CN107810201A - 使用klotho变体多肽的方法和组合物 - Google Patents

使用klotho变体多肽的方法和组合物 Download PDF

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Publication number
CN107810201A
CN107810201A CN201580075428.5A CN201580075428A CN107810201A CN 107810201 A CN107810201 A CN 107810201A CN 201580075428 A CN201580075428 A CN 201580075428A CN 107810201 A CN107810201 A CN 107810201A
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seq
amino acid
klotho
fgf23
sklotho
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郭冬林
C·伊贝邦乔
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Novartis AG
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Novartis AG
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CN201580075428.5A 2014-12-04 2015-12-02 使用klotho变体多肽的方法和组合物 Pending CN107810201A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462087516P 2014-12-04 2014-12-04
US62/087,516 2014-12-04
PCT/IB2015/059294 WO2016088059A1 (en) 2014-12-04 2015-12-02 Methods and compositions using klotho variant polypeptides

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CN107810201A true CN107810201A (zh) 2018-03-16

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US (2) US10654909B2 (enExample)
EP (1) EP3227319B1 (enExample)
JP (1) JP2017537926A (enExample)
KR (1) KR20170084332A (enExample)
CN (1) CN107810201A (enExample)
AU (1) AU2015356643B2 (enExample)
BR (1) BR112017011398A2 (enExample)
CA (1) CA2969307A1 (enExample)
EA (1) EA201791238A1 (enExample)
MX (2) MX2017007303A (enExample)
TW (1) TW201628641A (enExample)
WO (1) WO2016088059A1 (enExample)

Cited By (3)

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CN112695049A (zh) * 2020-08-20 2021-04-23 山东兴瑞生物科技有限公司 修饰间充质干细胞的融合基因、质粒、修饰得到干细胞及制备方法
CN112915193A (zh) * 2021-03-05 2021-06-08 南方医科大学南方医院 Kp-1在制备治疗慢性肺病的药物中的用途
CN112915192A (zh) * 2021-03-05 2021-06-08 南方医科大学南方医院 Kp-1在制备治疗慢性肝病的药物中的用途

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CN111712519A (zh) * 2017-12-13 2020-09-25 耶鲁大学 用于治疗或预防内分泌fgf23-相关疾病的组合物和方法
WO2019140250A1 (en) * 2018-01-12 2019-07-18 New York University SOLUBLE α-KLOTH PROTEINS, PROTEIN FRAGMENTS, AND USES THEREOF
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WO2024168241A2 (en) * 2023-02-10 2024-08-15 The Trustees Of Indiana University Stabilized fgf23 fusion proteins, compositions and a targeted therapy for hyperphosphatemia
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WO2025101851A1 (en) * 2023-11-10 2025-05-15 Regeneron Pharmaceuticals, Inc. Engineered alpha klotho polypeptides and uses thereof
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Citations (3)

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CN102015760A (zh) * 2008-01-28 2011-04-13 诺瓦提斯公司 使用klotho-fgf融合多肽的方法和组合物
WO2011092234A1 (en) * 2010-01-29 2011-08-04 Novartis Ag Methods and compositions using fgf23 fusion polypeptides
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