KR20170084332A - Klotho 변이체 폴리펩티드를 사용하는 방법 및 조성물 - Google Patents
Klotho 변이체 폴리펩티드를 사용하는 방법 및 조성물 Download PDFInfo
- Publication number
- KR20170084332A KR20170084332A KR1020177017910A KR20177017910A KR20170084332A KR 20170084332 A KR20170084332 A KR 20170084332A KR 1020177017910 A KR1020177017910 A KR 1020177017910A KR 20177017910 A KR20177017910 A KR 20177017910A KR 20170084332 A KR20170084332 A KR 20170084332A
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- KR
- South Korea
- Prior art keywords
- klotho
- seq
- fgf23
- fusion
- sklotho
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01031—Beta-glucuronidase (3.2.1.31)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Plant Pathology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462087516P | 2014-12-04 | 2014-12-04 | |
| US62/087,516 | 2014-12-04 | ||
| PCT/IB2015/059294 WO2016088059A1 (en) | 2014-12-04 | 2015-12-02 | Methods and compositions using klotho variant polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20170084332A true KR20170084332A (ko) | 2017-07-19 |
Family
ID=55024183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177017910A Ceased KR20170084332A (ko) | 2014-12-04 | 2015-12-02 | Klotho 변이체 폴리펩티드를 사용하는 방법 및 조성물 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10654909B2 (enExample) |
| EP (1) | EP3227319B1 (enExample) |
| JP (1) | JP2017537926A (enExample) |
| KR (1) | KR20170084332A (enExample) |
| CN (1) | CN107810201A (enExample) |
| AU (1) | AU2015356643B2 (enExample) |
| BR (1) | BR112017011398A2 (enExample) |
| CA (1) | CA2969307A1 (enExample) |
| EA (1) | EA201791238A1 (enExample) |
| MX (2) | MX2017007303A (enExample) |
| TW (1) | TW201628641A (enExample) |
| WO (1) | WO2016088059A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3031839B1 (fr) | 2015-01-19 | 2020-03-13 | Areva Stockage D'energie | Systeme electrique comprenant un empilement de cellules electrochimiques et procede de pilotage de ce systeme |
| CN107405382A (zh) | 2015-02-06 | 2017-11-28 | 加利福尼亚大学董事会 | 用于改善认知的方法和组合物 |
| AU2017363321B2 (en) * | 2016-11-22 | 2023-09-28 | Klotho Therapeutics, Inc. | Novel recombinant Klotho proteins and compositions and methods involving the same |
| EP3649157A4 (en) | 2017-07-06 | 2021-07-28 | Yale University | COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF DISEASES RELATED TO ENDOCRINE FGF |
| WO2019118620A1 (en) * | 2017-12-13 | 2019-06-20 | Yale University | Compositions and methods for treating or preventing endocrine fgf23-linked diseases |
| US12227777B2 (en) * | 2018-01-12 | 2025-02-18 | New York University | Soluble alpha-Klotho proteins, protein fragments, and uses thereof |
| US20220008520A1 (en) * | 2018-11-21 | 2022-01-13 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods and materials for reducing age-related striated muscle and cognitive decline |
| CN112695049A (zh) * | 2020-08-20 | 2021-04-23 | 山东兴瑞生物科技有限公司 | 修饰间充质干细胞的融合基因、质粒、修饰得到干细胞及制备方法 |
| CN112915192B (zh) * | 2021-03-05 | 2022-10-25 | 南方医科大学南方医院 | Kp-1在制备治疗慢性肝病的药物中的用途 |
| CN112915193B (zh) * | 2021-03-05 | 2022-09-13 | 南方医科大学南方医院 | Kp-1在制备治疗慢性肺病的药物中的用途 |
| EP4395807A4 (en) * | 2021-09-03 | 2025-09-24 | Uab Res Found | COMPOUNDS MODULATING FIBROBLAST GROWTH FACTOR 23 |
| WO2024168241A2 (en) * | 2023-02-10 | 2024-08-15 | The Trustees Of Indiana University | Stabilized fgf23 fusion proteins, compositions and a targeted therapy for hyperphosphatemia |
| EP4434534A1 (en) | 2023-03-22 | 2024-09-25 | ADvantage Therapeutics, Inc. | Klotho mrna |
| WO2025101851A1 (en) * | 2023-11-10 | 2025-05-15 | Regeneron Pharmaceuticals, Inc. | Engineered alpha klotho polypeptides and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| IL71691A (en) | 1984-04-27 | 1991-04-15 | Yeda Res & Dev | Production of interferon-ypsilon |
| US5128326A (en) | 1984-12-06 | 1992-07-07 | Biomatrix, Inc. | Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same |
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| WO2013027191A1 (en) * | 2011-08-25 | 2013-02-28 | Novartis Ag | Methods and compositions using fgf23 fusion polypeptides |
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2015
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- 2015-12-02 EA EA201791238A patent/EA201791238A1/ru unknown
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- 2015-12-02 MX MX2017007303A patent/MX2017007303A/es unknown
- 2015-12-02 EP EP15816527.4A patent/EP3227319B1/en not_active Not-in-force
- 2015-12-02 BR BR112017011398A patent/BR112017011398A2/pt not_active IP Right Cessation
- 2015-12-02 JP JP2017529778A patent/JP2017537926A/ja active Pending
- 2015-12-02 WO PCT/IB2015/059294 patent/WO2016088059A1/en not_active Ceased
- 2015-12-02 KR KR1020177017910A patent/KR20170084332A/ko not_active Ceased
- 2015-12-02 US US15/532,634 patent/US10654909B2/en active Active
- 2015-12-02 AU AU2015356643A patent/AU2015356643B2/en not_active Ceased
- 2015-12-03 TW TW104140597A patent/TW201628641A/zh unknown
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2017
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2020
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3227319A1 (en) | 2017-10-11 |
| JP2017537926A (ja) | 2017-12-21 |
| CN107810201A (zh) | 2018-03-16 |
| MX2017007303A (es) | 2017-08-25 |
| US20200362015A1 (en) | 2020-11-19 |
| TW201628641A (zh) | 2016-08-16 |
| EP3227319B1 (en) | 2019-11-27 |
| AU2015356643B2 (en) | 2019-01-24 |
| EA201791238A1 (ru) | 2018-02-28 |
| BR112017011398A2 (pt) | 2018-04-03 |
| WO2016088059A1 (en) | 2016-06-09 |
| AU2015356643A1 (en) | 2017-06-22 |
| US20180037623A1 (en) | 2018-02-08 |
| US10654909B2 (en) | 2020-05-19 |
| MX2021000030A (es) | 2021-03-25 |
| CA2969307A1 (en) | 2016-06-09 |
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