JP2010501191A5 - - Google Patents

Info

Publication number

JP2010501191A5

JP2010501191A5 JP2009525967A JP2009525967A JP2010501191A5 JP 2010501191 A5 JP2010501191 A5 JP 2010501191A5 JP 2009525967 A JP2009525967 A JP 2009525967A JP 2009525967 A JP2009525967 A JP 2009525967A JP 2010501191 A5 JP2010501191 A5 JP 2010501191A5

Authority

JP

Japan

Prior art keywords

fusion protein

component

nucleic acid

protein according

iii

Prior art date

2007-08-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 102000037865 fusion proteins Human genes 0.000 claims 18
• 108020001507 fusion proteins Proteins 0.000 claims 18
• 150000001413 amino acids Chemical class 0.000 claims 9
• 108020004707 nucleic acids Proteins 0.000 claims 9
• 102000039446 nucleic acids Human genes 0.000 claims 9
• 150000007523 nucleic acids Chemical class 0.000 claims 9
• 210000004027 cell Anatomy 0.000 claims 6
• 102000009123 Fibrin Human genes 0.000 claims 4
• 108010073385 Fibrin Proteins 0.000 claims 4
• BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 4
• 229950003499 fibrin Drugs 0.000 claims 4
• 102000005962 receptors Human genes 0.000 claims 4
• 108020003175 receptors Proteins 0.000 claims 4
• 238000005829 trimerization reaction Methods 0.000 claims 4
• 201000010099 disease Diseases 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 108010039471 Fas Ligand Protein Proteins 0.000 claims 2
• 102000015212 Fas Ligand Protein Human genes 0.000 claims 2
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 102000046283 TNF-Related Apoptosis-Inducing Ligand Human genes 0.000 claims 2
• 108700012411 TNFSF10 Proteins 0.000 claims 2
• 239000013543 active substance Substances 0.000 claims 2
• 230000004064 dysfunction Effects 0.000 claims 2
• 208000015122 neurodegenerative disease Diseases 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 208000035473 Communicable disease Diseases 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 241000724228 Enterobacteria phage RB69 Species 0.000 claims 1
• 241000701533 Escherichia virus T4 Species 0.000 claims 1
• 239000004471 Glycine Substances 0.000 claims 1
• 101100207063 Homo sapiens FASLG gene Proteins 0.000 claims 1
• 101100369992 Homo sapiens TNFSF10 gene Proteins 0.000 claims 1
• 101000830565 Homo sapiens Tumor necrosis factor ligand superfamily member 10 Proteins 0.000 claims 1
• 208000012659 Joint disease Diseases 0.000 claims 1
• 108091005804 Peptidases Proteins 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
• 208000025747 Rheumatic disease Diseases 0.000 claims 1
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 238000003776 cleavage reaction Methods 0.000 claims 1
• 210000003527 eukaryotic cell Anatomy 0.000 claims 1
• 102000044949 human TNFSF10 Human genes 0.000 claims 1
• 210000005260 human cell Anatomy 0.000 claims 1
• 208000027866 inflammatory disease Diseases 0.000 claims 1
• 208000019420 lymphoid neoplasm Diseases 0.000 claims 1
• 210000004962 mammalian cell Anatomy 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 208000030159 metabolic disease Diseases 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 230000004770 neurodegeneration Effects 0.000 claims 1
• 210000001236 prokaryotic cell Anatomy 0.000 claims 1
• 230000002062 proliferating effect Effects 0.000 claims 1
• 238000000746 purification Methods 0.000 claims 1
• 230000000552 rheumatic effect Effects 0.000 claims 1
• 230000007017 scission Effects 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 238000002054 transplantation Methods 0.000 claims 1
• 241001515965 unidentified phage Species 0.000 claims 1