EA201492114A1 - Композиции и способы для модулирования экспрессии генов - Google Patents

Композиции и способы для модулирования экспрессии генов

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Publication number
EA201492114A1
EA201492114A1 EA201492114A EA201492114A EA201492114A1 EA 201492114 A1 EA201492114 A1 EA 201492114A1 EA 201492114 A EA201492114 A EA 201492114A EA 201492114 A EA201492114 A EA 201492114A EA 201492114 A1 EA201492114 A1 EA 201492114A1
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Prior art keywords
methods
gene expression
compositions
modulating gene
oligonucleotides
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EA201492114A
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English (en)
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Артур М. Криг
Ромеш Субраманиан
Джеймс Максвиджен
Джинни Т. Ли
Original Assignee
Рана Терапьютикс, Инк.
ДЗЕ ДЖЕНЕРАЛ ХОСПИТАЛ КОРПОРЕЙШН д/б/а МАССАЧУСЕТС ДЖЕНЕРАЛ ХОСПИТАЛ
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49584310&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201492114(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Рана Терапьютикс, Инк., ДЗЕ ДЖЕНЕРАЛ ХОСПИТАЛ КОРПОРЕЙШН д/б/а МАССАЧУСЕТС ДЖЕНЕРАЛ ХОСПИТАЛ filed Critical Рана Терапьютикс, Инк.
Publication of EA201492114A1 publication Critical patent/EA201492114A1/ru

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Abstract

Аспекты настоящего изобретения предлагают способы отбора олигонуклеотида-кандидата для активации экспрессии целевого гена. Дополнительные аспекты настоящего изобретения относятся к способам отбора множества олигонуклеотидов, с помощью которых обогащено олигонуклеотидами, которые активируют экспрессию целевого гена. Дополнительные аспекты относятся к одноцепочечным олигонуклеотидам, которые модулируют экспрессию генов, и к содержащим их композициям и наборам. Также предложены способы модулирования экспрессии генов с помощью одноцепочечных олигонуклеотидов.
EA201492114A 2012-05-16 2013-05-16 Композиции и способы для модулирования экспрессии генов EA201492114A1 (ru)

Applications Claiming Priority (18)

Application Number Priority Date Filing Date Title
US201261647901P 2012-05-16 2012-05-16
US201261648051P 2012-05-16 2012-05-16
US201261647949P 2012-05-16 2012-05-16
US201261648058P 2012-05-16 2012-05-16
US201261647886P 2012-05-16 2012-05-16
US201261647925P 2012-05-16 2012-05-16
US201261647858P 2012-05-16 2012-05-16
US201261648041P 2012-05-16 2012-05-16
US201261648021P 2012-05-16 2012-05-16
US201261648016P 2012-05-16 2012-05-16
US201261719394P 2012-10-27 2012-10-27
US201361785832P 2013-03-14 2013-03-14
US201361785529P 2013-03-14 2013-03-14
US201361785885P 2013-03-14 2013-03-14
US201361785778P 2013-03-14 2013-03-14
US201361785956P 2013-03-14 2013-03-14
US201361786232P 2013-03-14 2013-03-14
PCT/US2013/041461 WO2013173652A1 (en) 2012-05-16 2013-05-16 Compositions and methods for modulating gene expression

Publications (1)

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EA201492114A1 true EA201492114A1 (ru) 2015-04-30

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US (2) US20150133362A1 (ru)
EP (2) EP2850189B8 (ru)
JP (1) JP2015518714A (ru)
KR (1) KR102028784B1 (ru)
CN (1) CN104583398A (ru)
AU (1) AU2013262663A1 (ru)
CA (1) CA2873809A1 (ru)
DK (1) DK2850189T3 (ru)
EA (1) EA201492114A1 (ru)
WO (1) WO2013173652A1 (ru)

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EP3511416A1 (en) 2019-07-17
AU2013262663A1 (en) 2015-01-22
EP2850189B1 (en) 2018-11-07
KR102028784B1 (ko) 2019-10-04
DK2850189T3 (en) 2019-02-25
JP2015518714A (ja) 2015-07-06
US20150218560A1 (en) 2015-08-06
WO2013173652A1 (en) 2013-11-21
KR20160073885A (ko) 2016-06-27
EP2850189A1 (en) 2015-03-25
EP2850189A4 (en) 2016-01-06
EP2850189B8 (en) 2019-01-23
CN104583398A (zh) 2015-04-29

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