JP2013507930A5 - - Google Patents
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- JP2013507930A5 JP2013507930A5 JP2012534396A JP2012534396A JP2013507930A5 JP 2013507930 A5 JP2013507930 A5 JP 2013507930A5 JP 2012534396 A JP2012534396 A JP 2012534396A JP 2012534396 A JP2012534396 A JP 2012534396A JP 2013507930 A5 JP2013507930 A5 JP 2013507930A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- chimeric
- sequence
- seq
- hfgf19
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25207409P | 2009-10-15 | 2009-10-15 | |
| US61/252,074 | 2009-10-15 | ||
| PCT/US2010/052852 WO2011047267A1 (en) | 2009-10-15 | 2010-10-15 | Chimeric fibroblast growth factors with altered receptor specificity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013507930A JP2013507930A (ja) | 2013-03-07 |
| JP2013507930A5 true JP2013507930A5 (enExample) | 2015-07-02 |
| JP6016636B2 JP6016636B2 (ja) | 2016-10-26 |
Family
ID=43876581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012534396A Expired - Fee Related JP6016636B2 (ja) | 2009-10-15 | 2010-10-15 | 改変したレセプター特異性を持つキメラ線維芽細胞増殖因子 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8535912B2 (enExample) |
| EP (1) | EP2488643A4 (enExample) |
| JP (1) | JP6016636B2 (enExample) |
| KR (1) | KR101952453B1 (enExample) |
| CN (1) | CN102656266B (enExample) |
| BR (1) | BR112012008907A2 (enExample) |
| CA (1) | CA2777717C (enExample) |
| MX (2) | MX2012004303A (enExample) |
| RU (1) | RU2573896C2 (enExample) |
| WO (1) | WO2011047267A1 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG193860A1 (en) | 2008-06-04 | 2013-10-30 | Amgen Inc | Fgf21 mutants and uses thereof |
| AU2010246038A1 (en) | 2009-05-05 | 2011-12-01 | Amgen Inc. | FGF21 mutants and uses thereof |
| JP2012530493A (ja) | 2009-06-17 | 2012-12-06 | アムジエン・インコーポレーテツド | キメラポリペプチドおよびその使用 |
| US8889621B2 (en) | 2009-10-30 | 2014-11-18 | New York University | Inhibiting binding of FGF23 to the binary FGFR-Klotho complex for the treatment of hypophosphatemia |
| CA2796459C (en) | 2010-04-16 | 2016-05-24 | Salk Institute For Biological Studies | Methods for treating metabolic disorders using fgf-1 |
| SG190082A1 (en) * | 2010-11-05 | 2013-06-28 | Covx Technologies Ireland Ltd | Anti-diabetic compounds |
| US8951966B2 (en) | 2011-07-01 | 2015-02-10 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides, and uses and methods thereof for treatment of metabolic disorders and diseases |
| RU2014133547A (ru) * | 2012-01-18 | 2016-03-10 | Дженентек, Инк. | Способы применения модуляторов fgf19 |
| WO2013131091A1 (en) | 2012-03-02 | 2013-09-06 | New York University | Chimeric fgf21 proteins with enhanced binding affinity for beta-klotho for the treatment of type ii diabetes, obesity and related metabolic disorders |
| US9464126B2 (en) | 2012-06-07 | 2016-10-11 | New York University | Chimeric fibroblast growth factor 21 proteins and methods of use |
| US9474785B2 (en) | 2012-06-07 | 2016-10-25 | New York University | Chimeric fibroblast growth factor 19 proteins and methods of use |
| US9657075B2 (en) * | 2012-06-07 | 2017-05-23 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
| EP3798228A1 (en) * | 2012-11-28 | 2021-03-31 | NGM Biopharmaceuticals, Inc. | Compositions and methods for treatment of metabolic disorders and diseases |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| MX383664B (es) * | 2012-12-27 | 2025-03-14 | Ngm Biopharmaceuticals Inc | Uso de un péptido para modular la homeostasis de los ácidos biliares o tratamiento de una enfermedad relacionada con los ácidos biliares. |
| WO2014130659A1 (en) * | 2013-02-22 | 2014-08-28 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
| GB201316592D0 (en) * | 2013-09-18 | 2013-10-30 | Levicept Ltd | Fusion protein |
| WO2015061361A1 (en) | 2013-10-21 | 2015-04-30 | Salk Institute For Biological Studies | Mutated fibroblast growth factor (fgf) 1 and methods of use |
| WO2015061331A1 (en) | 2013-10-21 | 2015-04-30 | Salk Institute For Biological Studies | Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use |
| NZ718962A (en) * | 2013-10-28 | 2019-12-20 | Ngm Biopharmaceuticals Inc | Cancer models and associated methods |
| RS60593B1 (sr) | 2014-01-24 | 2020-08-31 | Ngm Biopharmaceuticals Inc | Antitela koja vezuju domen 2 beta-kloto i postupci za njihovu upotrebu |
| CN103816533A (zh) * | 2014-02-27 | 2014-05-28 | 中国药科大学 | Fgf19通过抑制胆汁酸合成发挥抗炎作用的应用 |
| WO2015138278A1 (en) | 2014-03-11 | 2015-09-17 | Novartis Ag | Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling |
| CN106456714A (zh) | 2014-03-28 | 2017-02-22 | 纽约大学 | Fgf23融合蛋白 |
| US20170173114A1 (en) * | 2014-05-07 | 2017-06-22 | Joslin Diabetes Center, Inc. | Methods and compositions for induction of ucp1 expression |
| US10398758B2 (en) | 2014-05-28 | 2019-09-03 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions |
| EP3155005A4 (en) | 2014-06-16 | 2018-07-11 | NGM Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| WO2016048995A2 (en) * | 2014-09-23 | 2016-03-31 | Salk Institute For Biological Studies | Fgf19 truncations and mutants and uses thereof |
| SG11201702757YA (en) | 2014-10-23 | 2017-05-30 | Ngm Biopharmaceuticals Inc | Pharmaceutical compositions comprising peptide variants and methods of use thereof |
| US10434144B2 (en) | 2014-11-07 | 2019-10-08 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| EP3108893A1 (en) | 2015-06-25 | 2016-12-28 | Universite Claude Bernard - Lyon 1 | Novel therapeutic use of fgf19 |
| US11020454B2 (en) | 2015-07-15 | 2021-06-01 | Prosit Sole Biotechnology (Beijing) Co. Ltd | Fusion polypeptides and methods of use |
| US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
| JP2018535964A (ja) | 2015-10-30 | 2018-12-06 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 線維芽細胞増殖因子（ｆｇｆ）１アナログによるステロイド誘導性高血糖の処置 |
| JP6728352B2 (ja) | 2015-11-09 | 2020-07-22 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | 胆汁酸に関係した障害の治療方法 |
| WO2017116207A1 (ko) * | 2015-12-31 | 2017-07-06 | 한미약품 주식회사 | Fgf21 아날로그, fgf21 결합체, 및 이의 용도 |
| US11370841B2 (en) | 2016-08-26 | 2022-06-28 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
| US12534502B2 (en) | 2016-10-04 | 2026-01-27 | Svar Life Science Ab | FGF21 responsive reporter gene cell line |
| CN107056925B (zh) * | 2017-04-28 | 2022-01-14 | 中国科学院合肥物质科学研究院 | 人fgf21突变体、其制备方法及用途 |
| WO2019123427A1 (en) | 2017-12-22 | 2019-06-27 | Novartis Ag | Methods of treating metabolic disorders with fgf21 variants |
| RU2712770C1 (ru) * | 2019-05-21 | 2020-01-31 | Всеволод Викторович Мелехин | Способ ингибирования роста опухолевых клеток |
| US11542309B2 (en) | 2019-07-31 | 2023-01-03 | Salk Institute For Biological Studies | Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose |
| WO2021092140A1 (en) * | 2019-11-06 | 2021-05-14 | Ngm Biopharmaceuticals, Inc. | Methods of reducing lactate in liver disease patients using variants and fusions of fgf19/fgf21 polypeptides |
| CN112940100B (zh) * | 2019-12-10 | 2022-06-07 | 湖南赛奥维生物技术有限公司 | 一种碱性成纤维细胞生长因子替代物及其组合物和应用 |
| CN112972654B (zh) * | 2021-03-05 | 2022-07-01 | 温州医科大学慈溪生物医药研究院 | Fgf21在制备治疗脑神经损伤的药物中的应用 |
| CN116284327A (zh) * | 2023-03-28 | 2023-06-23 | 中国药科大学 | 一种靶向肿瘤的成纤维细胞生长因子19的重组蛋白及其应用 |
| KR102969557B1 (ko) * | 2023-10-16 | 2026-06-01 | (주)케어젠 | 피부 상태 개선 활성을 갖는 펩타이드 및 이의 용도 |
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| JP2012530493A (ja) * | 2009-06-17 | 2012-12-06 | アムジエン・インコーポレーテツド | キメラポリペプチドおよびその使用 |
| US8951966B2 (en) * | 2011-07-01 | 2015-02-10 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides, and uses and methods thereof for treatment of metabolic disorders and diseases |
-
2010
- 2010-10-15 CA CA2777717A patent/CA2777717C/en active Active
- 2010-10-15 EP EP20100824168 patent/EP2488643A4/en not_active Ceased
- 2010-10-15 US US12/905,776 patent/US8535912B2/en not_active Expired - Fee Related
- 2010-10-15 MX MX2012004303A patent/MX2012004303A/es not_active Application Discontinuation
- 2010-10-15 MX MX2015013444A patent/MX368790B/es unknown
- 2010-10-15 RU RU2012119800/10A patent/RU2573896C2/ru active
- 2010-10-15 KR KR1020127012353A patent/KR101952453B1/ko not_active Expired - Fee Related
- 2010-10-15 BR BR112012008907-2A patent/BR112012008907A2/pt not_active Application Discontinuation
- 2010-10-15 CN CN201080046715.0A patent/CN102656266B/zh not_active Expired - Fee Related
- 2010-10-15 JP JP2012534396A patent/JP6016636B2/ja not_active Expired - Fee Related
- 2010-10-15 WO PCT/US2010/052852 patent/WO2011047267A1/en not_active Ceased
-
2013
- 2013-08-07 US US13/961,766 patent/US20140148388A1/en not_active Abandoned
-
2017
- 2017-08-03 US US15/668,573 patent/US20180079806A1/en not_active Abandoned
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