροειδων γλυκοκορτικοειδων |
Country Status (29)
Country | Link |
---|---|
US (2) | US8247377B2 (el) |
EP (1) | EP2029549B1 (el) |
JP (1) | JP5497433B2 (el) |
KR (1) | KR101411276B1 (el) |
CN (1) | CN101501003B (el) |
AR (1) | AR061341A1 (el) |
AT (1) | ATE487703T1 (el) |
AU (1) | AU2007260067B2 (el) |
BR (1) | BRPI0713755A8 (el) |
CA (1) | CA2659564C (el) |
CR (1) | CR10489A (el) |
CY (1) | CY1111454T1 (el) |
DE (1) | DE602007010456D1 (el) |
DK (1) | DK2029549T3 (el) |
EA (1) | EA015540B1 (el) |
ES (1) | ES2355165T3 (el) |
GB (1) | GB0611587D0 (el) |
HK (1) | HK1127609A1 (el) |
HR (1) | HRP20110097T1 (el) |
IL (1) | IL195492A0 (el) |
MA (1) | MA30514B1 (el) |
MX (1) | MX2008015977A (el) |
NO (1) | NO20085100L (el) |
PL (1) | PL2029549T3 (el) |
PT (1) | PT2029549E (el) |
SI (1) | SI2029549T1 (el) |
TW (1) | TW200815360A (el) |
WO (1) | WO2007144327A2 (el) |
ZA (1) | ZA200810161B (el) |
Families Citing this family (23)
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GB0611587D0 (en) * | 2006-06-12 | 2006-07-19 | Glaxo Group Ltd | Novel compounds |
CN102137858B (zh) | 2008-05-23 | 2014-07-23 | 潘米拉制药有限责任公司 | 5-脂氧合酶-活化蛋白抑制剂 |
EP2487159A1 (en) | 2011-02-11 | 2012-08-15 | MSD Oss B.V. | RorgammaT inhibitors |
US10307167B2 (en) | 2012-12-14 | 2019-06-04 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
US10813630B2 (en) | 2011-08-09 | 2020-10-27 | Corquest Medical, Inc. | Closure system for atrial wall |
US10314594B2 (en) | 2012-12-14 | 2019-06-11 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
JP5601422B2 (ja) | 2011-08-18 | 2014-10-08 | 日本新薬株式会社 | ヘテロ環誘導体及び医薬 |
WO2014026330A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
WO2014026327A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 4-heteroaryl substituted benzoic acid compounds as rorgammat inhibitors and uses thereof |
WO2014026329A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | N-alkylated indole and indazole compounds as rorgammat inhibitors and uses thereof |
US20140142689A1 (en) | 2012-11-21 | 2014-05-22 | Didier De Canniere | Device and method of treating heart valve malfunction |
CN103468812B (zh) * | 2013-09-17 | 2015-02-25 | 安徽医科大学 | 一种检测糖皮质激素治疗sle疗效的试剂盒 |
US9566443B2 (en) | 2013-11-26 | 2017-02-14 | Corquest Medical, Inc. | System for treating heart valve malfunction including mitral regurgitation |
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US10842626B2 (en) | 2014-12-09 | 2020-11-24 | Didier De Canniere | Intracardiac device to correct mitral regurgitation |
CA2975997A1 (en) | 2015-02-11 | 2016-08-18 | Merck Sharp & Dohme Corp. | Substituted pyrazole compounds as rorgammat inhibitors and uses thereof |
CN104774950B (zh) * | 2015-04-21 | 2017-10-03 | 安徽医科大学 | 一种基于hsp90aa1基因型预测糖皮质激素治疗sle疗效的试剂盒 |
JP2018531957A (ja) | 2015-10-27 | 2018-11-01 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | RORγT阻害薬としての置換二環式ピラゾール化合物及びその使用 |
EP3368535B1 (en) | 2015-10-27 | 2020-12-02 | Merck Sharp & Dohme Corp. | Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof |
MX2018005004A (es) | 2015-10-27 | 2018-09-12 | Merck Sharp & Dohme | Compuestos de indazol substituidos como inhibidores de rorgammat y sus usos. |
CN110452203B (zh) * | 2019-08-29 | 2021-04-13 | 忻州师范学院 | 一种1-氧代-1,3-二氢-3-羟基苯并呋喃-5-甲酸的制备方法 |
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UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
ATE494285T1 (de) | 2003-10-14 | 2011-01-15 | Glaxo Group Ltd | Muscarinische acetylcholin-rezeptor-antagonisten |
WO2005044354A1 (en) | 2003-11-03 | 2005-05-19 | Glaxo Group Limited | A fluid dispensing device |
TW200524577A (en) | 2003-11-04 | 2005-08-01 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
AR050902A1 (es) | 2004-04-27 | 2006-12-06 | Glaxo Group Ltd | Compuesto de quinuclidina, composicion farmaceutica que lo comprende y su usopara preparar dicha composicion |
AR049384A1 (es) | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
WO2006000398A1 (en) | 2004-06-28 | 2006-01-05 | Glaxo Group Limited | 2,3-benzoxazin derivatives as non-steroidal glucocorticoid receptor modulators |
WO2006000401A1 (en) | 2004-06-28 | 2006-01-05 | Glaxo Group Limited | Substituted oxazines as glucocorticoid receptor modulators |
GB0418045D0 (en) | 2004-08-12 | 2004-09-15 | Glaxo Group Ltd | Compounds |
RU2391338C2 (ru) | 2004-10-19 | 2010-06-10 | Ф.Хоффманн-Ля Рош Аг | Производные хинолина |
ATE517908T1 (de) | 2005-01-10 | 2011-08-15 | Glaxo Group Ltd | Androstan-17-alpha-carbonat-derivate zur verwendung bei der behandlung allergischer und entzündlicher zustände |
US20090124588A1 (en) | 2005-01-10 | 2009-05-14 | Glaxo Group Limited | Androstane 17-Alpha-Carbonate for Use in the Treatment of Inflammatory and Allergic Conditions |
WO2006108699A1 (en) * | 2005-04-14 | 2006-10-19 | Glaxo Group Limited | Indazoles as glucocorticoid receptor ligands |
GB0513297D0 (en) | 2005-06-29 | 2005-08-03 | Glaxo Group Ltd | Novel compounds |
GB0611587D0 (en) * | 2006-06-12 | 2006-07-19 | Glaxo Group Ltd | Novel compounds |
WO2008000777A2 (en) * | 2006-06-29 | 2008-01-03 | Glaxo Group Limited | Phenyl- pyrazole derivatives, process for their preparation and their pharmaceutical use |
-
2006
- 2006-06-12 GB GBGB0611587.7A patent/GB0611587D0/en not_active Ceased
-
2007
- 2007-06-11 DE DE602007010456T patent/DE602007010456D1/de active Active
- 2007-06-11 EA EA200802322A patent/EA015540B1/ru not_active IP Right Cessation
- 2007-06-11 US US12/303,791 patent/US8247377B2/en active Active
- 2007-06-11 ES ES07765362T patent/ES2355165T3/es active Active
- 2007-06-11 AU AU2007260067A patent/AU2007260067B2/en active Active
- 2007-06-11 PL PL07765362T patent/PL2029549T3/pl unknown
- 2007-06-11 AT AT07765362T patent/ATE487703T1/de active
- 2007-06-11 AR ARP070102547A patent/AR061341A1/es unknown
- 2007-06-11 BR BRPI0713755A patent/BRPI0713755A8/pt not_active Application Discontinuation
- 2007-06-11 MX MX2008015977A patent/MX2008015977A/es active IP Right Grant
- 2007-06-11 PT PT07765362T patent/PT2029549E/pt unknown
- 2007-06-11 JP JP2009514772A patent/JP5497433B2/ja active Active
- 2007-06-11 EP EP07765362A patent/EP2029549B1/en active Active
- 2007-06-11 SI SI200730484T patent/SI2029549T1/sl unknown
- 2007-06-11 WO PCT/EP2007/055724 patent/WO2007144327A2/en active Application Filing
- 2007-06-11 DK DK07765362.4T patent/DK2029549T3/da active
- 2007-06-11 TW TW096121030A patent/TW200815360A/zh unknown
- 2007-06-11 CN CN2007800295932A patent/CN101501003B/zh active Active
- 2007-06-11 KR KR1020097000591A patent/KR101411276B1/ko active IP Right Grant
- 2007-06-11 CA CA2659564A patent/CA2659564C/en active Active
-
2008
- 2008-11-25 IL IL195492A patent/IL195492A0/en unknown
- 2008-11-28 ZA ZA200810161A patent/ZA200810161B/xx unknown
- 2008-12-08 NO NO20085100A patent/NO20085100L/no not_active Application Discontinuation
- 2008-12-10 CR CR10489A patent/CR10489A/es not_active Application Discontinuation
- 2008-12-12 MA MA31473A patent/MA30514B1/fr unknown
-
2009
- 2009-07-22 HK HK09106729.6A patent/HK1127609A1/xx unknown
-
2011
- 2011-02-02 CY CY20111100112T patent/CY1111454T1/el unknown
- 2011-02-08 HR HR20110097T patent/HRP20110097T1/hr unknown
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2012
- 2012-07-13 US US13/548,573 patent/US20120277279A1/en not_active Abandoned
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