JP2018533970A5 - - Google Patents
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- Publication number
- JP2018533970A5 JP2018533970A5 JP2018532498A JP2018532498A JP2018533970A5 JP 2018533970 A5 JP2018533970 A5 JP 2018533970A5 JP 2018532498 A JP2018532498 A JP 2018532498A JP 2018532498 A JP2018532498 A JP 2018532498A JP 2018533970 A5 JP2018533970 A5 JP 2018533970A5
- Authority
- JP
- Japan
- Prior art keywords
- modified
- amino acid
- nucleotide sequence
- acid sequence
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 239000002773 nucleotide Substances 0.000 claims 10
- 125000003729 nucleotide group Chemical group 0.000 claims 10
- 239000013598 vector Substances 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 238000007792 addition Methods 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000003780 insertion Methods 0.000 claims 3
- 230000037431 insertion Effects 0.000 claims 3
- 230000001254 nonsecretory effect Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 241001289435 Astragalus brachycalyx Species 0.000 claims 1
- 235000002917 Fraxinus ornus Nutrition 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 244000309459 oncolytic virus Species 0.000 claims 1
- 239000013600 plasmid vector Substances 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021215459A JP7438552B2 (ja) | 2015-09-09 | 2021-12-29 | 注射用医薬品、注射用調製物、および注射用医薬品の製造における使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510568718.5 | 2015-09-09 | ||
| CN201510568718.5A CN106520778A (zh) | 2015-09-09 | 2015-09-09 | 改造的白介素12及其在制备治疗肿瘤的药物中的用途 |
| PCT/CN2016/098527 WO2017041739A1 (zh) | 2015-09-09 | 2016-09-09 | 改造的白介素12及其在制备治疗肿瘤药物中的用途 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021215459A Division JP7438552B2 (ja) | 2015-09-09 | 2021-12-29 | 注射用医薬品、注射用調製物、および注射用医薬品の製造における使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018533970A JP2018533970A (ja) | 2018-11-22 |
| JP2018533970A5 true JP2018533970A5 (enExample) | 2019-10-17 |
| JP7340222B2 JP7340222B2 (ja) | 2023-09-07 |
Family
ID=58240596
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532498A Active JP7340222B2 (ja) | 2015-09-09 | 2016-09-09 | 腫瘍溶解性ウイルス、腫瘍溶解性ウイルスを含む薬物、医薬品の製造における使用、および腫瘍溶解性ウイルスの作製方法 |
| JP2021215459A Active JP7438552B2 (ja) | 2015-09-09 | 2021-12-29 | 注射用医薬品、注射用調製物、および注射用医薬品の製造における使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021215459A Active JP7438552B2 (ja) | 2015-09-09 | 2021-12-29 | 注射用医薬品、注射用調製物、および注射用医薬品の製造における使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11345732B2 (enExample) |
| EP (1) | EP3348643B1 (enExample) |
| JP (2) | JP7340222B2 (enExample) |
| CN (5) | CN106520778A (enExample) |
| WO (1) | WO2017041739A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108686202A (zh) * | 2017-04-06 | 2018-10-23 | 张晋宇 | 肿瘤免疫疗法 |
| US11358999B2 (en) | 2018-10-03 | 2022-06-14 | Xencor, Inc. | IL-12 heterodimeric Fc-fusion proteins |
| SG11202106460XA (en) * | 2018-12-21 | 2021-07-29 | Ottawa Hospital Res Inst | Modified orthopoxvirus vectors |
| CN115916233A (zh) | 2019-10-03 | 2023-04-04 | Xencor股份有限公司 | 靶向IL-12异源二聚体Fc融合蛋白 |
| CN113774031B (zh) * | 2020-06-10 | 2024-04-02 | 广州恩宝生物医药科技有限公司 | 一种复制型人腺病毒及其应用 |
| EP4536838A1 (en) * | 2022-06-10 | 2025-04-16 | Transgene | Recombinant virus expressing interleukin-12 |
| WO2025221669A1 (en) * | 2024-04-18 | 2025-10-23 | Promab Biotechnologies, Inc. | Fusion protein comprising il-12 and gm-csf |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2612785A1 (en) | 2005-06-30 | 2007-01-11 | Archemix Corp. | Polynucleotides and polypeptides of the il-12 family of cytokines |
| RU2304586C1 (ru) * | 2006-03-27 | 2007-08-20 | Михаил Николаевич Смирнов | Препарат интерлейкина-2 и способ его получения |
| CN102174479B (zh) * | 2011-03-02 | 2013-04-03 | 北京锤特生物科技有限公司 | 靶向性治疗人肿瘤的溶肿瘤腺病毒及其应用 |
| WO2016048903A1 (en) * | 2014-09-22 | 2016-03-31 | Intrexon Corporation | Improved therapeutic control of heterodimeric and single chain forms of interleukin-12 |
| AU2016338436B2 (en) * | 2015-10-14 | 2021-09-30 | Mighty Oak Medical, Inc. | Patient-matched apparatus and methods for performing surgical procedures |
-
2015
- 2015-09-09 CN CN201510568718.5A patent/CN106520778A/zh active Pending
-
2016
- 2016-09-09 CN CN202410669647.7A patent/CN118791625A/zh active Pending
- 2016-09-09 US US15/758,853 patent/US11345732B2/en active Active
- 2016-09-09 WO PCT/CN2016/098527 patent/WO2017041739A1/zh not_active Ceased
- 2016-09-09 CN CN202311154075.0A patent/CN117736296A/zh active Pending
- 2016-09-09 JP JP2018532498A patent/JP7340222B2/ja active Active
- 2016-09-09 CN CN201680022405.2A patent/CN108307642B/zh active Active
- 2016-09-09 EP EP16843677.2A patent/EP3348643B1/en active Active
- 2016-09-09 CN CN202410669656.6A patent/CN118852455A/zh active Pending
-
2021
- 2021-12-29 JP JP2021215459A patent/JP7438552B2/ja active Active
-
2022
- 2022-03-22 US US17/700,991 patent/US20220213161A1/en active Pending
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