BR112014028644A2 - Composições e métodos para modulação da expressão de atp2a2 - Google Patents

Composições e métodos para modulação da expressão de atp2a2

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Publication number
BR112014028644A2
BR112014028644A2 BR112014028644A BR112014028644A BR112014028644A2 BR 112014028644 A2 BR112014028644 A2 BR 112014028644A2 BR 112014028644 A BR112014028644 A BR 112014028644A BR 112014028644 A BR112014028644 A BR 112014028644A BR 112014028644 A2 BR112014028644 A2 BR 112014028644A2
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Brazil
Prior art keywords
methods
compositions
expression
atp2a2
modulation
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BR112014028644A
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English (en)
Inventor
M Krieg Arthur
Subramanian Romesh
Mcswiggen James
T Lee Jeannie
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Rana Therapeutics Inc
The General Hospital Corp D/B/A Massachusetts General Hospital
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Application filed by Rana Therapeutics Inc, The General Hospital Corp D/B/A Massachusetts General Hospital filed Critical Rana Therapeutics Inc
Publication of BR112014028644A2 publication Critical patent/BR112014028644A2/pt

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Abstract

COMPOSIÇÕES E MÉTODOS PARA MODULAÇÃO DA EXPRESSÃO DE ATP2A2. Aspectos da invenção proporcionam oligonucleotídeos de fita simples para ativação ou intensificação da expressão de ATP2A2. Aspectos adicionais proporcionam composições e estojos compreendendo oligonucleotideos de fita simples para ativação ou intensificação da expressão de ATP2A2. Também são proporcionados métodos para modulação da expressão de ATP2A2 usando os oligonucleotídeos de fita simples. Aspectos adicionais da invenção proporcionam métodos para seleção de um oligonucleotídeo candidato para ativação ou intensificação da expressão de ATP2A2.
BR112014028644A 2012-05-16 2013-05-16 Composições e métodos para modulação da expressão de atp2a2 BR112014028644A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261647925P 2012-05-16 2012-05-16
US201361785832P 2013-03-14 2013-03-14
PCT/US2013/041381 WO2013173598A1 (en) 2012-05-16 2013-05-16 Compositions and methods for modulating atp2a2 expression

Publications (1)

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BR112014028644A2 true BR112014028644A2 (pt) 2017-08-15

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US (1) US10174323B2 (pt)
EP (1) EP2850182A4 (pt)
JP (1) JP2015523853A (pt)
CN (1) CN104583401A (pt)
AU (1) AU2013262699A1 (pt)
BR (1) BR112014028644A2 (pt)
CA (1) CA2873766A1 (pt)
EA (1) EA201492120A1 (pt)
WO (1) WO2013173598A1 (pt)

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CN104583401A (zh) 2015-04-29
US20150159160A1 (en) 2015-06-11

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