BR112014028646A2 - Composições e métodos para modulação da expressão de pten - Google Patents

Composições e métodos para modulação da expressão de pten

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Publication number
BR112014028646A2
BR112014028646A2 BR112014028646A BR112014028646A BR112014028646A2 BR 112014028646 A2 BR112014028646 A2 BR 112014028646A2 BR 112014028646 A BR112014028646 A BR 112014028646A BR 112014028646 A BR112014028646 A BR 112014028646A BR 112014028646 A2 BR112014028646 A2 BR 112014028646A2
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Brazil
Prior art keywords
pten expression
methods
compositions
expression modulation
activating
Prior art date
Application number
BR112014028646A
Other languages
English (en)
Inventor
M Krieg Arthur
Subramanian Romesh
Mcswiggen James
T Lee Jeannie
Original Assignee
Rana Therapeutics Inc
The General Hospital Corp D/B/A Massachusetts General Hospital
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Publication date
Application filed by Rana Therapeutics Inc, The General Hospital Corp D/B/A Massachusetts General Hospital filed Critical Rana Therapeutics Inc
Publication of BR112014028646A2 publication Critical patent/BR112014028646A2/pt

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N2310/351—Conjugate

Abstract

COMPOSIÇÕES E MÉTODOS PARA MODULAÇÃO DA EXPRESSÃO DE PTEN. Aspectos da invenção proporcionam oligonucleotídeos de fita simples para ativação ou intensificação da expressão de PTEN. Aspectos adicionais proporcionam composições e estojos compreendendo oligonucleotídeos de fita simples para ativação ou intensificação da expressão de PTEN. Também são proporcionados métodos para modulação da expressão de PTEN usando os oligonucleotídeos de fita simples. Aspectos adicionais da invenção proporcionam métodos para seleção de um oligonucleotídeo candidato para ativação ou intensificação da expressão de PTEN.
BR112014028646A 2012-05-16 2013-05-16 Composições e métodos para modulação da expressão de pten BR112014028646A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261648041P 2012-05-16 2012-05-16
US201361785885P 2013-03-14 2013-03-14
PCT/US2013/041389 WO2013173605A1 (en) 2012-05-16 2013-05-16 Compositions and methods for modulating pten expression

Publications (1)

Publication Number Publication Date
BR112014028646A2 true BR112014028646A2 (pt) 2017-08-15

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Country Status (9)

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US (1) US20150159161A1 (pt)
EP (1) EP2850187A4 (pt)
JP (1) JP2015519057A (pt)
CN (1) CN104583400A (pt)
AU (1) AU2013262706A1 (pt)
BR (1) BR112014028646A2 (pt)
CA (1) CA2873776A1 (pt)
EA (1) EA201492118A1 (pt)
WO (1) WO2013173605A1 (pt)

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Publication number Publication date
CA2873776A1 (en) 2013-11-21
CN104583400A (zh) 2015-04-29
EP2850187A1 (en) 2015-03-25
EP2850187A4 (en) 2016-01-20
AU2013262706A1 (en) 2015-01-22
WO2013173605A1 (en) 2013-11-21
WO2013173605A8 (en) 2014-11-27
EA201492118A1 (ru) 2015-04-30
US20150159161A1 (en) 2015-06-11
JP2015519057A (ja) 2015-07-09

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