CY1124124T1 - Νεες υβριδικες πρωτεϊνες παγιδευσης προσδετη actriib για αγωγη νοσων μυϊκης απωλειας - Google Patents
Νεες υβριδικες πρωτεϊνες παγιδευσης προσδετη actriib για αγωγη νοσων μυϊκης απωλειαςInfo
- Publication number
- CY1124124T1 CY1124124T1 CY20211100411T CY211100411T CY1124124T1 CY 1124124 T1 CY1124124 T1 CY 1124124T1 CY 20211100411 T CY20211100411 T CY 20211100411T CY 211100411 T CY211100411 T CY 211100411T CY 1124124 T1 CY1124124 T1 CY 1124124T1
- Authority
- CY
- Cyprus
- Prior art keywords
- myostatin
- novel hybrid
- muscle wasting
- treatment
- activin
- Prior art date
Links
- 206010028289 Muscle atrophy Diseases 0.000 title abstract 2
- 201000000585 muscular atrophy Diseases 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 abstract 3
- 108010056852 Myostatin Proteins 0.000 abstract 3
- 239000003112 inhibitor Substances 0.000 abstract 2
- 108010059616 Activins Proteins 0.000 abstract 1
- 206010065687 Bone loss Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 108010090290 Growth Differentiation Factor 2 Proteins 0.000 abstract 1
- 102100040892 Growth/differentiation factor 2 Human genes 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 102100026818 Inhibin beta E chain Human genes 0.000 abstract 1
- 239000000488 activin Substances 0.000 abstract 1
- 108010023082 activin A Proteins 0.000 abstract 1
- 208000007502 anemia Diseases 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 210000002950 fibroblast Anatomy 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
Abstract
Η παρούσα αποκάλυψη περιγράφει νέα υβριδικά διαλυτά ActRIIB-ECD πολυπεπτίδια τα οποία διατηρούν πλήρως τη συγγένεια δέσμευσης για μυοστατίνη και ακτιβίνη Α αλλά επιδεικνύουν σημαντικά μειωμένη δέσμευση για BMPs, ειδικά ΒΜΡ-9. Οι νέες συνθέσεις που περιγράφονται στο παρόν μπορούν να χρησιμοποιηθούν για να παρασκευασθούν νέες υβριδικές πρωτεΐνες παγίδευσης προσδέτη ActRllB, οι οποίες μπορούν να χρησιμοποιηθούν για την τροποποίηση της αύξησης των μυών, των οστών, των χόνδρων, του λίπους, των ινοβλαστών, του αίματος και του νευρωνικού ιστού ώστε να αντιμετωπισθεί η μυϊκή απώλεια, η οστική απώλεια, η αναιμία, η φλεγμονή και η ίνωση κατά έναν θεραπευτικά λογικό τρόπο. Επειδή αυτοί οι νέοι αναστολείς μυοστατίνης/ακτιβίνης επόμενης γενιάς είναι ασφαλέστερα και πιο αποτελεσματικά μόρια σε σύγκριση με τους σήμερα διαθέσιμους αναστολείς μυοστατίνης, είναι χρήσιμα σε μια ευρεία ποικιλία κλινικών ενδείξεων.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562150994P | 2015-04-22 | 2015-04-22 | |
| US201562262356P | 2015-12-02 | 2015-12-02 | |
| PCT/US2016/027046 WO2016171948A1 (en) | 2015-04-22 | 2016-04-12 | Novel hybrid actriib ligand trap proteins for treating muscle wasting diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1124124T1 true CY1124124T1 (el) | 2022-05-27 |
Family
ID=57144520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20211100411T CY1124124T1 (el) | 2015-04-22 | 2021-05-14 | Νεες υβριδικες πρωτεϊνες παγιδευσης προσδετη actriib για αγωγη νοσων μυϊκης απωλειας |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US10913782B2 (el) |
| EP (2) | EP3286206B1 (el) |
| JP (2) | JP6959487B2 (el) |
| KR (1) | KR20180006386A (el) |
| CN (1) | CN107683287B (el) |
| AU (2) | AU2016251640B2 (el) |
| BR (1) | BR112017022658A2 (el) |
| CA (1) | CA2983440C (el) |
| CY (1) | CY1124124T1 (el) |
| DK (1) | DK3286206T3 (el) |
| ES (1) | ES2856001T3 (el) |
| HK (1) | HK1251588A1 (el) |
| HR (1) | HRP20210725T1 (el) |
| HU (1) | HUE054232T2 (el) |
| IL (1) | IL255070B (el) |
| LT (1) | LT3286206T (el) |
| MX (1) | MX2017013520A (el) |
| PL (1) | PL3286206T3 (el) |
| PT (1) | PT3286206T (el) |
| RS (1) | RS61881B1 (el) |
| RU (1) | RU2733492C2 (el) |
| SG (2) | SG11201708351XA (el) |
| SI (1) | SI3286206T1 (el) |
| WO (1) | WO2016171948A1 (el) |
| ZA (2) | ZA201707821B (el) |
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| US20160075772A1 (en) | 2014-09-12 | 2016-03-17 | Regeneron Pharmaceuticals, Inc. | Treatment of Fibrodysplasia Ossificans Progressiva |
| HUE062189T2 (hu) | 2014-12-03 | 2023-09-28 | Celgene Corp | Aktivin-ACTRII-antagonisták és alkalmazások mielodiszpláziás szindróma kezelésére |
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| AU2016359695A1 (en) | 2015-11-23 | 2018-06-14 | Acceleron Pharma Inc. | Methods for treating eye disorders |
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| EP3439741A4 (en) | 2016-04-06 | 2020-05-06 | Acceleron Pharma Inc. | ALK7 ANTAGONISTS AND USES THEREOF |
| CA3039525A1 (en) | 2016-10-05 | 2018-04-12 | Acceleron Pharma Inc. | Variant actriib proteins and uses thereof |
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