ATE151467T1 - Durch modifikationen an der 3'-terminalen phosphodiesterbindung stabilisierte dna moleküle, ihre verwendung als nukleinsäuresonden sowie als therapeutische mittel zur hemmung der expression spezifischer zielgene - Google Patents

Durch modifikationen an der 3'-terminalen phosphodiesterbindung stabilisierte dna moleküle, ihre verwendung als nukleinsäuresonden sowie als therapeutische mittel zur hemmung der expression spezifischer zielgene

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Publication number
ATE151467T1
ATE151467T1 AT88910300T AT88910300T ATE151467T1 AT E151467 T1 ATE151467 T1 AT E151467T1 AT 88910300 T AT88910300 T AT 88910300T AT 88910300 T AT88910300 T AT 88910300T AT E151467 T1 ATE151467 T1 AT E151467T1
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Prior art keywords
expression
therapeutic agents
inhibiting
nucleic acid
modifications
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AT88910300T
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English (en)
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Joseph A Walder
Roxanne Y Walder
Paul S Eder
John M Dagle
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Univ Iowa Res Found
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Publication of ATE151467T1 publication Critical patent/ATE151467T1/de

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/311—Phosphotriesters
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    • C12N2310/3521—Methyl
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3527—Other alkyl chain
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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AT88910300T 1987-11-30 1988-10-31 Durch modifikationen an der 3'-terminalen phosphodiesterbindung stabilisierte dna moleküle, ihre verwendung als nukleinsäuresonden sowie als therapeutische mittel zur hemmung der expression spezifischer zielgene ATE151467T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12656487A 1987-11-30 1987-11-30

Publications (1)

Publication Number Publication Date
ATE151467T1 true ATE151467T1 (de) 1997-04-15

Family

ID=22425523

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88910300T ATE151467T1 (de) 1987-11-30 1988-10-31 Durch modifikationen an der 3'-terminalen phosphodiesterbindung stabilisierte dna moleküle, ihre verwendung als nukleinsäuresonden sowie als therapeutische mittel zur hemmung der expression spezifischer zielgene

Country Status (7)

Country Link
US (3) US5491133A (de)
EP (1) EP0348458B1 (de)
JP (1) JP3019994B2 (de)
AT (1) ATE151467T1 (de)
CA (1) CA1339935C (de)
DE (1) DE3855864T2 (de)
WO (1) WO1989005358A1 (de)

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US5491133A (en) 1996-02-13
US5962425A (en) 1999-10-05
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