MX2015006548A - Proteinas vinculantes que comprenden al menos dos dominios de repeticion contra her2. - Google Patents

Proteinas vinculantes que comprenden al menos dos dominios de repeticion contra her2.

Info

Publication number
MX2015006548A
MX2015006548A MX2015006548A MX2015006548A MX2015006548A MX 2015006548 A MX2015006548 A MX 2015006548A MX 2015006548 A MX2015006548 A MX 2015006548A MX 2015006548 A MX2015006548 A MX 2015006548A MX 2015006548 A MX2015006548 A MX 2015006548A
Authority
MX
Mexico
Prior art keywords
repeat domains
binding proteins
against her2
domains against
repeat
Prior art date
Application number
MX2015006548A
Other languages
English (en)
Other versions
MX366223B (es
Inventor
Ulrike Fiedler
Heike Strobel
Igancio Dolado
Original Assignee
Molecular Partners Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Partners Ag filed Critical Molecular Partners Ag
Publication of MX2015006548A publication Critical patent/MX2015006548A/es
Publication of MX366223B publication Critical patent/MX366223B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

Abstract

La presente invención se refiere a una proteína vinculante o de unión, recombinante, que comprende al menos un primer y un segundo dominio de repetición, en donde cada uno de dichos dos dominios de repetición se vincula o une a la región extracelular del HER2 y en donde dichos dominios de repetición se vinculan o unen covalentemente.
MX2015006548A 2012-11-30 2013-12-02 Proteinas vinculantes que comprenden al menos dos dominios de repeticion contra her2. MX366223B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12195156.0A EP2738180A1 (en) 2012-11-30 2012-11-30 Binding proteins comprising at least two binding domains against HER2.
PCT/EP2013/075290 WO2014083208A1 (en) 2012-11-30 2013-12-02 Binding proteins comprising at least two repeat domains against her2

Publications (2)

Publication Number Publication Date
MX2015006548A true MX2015006548A (es) 2015-10-15
MX366223B MX366223B (es) 2019-07-03

Family

ID=47257683

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015006548A MX366223B (es) 2012-11-30 2013-12-02 Proteinas vinculantes que comprenden al menos dos dominios de repeticion contra her2.

Country Status (11)

Country Link
US (1) US10370414B2 (es)
EP (2) EP2738180A1 (es)
JP (1) JP6410724B2 (es)
KR (1) KR102290592B1 (es)
CN (1) CN104918959A (es)
AU (2) AU2013351096C9 (es)
CA (1) CA2892747C (es)
HK (1) HK1211297A1 (es)
MX (1) MX366223B (es)
RU (1) RU2664464C9 (es)
WO (1) WO2014083208A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI510246B (zh) 2010-04-30 2015-12-01 Molecular Partners Ag 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質
AU2011333666B2 (en) * 2010-11-26 2017-02-02 Molecular Partners Ag Improved capping modules for designed ankyrin repeat proteins
WO2014060365A1 (en) * 2012-10-15 2014-04-24 Universität Zürich Prorektorat Mnw Bispecific her2 ligands for cancer therapy
EP3004152B1 (en) 2013-05-31 2020-09-30 Molecular Partners AG Designed ankyrin repeat proteins binding to hepatocyte growth factor
AU2014357292B2 (en) 2013-11-27 2020-06-25 Zymeworks Bc Inc. Bispecific antigen-binding constructs targeting HER2
DK3253785T3 (da) 2015-02-06 2019-07-08 Navigo Proteins Gmbh Hidtil ukendte egfr-bindingsproteiner
MY179505A (en) 2015-04-02 2020-11-09 Molecular Partners Ag Recombinant binding proteins and their use
US10808042B2 (en) 2015-07-16 2020-10-20 Navigo Proteins Gmbh Immunoglobulin-binding proteins and their use in affinity purification
CA2991815A1 (en) 2015-07-20 2017-01-26 Navigo Proteins Gmbh Novel binding proteins based on di-ubiquitin muteins and methods for generation
AU2016295024B2 (en) * 2015-07-20 2018-12-20 Navigo Proteins Gmbh Her2 binding proteins based on di-ubiquitin muteins
WO2017191252A1 (en) 2016-05-04 2017-11-09 Navigo Proteins Gmbh Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker
RU2627215C1 (ru) * 2016-05-24 2017-08-03 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Нижегородский государственный университет им. Н.И. Лобачевского" Рекомбинантный таргетный токсин, специфичный к клеткам, экспрессирующим рецептор her2
JP6951417B2 (ja) 2016-08-11 2021-10-20 レプリゲン・コーポレイションＲｅｐｌｉｇｅｎ Ｃｏｒｐｏｒａｔｉｏｎ アフィニティークロマトグラフィーのためのＦＣ−結合タンパク質、並びにＦｃ−結合タンパク質を含むアフィニティー分離マトリックスおよびその使用
NZ751689A (en) 2016-09-22 2021-07-30 Molecular Partners Ag Recombinant binding proteins and their use
WO2019091918A1 (en) 2017-11-07 2019-05-16 Navigo Proteins Gmbh Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer
CN114269366A (zh) * 2019-06-04 2022-04-01 分子伴侣公司 重组fap结合蛋白及其用途
AU2020286715A1 (en) * 2019-06-04 2021-12-23 Molecular Partners Ag Recombinant 4-1 BB binding proteins and their use
CA3138805A1 (en) * 2019-06-04 2020-12-10 Johannes Schilling Designed ankyrin repeat domain with improved stability
CA3139051A1 (en) 2019-06-04 2020-12-10 Christian REICHEN Multispecific proteins
KR20220113491A (ko) * 2019-12-11 2022-08-12 몰리큘라 파트너스 아게 재조합 펩티드-mhc 복합체 결합 단백질 및 이의 생성 및 용도
CN115916815A (zh) 2020-05-06 2023-04-04 分子合作伙伴股份公司 新型锚蛋白重复结合蛋白及其用途
EP4149959A1 (en) 2020-05-14 2023-03-22 Molecular Partners AG Multispecific proteins
JP2023554351A (ja) 2020-12-16 2023-12-27 モレキュラー パートナーズ アクチェンゲゼルシャフト 新規の徐放性プロドラッグ
US11834504B2 (en) 2021-03-09 2023-12-05 Molecular Partners Ag DARPin based multi-specific t-cell engagers
EP4305063A1 (en) 2021-03-09 2024-01-17 Molecular Partners AG Protease cleavable prodrugs
CA3211368A1 (en) 2021-03-09 2022-09-15 Molecular Partners Ag Novel darpin based cd123 engagers
EP4304730A1 (en) 2021-03-09 2024-01-17 Molecular Partners AG Novel darpin based cd33 engagers
WO2023110983A1 (en) 2021-12-14 2023-06-22 Molecular Partners Ag Designed repeat domains with dual binding specificity and their use
WO2024028278A1 (en) 2022-08-01 2024-02-08 Molecular Partners Ag Charge modified designed repeat domains and their use
WO2024038307A1 (en) 2022-08-19 2024-02-22 Novartis Ag Dosing regimens for sars-cov-2 binding molecules

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68927933T2 (de) 1988-09-02 1997-08-14 Dyax Corp Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5348867A (en) 1991-11-15 1994-09-20 George Georgiou Expression of proteins on bacterial surface
US7371376B1 (en) 1996-10-18 2008-05-13 Genentech, Inc. Anti-ErbB2 antibodies
CA2196496A1 (en) 1997-01-31 1998-07-31 Stephen William Watson Michnick Protein fragment complementation assay for the detection of protein-protein interactions
WO1998048008A1 (en) 1997-04-23 1998-10-29 Plueckthun Andreas Methods for identifying nucleic acid molecules encoding (poly)peptides that interact with target molecules
JP4808315B2 (ja) 1998-12-02 2011-11-02 ブリストル−マイヤーズ スクウィブ カンパニー Ｄｎａ・蛋白質融合体とその利用
DK1332209T3 (da) 2000-09-08 2010-03-29 Univ Zuerich Samlinger af repeatproteiner indeholdende repeatmoduler
EP1778270A4 (en) * 2004-05-05 2009-09-02 Merrimack Pharmaceuticals Inc BIS-SPECIFIC BINDER FOR MODULATING BIOLOGICAL ACTIVITY
JP2008507520A (ja) * 2004-07-22 2008-03-13 ジェネンテック・インコーポレーテッド Ｈｅｒ２抗体組成物
JP5042218B2 (ja) 2005-07-08 2012-10-03 ユニバーシティ・オブ・チューリッヒ 融合ポリペプチドの翻訳と同時のトランスロケーションを使用するファージディスプレイ
WO2007103515A2 (en) 2006-03-06 2007-09-13 Amunix, Inc. Unstructured recombinant polymers and uses thereof
PL2173890T3 (pl) 2007-06-21 2011-07-29 Univ Muenchen Tech Białka czynne biologicznie o zwiększonej stabilności in vivo i (lub) in vitro
EP2198022B1 (en) 2007-09-24 2024-03-06 University Of Zurich Designed armadillo repeat proteins
AU2008328785A1 (en) 2007-11-27 2009-06-04 Ablynx N.V. Method for obtaining polypeptide constructs comprising two or more single domain antibodies
US20100260668A1 (en) * 2008-04-29 2010-10-14 Abbott Laboratories Dual Variable Domain Immunoglobulins and Uses Thereof
EP2358746B1 (en) 2008-11-03 2020-09-16 Molecular Partners AG Binding proteins inhibiting the vegf-a receptor interaction
TW201120210A (en) * 2009-11-05 2011-06-16 Hoffmann La Roche Glycosylated repeat-motif-molecule conjugates
TWI510246B (zh) 2010-04-30 2015-12-01 Molecular Partners Ag 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質
AU2011333666B2 (en) 2010-11-26 2017-02-02 Molecular Partners Ag Improved capping modules for designed ankyrin repeat proteins
EP2702069A4 (en) 2011-04-29 2015-04-29 Janssen Biotech Inc IL4 / IL13 BINDING REPEAT PROTEINS AND USES THEREOF
WO2012162418A1 (en) * 2011-05-23 2012-11-29 The University Of North Carolina At Chapel Hill Methods and compositions for heterodimeric targeting ligands
CN104508129A (zh) 2012-06-28 2015-04-08 分子伴侣公司 设计的与血小板衍生生长因子结合的锚蛋白重复序列蛋白
WO2014060365A1 (en) 2012-10-15 2014-04-24 Universität Zürich Prorektorat Mnw Bispecific her2 ligands for cancer therapy
EP3004152B1 (en) 2013-05-31 2020-09-30 Molecular Partners AG Designed ankyrin repeat proteins binding to hepatocyte growth factor

Also Published As

Publication number Publication date
WO2014083208A8 (en) 2014-10-30
RU2015120663A (ru) 2017-01-10
EP2925784B1 (en) 2021-02-17
AU2013351096C1 (en) 2018-11-08
EP2925784A1 (en) 2015-10-07
HK1211297A1 (en) 2016-05-20
MX366223B (es) 2019-07-03
CA2892747A1 (en) 2014-06-05
RU2664464C2 (ru) 2018-08-17
JP6410724B2 (ja) 2018-10-24
EP2738180A1 (en) 2014-06-04
US10370414B2 (en) 2019-08-06
BR112015012436A2 (pt) 2017-09-12
RU2664464C9 (ru) 2018-12-19
JP2015537044A (ja) 2015-12-24
AU2013351096C9 (en) 2019-01-31
WO2014083208A9 (en) 2014-12-24
WO2014083208A1 (en) 2014-06-05
KR20150091138A (ko) 2015-08-07
CA2892747C (en) 2022-07-19
CN104918959A (zh) 2015-09-16
AU2013351096A1 (en) 2015-07-09
AU2013351096B2 (en) 2018-08-09
AU2018256592A1 (en) 2018-11-22
US20150299265A1 (en) 2015-10-22
KR102290592B1 (ko) 2021-08-19

Similar Documents

Publication Publication Date Title
MX366223B (es) Proteinas vinculantes que comprenden al menos dos dominios de repeticion contra her2.
CY1119567T1 (el) Θεραπευτικα πεπτιδια
CY1122978T1 (el) Αντισωματα εναντι-vla-4
MX2014008102A (es) Inmunoglobulinas de dominio variable dual contra receptores.
IN2012DN00640A (es)
MX347535B (es) Proteinas de union modificadas que inhiben la interaccion de receptor vegf-a.
MY164906A (en) Dual variable region antibody-like binding proteins having cross-over binding region orientation
BR112014019579A2 (pt) Anticorpo de cadeia única, polinucleotídeo, vetor, célula hospedeira, método de produção de um anticorpo de cadeia única, heteromultímero e método de produção do heteromultímero
NZ729044A (en) 4-1bb binding molecules
SG10201902924RA (en) Antibodies that bind ebola glycoprotein and uses thereof
IN2015MN00139A (es)
MX342034B (es) Proteinas monovalentes que se unen a antigenos.
MX2019007921A (es) Nuevos agentes de union a ha.
UA110049C2 (uk) ЛІКУВАННЯ ОСТЕОАРТРИТУ ІМУНОГЛОБУЛІНОВИМ ЗВ'ЯЗУВАЛЬНИМ БІЛКОМ З ПОДВІЙНИМ ВАРІАБЕЛЬНИМ ДОМЕНОМ, ЩО ЗВ'ЯЗУЄ IL-1α І IL-1β
MX2012013406A (es) Variantes de union mejoradas anti-albumina serica.
MX2011008752A (es) Variantes de union a anti-albumina de suero mejoradas.
TR201903403T4 (tr) İmmünoglobulin preparatı.
NZ629553A (en) Anti-big-endothelin-1 (big-et-1) antibodies and uses thereof
MX2011008749A (es) Variantes de union a anti-albumina de suero mejoradas.
PH12015500752A1 (en) Her3 antigen binding proteins binding to the beta-hairpin of her3
WO2014160956A3 (en) Cartilage-binding fusion proteins
MX2016000344A (es) Un conjugado de fc de inmunoglobulina que mantiene la afinidad de union del fragmento fc de inmunoglobulina hacia fcrn.
EA201390955A1 (ru) Слитый белок robo1-fc для применения в лечении гепатокарциномы
PH12019500677A1 (en) Cmet monoclonal binding agents, drug conjugates thereof and uses thereof
MX2013002055A (es) Variantes anti-enlace de albumina de suero mejodas.

Legal Events

Date Code Title Description
FG Grant or registration