KR101952453B1 - 수용체 특이성이 변경된 키메라 섬유모세포 성장 인자 - Google Patents

수용체 특이성이 변경된 키메라 섬유모세포 성장 인자 Download PDF

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KR101952453B1
KR101952453B1 KR1020127012353A KR20127012353A KR101952453B1 KR 101952453 B1 KR101952453 B1 KR 101952453B1 KR 1020127012353 A KR1020127012353 A KR 1020127012353A KR 20127012353 A KR20127012353 A KR 20127012353A KR 101952453 B1 KR101952453 B1 KR 101952453B1
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polypeptide
fgf19
chimeric
sequence
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KR20120095392A (ko
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주니치로 소노다
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제넨테크, 인크.
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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KR1020127012353A 2009-10-15 2010-10-15 수용체 특이성이 변경된 키메라 섬유모세포 성장 인자 Expired - Fee Related KR101952453B1 (ko)

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US25207409P 2009-10-15 2009-10-15
US61/252,074 2009-10-15
PCT/US2010/052852 WO2011047267A1 (en) 2009-10-15 2010-10-15 Chimeric fibroblast growth factors with altered receptor specificity

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KR20120095392A KR20120095392A (ko) 2012-08-28
KR101952453B1 true KR101952453B1 (ko) 2019-02-26

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US (3) US8535912B2 (enExample)
EP (1) EP2488643A4 (enExample)
JP (1) JP6016636B2 (enExample)
KR (1) KR101952453B1 (enExample)
CN (1) CN102656266B (enExample)
BR (1) BR112012008907A2 (enExample)
CA (1) CA2777717C (enExample)
MX (2) MX2012004303A (enExample)
RU (1) RU2573896C2 (enExample)
WO (1) WO2011047267A1 (enExample)

Cited By (2)

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US12534502B2 (en) 2016-10-04 2026-01-27 Svar Life Science Ab FGF21 responsive reporter gene cell line
KR102969557B1 (ko) * 2023-10-16 2026-06-01 (주)케어젠 피부 상태 개선 활성을 갖는 펩타이드 및 이의 용도

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RU2014133547A (ru) * 2012-01-18 2016-03-10 Дженентек, Инк. Способы применения модуляторов fgf19
WO2013131091A1 (en) 2012-03-02 2013-09-06 New York University Chimeric fgf21 proteins with enhanced binding affinity for beta-klotho for the treatment of type ii diabetes, obesity and related metabolic disorders
US9464126B2 (en) 2012-06-07 2016-10-11 New York University Chimeric fibroblast growth factor 21 proteins and methods of use
US9474785B2 (en) 2012-06-07 2016-10-25 New York University Chimeric fibroblast growth factor 19 proteins and methods of use
US9657075B2 (en) * 2012-06-07 2017-05-23 New York University Chimeric fibroblast growth factor 23 proteins and methods of use
EP3798228A1 (en) * 2012-11-28 2021-03-31 NGM Biopharmaceuticals, Inc. Compositions and methods for treatment of metabolic disorders and diseases
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
MX383664B (es) * 2012-12-27 2025-03-14 Ngm Biopharmaceuticals Inc Uso de un péptido para modular la homeostasis de los ácidos biliares o tratamiento de una enfermedad relacionada con los ácidos biliares.
WO2014130659A1 (en) * 2013-02-22 2014-08-28 New York University Chimeric fibroblast growth factor 23 proteins and methods of use
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WO2015061331A1 (en) 2013-10-21 2015-04-30 Salk Institute For Biological Studies Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use
NZ718962A (en) * 2013-10-28 2019-12-20 Ngm Biopharmaceuticals Inc Cancer models and associated methods
RS60593B1 (sr) 2014-01-24 2020-08-31 Ngm Biopharmaceuticals Inc Antitela koja vezuju domen 2 beta-kloto i postupci za njihovu upotrebu
CN103816533A (zh) * 2014-02-27 2014-05-28 中国药科大学 Fgf19通过抑制胆汁酸合成发挥抗炎作用的应用
WO2015138278A1 (en) 2014-03-11 2015-09-17 Novartis Ag Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling
CN106456714A (zh) 2014-03-28 2017-02-22 纽约大学 Fgf23融合蛋白
US20170173114A1 (en) * 2014-05-07 2017-06-22 Joslin Diabetes Center, Inc. Methods and compositions for induction of ucp1 expression
US10398758B2 (en) 2014-05-28 2019-09-03 Ngm Biopharmaceuticals, Inc. Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions
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WO2016048995A2 (en) * 2014-09-23 2016-03-31 Salk Institute For Biological Studies Fgf19 truncations and mutants and uses thereof
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US10434144B2 (en) 2014-11-07 2019-10-08 Ngm Biopharmaceuticals, Inc. Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders
EP3108893A1 (en) 2015-06-25 2016-12-28 Universite Claude Bernard - Lyon 1 Novel therapeutic use of fgf19
US11020454B2 (en) 2015-07-15 2021-06-01 Prosit Sole Biotechnology (Beijing) Co. Ltd Fusion polypeptides and methods of use
US10800843B2 (en) 2015-07-29 2020-10-13 Ngm Biopharmaceuticals, Inc. Beta klotho-binding proteins
JP2018535964A (ja) 2015-10-30 2018-12-06 ソーク インスティテュート フォー バイオロジカル スタディーズ 線維芽細胞増殖因子（ｆｇｆ）１アナログによるステロイド誘導性高血糖の処置
JP6728352B2 (ja) 2015-11-09 2020-07-22 エヌジーエム バイオファーマシューティカルス，インコーポレーテッド 胆汁酸に関係した障害の治療方法
WO2017116207A1 (ko) * 2015-12-31 2017-07-06 한미약품 주식회사 Fgf21 아날로그, fgf21 결합체, 및 이의 용도
US11370841B2 (en) 2016-08-26 2022-06-28 Ngm Biopharmaceuticals, Inc. Methods of treating fibroblast growth factor 19-mediated cancers and tumors
CN107056925B (zh) * 2017-04-28 2022-01-14 中国科学院合肥物质科学研究院 人fgf21突变体、其制备方法及用途
WO2019123427A1 (en) 2017-12-22 2019-06-27 Novartis Ag Methods of treating metabolic disorders with fgf21 variants
RU2712770C1 (ru) * 2019-05-21 2020-01-31 Всеволод Викторович Мелехин Способ ингибирования роста опухолевых клеток
US11542309B2 (en) 2019-07-31 2023-01-03 Salk Institute For Biological Studies Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose
WO2021092140A1 (en) * 2019-11-06 2021-05-14 Ngm Biopharmaceuticals, Inc. Methods of reducing lactate in liver disease patients using variants and fusions of fgf19/fgf21 polypeptides
CN112940100B (zh) * 2019-12-10 2022-06-07 湖南赛奥维生物技术有限公司 一种碱性成纤维细胞生长因子替代物及其组合物和应用
CN112972654B (zh) * 2021-03-05 2022-07-01 温州医科大学慈溪生物医药研究院 Fgf21在制备治疗脑神经损伤的药物中的应用
CN116284327A (zh) * 2023-03-28 2023-06-23 中国药科大学 一种靶向肿瘤的成纤维细胞生长因子19的重组蛋白及其应用

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