EP1157275A4 - Neue transduktionsmoleküle und verfahren zum benutzen derselben - Google Patents
Neue transduktionsmoleküle und verfahren zum benutzen derselbenInfo
- Publication number
- EP1157275A4 EP1157275A4 EP00962058A EP00962058A EP1157275A4 EP 1157275 A4 EP1157275 A4 EP 1157275A4 EP 00962058 A EP00962058 A EP 00962058A EP 00962058 A EP00962058 A EP 00962058A EP 1157275 A4 EP1157275 A4 EP 1157275A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- same
- transduction molecules
- novel transduction
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title 1
- 230000026683 transduction Effects 0.000 title 1
- 238000010361 transduction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Environmental Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12275799P | 1999-02-28 | 1999-02-28 | |
US122757P | 1999-02-28 | ||
US15129199P | 1999-08-29 | 1999-08-29 | |
US151291P | 1999-08-29 | ||
PCT/US2000/005097 WO2000062067A1 (en) | 1999-02-28 | 2000-02-28 | Novel transduction molecules and methods for using same |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1157275A1 EP1157275A1 (de) | 2001-11-28 |
EP1157275A4 true EP1157275A4 (de) | 2003-01-15 |
Family
ID=26820859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00962058A Withdrawn EP1157275A4 (de) | 1999-02-28 | 2000-02-28 | Neue transduktionsmoleküle und verfahren zum benutzen derselben |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1157275A4 (de) |
JP (1) | JP2003514765A (de) |
AU (1) | AU7497000A (de) |
CA (1) | CA2364690A1 (de) |
WO (1) | WO2000062067A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE319447T1 (de) | 1999-08-16 | 2006-03-15 | Revaax Pharmaceuticals Llc | Pharmazeutische zubereitungen die clavulansäure oder derivate enthalten zur behandlund von neurologischen störungen |
US6881825B1 (en) | 1999-09-01 | 2005-04-19 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Identication of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and virues |
FR2816845B1 (fr) | 2000-11-20 | 2006-10-20 | Centre Nat Rech Scient | Vecteurs de transport a travers un epithelium a jonctions serrees |
US20020073441A1 (en) | 2000-12-13 | 2002-06-13 | Ross Brian D. | Compositions and methods for detecting proteolytic activity |
FR2818982B1 (fr) * | 2000-12-29 | 2003-10-31 | Univ Rennes | Inhibiteur specifique du systeme ubiquitine-proteasome et applications therapeutiques correspondantes |
WO2003006619A2 (en) * | 2001-07-13 | 2003-01-23 | Clf Medical Technology Acceleration Program, Inc | Calcineurin modulators |
FR2829940A1 (fr) * | 2001-09-27 | 2003-03-28 | Synt Em | Compositions pour la vectorisation d'anticorps a travers la barriere hematoencephalique et leur utilisation pour le diagnostic ou le traitement des maladies du systeme nerveux central |
DE60336341D1 (de) | 2002-05-04 | 2011-04-21 | Acorda Therapeutics Inc | Zusammensetzungen und verfahren zur förderung des neuronalen wachstums |
AU2003238872A1 (en) * | 2002-06-04 | 2003-12-19 | Avicena Group, Inc. | Methods of treating cognitive dysfunction by modulating brain energy metabolism |
EP1947116B1 (de) * | 2003-02-10 | 2017-06-21 | 2-BBB Medicines B.V. | Differenziell exprimierte Nukleinsäuren der Blut-Hirnschranke bei einer Entzündung |
US7166692B2 (en) | 2003-03-04 | 2007-01-23 | Canbrex Bio Science Walkersville, Inc. | Intracellular delivery of small molecules, proteins, and nucleic acids |
ES2887949T3 (es) | 2003-05-16 | 2021-12-29 | Acorda Therapeutics Inc | Mutantes degradantes de proteoglicanos para el tratamiento del SNC |
US7959914B2 (en) | 2003-05-16 | 2011-06-14 | Acorda Therapeutics, Inc. | Methods of reducing extravasation of inflammatory cells |
MX351062B (es) * | 2003-05-16 | 2017-09-29 | Acorda Therapeutics Inc | Proteinas de fusion para el tratamiento del snc. |
WO2005000887A1 (en) * | 2003-06-30 | 2005-01-06 | Universite De Lausanne | Rasgap derived peptide for selectively killing cancer cells |
CN1648135A (zh) * | 2004-01-20 | 2005-08-03 | 中国人民解放军军事医学科学院毒物药物研究所 | 转导肽-人源胆碱乙酰基转移酶融合蛋白及其应用 |
CA2566731C (en) | 2004-05-18 | 2012-07-24 | Acorda Therapeutics, Inc. | Methods of purifying chondroitinase and stable formulations thereof |
DK1988167T3 (da) * | 2005-02-17 | 2020-07-13 | Univ Sorbonne | Intracellulære inhiberende peptider |
WO2008036060A2 (en) | 2005-04-05 | 2008-03-27 | Allergan, Inc. | Clostridial toxin activity assays |
CA2623635C (en) | 2005-09-26 | 2013-04-02 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase abci mutants |
JP4677319B2 (ja) * | 2005-10-05 | 2011-04-27 | 東亞合成株式会社 | 神経分化抑制ペプチド及びその利用 |
AU2006304392B2 (en) | 2005-10-18 | 2014-05-01 | National Jewish Health | Conditionally immortalized long-term stem cells and methods of making and using such cells |
JP5102283B2 (ja) | 2006-04-07 | 2012-12-19 | ゲオルク−アウグスト−ウニヴェルジテート・ゲッティンゲン・シュティフトゥング・エッフェントリヒェン・レッヒツ | タンパク質置換治療のための合成mecp2配列 |
US7722864B2 (en) | 2006-10-10 | 2010-05-25 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase ABCI mutants |
JP2010521170A (ja) | 2007-03-13 | 2010-06-24 | ナショナル ジューイッシュ ヘルス | 抗体の生成方法 |
AU2009246876B2 (en) | 2008-05-16 | 2015-04-02 | Taiga Biotechnologies, Inc. | Antibodies and processes for preparing the same |
DK2313496T3 (en) | 2008-07-21 | 2014-12-15 | Taiga Biotechnologies Inc | Anukleære differentiated cells, and method for preparation thereof |
AU2009285547B2 (en) | 2008-08-28 | 2012-05-31 | Taiga Biotechnologies, Inc. | Modulators of MYC, methods of using the same, and methods of identifying agents that modulate MYC |
JP5626717B2 (ja) * | 2009-03-26 | 2014-11-19 | 学校法人日本大学 | レチノイン酸受容体αを含む融合タンパク質 |
US8940286B2 (en) * | 2009-06-22 | 2015-01-27 | The University Of Tokyo | Urate transporter, as well as method and kit for evaluating urate transport-related disease factor and inflammation-related disease factor, and test sample and drug |
EP3252068A3 (de) | 2009-10-12 | 2018-03-14 | Larry J. Smith | Verfahren und zusammensetzungen zur modulation der genexpression unter verwendung in-vivo- oder in-vitro-verabreichten arzneistoffen auf oligonukleotidbasis |
US9321847B2 (en) | 2010-09-20 | 2016-04-26 | Ramot At Tel Aviv University Ltd. | Activatable toxin complexes comprising a cleavable inhibitory peptide |
EP3919620A1 (de) | 2012-05-02 | 2021-12-08 | Sirna Therapeutics, Inc. | Zusammensetzungen mit kurzer interferierender nukleinsäure (sina) |
CA2879667C (en) | 2012-07-20 | 2021-11-16 | Taiga Biotechnologies, Inc. | Enhanced reconstitution and autoreconstitution of the hematopoietic compartment comprising a myc polypeptide |
US9365825B2 (en) | 2013-03-11 | 2016-06-14 | Taiga Biotechnologies, Inc. | Expansion of adult stem cells in vitro |
US10272115B2 (en) | 2013-03-11 | 2019-04-30 | Taiga Biotechnologies, Inc. | Production and use of red blood cells |
US20160102140A1 (en) * | 2013-05-30 | 2016-04-14 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods and compositions for treating brain diseases |
EP3548425B1 (de) | 2016-12-02 | 2023-03-29 | Taiga Biotechnologies, Inc. | Nanopartikelformulierungen |
SG11201912071QA (en) | 2017-06-22 | 2020-01-30 | Catalyst Biosciences Inc | Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use |
US10149898B2 (en) | 2017-08-03 | 2018-12-11 | Taiga Biotechnologies, Inc. | Methods and compositions for the treatment of melanoma |
PE20211664A1 (es) | 2018-12-28 | 2021-08-26 | Catalyst Biosciences Inc | Polipeptidos de activador de plasminogeno, tipo urocinasa, modificados y metodos de uso |
US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5652122A (en) * | 1989-12-21 | 1997-07-29 | Frankel; Alan | Nucleic acids encoding and methods of making tat-derived transport polypeptides |
WO1999029721A1 (en) * | 1997-12-10 | 1999-06-17 | Washington University | Anti-pathogen system and methods of use thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5672683A (en) * | 1989-09-07 | 1997-09-30 | Alkermes, Inc. | Transferrin neuropharmaceutical agent fusion protein |
US5328984A (en) * | 1991-03-04 | 1994-07-12 | The United States As Represented By The Department Of Health & Human Services | Recombinant chimeric proteins deliverable across cellular membranes into cytosol of target cells |
JP4129298B2 (ja) * | 1997-05-15 | 2008-08-06 | サイトジェン コーポレーション | 胃腸管(git)輸送受容体に結合するランダムペプチド、及び関連した方法 |
-
2000
- 2000-02-28 CA CA002364690A patent/CA2364690A1/en not_active Abandoned
- 2000-02-28 JP JP2000611079A patent/JP2003514765A/ja active Pending
- 2000-02-28 EP EP00962058A patent/EP1157275A4/de not_active Withdrawn
- 2000-02-28 WO PCT/US2000/005097 patent/WO2000062067A1/en not_active Application Discontinuation
- 2000-02-28 AU AU74970/00A patent/AU7497000A/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5652122A (en) * | 1989-12-21 | 1997-07-29 | Frankel; Alan | Nucleic acids encoding and methods of making tat-derived transport polypeptides |
WO1999029721A1 (en) * | 1997-12-10 | 1999-06-17 | Washington University | Anti-pathogen system and methods of use thereof |
Non-Patent Citations (6)
Title |
---|
BONIFACI N ET AL: "NUCLEAR TRANSLOCATION OF AN EXOGENOUS FUSION PROTEIN CONTAINING HIV TAT REQUIRES UNFOLDING", AIDS, LONDON, GB, vol. 9, no. 9, 1995, pages 995 - 1000, XP002913782, ISSN: 0269-9370 * |
CHEN L L ET AL: "INCREASED CELLULAR UPTAKE OF THE HUMAN IMMUNODEFICIENCY VIRUS-1 TATPROTEIN AFTER MODIFICATION WITH BIOTIN", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 227, 1995, pages 168 - 169,172-175, XP002917757, ISSN: 0003-2697 * |
NAGAHARA H ET AL: "TRANSDUCTION OF FULL-LENGTH TAT FUSION PROTEINS INTO MAMMALIAN CELLS: TAT-P27KIP1 INDUCES CELL MIGRATION", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 4, no. 12, December 1998 (1998-12-01), pages 1449 - 1452, XP002927987, ISSN: 1078-8956 * |
PHELAN A ET AL: "INTERCELLULAR DELIVERY OF FUNCTIONAL P53 BY THE HERPESVIRUS PROTEIN VP22", NATURE BIOTECHNOLOGY, NATURE PUB. CO, NEW YORK, NY, US, vol. 16, no. 5, May 1998 (1998-05-01), pages 440 - 443, XP000979081, ISSN: 1087-0156 * |
SCHWARZE S ET AL: "In vivo protein transduction: delivery of a biologically active protein into the mouse", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 285, no. 5433, 3 September 1999 (1999-09-03), pages 1569 - 1572, XP002140133, ISSN: 0036-8075 * |
See also references of WO0062067A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU7497000A (en) | 2000-11-14 |
EP1157275A1 (de) | 2001-11-28 |
WO2000062067A9 (en) | 2002-07-11 |
WO2000062067A1 (en) | 2000-10-19 |
JP2003514765A (ja) | 2003-04-22 |
CA2364690A1 (en) | 2000-10-19 |
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Legal Events
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