PT3286206T - Novas proteínas híbridas bloqueadoras de ligando actriib para tratar doenças de desgaste muscular - Google Patents
Novas proteínas híbridas bloqueadoras de ligando actriib para tratar doenças de desgaste muscularInfo
- Publication number
- PT3286206T PT3286206T PT167836030T PT16783603T PT3286206T PT 3286206 T PT3286206 T PT 3286206T PT 167836030 T PT167836030 T PT 167836030T PT 16783603 T PT16783603 T PT 16783603T PT 3286206 T PT3286206 T PT 3286206T
- Authority
- PT
- Portugal
- Prior art keywords
- muscle wasting
- novel hybrid
- treating muscle
- actriib ligand
- wasting diseases
- Prior art date
Links
- 206010028289 Muscle atrophy Diseases 0.000 title 1
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 201000000585 muscular atrophy Diseases 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562150994P | 2015-04-22 | 2015-04-22 | |
| US201562262356P | 2015-12-02 | 2015-12-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3286206T true PT3286206T (pt) | 2021-04-01 |
Family
ID=57144520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT167836030T PT3286206T (pt) | 2015-04-22 | 2016-04-12 | Novas proteínas híbridas bloqueadoras de ligando actriib para tratar doenças de desgaste muscular |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US10913782B2 (pt) |
| EP (2) | EP3878857A1 (pt) |
| JP (2) | JP6959487B2 (pt) |
| KR (1) | KR20180006386A (pt) |
| CN (1) | CN107683287B (pt) |
| AU (2) | AU2016251640B2 (pt) |
| BR (1) | BR112017022658A2 (pt) |
| CA (1) | CA2983440C (pt) |
| CY (1) | CY1124124T1 (pt) |
| DK (1) | DK3286206T3 (pt) |
| ES (1) | ES2856001T3 (pt) |
| HK (1) | HK1251588A1 (pt) |
| HR (1) | HRP20210725T1 (pt) |
| HU (1) | HUE054232T2 (pt) |
| IL (1) | IL255070B (pt) |
| LT (1) | LT3286206T (pt) |
| MX (1) | MX2017013520A (pt) |
| PL (1) | PL3286206T3 (pt) |
| PT (1) | PT3286206T (pt) |
| RS (1) | RS61881B1 (pt) |
| RU (1) | RU2733492C2 (pt) |
| SG (2) | SG11201708351XA (pt) |
| SI (1) | SI3286206T1 (pt) |
| WO (1) | WO2016171948A1 (pt) |
| ZA (2) | ZA201707821B (pt) |
Families Citing this family (20)
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| US20100028332A1 (en) * | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
| AU2015274277B2 (en) | 2014-06-13 | 2021-03-18 | Acceleron Pharma, Inc. | Methods and compositions for treating ulcers |
| JP6810702B2 (ja) | 2015-04-06 | 2021-01-06 | アクセルロン ファーマ インコーポレイテッド | シングルアームｉ型およびｉｉ型受容体融合タンパク質およびその使用 |
| MA41919A (fr) | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | Hétéromultimères alk4:actriib et leurs utilisations |
| WO2016164503A1 (en) | 2015-04-06 | 2016-10-13 | Acceleron Pharma Inc. | Alk7:actriib heteromultimers and uses thereof |
| EP3496739B1 (en) | 2016-07-15 | 2021-04-28 | Acceleron Pharma Inc. | Compositions comprising actriia polypeptides for use in treating pulmonary hypertension |
| CN110036025B (zh) | 2016-10-05 | 2024-03-22 | 阿塞勒隆制药公司 | 变体ActRIIB蛋白及其用途 |
| KR20190075078A (ko) | 2016-10-05 | 2019-06-28 | 악셀레론 파마 인코포레이티드 | ALK4:ActRIIB 이형다량체 및 이의 용도 |
| JOP20190085A1 (ar) * | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
| CA3043184A1 (en) | 2016-11-10 | 2018-05-17 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
| WO2018175460A1 (en) * | 2017-03-24 | 2018-09-27 | Novartis Ag | Methods for preventing and treating heart disease |
| KR20200085832A (ko) | 2017-11-09 | 2020-07-15 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법 |
| CA3087008A1 (en) * | 2018-01-12 | 2019-07-18 | Keros Therapeutics, Inc. | Activin receptor type iib variants and methods of use thereof |
| JP2022534966A (ja) * | 2019-05-30 | 2022-08-04 | アクセレロン ファーマ インコーポレーテッド | Ａｃｔｒｉｉ結合性タンパク質及びその使用 |
| WO2021158695A1 (en) * | 2020-02-03 | 2021-08-12 | Acceleron Pharma Inc. | Compositions and methods for treating pulmonary hypertension |
| AU2021217966A1 (en) * | 2020-02-03 | 2022-09-29 | Acceleron Pharma Inc. | Variant ActRIIBb proteins and uses thereof |
| KR20230004515A (ko) * | 2020-03-20 | 2023-01-06 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 ii 키메라 및 이의 사용 방법 |
| IL300362A (en) * | 2020-08-20 | 2023-04-01 | Regeneron Pharma | Methods to prevent and treat poor cardiac function and covid-19 with activin A antagonists |
| WO2022150590A1 (en) * | 2021-01-08 | 2022-07-14 | Acceleron Pharma Inc. | Compositions and methods for treating pulmonary hypertension |
| US11945856B2 (en) * | 2022-01-28 | 2024-04-02 | 35Pharma Inc. | Activin receptor type IIB variants and uses thereof |
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-
2016
- 2016-04-12 PL PL16783603T patent/PL3286206T3/pl unknown
- 2016-04-12 RS RS20210563A patent/RS61881B1/sr unknown
- 2016-04-12 AU AU2016251640A patent/AU2016251640B2/en active Active
- 2016-04-12 US US15/568,232 patent/US10913782B2/en active Active
- 2016-04-12 HU HUE16783603A patent/HUE054232T2/hu unknown
- 2016-04-12 RU RU2017138537A patent/RU2733492C2/ru active
- 2016-04-12 CA CA2983440A patent/CA2983440C/en active Active
- 2016-04-12 BR BR112017022658A patent/BR112017022658A2/pt active Search and Examination
- 2016-04-12 LT LTEP16783603.0T patent/LT3286206T/lt unknown
- 2016-04-12 EP EP21156657.5A patent/EP3878857A1/en not_active Withdrawn
- 2016-04-12 SI SI201631191T patent/SI3286206T1/sl unknown
- 2016-04-12 SG SG11201708351XA patent/SG11201708351XA/en unknown
- 2016-04-12 PT PT167836030T patent/PT3286206T/pt unknown
- 2016-04-12 WO PCT/US2016/027046 patent/WO2016171948A1/en active Application Filing
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