MX2017013520A - Nuevas proteinas hibridas de bloqueo del ligando actriib para tratar enfermedades de atrofia muscular. - Google Patents
Nuevas proteinas hibridas de bloqueo del ligando actriib para tratar enfermedades de atrofia muscular.Info
- Publication number
- MX2017013520A MX2017013520A MX2017013520A MX2017013520A MX2017013520A MX 2017013520 A MX2017013520 A MX 2017013520A MX 2017013520 A MX2017013520 A MX 2017013520A MX 2017013520 A MX2017013520 A MX 2017013520A MX 2017013520 A MX2017013520 A MX 2017013520A
- Authority
- MX
- Mexico
- Prior art keywords
- myostatin
- novel hybrid
- novel
- muscle wasting
- ligand trap
- Prior art date
Links
- 206010028289 Muscle atrophy Diseases 0.000 title abstract 2
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- 201000000585 muscular atrophy Diseases 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 abstract 3
- 108010056852 Myostatin Proteins 0.000 abstract 3
- 239000003112 inhibitor Substances 0.000 abstract 2
- 108010059616 Activins Proteins 0.000 abstract 1
- 206010065687 Bone loss Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 108010090290 Growth Differentiation Factor 2 Proteins 0.000 abstract 1
- 102100040892 Growth/differentiation factor 2 Human genes 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 102100026818 Inhibin beta E chain Human genes 0.000 abstract 1
- 239000000488 activin Substances 0.000 abstract 1
- 108010023082 activin A Proteins 0.000 abstract 1
- 208000007502 anemia Diseases 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 210000002950 fibroblast Anatomy 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente exposición describe nuevos polipéptidos híbridos solubles de ActRIIB-ECD que retienen totalmente la afinidad de enlace para miostatina y activina A, pero demuestran un enlace significativamente reducido a BMPs, específicamente BMP-9. Las nuevas composiciones descritas en la presente pueden utilizarse para preparar nuevas proteínas híbridas de bloqueo de ligando de ActRIIB, que pueden utilizarse para modular el crecimiento de tejido muscular, óseo, cartilaginoso, graso, fibroblástico, sanguíneo y neuronal para contrarrestar la atrofia muscular, la pérdida ósea, la anemia, la inflamación y la fibrosis de manera terapéuticamente significativa. Debido a que estos nuevos inhibidores de miostatina/activina de próxima generación son moléculas más seguras y más efectivas que los inhibidores de miostatina disponibles actualmente, éstos son útiles en una amplia variedad de indicaciones clínicas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562150994P | 2015-04-22 | 2015-04-22 | |
US201562262356P | 2015-12-02 | 2015-12-02 | |
PCT/US2016/027046 WO2016171948A1 (en) | 2015-04-22 | 2016-04-12 | Novel hybrid actriib ligand trap proteins for treating muscle wasting diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017013520A true MX2017013520A (es) | 2018-05-22 |
Family
ID=57144520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017013520A MX2017013520A (es) | 2015-04-22 | 2016-04-12 | Nuevas proteinas hibridas de bloqueo del ligando actriib para tratar enfermedades de atrofia muscular. |
Country Status (25)
Country | Link |
---|---|
US (3) | US10913782B2 (es) |
EP (2) | EP3878857A1 (es) |
JP (2) | JP6959487B2 (es) |
KR (1) | KR20180006386A (es) |
CN (1) | CN107683287B (es) |
AU (2) | AU2016251640B2 (es) |
BR (1) | BR112017022658A2 (es) |
CA (1) | CA2983440C (es) |
CY (1) | CY1124124T1 (es) |
DK (1) | DK3286206T3 (es) |
ES (1) | ES2856001T3 (es) |
HK (1) | HK1251588A1 (es) |
HR (1) | HRP20210725T1 (es) |
HU (1) | HUE054232T2 (es) |
IL (1) | IL255070B (es) |
LT (1) | LT3286206T (es) |
MX (1) | MX2017013520A (es) |
PL (1) | PL3286206T3 (es) |
PT (1) | PT3286206T (es) |
RS (1) | RS61881B1 (es) |
RU (1) | RU2733492C2 (es) |
SG (2) | SG11201708351XA (es) |
SI (1) | SI3286206T1 (es) |
WO (1) | WO2016171948A1 (es) |
ZA (2) | ZA201707821B (es) |
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WO2017079591A2 (en) | 2015-11-04 | 2017-05-11 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels and treating ineffective erythropoiesis |
EP3380121B1 (en) | 2015-11-23 | 2023-12-20 | Acceleron Pharma Inc. | Actrii antagonist for use in treating eye disorders |
US20170240639A1 (en) | 2016-02-22 | 2017-08-24 | Acceleron Pharma Inc. | Actrii antagonists for use in increasing immune activity |
WO2017177013A1 (en) | 2016-04-06 | 2017-10-12 | Acceleron Pharma Inc. | Alk7 antagonists and uses thereof |
BR112019006918A2 (pt) | 2016-10-05 | 2019-06-25 | Acceleron Pharma Inc | proteínas actriib variantes e usos das mesmas |
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