SG10201703067QA - Variants Of Activin IIB Receptor Polypeptides And Uses Thereof - Google Patents

Variants Of Activin IIB Receptor Polypeptides And Uses Thereof

Info

Publication number
SG10201703067QA
SG10201703067QA SG10201703067QA SG10201703067QA SG10201703067QA SG 10201703067Q A SG10201703067Q A SG 10201703067QA SG 10201703067Q A SG10201703067Q A SG 10201703067QA SG 10201703067Q A SG10201703067Q A SG 10201703067QA SG 10201703067Q A SG10201703067Q A SG 10201703067QA
Authority
SG
Singapore
Prior art keywords
variants
receptor polypeptides
iib receptor
activin iib
activin
Prior art date
Application number
SG10201703067QA
Inventor
Jeonghoon Sun
Lei-Ting Tony Tam
Mark Leo Michaels
Thomas C Boone
Rohini Deshpande
Yue-Sheng Li
Hq Han
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41693455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201703067Q(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SG10201703067QA publication Critical patent/SG10201703067QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
SG10201703067QA 2008-11-26 2009-11-24 Variants Of Activin IIB Receptor Polypeptides And Uses Thereof SG10201703067QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20025008P 2008-11-26 2008-11-26
US25906009P 2009-11-06 2009-11-06

Publications (1)

Publication Number Publication Date
SG10201703067QA true SG10201703067QA (en) 2017-05-30

Family

ID=41693455

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201703067QA SG10201703067QA (en) 2008-11-26 2009-11-24 Variants Of Activin IIB Receptor Polypeptides And Uses Thereof
SG2011037777A SG171813A1 (en) 2008-11-26 2009-11-24 Variants of activin iib receptor polypeptides and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG2011037777A SG171813A1 (en) 2008-11-26 2009-11-24 Variants of activin iib receptor polypeptides and uses thereof

Country Status (38)

Country Link
US (5) US8410043B2 (en)
EP (2) EP2370463B1 (en)
JP (3) JP5611222B2 (en)
KR (3) KR101778134B1 (en)
CN (2) CN102245634B (en)
AR (1) AR074397A1 (en)
AU (1) AU2009320364B2 (en)
BR (1) BRPI0920962A2 (en)
CA (2) CA2997971A1 (en)
CL (1) CL2011001239A1 (en)
CO (1) CO6382163A2 (en)
CR (2) CR20160443A (en)
CY (1) CY1118754T1 (en)
DK (1) DK2370463T3 (en)
EA (2) EA201791940A3 (en)
ES (1) ES2600491T3 (en)
HK (1) HK1162545A1 (en)
HR (1) HRP20161450T1 (en)
HU (1) HUE032090T2 (en)
IL (2) IL212773A (en)
LT (1) LT2370463T (en)
MA (1) MA32936B1 (en)
ME (1) ME02652B (en)
MX (1) MX2011005505A (en)
MY (1) MY159483A (en)
NZ (2) NZ604818A (en)
PE (2) PE20150680A1 (en)
PL (1) PL2370463T3 (en)
PT (1) PT2370463T (en)
RS (1) RS55369B1 (en)
SG (2) SG10201703067QA (en)
SI (1) SI2370463T1 (en)
SM (1) SMT201600417B (en)
TN (1) TN2011000238A1 (en)
TW (1) TWI486166B (en)
UA (1) UA107921C2 (en)
WO (1) WO2010062383A2 (en)
ZA (1) ZA201104648B (en)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8067562B2 (en) 2005-11-01 2011-11-29 Amgen Inc. Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1
US8128933B2 (en) 2005-11-23 2012-03-06 Acceleron Pharma, Inc. Method of promoting bone growth by an anti-activin B antibody
CN104844713B (en) 2005-11-23 2021-05-14 阿塞勒隆制药公司 Activin-ActRIIa antagonists and uses thereof for promoting bone growth
CL2007002567A1 (en) 2006-09-08 2008-02-01 Amgen Inc ISOLATED PROTEINS FROM LINK TO ACTIVINE TO HUMAN.
US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
BRPI0806861A2 (en) 2007-02-01 2014-08-05 Acceleron Pharma Inc ATIVIN-ACTRIE ANTAGONISTS AND USES TO TREAT OR PREVENT BREAST CANCER
TW201940502A (en) 2007-02-02 2019-10-16 美商艾瑟勒朗法瑪公司 Variants derived from ActRIIB and uses therefor
TWI525102B (en) 2007-02-09 2016-03-11 艾瑟勒朗法瑪公司 Pharmaceutical composition comprising an actriia-fc fusion protein; use of an actriia-fc fusion protein for treatment or prevention of cancer-related bone loss; use of an actriia-fc fusion protein for the treatment or prevention of multiple myeloma
US8501678B2 (en) 2007-03-06 2013-08-06 Atara Biotherapeutics, Inc. Variant activin receptor polypeptides and uses thereof
TW201718635A (en) 2007-03-06 2017-06-01 安美基公司 Variant activin receptor polypeptides and uses thereof
CN103877564A (en) 2007-09-18 2014-06-25 阿塞勒隆制药公司 Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion
TWI784538B (en) 2008-08-14 2022-11-21 美商艾瑟勒朗法瑪公司 Use of gdf traps to increase red blood cell levels
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
EA201791940A3 (en) 2008-11-26 2018-04-30 Амген Инк. OPTIONS OF POLYPEPTIDES OF ACTIVIN IIB RECEPTOR AND THEIR USE
KR20180026795A (en) 2009-06-12 2018-03-13 악셀레론 파마 인코포레이티드 TRUNCATED ActRIIB-FC FUSION PROTEINS
ES2658292T3 (en) 2009-11-17 2018-03-09 Acceleron Pharma, Inc. ActRIIB proteins and variants and uses thereof with respect to the induction of utrophin for the treatment of muscular dystrophy
CA2804501C (en) * 2010-07-06 2021-01-26 Novartis Ag Noro virus derived immunogenic compositions and methods
SG187867A1 (en) 2010-08-16 2013-03-28 Amgen Inc Antibodies that bind myostatin, compositions and methods
CN103298832A (en) 2010-11-08 2013-09-11 阿塞勒隆制药公司 ACTRIIA binding agents and uses thereof
EP2793925B1 (en) 2011-12-19 2019-03-20 Amgen Inc. Variant activin receptor polypeptides, alone or in combination with chemotherapy, and uses thereof
BR112014031028A2 (en) 2012-06-11 2017-08-15 Amgen Inc ANTIGEN-BINDING PROTEIN ISOLATED, NUCLLEIC ACID ISOLATED, EXPRESSION VECTOR, HOST CELL, METHOD FOR PRODUCING AN ANTIGEN-BINDING PROTEIN, COMPOSITION, METHOD FOR REDUCING OR BLOCKING THE ACTIVITY OF MYOSTATIN, ACTIVIN A OR GDF-11, METHOD FOR ENHANCEMENT MUSCLE MASS FIRMNESS OR INCREASE THE MUSCLE MASS FIRMITY TO FAT MASS RATIO IN AN INDIVIDUAL IN NEED OF THE MENTIONED TREATMENT, METHOD FOR TREATMENT OR PREVENTION OF A HARMFUL DISEASE OF MUSCLE IN AN INDIVIDUAL SUFFERING FROM THE SAID DISORDER AND DUAL ANTAGONIST RECEPTOR ANTIBODY
EP3964224A1 (en) 2012-11-02 2022-03-09 Celgene Corporation Activin-actrii antagonists and uses for use in treating renal disease
JP2016508504A (en) 2013-02-01 2016-03-22 サンタ マリア バイオセラピューティクス インコーポレイテッド Administration of anti-activin-A compound to a subject
US20140220033A1 (en) * 2013-02-01 2014-08-07 Santa Maria Biotherapeutics, Inc. Administration of an Anti-Activin-A Compound to a Subject
TWI655207B (en) * 2013-07-30 2019-04-01 再生元醫藥公司 Anti-activin A antibody and use thereof
CN104693270B (en) * 2013-12-10 2018-10-16 清华大学 A kind of connection peptide for fusion protein
EP3094751A4 (en) * 2014-01-14 2017-06-07 Santa Maria Biotherapeutics, Inc. Activin inhibitor response prediction and uses for treatment
JP2017519009A (en) * 2014-06-13 2017-07-13 サンタ マリア バイオセラピューティクス インコーポレイテッド Formulated receptor polypeptides and related methods
BR122023023170A2 (en) 2014-06-13 2024-02-20 Acceleron Pharma Inc. USE OF AN ACTRII ANTAGONIST IN THE TREATMENT OR PREVENTION OF SKIN ULCERS ASSOCIATED WITH BETA-THALASSEMIA
MA41052A (en) * 2014-10-09 2017-08-15 Celgene Corp TREATMENT OF CARDIOVASCULAR DISEASE USING ACTRII LIGAND TRAPS
SI3280727T1 (en) * 2015-04-06 2021-07-30 Acceleron Pharma Inc. Single-arm type i and type ii receptor fusion proteins and uses thereof
EP3889171A1 (en) 2015-04-06 2021-10-06 Acceleron Pharma Inc. Tgf-beta superfamily type i and type ii receptor heteromultimers and uses thereof
MA41919A (en) 2015-04-06 2018-02-13 Acceleron Pharma Inc ALK4 HETEROMULTIMERS: ACTRIIB AND THEIR USES
ES2856001T3 (en) 2015-04-22 2021-09-27 Biogen Ma Inc New hybrid actriib ligand blocking proteins to treat muscle atrophy diseases
EP3426680A4 (en) 2016-03-10 2020-03-11 Acceleron Pharma Inc. Activin type 2 receptor binding proteins and uses thereof
US10934532B2 (en) 2016-10-05 2021-03-02 Acceleron Pharma Inc. ALK4.ActRIIB heteromultimers
AU2017357944A1 (en) 2016-11-10 2019-06-20 Keros Therapeutics, Inc. Activin receptor type IIa variants and methods of use thereof
KR20200085832A (en) 2017-11-09 2020-07-15 케로스 테라퓨틱스, 인크. Activin receptor type IIA variants and methods of use thereof
EP3737406A4 (en) 2018-01-12 2021-11-03 Keros Therapeutics, Inc. Activin receptor type iib variants and methods of use thereof
CN109320597B (en) * 2018-10-26 2021-10-26 中国农业科学院特产研究所 Fox subfamily activin A protein and preparation and application thereof
WO2023108137A1 (en) 2021-12-10 2023-06-15 Biogen Ma Inc. Modified actriib proteins and methods of use thereof

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4411993A (en) 1981-04-29 1983-10-25 Steven Gillis Hybridoma antibody which inhibits interleukin 2 activity
USRE32011E (en) 1981-12-14 1985-10-22 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
EP0088046B1 (en) 1982-02-17 1987-12-09 Ciba-Geigy Ag Lipids in the aqueous phase
US4543439A (en) 1982-12-13 1985-09-24 Massachusetts Institute Of Technology Production and use of monoclonal antibodies to phosphotyrosine-containing proteins
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
EP0143949B1 (en) 1983-11-01 1988-10-12 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Pharmaceutical composition containing urokinase
US4902614A (en) 1984-12-03 1990-02-20 Teijin Limited Monoclonal antibody to human protein C
US5618920A (en) 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US5750375A (en) 1988-01-22 1998-05-12 Zymogenetics, Inc. Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions
US5567584A (en) 1988-01-22 1996-10-22 Zymogenetics, Inc. Methods of using biologically active dimerized polypeptide fusions to detect PDGF
JP2877509B2 (en) 1989-05-19 1999-03-31 アムジエン・インコーポレーテツド Metalloproteinase inhibitors
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
US6565841B1 (en) 1991-03-15 2003-05-20 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
US6162896A (en) 1991-05-10 2000-12-19 The Salk Institute For Biological Studies Recombinant vertebrate activin receptors
US5885794A (en) 1991-05-10 1999-03-23 The Salk Institute For Biological Studies Recombinant production of vertebrate activin receptor polypeptides and identification of receptor DNAs in the activin/TGF-β superfamily
US20050186593A1 (en) 1991-05-10 2005-08-25 The Salk Institute For Biological Studies Cloning and recombinant production of CRF receptor(s)
WO1993015722A1 (en) 1992-02-07 1993-08-19 Syntex (Usa) Inc. Controlled delivery of pharmaceuticals from preformed porous microparticles
US6153407A (en) 1992-07-28 2000-11-28 Beth Israel Deaconess Medical Center Erythropoietin DNA having modified 5' and 3' sequences and its use to prepare EPO therapeutics
GB9223377D0 (en) 1992-11-04 1992-12-23 Medarex Inc Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes
US5837821A (en) 1992-11-04 1998-11-17 City Of Hope Antibody construct
CA2157577C (en) 1993-03-19 2009-11-17 Se-Jin Lee Growth differentiation factor-8
US5994618A (en) 1997-02-05 1999-11-30 Johns Hopkins University School Of Medicine Growth differentiation factor-8 transgenic mice
US6465239B1 (en) 1993-03-19 2002-10-15 The John Hopkins University School Of Medicine Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species
US6607884B1 (en) 1993-03-19 2003-08-19 The Johns Hopkins University School Of Medicine Methods of detecting growth differentiation factor-8
AU702163B2 (en) 1994-04-29 1999-02-18 Creative Biomolecules, Inc. Morphogenic protein-specific cell surface receptors and uses therefor
US6891082B2 (en) 1997-08-01 2005-05-10 The Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a truncated activintype II receptor
US6656475B1 (en) 1997-08-01 2003-12-02 The Johns Hopkins University School Of Medicine Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
US6472179B2 (en) 1998-09-25 2002-10-29 Regeneron Pharmaceuticals, Inc. Receptor based antagonists and methods of making and using
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
IL143034A0 (en) 1998-11-13 2002-04-21 Immunex Corp Human tslp dna and polypeptides
MXPA01007366A (en) 1999-01-21 2002-06-04 Metamorphix Inc Growth differentiation factor inhibitors and uses therefor.
JP4487376B2 (en) 2000-03-31 2010-06-23 味の素株式会社 Kidney disease treatment
US6812339B1 (en) * 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
GB0209896D0 (en) 2002-04-30 2002-06-05 Molmed Spa Conjugate
US20040223966A1 (en) 2002-10-25 2004-11-11 Wolfman Neil M. ActRIIB fusion polypeptides and uses therefor
US7511012B2 (en) 2002-12-20 2009-03-31 Amgen Inc. Myostatin binding agents
UA85055C2 (en) 2003-06-02 2008-12-25 Уайт Use of myostatin (gdf8) inhibitor in conjunction with corticosteroid for treating neuromuscular disorder
CN103212084B (en) 2003-11-13 2018-07-13 韩美科学株式会社 Contain pharmaceutical composition of the immunoglobulin FC region as carrier
US8110665B2 (en) 2003-11-13 2012-02-07 Hanmi Holdings Co., Ltd. Pharmaceutical composition comprising an immunoglobulin FC region as a carrier
EP2314617B1 (en) 2004-07-23 2015-06-24 Acceleron Pharma Inc. ActRII receptor polypeptides
US20060034831A1 (en) 2004-08-12 2006-02-16 Wyeth Combination therapy for diabetes, obesity and cardiovascular diseases using GDF-8 inhibitors
CA2580796C (en) 2004-09-24 2013-03-26 Amgen Inc. Modified fc molecules having peptides inserted in internal loop regions
KR100754667B1 (en) 2005-04-08 2007-09-03 한미약품 주식회사 Immunoglobulin Fc fragment modified by non-peptide polymer and pharmaceutical composition comprising the same
UA94060C2 (en) 2005-09-07 2011-04-11 Эмджен Фримонт Инк. Monoclonal antibodies that specifically binds alk-1
US8067562B2 (en) * 2005-11-01 2011-11-29 Amgen Inc. Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1
WO2007105377A2 (en) * 2006-03-02 2007-09-20 Ishihara Sangyo Kaisha, Ltd. Solid herbicidal composition
CL2007002567A1 (en) 2006-09-08 2008-02-01 Amgen Inc ISOLATED PROTEINS FROM LINK TO ACTIVINE TO HUMAN.
BRPI0720476B1 (en) 2006-12-18 2022-05-31 Acceleron Pharma Inc Use of an actii polypeptide to treat anemia in a human patient
TW201940502A (en) 2007-02-02 2019-10-16 美商艾瑟勒朗法瑪公司 Variants derived from ActRIIB and uses therefor
TW201718635A (en) 2007-03-06 2017-06-01 安美基公司 Variant activin receptor polypeptides and uses thereof
US8501678B2 (en) 2007-03-06 2013-08-06 Atara Biotherapeutics, Inc. Variant activin receptor polypeptides and uses thereof
EP2578684B1 (en) * 2007-03-19 2016-02-24 National Research Council Of Canada Antagonists of ligands and uses thereof
CN103877564A (en) 2007-09-18 2014-06-25 阿塞勒隆制药公司 Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion
ES2554812T3 (en) 2007-11-09 2015-12-23 Genentech, Inc. Activin receptor-type kinase 1 antagonist compositions and methods of use
US20100015144A1 (en) 2008-06-26 2010-01-21 Acceleron Pharma Inc. Methods for dosing an activin-actriia antagonist and monitoring of treated patients
TWI784538B (en) 2008-08-14 2022-11-21 美商艾瑟勒朗法瑪公司 Use of gdf traps to increase red blood cell levels
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
EA201791940A3 (en) 2008-11-26 2018-04-30 Амген Инк. OPTIONS OF POLYPEPTIDES OF ACTIVIN IIB RECEPTOR AND THEIR USE
WO2010083034A1 (en) 2009-01-13 2010-07-22 Acceleron Pharma Inc. Methods for increasing adiponectin
NO2424895T3 (en) 2009-04-27 2018-02-03
CN102482339B (en) 2009-06-08 2015-06-17 阿塞勒隆制药公司 Methods for increasing thermogenic adipocytes
US20120295814A1 (en) 2010-01-08 2012-11-22 The Brigham And Women's Hospital, Inc. CA-125 Immune Complexes as Biomarkers of Ovarian Cancer
CA2794513A1 (en) 2010-03-31 2011-10-06 Aeterna Zentaris Gmbh Perifosine and capecitabine as a combined treatment for cancer
CN103298832A (en) 2010-11-08 2013-09-11 阿塞勒隆制药公司 ACTRIIA binding agents and uses thereof
WO2013106715A1 (en) 2012-01-13 2013-07-18 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
WO2013180295A1 (en) 2012-06-01 2013-12-05 日本電信電話株式会社 Packet transfer processing method and packet transfer processing device
US9300829B2 (en) 2014-04-04 2016-03-29 Canon Kabushiki Kaisha Image reading apparatus and correction method thereof

Also Published As

Publication number Publication date
US20200283504A9 (en) 2020-09-10
SMT201600417B (en) 2017-01-10
JP5969557B2 (en) 2016-08-17
AU2009320364A1 (en) 2010-06-03
CA2997971A1 (en) 2010-06-03
KR20170036114A (en) 2017-03-31
ME02652B (en) 2017-06-20
ES2600491T3 (en) 2017-02-09
EA201791940A2 (en) 2018-01-31
JP2016199577A (en) 2016-12-01
JP2015037403A (en) 2015-02-26
US20130225484A1 (en) 2013-08-29
EP3101029A1 (en) 2016-12-07
MY159483A (en) 2017-01-13
US10308704B2 (en) 2019-06-04
MA32936B1 (en) 2012-01-02
TWI486166B (en) 2015-06-01
CN102245634A (en) 2011-11-16
IL212773A0 (en) 2011-07-31
IL212773A (en) 2016-10-31
NZ627111A (en) 2015-10-30
HRP20161450T1 (en) 2017-01-13
RS55369B1 (en) 2017-03-31
WO2010062383A2 (en) 2010-06-03
US8410043B2 (en) 2013-04-02
PL2370463T3 (en) 2017-03-31
CR20110364A (en) 2011-09-07
KR20110106322A (en) 2011-09-28
EA201791940A3 (en) 2018-04-30
CN104371024A (en) 2015-02-25
DK2370463T3 (en) 2016-11-28
SG171813A1 (en) 2011-07-28
CA2743850A1 (en) 2010-06-03
US20190389932A1 (en) 2019-12-26
NZ604818A (en) 2014-07-25
CA2743850C (en) 2018-04-17
US20230295267A1 (en) 2023-09-21
JP2012509687A (en) 2012-04-26
HK1162545A1 (en) 2012-08-31
BRPI0920962A2 (en) 2016-07-12
EA201100832A1 (en) 2011-12-30
KR20170105124A (en) 2017-09-18
AU2009320364B2 (en) 2013-05-16
CN102245634B (en) 2014-10-08
JP5611222B2 (en) 2014-10-22
US11685770B2 (en) 2023-06-27
UA107921C2 (en) 2015-03-10
CR20160443A (en) 2016-11-08
IL248128A0 (en) 2016-11-30
KR101778134B1 (en) 2017-09-13
KR101720143B1 (en) 2017-03-27
EP2370463A2 (en) 2011-10-05
AR074397A1 (en) 2011-01-12
US20100168020A1 (en) 2010-07-01
CY1118754T1 (en) 2017-07-12
HUE032090T2 (en) 2017-09-28
CO6382163A2 (en) 2012-02-15
TW201021826A (en) 2010-06-16
PE20120206A1 (en) 2012-03-09
EP2370463B1 (en) 2016-08-31
PE20150680A1 (en) 2015-05-16
US9273114B2 (en) 2016-03-01
WO2010062383A3 (en) 2010-08-19
TN2011000238A1 (en) 2012-12-17
EP3101029B1 (en) 2019-04-03
SI2370463T1 (en) 2017-01-31
PT2370463T (en) 2016-11-04
LT2370463T (en) 2016-12-12
US20160137718A1 (en) 2016-05-19
MX2011005505A (en) 2011-09-01
CL2011001239A1 (en) 2011-09-16
US20170183391A9 (en) 2017-06-29
ZA201104648B (en) 2012-03-28

Similar Documents

Publication Publication Date Title
ZA201104648B (en) Variants of activin iib receptor polypeptides and uses thereof
IL248322A0 (en) Variant activin receptor polypeptides and uses thereof
HUS2100008I1 (en) Combination of halauxifen-methyl and florasulam
HK1203980A1 (en) Il-17ra-il-17rb antagonists and uses thereof il-17ra-il-17rb
IL229507A0 (en) Peripheral opioid receptor antagonists and uses thereof
HK1167392A1 (en) Adenosine receptor ligands and uses thereof
IL207730A0 (en) Forms of rifaximin and uses thereof
GB0916578D0 (en) Polypeptides and uses thereof
EP2167111A4 (en) Polypeptides and methods of use
GB0916576D0 (en) Polypeptides and uses thereof
SI2483292T1 (en) Variant lovd polypeptides and their uses
IL210773A0 (en) Neuropeptide-2 receptor (y-2r) agonists and uses thereof
EP2273266A4 (en) Parasporin-1 receptor and use thereof
ZA201007681B (en) Cd4-related polypeptides and methods of use
HK1146065A1 (en) Nlrr-1 antagonists and uses thereof nlrr-1
ZA200906169B (en) Variant activin receptor polypeptides and uses thereof
GB0807710D0 (en) Receptor and modulators thereof
GB0800698D0 (en) F2 polypeptides and usesthereof
GB0800700D0 (en) F9 polypeptides and uses thereof
GB0800701D0 (en) F10 Polypeptides and uses thereof
GB0800699D0 (en) F7 polypeptides and use thereof