MX2016000344A - Un conjugado de fc de inmunoglobulina que mantiene la afinidad de union del fragmento fc de inmunoglobulina hacia fcrn. - Google Patents
Un conjugado de fc de inmunoglobulina que mantiene la afinidad de union del fragmento fc de inmunoglobulina hacia fcrn.Info
- Publication number
- MX2016000344A MX2016000344A MX2016000344A MX2016000344A MX2016000344A MX 2016000344 A MX2016000344 A MX 2016000344A MX 2016000344 A MX2016000344 A MX 2016000344A MX 2016000344 A MX2016000344 A MX 2016000344A MX 2016000344 A MX2016000344 A MX 2016000344A
- Authority
- MX
- Mexico
- Prior art keywords
- immunoglobulin
- conjugate
- binding strength
- fragment
- fcrn binding
- Prior art date
Links
- 101150050927 Fcgrt gene Proteins 0.000 title 1
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 abstract 4
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 abstract 4
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 abstract 3
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
La presente invención se refiere a un conjugado de polipéptido fisiológicamente activo y fragmento Fc de inmunoglobulina que comprende un polipéptido fisiológicamente activo unido a través de un enlazador no peptídico a un fragmento Fc de inmunoglobulina que tiene una región de unión a FcRn y mantiene la afinidad de unión intrínseca del fragmento Fc de inmunoglobulina, un método de preparación del conjugado, un método de mantenimiento de la afinidad de unión intrínseca del conjugado hacia FcRn y una composición que comprende el conjugado que mantiene la afinidad de unión intrínseca del fragmento Fc de inmunoglobulina hacia FcRn.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20130082509 | 2013-07-12 | ||
PCT/KR2014/006328 WO2015005747A1 (ko) | 2013-07-12 | 2014-07-14 | FcRn 결합력이 유지되는 면역글로불린 Fc 결합체 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016000344A true MX2016000344A (es) | 2016-05-05 |
Family
ID=52280325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016000344A MX2016000344A (es) | 2013-07-12 | 2014-07-14 | Un conjugado de fc de inmunoglobulina que mantiene la afinidad de union del fragmento fc de inmunoglobulina hacia fcrn. |
Country Status (22)
Country | Link |
---|---|
US (2) | US20160152684A1 (es) |
EP (1) | EP3020732B1 (es) |
JP (2) | JP2016525099A (es) |
KR (2) | KR101872559B1 (es) |
CN (2) | CN105593243A (es) |
AR (1) | AR096890A1 (es) |
AU (1) | AU2014287879B2 (es) |
CA (1) | CA2917838C (es) |
DK (1) | DK3020732T3 (es) |
EA (1) | EA034297B1 (es) |
ES (1) | ES2799326T3 (es) |
HK (1) | HK1221957A1 (es) |
HU (1) | HU231424B1 (es) |
IL (1) | IL243567B (es) |
MX (1) | MX2016000344A (es) |
MY (1) | MY180374A (es) |
NO (1) | NO20160182A1 (es) |
PH (1) | PH12016500111A1 (es) |
PT (1) | PT3020732T (es) |
TW (1) | TWI693236B (es) |
UA (1) | UA119644C2 (es) |
WO (1) | WO2015005747A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20130049671A (ko) | 2011-11-04 | 2013-05-14 | 한미사이언스 주식회사 | 생리활성 폴리펩타이드 결합체 제조 방법 |
AR090281A1 (es) | 2012-03-08 | 2014-10-29 | Hanmi Science Co Ltd | Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo |
HU231358B1 (hu) * | 2014-03-31 | 2023-03-28 | Hanmi Pharm. Co., Ltd | Eljárás fehérjék és peptidek oldhatóságának javítására immunoglobulin Fc fragmentum kapcsolás alkalmazása révén |
AR107483A1 (es) * | 2016-01-29 | 2018-05-02 | Hanmi Pharm Ind Co Ltd | Conjugado de enzimas terapéuticas |
US20190352335A1 (en) * | 2016-12-19 | 2019-11-21 | Hanmi Pharm. Co., Ltd. | Brain targeting long-acting protein conjugate |
US20220273808A1 (en) * | 2019-07-18 | 2022-09-01 | Hanmi Pharm. Co., Ltd | Novel method of preparing protein conjugate |
KR102382593B1 (ko) * | 2020-01-29 | 2022-04-05 | 고려대학교 산학협력단 | pH-감응성 Fc 변이체 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
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US6030613A (en) * | 1995-01-17 | 2000-02-29 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
EP0904107B1 (en) | 1996-03-18 | 2004-10-20 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
UA91325C2 (ru) * | 2002-12-26 | 2010-07-26 | Маунтин Вью Фармасьютикалз, Инк. | Полимерные конъюгаты цитокинов, хемокинов, факторов роста, полипептидных гормонов и их антагонистов с сохраненной активностью рецепторного связывания |
US20050176108A1 (en) * | 2003-03-13 | 2005-08-11 | Young-Min Kim | Physiologically active polypeptide conjugate having prolonged in vivo half-life |
ES2378167T3 (es) * | 2003-11-13 | 2012-04-09 | Hanmi Holdings Co., Ltd | Complejo de proteína que utiliza fragmento de inmunoglobulina y el método para su preparación |
KR100609434B1 (ko) | 2004-12-30 | 2006-08-03 | 한국항공우주연구원 | 트랜스버살 필터 |
KR100754667B1 (ko) * | 2005-04-08 | 2007-09-03 | 한미약품 주식회사 | 비펩타이드성 중합체로 개질된 면역글로불린 Fc 단편 및이를 포함하는 약제학적 조성물 |
US7625564B2 (en) * | 2006-01-27 | 2009-12-01 | Novagen Holding Corporation | Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo |
JP2008169195A (ja) * | 2007-01-05 | 2008-07-24 | Hanmi Pharmaceutical Co Ltd | キャリア物質を用いたインスリン分泌ペプチド薬物結合体 |
KR20080098216A (ko) * | 2007-05-04 | 2008-11-07 | 한미약품 주식회사 | 캐리어 물질을 이용한 나트륨 배설 펩타이드 약물 결합체 |
EP2162472B1 (en) * | 2007-05-30 | 2013-02-27 | Postech Academy-Industry- Foundation | Immunoglobulin fusion proteins |
JP2009019027A (ja) | 2007-07-16 | 2009-01-29 | Hanmi Pharmaceutical Co Ltd | アミノ末端のアミノ酸が変異したインスリン分泌ペプチド誘導体 |
ES2523043T3 (es) * | 2008-07-23 | 2014-11-20 | Hanmi Science Co., Ltd. | Un complejo polipeptídico que comprende un polímero no peptidílico que tiene tres extremos funcionales |
EP2545079A2 (en) * | 2010-03-11 | 2013-01-16 | Rinat Neuroscience Corporation | ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING |
AR081066A1 (es) * | 2010-04-02 | 2012-06-06 | Hanmi Holdings Co Ltd | Conjugado de insulina donde se usa un fragmento de inmunoglobulina |
KR101333958B1 (ko) * | 2010-10-20 | 2013-11-27 | 주식회사 한독 | 인간 인터루킨-1 수용체 길항제-하이브리드 Fc 융합단백질 |
UA113626C2 (xx) * | 2011-06-02 | 2017-02-27 | Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії | |
SG10201604564XA (en) | 2011-06-10 | 2016-07-28 | Hanmi Science Co Ltd | Novel oxyntomodulin derivatives and pharmaceutical composition for treating obesity comprising the same |
UA114709C2 (uk) * | 2011-06-17 | 2017-07-25 | Ханмі Сайенс Ко., Лтд. | Кон'югат, що містить похідну оксинтомодуліну, fc-ділянку імуноглобуліну та непептидильний полімер, та його застосування |
US9789202B2 (en) * | 2011-09-05 | 2017-10-17 | Hanmi Science Co., Ltd. | Method for treating cancer using an interferon alpha conjugate |
KR20130049671A (ko) * | 2011-11-04 | 2013-05-14 | 한미사이언스 주식회사 | 생리활성 폴리펩타이드 결합체 제조 방법 |
KR102041412B1 (ko) * | 2011-12-30 | 2019-11-11 | 한미사이언스 주식회사 | 면역글로불린 Fc 단편 유도체 |
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2014
- 2014-07-11 AR ARP140102575A patent/AR096890A1/es unknown
- 2014-07-14 CN CN201480049342.0A patent/CN105593243A/zh active Pending
- 2014-07-14 AU AU2014287879A patent/AU2014287879B2/en active Active
- 2014-07-14 HU HUP1600206A patent/HU231424B1/hu unknown
- 2014-07-14 CN CN202310310247.2A patent/CN116082528A/zh active Pending
- 2014-07-14 PT PT148227218T patent/PT3020732T/pt unknown
- 2014-07-14 MY MYPI2016000028A patent/MY180374A/en unknown
- 2014-07-14 JP JP2016525294A patent/JP2016525099A/ja active Pending
- 2014-07-14 MX MX2016000344A patent/MX2016000344A/es active IP Right Grant
- 2014-07-14 EP EP14822721.8A patent/EP3020732B1/en active Active
- 2014-07-14 DK DK14822721.8T patent/DK3020732T3/da active
- 2014-07-14 CA CA2917838A patent/CA2917838C/en active Active
- 2014-07-14 UA UAA201600304A patent/UA119644C2/uk unknown
- 2014-07-14 WO PCT/KR2014/006328 patent/WO2015005747A1/ko active Application Filing
- 2014-07-14 ES ES14822721T patent/ES2799326T3/es active Active
- 2014-07-14 KR KR1020140088530A patent/KR101872559B1/ko active Application Filing
- 2014-07-14 EA EA201690114A patent/EA034297B1/ru unknown
- 2014-07-14 TW TW103124093A patent/TWI693236B/zh active
- 2014-07-14 US US14/904,543 patent/US20160152684A1/en not_active Abandoned
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2016
- 2016-01-11 IL IL243567A patent/IL243567B/en active IP Right Grant
- 2016-01-12 PH PH12016500111A patent/PH12016500111A1/en unknown
- 2016-02-03 NO NO20160182A patent/NO20160182A1/en unknown
- 2016-08-23 HK HK16110033.0A patent/HK1221957A1/zh unknown
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2018
- 2018-06-19 KR KR1020180070435A patent/KR102076718B1/ko active IP Right Grant
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2020
- 2020-04-27 JP JP2020078005A patent/JP6880278B2/ja active Active
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2022
- 2022-08-03 US US17/880,358 patent/US20220380437A1/en active Pending
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Legal Events
Date | Code | Title | Description |
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FG | Grant or registration |