EA201492119A1 - Композиции и способы для модулирования экспрессии apoa1 и abca1 - Google Patents

Композиции и способы для модулирования экспрессии apoa1 и abca1

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Publication number
EA201492119A1
EA201492119A1 EA201492119A EA201492119A EA201492119A1 EA 201492119 A1 EA201492119 A1 EA 201492119A1 EA 201492119 A EA201492119 A EA 201492119A EA 201492119 A EA201492119 A EA 201492119A EA 201492119 A1 EA201492119 A1 EA 201492119A1
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Prior art keywords
abca1
expression
apoa1
methods
modulating
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EA201492119A
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English (en)
Inventor
Артур М. Криг
Ромеш Субраманиан
Джеймс Максвиджен
Джинни Т. Ли
Original Assignee
Рана Терапьютикс, Инк.
ДЗЕ ДЖЕНЕРАЛ ХОСПИТАЛ КОРПОРЕЙШН д/б/а МАССАЧУСЕТС ДЖЕНЕРАЛ ХОСПИТАЛ
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Application filed by Рана Терапьютикс, Инк., ДЗЕ ДЖЕНЕРАЛ ХОСПИТАЛ КОРПОРЕЙШН д/б/а МАССАЧУСЕТС ДЖЕНЕРАЛ ХОСПИТАЛ filed Critical Рана Терапьютикс, Инк.
Publication of EA201492119A1 publication Critical patent/EA201492119A1/ru

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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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Abstract

Аспекты настоящего изобретения относятся к одноцепочечным олигонуклеотидам для активации или усиления экспрессии АРОА1 или АВСА1. Дополнительные аспекты относятся к композициям и наборам, содержащим одноцепочечные олигонуклеотиды для активации или усиления экспрессии АРОА1 или АВСА1. Также предложены способы модулирования экспрессии АРОА1 или АВСА1 с использованием одноцепочечных олигонуклеотидов. Дополнительные аспекты настоящего изобретения относятся к способам отбора олигонуклеотида-кандидата для активации или усиления экспрессии АРОА1 или АВСА1.
EA201492119A 2012-05-16 2013-05-16 Композиции и способы для модулирования экспрессии apoa1 и abca1 EA201492119A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261647949P 2012-05-16 2012-05-16
US201361785778P 2013-03-14 2013-03-14
PCT/US2013/041455 WO2013173647A1 (en) 2012-05-16 2013-05-16 Compositions and methods for modulating apoa1 and abca1 expression

Publications (1)

Publication Number Publication Date
EA201492119A1 true EA201492119A1 (ru) 2015-05-29

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US (1) US20150191722A1 (ru)
EP (1) EP2849801A4 (ru)
JP (1) JP2015523855A (ru)
CN (1) CN104582737A (ru)
AU (1) AU2013262658A1 (ru)
BR (1) BR112014028645A2 (ru)
CA (1) CA2873801A1 (ru)
EA (1) EA201492119A1 (ru)
WO (1) WO2013173647A1 (ru)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9920317B2 (en) 2010-11-12 2018-03-20 The General Hospital Corporation Polycomb-associated non-coding RNAs
EP3702460A1 (en) 2010-11-12 2020-09-02 The General Hospital Corporation Polycomb-associated non-coding rnas
AU2012308320C1 (en) 2011-09-14 2018-08-23 Translate Bio Ma, Inc. Multimeric oligonucleotide compounds
WO2013148260A1 (en) 2012-03-30 2013-10-03 Washington University Methods for modulating tau expression for reducing seizure and modifying a neurodegenerative syndrome
WO2013173645A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics, Inc. Compositions and methods for modulating utrn expression
EP2850190B1 (en) 2012-05-16 2020-07-08 Translate Bio MA, Inc. Compositions and methods for modulating mecp2 expression
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
US10174315B2 (en) 2012-05-16 2019-01-08 The General Hospital Corporation Compositions and methods for modulating hemoglobin gene family expression
DK2850186T3 (en) 2012-05-16 2019-04-08 Translate Bio Ma Inc COMPOSITIONS AND PROCEDURES FOR MODULATING SMN GENFAMILY EXPRESSION
WO2013173598A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics, Inc. Compositions and methods for modulating atp2a2 expression
EP2895200B1 (en) 2012-09-14 2019-11-06 Translate Bio MA, Inc. Multimeric oligonucleotide compounds
EP2971142B1 (en) 2013-03-14 2020-06-24 Ionis Pharmaceuticals, Inc. Compositions and methods for modulating tau expression
EP3730614A3 (en) * 2013-07-02 2020-12-30 Ionis Pharmaceuticals, Inc. Modulators of growth hormone receptor
TWI657819B (zh) 2013-07-19 2019-05-01 美商Ionis製藥公司 用於調節τ蛋白表現之組合物
WO2015023941A1 (en) 2013-08-16 2015-02-19 Rana Therapeutics, Inc. Oligonucleotides targeting euchromatin regions of genes
WO2015162422A1 (en) * 2014-04-22 2015-10-29 Mina Therapeutics Limited Sarna compositions and methods of use
KR102149571B1 (ko) 2014-05-01 2020-08-31 아이오니스 파마수티컬즈, 인코포레이티드 성장 호르몬 수용체 발현을 조절하기 위한 조성물 및 방법
CA2966044A1 (en) 2014-10-30 2016-05-06 The General Hospital Corporation Methods for modulating atrx-dependent gene repression
EP3256590A4 (en) * 2015-02-13 2018-10-03 Translate Bio Ma, Inc. Targeting oligonucleotides and uses thereof to modulate gene expression
EP3256591A4 (en) 2015-02-13 2018-08-08 Translate Bio Ma, Inc. Hybrid oligonucleotides and uses thereof
WO2016149455A2 (en) 2015-03-17 2016-09-22 The General Hospital Corporation The rna interactome of polycomb repressive complex 1 (prc1)
JOP20190065A1 (ar) 2016-09-29 2019-03-28 Ionis Pharmaceuticals Inc مركبات وطرق لتقليل التعبير عن tau
JP7130639B2 (ja) 2016-11-01 2022-09-05 ザ・リサーチ・ファウンデーション・フォー・ザ・ステイト・ユニヴァーシティ・オブ・ニューヨーク ５－ハロウラシル修飾マイクロｒｎａ及びがんの処置におけるその使用
AU2017368050A1 (en) 2016-11-29 2019-06-20 Puretech Lyt, Inc. Exosomes for delivery of therapeutic agents
US20200208152A1 (en) 2017-09-08 2020-07-02 Mina Therapeutics Limited Stabilized sarna compositions and methods of use
EP3679138B1 (en) 2017-09-08 2023-03-22 MiNA Therapeutics Limited Hnf4a sarna compositions and methods of use
GB2610100B (en) * 2017-10-23 2023-08-16 Stoke Therapeutics Inc Antisense oligomers for treatment of non-sense mediated RNA decay based conditions and diseases
CA3088071A1 (en) * 2018-02-09 2019-08-15 Genentech, Inc. Oligonucleotides for modulating tmem106b expression
PE20210346A1 (es) * 2018-07-03 2021-02-25 Hoffmann La Roche Oligonucleotidos para modular la expresion de tau
EP3847026B1 (en) 2018-09-04 2024-08-28 Prototype and Production Systems, Inc. Mobile printhead cleaner for print module
EP4017539A1 (en) 2019-08-19 2022-06-29 MiNA Therapeutics Limited Oligonucleotide conjugate compositions and methods of use
US20220193110A1 (en) * 2020-12-17 2022-06-23 Washington University Nxtar-derived oligonucleotides and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1100895B1 (en) * 1999-03-15 2007-06-13 University of British Columbia Abc1 polypeptide and methods and reagents for modulating cholesterol levels
AU2567002A (en) * 2000-11-20 2002-05-27 Univ Illinois Membrane scaffold proteins
AU2002344853A1 (en) * 2001-06-14 2003-01-02 Active Pass Pharmaceuticals, Inc. Abca10 transporter
US7259150B2 (en) * 2001-08-07 2007-08-21 Isis Pharmaceuticals, Inc. Modulation of apolipoprotein (a) expression
US20050265927A1 (en) * 2004-05-17 2005-12-01 Yale University Intranasal delivery of nucleic acid molecules
WO2008103761A2 (en) * 2007-02-20 2008-08-28 Sequenom, Inc. Methods and compositions for cancer diagnosis and treatment based on nucleic acid methylation
MY188457A (en) * 2008-10-03 2021-12-10 Opko Curna Llc Treatment of apolipoprotein-a1 related diseases by inhibition of natural antisense transcript to apolipoprotein-a1
GB0821457D0 (en) * 2008-11-24 2008-12-31 Trillion Genomics Ltd Oligonucleotides
CA2761152A1 (en) * 2009-05-06 2010-11-11 Opko Curna, Llc Treatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene
EP2655621B1 (en) * 2010-12-20 2018-05-23 The General Hospital Corporation Polycomb-associated non-coding rnas
WO2013173652A1 (en) * 2012-05-16 2013-11-21 Rana Therapeutics, Inc. Compositions and methods for modulating gene expression

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WO2013173647A1 (en) 2013-11-21
AU2013262658A1 (en) 2015-01-22
EP2849801A4 (en) 2016-05-25
CN104582737A (zh) 2015-04-29
BR112014028645A2 (pt) 2017-06-27
JP2015523855A (ja) 2015-08-20
US20150191722A1 (en) 2015-07-09
CA2873801A1 (en) 2013-11-21
EP2849801A1 (en) 2015-03-25

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