CN102174479B - 靶向性治疗人肿瘤的溶肿瘤腺病毒及其应用 - Google Patents
靶向性治疗人肿瘤的溶肿瘤腺病毒及其应用 Download PDFInfo
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Abstract
Description
Claims (1)
Priority Applications (5)
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CN2011100500460A CN102174479B (zh) | 2011-03-02 | 2011-03-02 | 靶向性治疗人肿瘤的溶肿瘤腺病毒及其应用 |
EP12752828.9A EP2682459B1 (en) | 2011-03-02 | 2012-02-29 | Oncolytic adenovirus for target therapy of human tumor and use thereof |
PCT/CN2012/071754 WO2012116636A1 (zh) | 2011-03-02 | 2012-02-29 | 靶向性治疗人肿瘤的溶肿瘤腺病毒及其应用 |
JP2013555736A JP2014509197A (ja) | 2011-03-02 | 2012-02-29 | 標的性治療人腫瘍治療の腫瘍溶解性アデノウイルス及びその応用 |
US14/016,149 US20130345295A1 (en) | 2011-03-02 | 2013-09-02 | Targeted oncolytic adenovirus for treatment of human tumors, constrcution method and application thereof |
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CN2011100500460A CN102174479B (zh) | 2011-03-02 | 2011-03-02 | 靶向性治疗人肿瘤的溶肿瘤腺病毒及其应用 |
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CN102174479A CN102174479A (zh) | 2011-09-07 |
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EP (1) | EP2682459B1 (zh) |
JP (1) | JP2014509197A (zh) |
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CN102174479B (zh) * | 2011-03-02 | 2013-04-03 | 北京锤特生物科技有限公司 | 靶向性治疗人肿瘤的溶肿瘤腺病毒及其应用 |
KR102089121B1 (ko) | 2013-03-14 | 2020-03-13 | 더 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 종양살상형 아데노바이러스 조성물 |
CN106520778A (zh) * | 2015-09-09 | 2017-03-22 | 北京锤特生物科技有限公司 | 改造的白介素12及其在制备治疗肿瘤的药物中的用途 |
CN117384961A (zh) | 2016-02-23 | 2024-01-12 | 萨克生物研究学院 | 对病毒动力学影响最小的治疗性腺病毒中的外源基因表达 |
EP3390428B1 (en) | 2016-02-23 | 2019-09-25 | Salk Institute for Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
CN106591368A (zh) * | 2016-10-12 | 2017-04-26 | 郑州大学 | 携带il‑15r/il‑15融合基因的b亚群腺病毒11载体及其构建和用途 |
CN110062630A (zh) | 2016-12-12 | 2019-07-26 | 萨克生物研究学院 | 肿瘤靶向合成腺病毒及其用途 |
CN111925997B (zh) * | 2020-06-05 | 2023-04-14 | 浙江理工大学绍兴生物医药研究院有限公司 | 表达白介素33的重组溶瘤腺病毒的构建及其应用方法 |
CN115120744A (zh) * | 2021-03-24 | 2022-09-30 | 四川大学 | 重组人内皮抑素腺病毒与抗pd-1抗体或抗pd-l1抗体在制备抗肿瘤药物中的用途 |
CN113244411B (zh) * | 2021-06-25 | 2021-09-17 | 诺赛联合(北京)生物医学科技有限公司 | 一种基因修饰的溶瘤病毒诱导ctl细胞方法及其在肿瘤治疗的用途 |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN1298451A (zh) * | 1998-04-24 | 2001-06-06 | 昂尼克斯药物公司 | 用于治疗疾病的腺病毒载体 |
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US5994104A (en) * | 1996-11-08 | 1999-11-30 | Royal Free Hospital School Of Medicine | Interleukin-12 fusion protein |
CN1094974C (zh) * | 1998-12-31 | 2002-11-27 | 上海华晨生物技术研究所 | 表达人白细胞介素12的重组腺病毒及其制法和用途 |
DE10248141B4 (de) * | 2002-10-11 | 2007-04-19 | Universitätsklinikum Hamburg-Eppendorf | Nukleinsäuren und deren Verwendung für die Gentherapie |
CN1259106C (zh) * | 2002-12-23 | 2006-06-14 | 中国科学院上海生命科学研究院 | 一种抗癌靶向基因病毒药物的制备方法 |
WO2005086922A2 (en) * | 2004-03-10 | 2005-09-22 | Board Of Regents, University Of Texas System | Oncolytic adenovirus armed with therapeutic genes |
CN100361710C (zh) * | 2004-06-07 | 2008-01-16 | 成都康弘生物科技有限公司 | 肿瘤细胞专一表达免疫调节因子gm-csf的溶瘤性腺病毒重组体的构建及其应用 |
DE102005055128B4 (de) * | 2005-11-15 | 2015-04-02 | Universität Rostock | Viraler Vektor, dessen Verwendung zur Therapie von Leberzellkarzinomen und pharmazeutische Mittel umfassend den Vektor |
ES2276623B1 (es) * | 2005-12-12 | 2008-06-01 | Proyecto De Biomedicina Cima, S.L | Nuevos adenovirus recombinantes de replicacion condicionada (crad). |
WO2008134878A1 (en) * | 2007-05-04 | 2008-11-13 | University Health Network | Compositions and methods for cancer treatment |
KR101655487B1 (ko) * | 2007-10-08 | 2016-09-08 | 인트렉손 코포레이션 | 가공된 수지상 세포 및 암의 치료를 위한 이의 용도 |
CN101643750B (zh) * | 2009-09-11 | 2010-11-10 | 郑州大学 | 靶向性溶肿瘤腺病毒载体Ad-TD-gene的构建方法及应用 |
CN102174479B (zh) * | 2011-03-02 | 2013-04-03 | 北京锤特生物科技有限公司 | 靶向性治疗人肿瘤的溶肿瘤腺病毒及其应用 |
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2011
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2012
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2013
- 2013-09-02 US US14/016,149 patent/US20130345295A1/en not_active Abandoned
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Also Published As
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EP2682459B1 (en) | 2017-12-20 |
WO2012116636A1 (zh) | 2012-09-07 |
JP2014509197A (ja) | 2014-04-17 |
EP2682459A4 (en) | 2014-12-10 |
US20130345295A1 (en) | 2013-12-26 |
CN102174479A (zh) | 2011-09-07 |
EP2682459A1 (en) | 2014-01-08 |
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