JP2021501581A5 - - Google Patents
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- Publication number
- JP2021501581A5 JP2021501581A5 JP2020524267A JP2020524267A JP2021501581A5 JP 2021501581 A5 JP2021501581 A5 JP 2021501581A5 JP 2020524267 A JP2020524267 A JP 2020524267A JP 2020524267 A JP2020524267 A JP 2020524267A JP 2021501581 A5 JP2021501581 A5 JP 2021501581A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleotide sequence
- polypeptide
- gene locus
- sequence encoding
- polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002773 nucleotide Substances 0.000 claims 20
- 125000003729 nucleotide group Chemical group 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims 17
- 108091033319 polynucleotide Proteins 0.000 claims 15
- 239000002157 polynucleotide Substances 0.000 claims 15
- 102000040430 polynucleotide Human genes 0.000 claims 15
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 210000001744 T-lymphocyte Anatomy 0.000 claims 7
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- SOEGEPHNZOISMT-BYPYZUCNSA-N Gly-Ser-Gly Chemical compound NCC(=O)N[C@@H](CO)C(=O)NCC(O)=O SOEGEPHNZOISMT-BYPYZUCNSA-N 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 1
- 102100035233 Furin Human genes 0.000 claims 1
- 108090001126 Furin Proteins 0.000 claims 1
- 102000002265 Human Growth Hormone Human genes 0.000 claims 1
- 108010000521 Human Growth Hormone Proteins 0.000 claims 1
- 239000000854 Human Growth Hormone Substances 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000006801 homologous recombination Effects 0.000 claims 1
- 238000002744 homologous recombination Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023150855A JP2024009805A (ja) | 2017-10-30 | 2023-09-19 | 初代細胞の遺伝子編集 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762579113P | 2017-10-30 | 2017-10-30 | |
| US201762579114P | 2017-10-30 | 2017-10-30 | |
| US62/579,113 | 2017-10-30 | ||
| US62/579,114 | 2017-10-30 | ||
| PCT/US2018/058230 WO2019089610A1 (en) | 2017-10-30 | 2018-10-30 | Primary cell gene editing |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023150855A Division JP2024009805A (ja) | 2017-10-30 | 2023-09-19 | 初代細胞の遺伝子編集 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021501581A JP2021501581A (ja) | 2021-01-21 |
| JP2021501581A5 true JP2021501581A5 (enExample) | 2021-12-09 |
| JP7397791B2 JP7397791B2 (ja) | 2023-12-13 |
Family
ID=66332290
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020524267A Active JP7397791B2 (ja) | 2017-10-30 | 2018-10-30 | 初代細胞の遺伝子編集 |
| JP2023150855A Pending JP2024009805A (ja) | 2017-10-30 | 2023-09-19 | 初代細胞の遺伝子編集 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023150855A Pending JP2024009805A (ja) | 2017-10-30 | 2023-09-19 | 初代細胞の遺伝子編集 |
Country Status (13)
| Country | Link |
|---|---|
| US (7) | US10550406B2 (enExample) |
| EP (1) | EP3703712A4 (enExample) |
| JP (2) | JP7397791B2 (enExample) |
| CN (2) | CN117904055A (enExample) |
| AU (1) | AU2018357861B2 (enExample) |
| BR (1) | BR112020008704A2 (enExample) |
| CA (1) | CA3081320A1 (enExample) |
| IL (1) | IL274351B2 (enExample) |
| MX (1) | MX2020004541A (enExample) |
| RU (1) | RU2020116585A (enExample) |
| SG (1) | SG11202004026QA (enExample) |
| TW (1) | TWI716758B (enExample) |
| WO (1) | WO2019089610A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017248259A1 (en) * | 2016-04-07 | 2018-10-25 | Bluebird Bio, Inc. | Chimeric antigen receptor T cell compositions |
| MY200418A (en) | 2017-06-15 | 2023-12-25 | Univ California | Targeted non-viral dna insertions |
| SG11202003798TA (en) * | 2017-10-27 | 2020-05-28 | Univ California | Targeted replacement of endogenous t cell receptors |
| EP3703712A4 (en) * | 2017-10-30 | 2021-09-22 | PACT Pharma, Inc. | EDITING PRIMARY CELL GENES |
| KR20200138334A (ko) | 2018-04-02 | 2020-12-09 | 팩트 파마, 인크. | 펩티드-MHC comPACT |
| CA3116132A1 (en) * | 2018-10-16 | 2020-04-23 | Intellia Therapeutics, Inc. | Compositions and methods for immunotherapy |
| MX2021013218A (es) | 2019-05-01 | 2021-12-10 | Pact Pharma Inc | Composiciones y metodos para el tratamiento del cancer usando una terapia con celulas t modificadas con tet2. |
| AU2020325225A1 (en) * | 2019-08-05 | 2022-03-24 | Cartherics Pty. Ltd. | Immune cells expressing modified cell receptors and methods of making |
| US12359247B2 (en) | 2019-08-26 | 2025-07-15 | Adoc Ssf, Llc | Methods of performing GUIDE-Seq on primary human T cells |
| IL291935A (en) * | 2019-10-08 | 2022-06-01 | Pact Pharma Inc | Methods for immunotherapy of genetically modified autologous t cells |
| EP4041293A1 (en) * | 2019-10-10 | 2022-08-17 | PACT Pharma, Inc. | Method of treating immunotherapy non-responders with an autologous cell therapy |
| EP4110356A4 (en) * | 2020-02-28 | 2024-03-27 | Wisconsin Alumni Research Foundation | NON-VIRAL GENERATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS OBTAINED BY GENE EDITING |
| AU2021261011A1 (en) * | 2020-04-24 | 2022-11-10 | Pact Pharma, Inc. | Methods of determining gene editing efficiencies in cells |
| WO2021252898A1 (en) * | 2020-06-12 | 2021-12-16 | Pact Pharma, Inc. | Compositions and methods of manufacturing autologous t cell therapies |
| IL300994A (en) * | 2020-08-28 | 2023-04-01 | Arsenal Biosciences Inc | Transgenic immune cells with priming receptors |
| TW202233830A (zh) * | 2020-10-27 | 2022-09-01 | 美商Ｐａｃｔ製藥公司 | 使用下一代工程化t細胞療法治療癌症之組合物及方法 |
| WO2022204443A1 (en) * | 2021-03-24 | 2022-09-29 | Genentech, Inc. | Efficient tcr gene editing in t lymphocytes |
| TW202309272A (zh) * | 2021-03-24 | 2023-03-01 | 美商建南德克公司 | Ｔ淋巴球中之高效ｔｃｒ基因編輯 |
| WO2022242644A1 (zh) * | 2021-05-18 | 2022-11-24 | 赛斯尔擎生物技术（上海）有限公司 | 修饰细胞的方法 |
| JP2024523014A (ja) | 2021-06-11 | 2024-06-25 | パクト ファーマ インコーポレイテッド | 細胞製剤を査定する方法 |
| US20260232734A1 (en) | 2023-02-27 | 2026-08-13 | Adaptive Biotechnologies Corporation | Therapeutic T-Cell Receptors Targeting KRAS G12D |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8895020B2 (en) | 2002-04-19 | 2014-11-25 | Washington University | Single chain trimers and uses therefor |
| WO2005017149A1 (en) * | 2003-06-03 | 2005-02-24 | Cell Genesys, Inc. | Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site |
| US8992937B2 (en) | 2006-08-28 | 2015-03-31 | Washington University | Disulfide trap MHC class I molecules and uses therefor |
| WO2013177533A1 (en) * | 2012-05-25 | 2013-11-28 | California Institute Of Technology | Expression of secreted and cell-surface polypeptides |
| AU2014235968B2 (en) * | 2013-03-21 | 2018-05-24 | Ospedale San Raffaele Srl | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
| KR102546296B1 (ko) | 2014-10-31 | 2023-06-21 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 변형된 t 세포에서 유전자 발현의 변경 및 그의 용도 |
| US20190030071A1 (en) * | 2014-11-03 | 2019-01-31 | IMMURES S.r.I. | T cell receptors |
| ES2768984T3 (es) * | 2015-10-05 | 2020-06-24 | Prec Biosciences Inc | Meganucleasas diseñadas con secuencias de reconocimiento encontradas en el gen de la región constante alfa del receptor de células T humanas |
| ES2803728T3 (es) * | 2015-10-05 | 2021-01-29 | Prec Biosciences Inc | Células genéticamente modificadas que comprenden un gen de región constante alfa del receptor de linfocitos T humano modificado |
| US20190241910A1 (en) | 2016-03-11 | 2019-08-08 | Bluebird Bio, Inc. | Genome edited immune effector cells |
| SG11202003798TA (en) | 2017-10-27 | 2020-05-28 | Univ California | Targeted replacement of endogenous t cell receptors |
| EP3703712A4 (en) * | 2017-10-30 | 2021-09-22 | PACT Pharma, Inc. | EDITING PRIMARY CELL GENES |
-
2018
- 2018-10-30 EP EP18872062.7A patent/EP3703712A4/en active Pending
- 2018-10-30 RU RU2020116585A patent/RU2020116585A/ru unknown
- 2018-10-30 TW TW107138453A patent/TWI716758B/zh active
- 2018-10-30 WO PCT/US2018/058230 patent/WO2019089610A1/en not_active Ceased
- 2018-10-30 CA CA3081320A patent/CA3081320A1/en active Pending
- 2018-10-30 CN CN202410054719.7A patent/CN117904055A/zh active Pending
- 2018-10-30 BR BR112020008704-1A patent/BR112020008704A2/pt not_active Application Discontinuation
- 2018-10-30 AU AU2018357861A patent/AU2018357861B2/en active Active
- 2018-10-30 CN CN201880085053.4A patent/CN111918659B/zh active Active
- 2018-10-30 JP JP2020524267A patent/JP7397791B2/ja active Active
- 2018-10-30 IL IL274351A patent/IL274351B2/en unknown
- 2018-10-30 SG SG11202004026QA patent/SG11202004026QA/en unknown
- 2018-10-30 MX MX2020004541A patent/MX2020004541A/es unknown
-
2019
- 2019-08-27 US US16/552,786 patent/US10550406B2/en active Active
- 2019-08-27 US US16/552,714 patent/US10584357B2/en active Active
-
2020
- 2020-02-05 US US16/782,815 patent/US10676758B1/en active Active
- 2020-02-05 US US16/782,450 patent/US10711283B2/en active Active
- 2020-06-04 US US16/893,166 patent/US20200299730A1/en not_active Abandoned
-
2021
- 2021-08-12 US US17/400,974 patent/US20210395783A1/en not_active Abandoned
-
2023
- 2023-09-19 JP JP2023150855A patent/JP2024009805A/ja active Pending
-
2025
- 2025-04-25 US US19/189,452 patent/US20250250587A1/en active Pending
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