|
JPH0637520B2
(ja)
|
1985-07-03 |
1994-05-18 |
味の素株式会社 |
ポリペプチド
|
|
AU597574B2
(en)
|
1986-03-07 |
1990-06-07 |
Massachusetts Institute Of Technology |
Method for enhancing glycoprotein stability
|
|
US4973577A
(en)
|
1986-04-04 |
1990-11-27 |
The Salk Institute For Biological Studies |
FSH-releasing peptides
|
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5198346A
(en)
|
1989-01-06 |
1993-03-30 |
Protein Engineering Corp. |
Generation and selection of novel DNA-binding proteins and polypeptides
|
|
US5096815A
(en)
|
1989-01-06 |
1992-03-17 |
Protein Engineering Corporation |
Generation and selection of novel dna-binding proteins and polypeptides
|
|
US5078486A
(en)
|
1989-10-13 |
1992-01-07 |
Evans David W |
Self-calibrating vision test apparatus
|
|
EP0548276A4
(en)
|
1990-09-13 |
1993-12-29 |
Children's Hospital Medical Center Of Northern California |
Method for increasing red blood cell production by treatment with activin or activin-related peptides
|
|
US5208219A
(en)
|
1991-02-14 |
1993-05-04 |
Celtrix Pharmaceuticals Inc. |
Method for inducing bone growth
|
|
US5118667A
(en)
|
1991-05-03 |
1992-06-02 |
Celtrix Pharmaceuticals, Inc. |
Bone growth factors and inhibitors of bone resorption for promoting bone formation
|
|
US20050186593A1
(en)
|
1991-05-10 |
2005-08-25 |
The Salk Institute For Biological Studies |
Cloning and recombinant production of CRF receptor(s)
|
|
US5885794A
(en)
|
1991-05-10 |
1999-03-23 |
The Salk Institute For Biological Studies |
Recombinant production of vertebrate activin receptor polypeptides and identification of receptor DNAs in the activin/TGF-β superfamily
|
|
JPH06500574A
(ja)
|
1991-05-10 |
1994-01-20 |
ザ ソーク インスティテュート フォア バイオロジカル スタディーズ |
アクチビン／ＴＧＦ―βスーパーファミリーのレセプターのクローニングおよび組換えによる産生
|
|
US6162896A
(en)
|
1991-05-10 |
2000-12-19 |
The Salk Institute For Biological Studies |
Recombinant vertebrate activin receptors
|
|
AU652472B2
(en)
|
1991-06-25 |
1994-08-25 |
Genetics Institute, Llc |
BMP-9 compositions
|
|
US6287816B1
(en)
|
1991-06-25 |
2001-09-11 |
Genetics Institute, Inc. |
BMP-9 compositions
|
|
US6692925B1
(en)
|
1992-11-17 |
2004-02-17 |
Ludwig Institute For Cancer Research |
Proteins having serine/threonine kinase domains, corresponding nucleic acid molecules, and their use
|
|
WO1994015965A1
(en)
|
1993-01-12 |
1994-07-21 |
Johns Hopkins University School Of Medicine |
Growth differentiation factor-3
|
|
US5637480A
(en)
|
1993-05-12 |
1997-06-10 |
Genetics Institute, Inc. |
DNA molecules encoding bone morphogenetic protein-10
|
|
EP0698095B1
(en)
|
1993-05-12 |
2004-04-28 |
Genetics Institute, LLC |
Bmp-10 compositions
|
|
US5677196A
(en)
|
1993-05-18 |
1997-10-14 |
University Of Utah Research Foundation |
Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
|
|
US5831050A
(en)
|
1993-06-07 |
1998-11-03 |
Creative Biomolecules, Inc. |
Morphogen cell surface receptor
|
|
DE69434934D1
(de)
|
1993-10-14 |
2007-04-12 |
Harvard College |
Verfahren zur induzierung und zur erhaltung neuronalen zellen
|
|
US5525490A
(en)
|
1994-03-29 |
1996-06-11 |
Onyx Pharmaceuticals, Inc. |
Reverse two-hybrid method
|
|
US5658876A
(en)
|
1994-04-28 |
1997-08-19 |
The General Hospital Corporation |
Activin antagonists as novel contraceptives
|
|
CA2194660C
(en)
|
1994-07-08 |
2009-09-29 |
Se-Jin Lee |
Growth differentiation factor-11
|
|
US5885574A
(en)
|
1994-07-26 |
1999-03-23 |
Amgen Inc. |
Antibodies which activate an erythropoietin receptor
|
|
US5545616A
(en)
|
1994-09-22 |
1996-08-13 |
Genentech, Inc. |
Method for predicting and/or preventing preterm labor
|
|
US5760010A
(en)
|
1995-01-01 |
1998-06-02 |
Klein; Ira |
Method of treating liver disorders with a macrolide antibiotic
|
|
US5814565A
(en)
|
1995-02-23 |
1998-09-29 |
University Of Utah Research Foundation |
Integrated optic waveguide immunosensor
|
|
DE69636866D1
(en)
|
1995-04-11 |
2007-03-15 |
Gen Hospital Corp |
Reverse "two-hybrid"-systeme
|
|
EP0771873A3
(en)
|
1995-10-27 |
1998-03-04 |
Takeda Chemical Industries, Ltd. |
Neuronal cell-specific receptor protein
|
|
GB9526131D0
(en)
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Recombinant chimeric receptors
|
|
US20050244867A1
(en)
|
1996-03-26 |
2005-11-03 |
Human Genome Sciences, Inc. |
Growth factor HTTER36
|
|
US6004780A
(en)
|
1996-03-26 |
1999-12-21 |
Human Genome Sciences, Inc. |
Growth factor HTTER36
|
|
BR9712675A
(pt)
|
1996-10-25 |
1999-10-19 |
Searle & Co |
Agonistas do receptor de eritropoietina circularmente permutados.
|
|
US6605699B1
(en)
|
1997-01-21 |
2003-08-12 |
Human Genome Sciences, Inc. |
Galectin-11 polypeptides
|
|
US6034062A
(en)
|
1997-03-13 |
2000-03-07 |
Genetics Institute, Inc. |
Bone morphogenetic protein (BMP)-9 compositions and their uses
|
|
US6231880B1
(en)
|
1997-05-30 |
2001-05-15 |
Susan P. Perrine |
Compositions and administration of compositions for the treatment of blood disorders
|
|
ATE417927T1
(de)
|
1997-07-30 |
2009-01-15 |
Univ Emory |
Neue knochenmineralisierungsproteine, dna, vektoren, expressionssysteme
|
|
US6656475B1
(en)
|
1997-08-01 |
2003-12-02 |
The Johns Hopkins University School Of Medicine |
Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
|
|
US6891082B2
(en)
|
1997-08-01 |
2005-05-10 |
The Johns Hopkins University School Of Medicine |
Transgenic non-human animals expressing a truncated activintype II receptor
|
|
AU8666398A
(en)
|
1997-08-01 |
1999-02-22 |
Johns Hopkins University School Of Medicine, The |
Methods to identify growth differentiation factor (gdf) receptors
|
|
US6696260B1
(en)
|
1997-08-01 |
2004-02-24 |
The Johns Hopkins University School Of Medicine |
Methods to identify growth differentiation factor (GDF) binding proteins
|
|
US6953662B2
(en)
|
1997-08-29 |
2005-10-11 |
Human Genome Sciences, Inc. |
Follistatin-3
|
|
US6372454B2
(en)
|
1997-08-29 |
2002-04-16 |
Human Genome Sciences, Inc. |
Nucleic acid molecules encoding Follistatin-3
|
|
JP3992298B2
(ja)
|
1997-10-03 |
2007-10-17 |
中外製薬株式会社 |
天然ヒト型化抗体
|
|
US6696411B1
(en)
|
1998-04-22 |
2004-02-24 |
Cornell Research Foundation, Inc. |
Canine erythropoietin gene and recombinant protein
|
|
CN1317967A
(zh)
|
1998-09-17 |
2001-10-17 |
伊莱利利公司 |
蛋白质制剂
|
|
AU5502799A
(en)
|
1998-09-22 |
2000-04-10 |
Long Yu |
New human growth differentiation factor encoding sequence and polypeptide encoded by such dna sequence and producing method thereof
|
|
US6472179B2
(en)
|
1998-09-25 |
2002-10-29 |
Regeneron Pharmaceuticals, Inc. |
Receptor based antagonists and methods of making and using
|
|
US6548634B1
(en)
|
1998-09-30 |
2003-04-15 |
Chiron Corporation |
Synthetic peptides having FGF receptor affinity
|
|
US6238860B1
(en)
|
1998-11-05 |
2001-05-29 |
Dyax Corp. |
Binding moieties for human parvovirus B19
|
|
US6777205B1
(en)
|
1998-11-06 |
2004-08-17 |
Sterrenbeld Biotechnologie North America, Inc. |
Host cells expressing recombinant human erythropoietin
|
|
US20040009535A1
(en)
|
1998-11-27 |
2004-01-15 |
Celltech R&D, Inc. |
Compositions and methods for increasing bone mineralization
|
|
AU772694B2
(en)
|
1999-01-21 |
2004-05-06 |
Metamorphix International, Inc. |
Growth differentiation factor inhibitors and uses therefor
|
|
US6914128B1
(en)
|
1999-03-25 |
2005-07-05 |
Abbott Gmbh & Co. Kg |
Human antibodies that bind human IL-12 and methods for producing
|
|
EP1174149A1
(en)
|
1999-04-19 |
2002-01-23 |
Kyowa Hakko Kogyo Co., Ltd. |
Proliferation inhibitor for androgen-independent tumor
|
|
US6468543B1
(en)
|
1999-05-03 |
2002-10-22 |
Zymogenetics, Inc. |
Methods for promoting growth of bone using ZVEGF4
|
|
SK8292002A3
(en)
|
1999-11-12 |
2002-12-03 |
Maxygen Holdings Ltd |
A conjugate exhibiting interferon gamma activity, nucleotide sequence encoding for a polypeptide fraction of conjugate, an expression vector and a host cell containing nucleotide sequence, pharmaceutical composition comprising the same and use thereof
|
|
AU777166B2
(en)
|
1999-12-15 |
2004-10-07 |
Research Development Foundation |
Betaglycan as an inhibin receptor and uses thereof
|
|
US20030224501A1
(en)
|
2000-03-17 |
2003-12-04 |
Young Paul E. |
Bone morphogenic protein polynucleotides, polypeptides, and antibodies
|
|
JP4487376B2
(ja)
|
2000-03-31 |
2010-06-23 |
味の素株式会社 |
腎疾患治療剤
|
|
PL219131B1
(pl)
|
2000-05-15 |
2015-03-31 |
Hoffmann La Roche |
Ciekła kompozycja farmaceutyczna, sposób jej wytwarzania oraz jej zastosowanie
|
|
US6627424B1
(en)
|
2000-05-26 |
2003-09-30 |
Mj Bioworks, Inc. |
Nucleic acid modifying enzymes
|
|
AU2001269709A1
(en)
|
2000-07-19 |
2002-02-05 |
Eli Lilly And Company |
Nucleic acids, vectors, host cells, polypeptides, and uses thereof
|
|
US6632180B1
(en)
|
2000-09-07 |
2003-10-14 |
John H. Laragh |
Method for evaluating and treating hypertension
|
|
DE10045591A1
(de)
|
2000-09-15 |
2002-04-04 |
Klaus Pfizenmaier |
Ortsspezifische, antikörpervermittelte Aktivierung proapoptotischer Zytokine - AMAIZe (Antibody-Mediated Apoptosis Inducing Zytokine)
|
|
CA2418835A1
(en)
|
2000-10-16 |
2002-04-25 |
Phylos, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US7087224B2
(en)
|
2000-10-31 |
2006-08-08 |
Amgen Inc. |
Method of treating anemia by administering IL-1ra
|
|
DK1345959T3
(da)
|
2000-11-20 |
2011-09-05 |
Univ Illinois |
Membranscaffoldproteiner
|
|
US20030082233A1
(en)
|
2000-12-01 |
2003-05-01 |
Lyons Karen M. |
Method and composition for modulating bone growth
|
|
AU2002236558A1
(en)
|
2000-12-01 |
2002-06-11 |
Regents Of The University Of California |
Method and composition for modulating bone growth
|
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
TWI329129B
(en)
|
2001-02-08 |
2010-08-21 |
Wyeth Corp |
Modified and stabilized gdf propeptides and uses thereof
|
|
US20040132675A1
(en)
|
2002-02-08 |
2004-07-08 |
Calvin Kuo |
Method for treating cancer and increasing hematocrit levels
|
|
US7294472B2
(en)
|
2001-03-14 |
2007-11-13 |
Caden Biosciences |
Method for identifying modulators of G protein coupled receptor signaling
|
|
WO2002074340A1
(fr)
|
2001-03-16 |
2002-09-26 |
Takeda Chemical Industries, Ltd. |
Procede de fabrication d'une preparation a liberation continue
|
|
DK1390535T3
(da)
|
2001-04-26 |
2010-12-06 |
Amgen Mountain View Inc |
Kombinatoriske biblioteker af monomer-domæner
|
|
BRPI0209933B8
(pt)
|
2001-05-24 |
2021-05-25 |
Zymogenetics Inc |
proteína de fusão, e, molécula de ácido nucleico
|
|
EP1390497A2
(en)
|
2001-05-25 |
2004-02-25 |
Genset |
Human cdnas and proteins and uses thereof
|
|
AUPR638101A0
(en)
|
2001-07-13 |
2001-08-09 |
Bioa Pty Limited |
Composition and method for treatment of disease
|
|
US6855344B2
(en)
|
2001-07-17 |
2005-02-15 |
Integrated Chinese Medicine Holdings, Ltd. |
Compositions and methods for prostate and kidney health and disorders, an herbal preparation
|
|
US7396642B2
(en)
|
2001-07-17 |
2008-07-08 |
Teijin Limited |
Methods of screening for a compound that enhances thermogenesis
|
|
KR100453877B1
(ko)
|
2001-07-26 |
2004-10-20 |
메덱스젠 주식회사 |
연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체
|
|
US7320789B2
(en)
|
2001-09-26 |
2008-01-22 |
Wyeth |
Antibody inhibitors of GDF-8 and uses thereof
|
|
US6784154B2
(en)
|
2001-11-01 |
2004-08-31 |
University Of Utah Research Foundation |
Method of use of erythropoietin to treat ischemic acute renal failure
|
|
CN102552263A
(zh)
|
2001-12-06 |
2012-07-11 |
法布罗根股份有限公司 |
提高内源性红细胞生成素(epo)的方法
|
|
US20060234918A1
(en)
|
2001-12-19 |
2006-10-19 |
Voyager Pharmaceutical Corporation |
Methods for treating and preventing cancers that express the hypothalamic-pituitary-gonadal axis of hormones and receptors
|
|
US20030144203A1
(en)
|
2001-12-19 |
2003-07-31 |
Voyager Pharmaceutical Corporation |
Methods for slowing senescence and treating and preventing diseases associated with senescence
|
|
US6998118B2
(en)
|
2001-12-21 |
2006-02-14 |
The Salk Institute For Biological Studies |
Targeted retrograde gene delivery for neuronal protection
|
|
EP1573002A4
(en)
|
2002-02-11 |
2008-07-16 |
Genentech Inc |
ANTIBODY VARIANTS WITH FASTER ANTIGEN ASSOCIATION SPEEDS
|
|
CA2476887A1
(en)
|
2002-02-21 |
2003-09-04 |
Wyeth |
Gasp1:a follistatin domain containing protein
|
|
BR0307871A
(pt)
|
2002-02-21 |
2005-04-12 |
Wyeth Corp |
Proteìnas contendo domìnio de folistatina
|
|
US20030219846A1
(en)
|
2002-02-28 |
2003-11-27 |
Pfizer Inc. |
Assay for activity of the ActRIIB kinase
|
|
AU2003232485A1
(en)
|
2002-04-18 |
2003-10-27 |
Mtm Laboratories Ag |
Neopeptides and methods useful for detection and treatment of cancer
|
|
DE10234192B4
(de)
|
2002-07-26 |
2009-11-26 |
Epoplus Gmbh Co.Kg |
Verwendung von Erythropoetin
|
|
KR20050083635A
(ko)
|
2002-08-16 |
2005-08-26 |
와이어쓰 |
Ｂｍｐ-2 에스트로겐 반응 요소 및 이의 사용 방법
|
|
JP2006510606A
(ja)
|
2002-10-15 |
2006-03-30 |
セルジーン・コーポレーション |
骨髄異形成症候群を治療および管理するための選択的サイトカイン阻害剤の使用方法およびそれを含む組成物
|
|
AR047392A1
(es)
|
2002-10-22 |
2006-01-18 |
Wyeth Corp |
Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines
|
|
US20040223966A1
(en)
|
2002-10-25 |
2004-11-11 |
Wolfman Neil M. |
ActRIIB fusion polypeptides and uses therefor
|
|
AU2002953327A0
(en)
|
2002-12-12 |
2003-01-09 |
Monash University |
Methods of diagnosing prognosing and treating activin associated diseases and conditions
|
|
WO2004064770A2
(en)
|
2003-01-17 |
2004-08-05 |
Government Of The United States Of America As Represented By The Secretary, Department Of Health Andhuman Services |
Use of smad3 inhibitor in the treatment of fibrosis dependent on epithelial to mesenchymal transition as in the eye and kidney
|
|
DK1592416T3
(da)
|
2003-02-07 |
2009-04-20 |
Prometic Biosciences Inc |
Fedtsyrer med middel kædelængde, glycerider og analoger som stimulatorer af erythropoiesis
|
|
US20040197828A1
(en)
|
2003-03-26 |
2004-10-07 |
Gaddy Dana P. |
Method for diagnosis and treatment of bone turnover
|
|
WO2010019832A2
(en)
|
2008-08-13 |
2010-02-18 |
Designer Molecules, Inc. |
Amide-extended crosslinking compounds and methods for use thereof
|
|
WO2005028517A2
(en)
|
2003-05-09 |
2005-03-31 |
The General Hospital Corporation |
SOLUBLE TGF-β TYPE III RECEPTOR FUSION PROTEINS
|
|
BRPI0410927A
(pt)
|
2003-06-02 |
2006-06-27 |
Wyeth Corp |
métodos terapêuticos e profiláticos para distúrbios neuromusculares
|
|
EP1636270B1
(en)
|
2003-06-16 |
2016-07-20 |
UCB Pharma S.A. |
Antibodies specific for sclerostin and methods for increasing bone mineralization
|
|
US7611465B2
(en)
|
2003-07-15 |
2009-11-03 |
Board Of Regents, The University Of Texas System |
Rapid and accurate detection of bone quality using ultrasound critical angle reflectometry
|
|
WO2005009460A2
(en)
|
2003-07-25 |
2005-02-03 |
Medexis, S.A. |
Pharmaceutical composition comprising activin a, alk-4 or derivatives thereof for the treatment of ophthalmic disorders or cancer
|
|
DE10335211A1
(de)
|
2003-08-01 |
2005-02-17 |
Robert Bosch Gmbh |
Kraftstoff-Einspritzvorrichtung für eine Brennkraftmaschine
|
|
WO2005025601A1
(en)
|
2003-09-15 |
2005-03-24 |
Monash University |
Follistatin isoforms and uses thereof
|
|
US8895540B2
(en)
|
2003-11-26 |
2014-11-25 |
DePuy Synthes Products, LLC |
Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
|
|
PL1706428T3
(pl)
|
2004-01-22 |
2010-02-26 |
Merck Patent Gmbh |
Przeciwciała przeciwnowotworowe o zredukowanym wiązaniu dopełniacza
|
|
US20050197292A1
(en)
|
2004-01-30 |
2005-09-08 |
Glennda Smithson |
Compositions and methods for treating T-cell mediated pathological conditions
|
|
EP1732589A2
(en)
|
2004-03-26 |
2006-12-20 |
Acceleron Pharma Inc. |
Bmp-3 propeptides and related methods
|
|
US7459527B2
(en)
|
2004-03-31 |
2008-12-02 |
Xencor, Inc. |
BMP-7 variants with improved properties
|
|
US7741284B2
(en)
|
2004-05-12 |
2010-06-22 |
Acceleron Pharma Inc. |
BMP10 propeptides and related methods
|
|
US7465706B2
(en)
|
2004-06-24 |
2008-12-16 |
Acceleron Pharma Inc. |
GDF3 propeptides and related methods
|
|
EP1771470B1
(en)
|
2004-07-23 |
2013-06-26 |
Acceleron Pharma Inc. |
Actrii receptor polypeptides, methods and compositions
|
|
EP1794191B1
(en)
|
2004-08-05 |
2016-05-18 |
The Regents of The University of California |
Molecules with effects on cellular development and function
|
|
AU2005272646A1
(en)
|
2004-08-12 |
2006-02-23 |
Wyeth |
Combination therapy for diabetes, obesity, and cardiovascular diseases using GDF-8 inhibitors
|
|
WO2006039400A2
(en)
|
2004-09-29 |
2006-04-13 |
Mount Sinai School Of Medicine Of New York University |
Fsh and fsh receptor modulator compositions and methods for inhibiting osteoclastic bone resorption and bone loss in osteoporosis
|
|
WO2006052842A2
(en)
|
2004-11-09 |
2006-05-18 |
The Trustees Of The University Of Pennsylvania |
Methods for diagnosis of myelodysplastic syndromes (mds)
|
|
EP1824796A4
(en)
|
2004-11-16 |
2010-02-17 |
Avidia Res Inst |
PROTEIN SKELETONS AND USES THEREOF
|
|
NZ538097A
(en)
|
2005-02-07 |
2006-07-28 |
Ovita Ltd |
Method and compositions for improving wound healing
|
|
US7968091B2
(en)
|
2005-02-16 |
2011-06-28 |
The General Hospital Corporation |
Methods and compositions to regulate iron metabolism
|
|
JPWO2006115274A1
(ja)
|
2005-04-26 |
2008-12-18 |
味の素株式会社 |
骨髄赤血球前駆細胞分化促進剤
|
|
JP2007099764A
(ja)
|
2005-09-09 |
2007-04-19 |
Ajinomoto Co Inc |
血糖低下剤
|
|
EA015351B1
(ru)
|
2005-09-28 |
2011-06-30 |
Займодженетикс, Инк. |
Антагонисты il-17a и il-17f и способы их применения
|
|
US8067562B2
(en)
|
2005-11-01 |
2011-11-29 |
Amgen Inc. |
Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1
|
|
KR20190006086A
(ko)
|
2005-11-23 |
2019-01-16 |
악셀레론 파마 인코포레이티드 |
액티빈-ａｃｔｒⅱａ 길항제 및 골 성장을 촉진하기 위한 이들의 용도
|
|
US8128933B2
(en)
|
2005-11-23 |
2012-03-06 |
Acceleron Pharma, Inc. |
Method of promoting bone growth by an anti-activin B antibody
|
|
JP2009518422A
(ja)
|
2005-12-06 |
2009-05-07 |
アムジェン インコーポレイテッド |
ミオスタチン・アンタゴニストの使用
|
|
EP1966183A4
(en)
|
2005-12-20 |
2010-12-29 |
Merck Frosst Canada Ltd |
HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A-DELTA-9-DESATURASE
|
|
MX2008008340A
(es)
|
2005-12-21 |
2008-09-03 |
Schering Corp |
Tratamiento de enfermedad de higado graso no alcoholica usando agentes reductores de colesterol y/o antagonista/agonista inverso de receptor de histamina 3.
|
|
EP1973909A2
(en)
|
2005-12-22 |
2008-10-01 |
Biogen Idec MA Inc. |
Transforming growth factor modulators
|
|
JP4925364B2
(ja)
|
2006-01-20 |
2012-04-25 |
ベックマン コールター， インコーポレイテッド |
鉄欠乏を検出する方法
|
|
EP1976377A4
(en)
|
2006-01-25 |
2010-06-23 |
Wellstat Therapeutics Corp |
COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
|
|
US20100227901A1
(en)
|
2006-02-28 |
2010-09-09 |
Wellstat Therapeutics Corporation |
Compounds for the treatment of metabolic disorders
|
|
WO2007109668A2
(en)
*
|
2006-03-20 |
2007-09-27 |
The Uab Research Foundation |
Compositions and methods for improving bone mass through modulation of novel receptors of pth and fragments thereof
|
|
US20080102065A1
(en)
|
2006-04-14 |
2008-05-01 |
Borges Luis G |
Erythropoietin receptor extended duration limited agonists
|
|
WO2007123391A1
(en)
|
2006-04-20 |
2007-11-01 |
Academisch Ziekenhuis Leiden |
Therapeutic intervention in a genetic disease in an individual by modifying expression of an aberrantly expressed gene.
|
|
CN101489544A
(zh)
|
2006-05-09 |
2009-07-22 |
海玛奎斯特医药公司 |
治疗血液病的方法
|
|
PL2048948T3
(pl)
|
2006-07-21 |
2012-07-31 |
Lyne Laboratories Inc |
Płynne kompozycje octanu wapnia
|
|
GB0615129D0
(en)
|
2006-07-29 |
2006-09-06 |
Univ Cardiff |
Anti-cancer activity of BMP-9 and BMP-10 and their use in cancer therapies
|
|
WO2008030367A2
(en)
|
2006-09-01 |
2008-03-13 |
The General Hospital Corporation |
Selective myostatin inhibitors
|
|
CL2007002567A1
(es)
|
2006-09-08 |
2008-02-01 |
Amgen Inc |
Proteinas aisladas de enlace a activina a humana.
|
|
US7547781B2
(en)
|
2006-09-11 |
2009-06-16 |
Curis, Inc. |
Quinazoline based EGFR inhibitors containing a zinc binding moiety
|
|
JP5468187B2
(ja)
|
2006-09-26 |
2014-04-09 |
ポリプラスチックス株式会社 |
ポリアセタール樹脂組成物
|
|
WO2008060139A1
(en)
|
2006-11-17 |
2008-05-22 |
Erasmus University Medical Center Rotterdam |
Methods for controlling mineralization of extracellular matrix, therapeutic methods based thereon and medicaments for use therein
|
|
WO2008073292A2
(en)
|
2006-12-08 |
2008-06-19 |
Caritas St. Elizabeth's Medical Center Of Boston, Inc. |
Method for protecting renal tubular epithelial cells from radiocontrast nephro parhy (rcn)
|
|
JP5632582B2
(ja)
|
2006-12-14 |
2014-11-26 |
中外製薬株式会社 |
抗Ｃｌａｕｄｉｎ３モノクローナル抗体およびそれを用いる癌の治療および診断
|
|
US20100028332A1
(en)
|
2006-12-18 |
2010-02-04 |
Acceleron Pharma Inc. |
Antagonists of actriib and uses for increasing red blood cell levels
|
|
US8895016B2
(en)
|
2006-12-18 |
2014-11-25 |
Acceleron Pharma, Inc. |
Antagonists of activin-actriia and uses for increasing red blood cell levels
|
|
DK2124999T3
(da)
|
2006-12-18 |
2013-01-14 |
Acceleron Pharma Inc |
Activin-actrii antagonister og anvendelser til behandling af anæmi
|
|
EP2111229B1
(en)
|
2007-02-01 |
2013-04-10 |
Acceleron Pharma, Inc. |
Pharmaceutical compositions comprising Activin-ActRIIA antagonists for use in preventing or treating breast cancer metastasis or breast cancer related bone loss
|
|
TWI782836B
(zh)
|
2007-02-02 |
2022-11-01 |
美商艾瑟勒朗法瑪公司 |
衍生自ActRIIB的變體與其用途
|
|
ES2756725T3
(es)
|
2007-02-09 |
2020-04-27 |
Acceleron Pharma Inc |
Composiciones farmacéuticas que comprenden antagonistas de Activina-ActRIIA
|
|
TWI573802B
(zh)
|
2007-03-06 |
2017-03-11 |
安美基公司 |
變異之活動素受體多肽及其用途
|
|
US8501678B2
(en)
|
2007-03-06 |
2013-08-06 |
Atara Biotherapeutics, Inc. |
Variant activin receptor polypeptides and uses thereof
|
|
US20090017019A1
(en)
|
2007-06-01 |
2009-01-15 |
Wyeth |
Methods and compositions for modulating bmp-10 activity
|
|
WO2009009059A1
(en)
|
2007-07-09 |
2009-01-15 |
Biogen Idec Ma Inc. |
Spiro compounds as antagonists of tgf-beta
|
|
GB0715087D0
(en)
|
2007-08-03 |
2007-09-12 |
Summit Corp Plc |
Drug combinations for the treatment of duchenne muscular dystrophy
|
|
JP2010535708A
(ja)
|
2007-08-03 |
2010-11-25 |
ビオマリン アイジーエー リミテッド |
デュシェンヌ型筋ジストロフィーの治療のための薬物併用
|
|
GB0715938D0
(en)
|
2007-08-15 |
2007-09-26 |
Vastox Plc |
Method of treatment of duchenne muscular dystrophy
|
|
WO2009025651A1
(en)
|
2007-08-17 |
2009-02-26 |
University Of Maine System Board Of Trustees |
Biologically active peptide and method of using the same
|
|
US20100279409A1
(en)
|
2007-09-13 |
2010-11-04 |
Neil Robson |
Method for modifying celluar immune resonse by modulating activin activity
|
|
EP3243524A1
(en)
|
2007-09-18 |
2017-11-15 |
Acceleron Pharma Inc. |
Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion
|
|
PE20091163A1
(es)
|
2007-11-01 |
2009-08-09 |
Wyeth Corp |
Anticuerpos para gdf8
|
|
CN101925611A
(zh)
|
2007-11-21 |
2010-12-22 |
安姆根有限公司 |
Wise结合剂和表位
|
|
JP5638961B2
(ja)
|
2008-03-13 |
2014-12-10 |
ザ ジェネラル ホスピタル コーポレイション |
Ｂｍｐシグナル伝達経路のインヒビター
|
|
WO2009146148A2
(en)
|
2008-04-04 |
2009-12-03 |
Tactair Fluid Controls, Inc. |
Locking mechanism with bi-modal actuator
|
|
CN102083969A
(zh)
|
2008-05-06 |
2011-06-01 |
乔斯林糖尿病中心股份有限公司 |
诱导褐色脂肪形成的方法和组合物
|
|
WO2009137075A1
(en)
|
2008-05-06 |
2009-11-12 |
Acceleron Pharma Inc. |
Anti-activin antibodies and uses for promoting bone growth
|
|
JP2011521969A
(ja)
|
2008-05-30 |
2011-07-28 |
スムマ ヘルス システムズ エルエルシー |
眼疾患を治療するためのＴＧＦ−β受容体阻害剤又はアクチビン様キナーゼ（ＡＬＫ）５阻害剤、Ａ−８３−０１及びＳＢ−４３１５４２の使用方法及び創傷治療条件
|
|
AU2009262970A1
(en)
|
2008-06-26 |
2009-12-30 |
Acceleron Pharma Inc. |
Methods for dosing an activin-ActRIIa antagonist and monitoring of treated patients
|
|
JP5773868B2
(ja)
|
2008-06-26 |
2015-09-02 |
アクセルロン ファーマ， インコーポレイテッド |
アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用
|
|
US8216997B2
(en)
|
2008-08-14 |
2012-07-10 |
Acceleron Pharma, Inc. |
Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
|
|
SMT202300222T1
(it)
|
2008-08-14 |
2023-09-06 |
Acceleron Pharma Inc |
Trappole di gdf
|
|
WO2010059861A1
(en)
|
2008-11-20 |
2010-05-27 |
University Of Southern California |
Compositions and methods to modulate hair growth
|
|
SG10201703067QA
(en)
|
2008-11-26 |
2017-05-30 |
Amgen Inc |
Variants Of Activin IIB Receptor Polypeptides And Uses Thereof
|
|
US8138142B2
(en)
|
2009-01-13 |
2012-03-20 |
Acceleron Pharma Inc. |
Methods for increasing adiponectin in a patient in need thereof
|
|
BRPI1008815A2
(pt)
*
|
2009-02-05 |
2018-02-14 |
Digna Biotech, S.L |
composições farmacêuticas compreendendo peptídeos inibidores de tgf-beta1
|
|
US8110355B2
(en)
|
2009-02-20 |
2012-02-07 |
GenRemedy, LLC |
Methods for identifying agents that inhibit cell migration, promote cell adhesion and prevent metastasis
|
|
WO2010121162A1
(en)
|
2009-04-17 |
2010-10-21 |
Summa Health Systems Llc |
Use of transforming growth factor-b receptor inhibitors to suppress ocular scarring
|
|
JP5766179B2
(ja)
|
2009-04-27 |
2015-08-19 |
ノバルティス アーゲー |
筋肉増殖を増加させるための組成物および方法
|
|
BRPI1010587A2
(pt)
|
2009-06-08 |
2019-04-09 |
Acceleron Pharma Inc. |
métodos para aumentar adipócitos termogênicos
|
|
EP2440577A4
(en)
|
2009-06-12 |
2013-01-23 |
Acceleron Pharma Inc |
SHORTEN ACTRIIB FC FUSION PROTEINS
|
|
KR20180085825A
(ko)
|
2009-08-13 |
2018-07-27 |
악셀레론 파마 인코포레이티드 |
적혈구 수준을 증가시키기 위한 ｇｄｆ 트랩과 에리트로포이에틴 수용체 활성인자의 병용
|
|
BR112012005225B8
(pt)
|
2009-09-09 |
2023-01-10 |
Acceleron Pharma Inc |
Uso de uma proteína de fusão actriib-fc para o tratamento de um transtorno relacionado ao osso ou associado à perda de músculo por crescimento muscular insuficiente
|
|
EP3818988A1
(en)
|
2009-11-03 |
2021-05-12 |
Acceleron Pharma Inc. |
Methods for treating fatty liver disease
|
|
JP6267425B2
(ja)
|
2009-11-17 |
2018-01-24 |
アクセルロン ファーマ， インコーポレイテッド |
筋ジストロフィー治療のためのユートロフィン誘導に関するａｃｔｒｉｉｂタンパク質およびその改変体およびその使用
|
|
WO2012027065A2
(en)
|
2010-08-27 |
2012-03-01 |
Celgene Corporation |
Combination therapy for treatment of disease
|
|
US8580922B2
(en)
|
2011-03-04 |
2013-11-12 |
Shire Human Genetic Therapies, Inc. |
Peptide linkers for polypeptide compositions and methods for using same
|
|
HUE040276T2
(hu)
|
2011-07-01 |
2019-02-28 |
Novartis Ag |
Eljárás metabolikus rendellenességek kezelésére
|
|
BR112014009528B1
(pt)
|
2011-10-17 |
2020-12-29 |
Acceleron Pharma, Inc. |
usos de polipeptídeos actriib para a fabricação de um medicamento para tratar eritropoiese ineficaz
|
|
US8765385B2
(en)
|
2011-10-27 |
2014-07-01 |
Ravindra Kumar |
Method of detection of neutralizing anti-actriib antibodies
|
|
WO2013063536A1
(en)
|
2011-10-27 |
2013-05-02 |
Acceleron Pharma, Inc. |
Actriib binding agents and uses thereof
|
|
CN104023731A
(zh)
|
2011-10-28 |
2014-09-03 |
帕仁塔生物科技有限公司 |
治疗粘液分泌亢进的方法
|
|
HK1203384A1
(en)
|
2011-12-19 |
2015-12-11 |
Amgen Inc. |
Variant activin receptor polypeptides, alone or in combination with chemotherapy, and uses thereof
|
|
EA201491578A1
(ru)
|
2012-03-30 |
2015-04-30 |
Шир Хьюман Дженетик Терапис, Инк. |
Подкожное введение идуронат-2-сульфатазы
|
|
US9254311B2
(en)
|
2012-04-02 |
2016-02-09 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins
|
|
EP2861620A2
(en)
|
2012-06-14 |
2015-04-22 |
The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center |
Use of blocking agents of bone morphogenie protein (bmp) signaling for the treatment of neuroinflammatory and neurodegenerative diseases
|
|
CN104411720B
(zh)
|
2012-07-02 |
2018-05-11 |
协和发酵麒麟株式会社 |
以抗bmp9抗体作为有效成分的、对肾性贫血、癌性贫血等贫血的治疗剂
|
|
AU2013334660B2
(en)
|
2012-10-24 |
2018-08-09 |
Celgene Corporation |
Methods for treating anemia
|
|
CN104968801B
(zh)
|
2012-10-24 |
2021-06-15 |
细胞基因公司 |
用于治疗贫血症的生物标志物
|
|
WO2014064292A1
(en)
|
2012-10-26 |
2014-05-01 |
Universite Pierre Et Marie Curie (Paris 6) |
A method for preventing or treating atrial fibrillation
|
|
NZ707477A
(en)
|
2012-11-02 |
2019-09-27 |
Celgene Corp |
Activin-actrii antagonists and uses for treating bone and other disorders
|
|
EP2916827B1
(en)
|
2012-11-08 |
2020-06-10 |
Clearside Biomedical Inc. |
Methods for the treatment of ocular disease in human subjects
|
|
CN103047581B
(zh)
|
2012-12-04 |
2015-04-01 |
京东方科技集团股份有限公司 |
背光模组及具有该背光模组的显示装置
|
|
US20150328249A1
(en)
|
2012-12-11 |
2015-11-19 |
Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center |
Modulation of myofiber repair by anti-myostatin strategies and/or ppar gamma ligands, alone or in combination with stem cells, for the therapy of critical limb ischemia and other ischemic processes affecting the skeletal muscle
|
|
US20140220033A1
(en)
|
2013-02-01 |
2014-08-07 |
Santa Maria Biotherapeutics, Inc. |
Administration of an Anti-Activin-A Compound to a Subject
|
|
TW201920262A
(zh)
|
2013-07-30 |
2019-06-01 |
美商再生元醫藥公司 |
抗活化素ａ之抗體及其用途
|
|
KR20160042987A
(ko)
|
2013-08-14 |
2016-04-20 |
노파르티스 아게 |
산발성 봉입체 근염을 치료하는 방법
|
|
CA2932463A1
(en)
|
2013-12-16 |
2015-06-25 |
Paranta Biosciences Limited |
Method of diagnosis and treatment
|
|
EP3094751A4
(en)
|
2014-01-14 |
2017-06-07 |
Santa Maria Biotherapeutics, Inc. |
Activin inhibitor response prediction and uses for treatment
|
|
US20170248609A1
(en)
|
2014-01-27 |
2017-08-31 |
Novartis Ag |
Biomarkers predictive of muscle atrophy, method and use
|
|
MA39722A
(fr)
|
2014-03-21 |
2021-06-02 |
Acceleron Pharma Inc |
Composition pour son utilisation dans une methode de traitement ou de prevention de l'anemie par l'inhibition de l'activine b et du gdf11
|
|
WO2015152183A1
(ja)
|
2014-03-31 |
2015-10-08 |
大日本住友製薬株式会社 |
進行性骨化性線維異形成症の予防剤及び治療剤
|
|
MX388380B
(es)
|
2014-04-18 |
2025-03-19 |
Acceleron Pharma Inc |
Composiciones para usarse en el incremento de los niveles de glóbulos rojos y el tratamiento de enfermedad de células falciformes.
|
|
TW201622746A
(zh)
|
2014-04-24 |
2016-07-01 |
諾華公司 |
改善或加速髖部骨折術後身體復原之方法
|
|
WO2015192111A1
(en)
|
2014-06-13 |
2015-12-17 |
Acceleron Pharma, Inc. |
Methods and compositions for treating ulcers
|
|
KR20170035891A
(ko)
|
2014-06-13 |
2017-03-31 |
산타 마리아 바이오테라퓨틱스, 인코포레이티드 |
제형화된 수용체 폴리펩타이드 및 관련 방법
|
|
MA41052A
(fr)
|
2014-10-09 |
2017-08-15 |
Celgene Corp |
Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
|
|
JP2018501307A
(ja)
|
2014-12-03 |
2018-01-18 |
セルジーン コーポレイション |
アクチビン−ＡｃｔＲＩＩアンタゴニスト及び貧血を治療するための使用
|
|
MA41119A
(fr)
|
2014-12-03 |
2017-10-10 |
Acceleron Pharma Inc |
Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique
|
|
CN107847562A
(zh)
|
2015-05-13 |
2018-03-27 |
细胞基因公司 |
使用 ACTRII 配体陷阱治疗 β‑地中海贫血
|
|
MA42160A
(fr)
|
2015-05-20 |
2018-03-28 |
Maria Cappellini |
Procédés de culture de cellules in vitro pour la beta-thalassemie a l'aide de pieges a ligands du recepteur de l'activine de type ii
|
|
HK1256638A1
(zh)
|
2015-08-04 |
2019-09-27 |
Acceleron Pharma Inc. |
用於治疗骨髓增生性病症的方法
|
|
US11123430B2
(en)
|
2015-11-04 |
2021-09-21 |
Acceleron Pharma Inc. |
Methods for increasing red blood cell levels and treating ineffective erythropoiesis
|
|
CA3005975A1
(en)
|
2015-11-23 |
2017-06-01 |
Acceleron Pharma Inc. |
Methods for treating eye disorders
|
|
PL3490582T3
(pl)
|
2016-07-27 |
2024-09-23 |
Acceleron Pharma Inc. |
Kompozycje do zastosowania w leczeniu mielofibrozy
|