JP2013507930A5 - - Google Patents
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- JP2013507930A5 JP2013507930A5 JP2012534396A JP2012534396A JP2013507930A5 JP 2013507930 A5 JP2013507930 A5 JP 2013507930A5 JP 2012534396 A JP2012534396 A JP 2012534396A JP 2012534396 A JP2012534396 A JP 2012534396A JP 2013507930 A5 JP2013507930 A5 JP 2013507930A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- chimeric
- sequence
- seq
- hfgf19
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25207409P | 2009-10-15 | 2009-10-15 | |
| US61/252,074 | 2009-10-15 | ||
| PCT/US2010/052852 WO2011047267A1 (en) | 2009-10-15 | 2010-10-15 | Chimeric fibroblast growth factors with altered receptor specificity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013507930A JP2013507930A (ja) | 2013-03-07 |
| JP2013507930A5 true JP2013507930A5 (enExample) | 2015-07-02 |
| JP6016636B2 JP6016636B2 (ja) | 2016-10-26 |
Family
ID=43876581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012534396A Expired - Fee Related JP6016636B2 (ja) | 2009-10-15 | 2010-10-15 | 改変したレセプター特異性を持つキメラ線維芽細胞増殖因子 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8535912B2 (enExample) |
| EP (1) | EP2488643A4 (enExample) |
| JP (1) | JP6016636B2 (enExample) |
| KR (1) | KR101952453B1 (enExample) |
| CN (1) | CN102656266B (enExample) |
| BR (1) | BR112012008907A2 (enExample) |
| CA (1) | CA2777717C (enExample) |
| MX (2) | MX368790B (enExample) |
| RU (1) | RU2573896C2 (enExample) |
| WO (1) | WO2011047267A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
| AU2010246038A1 (en) | 2009-05-05 | 2011-12-01 | Amgen Inc. | FGF21 mutants and uses thereof |
| EP2443145A1 (en) | 2009-06-17 | 2012-04-25 | Amgen, Inc | Chimeric fgf19 polypeptides and uses thereof |
| US8889621B2 (en) | 2009-10-30 | 2014-11-18 | New York University | Inhibiting binding of FGF23 to the binary FGFR-Klotho complex for the treatment of hypophosphatemia |
| EP2558115B1 (en) | 2010-04-16 | 2019-07-31 | The Salk Institute for Biological Studies | Methods for treating metabolic disorders using fgf |
| RU2013118441A (ru) * | 2010-11-05 | 2014-12-10 | КовЭкс Текнолоджиз Айэлэнд Лимитед | Антидиабетические соединения |
| WO2013006486A2 (en) * | 2011-07-01 | 2013-01-10 | Ngm Biopharmaceuticals, Inc. | Compositions, uses and methods for treatment of metabolic disorders and diseases |
| BR112014017626A2 (pt) * | 2012-01-18 | 2018-05-22 | Genentech Inc | métodos para tratar uma doença ou disfunção, métodos de identificação de um indivíduo, método para prever se um indivíduo com uma doença ou disfunção tem mais ou menos probabilidade para desenvolver toxicidade ao tratamento, método para determinar se um indivíduo com uma doença ou disfunção deve continuar ou suspender o tratamento que compreende um modulador de fgf19, método de otimização de eficácia terapêutica e método de ensaio |
| WO2013131091A1 (en) * | 2012-03-02 | 2013-09-06 | New York University | Chimeric fgf21 proteins with enhanced binding affinity for beta-klotho for the treatment of type ii diabetes, obesity and related metabolic disorders |
| US9657075B2 (en) * | 2012-06-07 | 2017-05-23 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
| US9474785B2 (en) * | 2012-06-07 | 2016-10-25 | New York University | Chimeric fibroblast growth factor 19 proteins and methods of use |
| US9464126B2 (en) * | 2012-06-07 | 2016-10-11 | New York University | Chimeric fibroblast growth factor 21 proteins and methods of use |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| ES2828505T3 (es) | 2012-11-28 | 2021-05-26 | Ngm Biopharmaceuticals Inc | Composiciones y métodos para el tratamiento de trastornos y enfermedades metabólicos |
| SG10202100667SA (en) * | 2012-12-27 | 2021-02-25 | Ngm Biopharmaceuticals Inc | Methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| WO2014130659A1 (en) * | 2013-02-22 | 2014-08-28 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
| GB201316592D0 (en) * | 2013-09-18 | 2013-10-30 | Levicept Ltd | Fusion protein |
| WO2015061331A1 (en) | 2013-10-21 | 2015-04-30 | Salk Institute For Biological Studies | Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use |
| CN105828833A (zh) | 2013-10-21 | 2016-08-03 | 萨克生物研究学院 | 突变的成纤维细胞生长因子(fgf)1及使用方法 |
| EP3062881B1 (en) * | 2013-10-28 | 2019-10-02 | NGM Biopharmaceuticals, Inc. | Cancer models and associated methods |
| NZ722377A (en) | 2014-01-24 | 2022-09-30 | Ngm Biopharmaceuticals Inc | Binding proteins and methods of use thereof |
| CN103816533A (zh) * | 2014-02-27 | 2014-05-28 | 中国药科大学 | Fgf19通过抑制胆汁酸合成发挥抗炎作用的应用 |
| WO2015138278A1 (en) | 2014-03-11 | 2015-09-17 | Novartis Ag | Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling |
| CA2943361A1 (en) | 2014-03-28 | 2015-10-01 | New York University | Fgf23 fusion proteins |
| US20170173114A1 (en) * | 2014-05-07 | 2017-06-22 | Joslin Diabetes Center, Inc. | Methods and compositions for induction of ucp1 expression |
| US10398758B2 (en) | 2014-05-28 | 2019-09-03 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions |
| US10456449B2 (en) | 2014-06-16 | 2019-10-29 | Ngm Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| WO2016048995A2 (en) * | 2014-09-23 | 2016-03-31 | Salk Institute For Biological Studies | Fgf19 truncations and mutants and uses thereof |
| CN107108711B (zh) | 2014-10-23 | 2021-11-23 | 恩格姆生物制药公司 | 包含肽变异体的药物组合物及其使用方法 |
| WO2016073855A1 (en) | 2014-11-07 | 2016-05-12 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| EP3108893A1 (en) * | 2015-06-25 | 2016-12-28 | Universite Claude Bernard - Lyon 1 | Novel therapeutic use of fgf19 |
| US11020454B2 (en) | 2015-07-15 | 2021-06-01 | Prosit Sole Biotechnology (Beijing) Co. Ltd | Fusion polypeptides and methods of use |
| US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
| EP3368059A4 (en) | 2015-10-30 | 2019-03-27 | Salk Institute for Biological Studies | TREATMENT OF STEROID-INDUCED HYPERGLYCEMIA WITH FIBROBLAST GROWTH FACTOR (FGF) -1 ANALOGUE |
| WO2017083276A1 (en) | 2015-11-09 | 2017-05-18 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders |
| KR20170080526A (ko) * | 2015-12-31 | 2017-07-10 | 한미약품 주식회사 | Fgf21 아날로그, fgf21 결합체, 및 이의 용도 |
| EP3503882A4 (en) | 2016-08-26 | 2020-07-29 | NGM Biopharmaceuticals, Inc. | METHOD FOR TREATING FIBROBLAST GROWTH FACTOR-19-MEDIATED CARCINOMAS AND TUMORS |
| US20240076332A1 (en) * | 2016-10-04 | 2024-03-07 | Svar Life Science Ab | FGF21 Responsive Reporter Gene Cell Line |
| CN107056925B (zh) * | 2017-04-28 | 2022-01-14 | 中国科学院合肥物质科学研究院 | 人fgf21突变体、其制备方法及用途 |
| CN119386161A (zh) | 2017-12-22 | 2025-02-07 | 诺华股份有限公司 | 用fgf21变体治疗代谢障碍的方法 |
| RU2712770C1 (ru) * | 2019-05-21 | 2020-01-31 | Всеволод Викторович Мелехин | Способ ингибирования роста опухолевых клеток |
| US11542309B2 (en) | 2019-07-31 | 2023-01-03 | Salk Institute For Biological Studies | Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose |
| WO2021092140A1 (en) * | 2019-11-06 | 2021-05-14 | Ngm Biopharmaceuticals, Inc. | Methods of reducing lactate in liver disease patients using variants and fusions of fgf19/fgf21 polypeptides |
| CN112940100B (zh) * | 2019-12-10 | 2022-06-07 | 湖南赛奥维生物技术有限公司 | 一种碱性成纤维细胞生长因子替代物及其组合物和应用 |
| CN112972654B (zh) * | 2021-03-05 | 2022-07-01 | 温州医科大学慈溪生物医药研究院 | Fgf21在制备治疗脑神经损伤的药物中的应用 |
| CN116284327A (zh) * | 2023-03-28 | 2023-06-23 | 中国药科大学 | 一种靶向肿瘤的成纤维细胞生长因子19的重组蛋白及其应用 |
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| WO2013006486A2 (en) * | 2011-07-01 | 2013-01-10 | Ngm Biopharmaceuticals, Inc. | Compositions, uses and methods for treatment of metabolic disorders and diseases |
-
2010
- 2010-10-15 KR KR1020127012353A patent/KR101952453B1/ko not_active Expired - Fee Related
- 2010-10-15 WO PCT/US2010/052852 patent/WO2011047267A1/en not_active Ceased
- 2010-10-15 CN CN201080046715.0A patent/CN102656266B/zh not_active Expired - Fee Related
- 2010-10-15 MX MX2015013444A patent/MX368790B/es unknown
- 2010-10-15 EP EP20100824168 patent/EP2488643A4/en not_active Ceased
- 2010-10-15 JP JP2012534396A patent/JP6016636B2/ja not_active Expired - Fee Related
- 2010-10-15 CA CA2777717A patent/CA2777717C/en active Active
- 2010-10-15 US US12/905,776 patent/US8535912B2/en not_active Expired - Fee Related
- 2010-10-15 MX MX2012004303A patent/MX2012004303A/es not_active Application Discontinuation
- 2010-10-15 BR BR112012008907-2A patent/BR112012008907A2/pt not_active Application Discontinuation
- 2010-10-15 RU RU2012119800/10A patent/RU2573896C2/ru active
-
2013
- 2013-08-07 US US13/961,766 patent/US20140148388A1/en not_active Abandoned
-
2017
- 2017-08-03 US US15/668,573 patent/US20180079806A1/en not_active Abandoned
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