HK1211297A1 - 包含至少两个针对her2的重复序列结构域的结合蛋白 - Google Patents

包含至少两个针对her2的重复序列结构域的结合蛋白 Download PDF

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Publication number
HK1211297A1
HK1211297A1 HK15110090.1A HK15110090A HK1211297A1 HK 1211297 A1 HK1211297 A1 HK 1211297A1 HK 15110090 A HK15110090 A HK 15110090A HK 1211297 A1 HK1211297 A1 HK 1211297A1
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HK
Hong Kong
Prior art keywords
repeat
domain
seq
her2
amino acid
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HK15110090.1A
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English (en)
Chinese (zh)
Inventor
烏爾麗克‧菲德勒
乌尔丽克‧菲德勒
伊格納西奧‧多拉多
伊格纳西奥‧多拉多
海克‧施特羅貝爾
海克‧施特罗贝尔
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分子组合公司
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Publication of HK1211297A1 publication Critical patent/HK1211297A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cell Biology (AREA)
HK15110090.1A 2012-11-30 2013-12-02 包含至少两个针对her2的重复序列结构域的结合蛋白 HK1211297A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12195156.0A EP2738180A1 (en) 2012-11-30 2012-11-30 Binding proteins comprising at least two binding domains against HER2.
EP12195156.0 2012-11-30
PCT/EP2013/075290 WO2014083208A1 (en) 2012-11-30 2013-12-02 Binding proteins comprising at least two repeat domains against her2

Publications (1)

Publication Number Publication Date
HK1211297A1 true HK1211297A1 (zh) 2016-05-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
HK15110090.1A HK1211297A1 (zh) 2012-11-30 2013-12-02 包含至少两个针对her2的重复序列结构域的结合蛋白

Country Status (11)

Country Link
US (1) US10370414B2 (enExample)
EP (2) EP2738180A1 (enExample)
JP (1) JP6410724B2 (enExample)
KR (1) KR102290592B1 (enExample)
CN (1) CN104918959A (enExample)
AU (2) AU2013351096C9 (enExample)
CA (1) CA2892747C (enExample)
HK (1) HK1211297A1 (enExample)
MX (1) MX366223B (enExample)
RU (1) RU2664464C9 (enExample)
WO (1) WO2014083208A1 (enExample)

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EP3980452A1 (en) * 2019-06-04 2022-04-13 Molecular Partners AG Recombinant 4-1bb binding proteins and their use
JP2022535564A (ja) 2019-06-04 2022-08-09 モレキュラー パートナーズ アクチェンゲゼルシャフト 多選択性タンパク質
CN118638240A (zh) 2019-07-26 2024-09-13 柳韩洋行 抗her2/抗4-1bb双特异性抗体及其用途
AU2020402581A1 (en) 2019-12-11 2022-06-23 Molecular Partners Ag Designed ankyrin repeat domains with altered surface residues
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Also Published As

Publication number Publication date
WO2014083208A9 (en) 2014-12-24
AU2013351096A1 (en) 2015-07-09
US20150299265A1 (en) 2015-10-22
CN104918959A (zh) 2015-09-16
BR112015012436A2 (pt) 2017-09-12
AU2013351096C1 (en) 2018-11-08
AU2018256592A1 (en) 2018-11-22
RU2015120663A (ru) 2017-01-10
MX2015006548A (es) 2015-10-15
JP2015537044A (ja) 2015-12-24
RU2664464C2 (ru) 2018-08-17
KR102290592B1 (ko) 2021-08-19
CA2892747A1 (en) 2014-06-05
JP6410724B2 (ja) 2018-10-24
EP2738180A1 (en) 2014-06-04
MX366223B (es) 2019-07-03
EP2925784A1 (en) 2015-10-07
US10370414B2 (en) 2019-08-06
EP2925784B1 (en) 2021-02-17
CA2892747C (en) 2022-07-19
AU2013351096C9 (en) 2019-01-31
KR20150091138A (ko) 2015-08-07
AU2013351096B2 (en) 2018-08-09
WO2014083208A1 (en) 2014-06-05
WO2014083208A8 (en) 2014-10-30
RU2664464C9 (ru) 2018-12-19

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