JP2019525744A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019525744A5 JP2019525744A5 JP2018568203A JP2018568203A JP2019525744A5 JP 2019525744 A5 JP2019525744 A5 JP 2019525744A5 JP 2018568203 A JP2018568203 A JP 2018568203A JP 2018568203 A JP2018568203 A JP 2018568203A JP 2019525744 A5 JP2019525744 A5 JP 2019525744A5
- Authority
- JP
- Japan
- Prior art keywords
- toxoplasma
- nucleic acid
- acid construct
- protein
- construct according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000223996 Toxoplasma Species 0.000 claims 16
- 150000007523 nucleic acids Chemical group 0.000 claims 14
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 102000040739 Secretory proteins Human genes 0.000 claims 5
- 108091058545 Secretory proteins Proteins 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 210000003169 central nervous system Anatomy 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 239000008187 granular material Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 1
- 108010051219 Cre recombinase Proteins 0.000 claims 1
- 102000009073 Macrophage Migration-Inhibitory Factors Human genes 0.000 claims 1
- 108010048043 Macrophage Migration-Inhibitory Factors Proteins 0.000 claims 1
- 241000223997 Toxoplasma gondii Species 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 230000001861 immunosuppressant effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
- 230000001018 virulence Effects 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022151508A JP7497397B2 (ja) | 2016-06-29 | 2022-09-22 | タンパク質を中枢神経系（ｃｎｓ）に送達するための、組換え寄生虫 |
| JP2024087211A JP7748681B2 (ja) | 2016-06-29 | 2024-05-29 | タンパク質を中枢神経系（ｃｎｓ）に送達するための、組換え寄生虫 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662355898P | 2016-06-29 | 2016-06-29 | |
| US62/355,898 | 2016-06-29 | ||
| PCT/IL2017/050731 WO2018002938A1 (en) | 2016-06-29 | 2017-06-29 | Engineered parasites for delivering protein to the central nervous system (cns) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022151508A Division JP7497397B2 (ja) | 2016-06-29 | 2022-09-22 | タンパク質を中枢神経系（ｃｎｓ）に送達するための、組換え寄生虫 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019525744A JP2019525744A (ja) | 2019-09-12 |
| JP2019525744A5 true JP2019525744A5 (enExample) | 2020-07-27 |
| JP7148415B2 JP7148415B2 (ja) | 2022-10-05 |
Family
ID=60786743
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018568203A Active JP7148415B2 (ja) | 2016-06-29 | 2017-06-29 | タンパク質を中枢神経系（ｃｎｓ）に送達するための、組換え寄生虫 |
| JP2022151508A Active JP7497397B2 (ja) | 2016-06-29 | 2022-09-22 | タンパク質を中枢神経系（ｃｎｓ）に送達するための、組換え寄生虫 |
| JP2024087211A Active JP7748681B2 (ja) | 2016-06-29 | 2024-05-29 | タンパク質を中枢神経系（ｃｎｓ）に送達するための、組換え寄生虫 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022151508A Active JP7497397B2 (ja) | 2016-06-29 | 2022-09-22 | タンパク質を中枢神経系（ｃｎｓ）に送達するための、組換え寄生虫 |
| JP2024087211A Active JP7748681B2 (ja) | 2016-06-29 | 2024-05-29 | タンパク質を中枢神経系（ｃｎｓ）に送達するための、組換え寄生虫 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US11260081B2 (enExample) |
| EP (1) | EP3478301A4 (enExample) |
| JP (3) | JP7148415B2 (enExample) |
| KR (1) | KR102513120B1 (enExample) |
| CN (1) | CN109757100A (enExample) |
| AU (1) | AU2017289886A1 (enExample) |
| CA (1) | CA3028334A1 (enExample) |
| WO (1) | WO2018002938A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7148415B2 (ja) * | 2016-06-29 | 2022-10-05 | ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド | タンパク質を中枢神経系（ｃｎｓ）に送達するための、組換え寄生虫 |
| BR112020021903A2 (pt) | 2018-04-27 | 2021-03-02 | Rocket Pharmaceuticals, Ltd. | terapia genética para degeneração do snc |
| CN109369796A (zh) * | 2018-09-27 | 2019-02-22 | 华中农业大学 | 一种检测羊弓形虫IgG抗体的酶联免疫方法 |
| CN110117609B (zh) * | 2019-05-20 | 2023-06-02 | 安徽农业大学 | 一种真菌基因敲除双荧光筛选方法 |
| EP3976071A1 (en) * | 2019-05-29 | 2022-04-06 | Université de Tours | Toxoplasma platform for treating cancer |
| EP3980059A1 (en) * | 2019-06-10 | 2022-04-13 | Infectious Disease Research Institute | Methods and compositions of astrovirus replicons |
| CN115379834A (zh) | 2020-03-11 | 2022-11-22 | 马萨诸塞眼科耳科诊所 | 用于nmnat1相关视网膜变性的基因疗法 |
| US11497801B2 (en) * | 2021-02-19 | 2022-11-15 | Sherryll Layton | Compositions and methods of enhancing immune responses |
| KR102561980B1 (ko) * | 2021-03-16 | 2023-08-01 | 한양대학교 에리카산학협력단 | 톡소포자충 gra9 단백질 또는 상기 단백질을 암호화하는 유전자를 유효성분으로 포함하는, 염증성 질환 예방 또는 치료용 약학적 조성물 |
| CN114524869B (zh) * | 2022-01-25 | 2023-06-09 | 华中农业大学 | 弓形虫微线体蛋白MIC17a及其应用 |
| KR102834734B1 (ko) * | 2022-04-28 | 2025-07-16 | 경희대학교 산학협력단 | 톡소포자충의 항원 rop4를 포함하는 재조합 백시니아 바이러스 백신 |
| WO2024064918A2 (en) * | 2022-09-23 | 2024-03-28 | Novome Biotechnologies, Inc. | Recombinant fusion polypeptides for secreting soluble, heterologous cargo |
| WO2025026988A1 (en) * | 2023-07-28 | 2025-02-06 | Theranexus | Mutated tfeb for treating lysosomal disorders |
| EP4560316A1 (en) * | 2023-11-23 | 2025-05-28 | Biokit Research & Development S.L.U. | Antigenic regions for the detection of anti-toxoplasma gondii igm antibodies |
| CN117925759B (zh) * | 2024-01-23 | 2024-07-02 | 通化康元生物科技有限公司 | 林蛙多肽制剂及其在食品和化妆品中的应用 |
| WO2025235741A1 (en) * | 2024-05-09 | 2025-11-13 | Grann Pharmaceuticals Inc. | Compositions and methods for modulating mecp2 activity |
| CN119925428B (zh) * | 2025-04-07 | 2025-07-11 | 天津捷昂康生物科技发展有限公司 | 一种树突状细胞在预防和/或治疗脱髓鞘疾病中的应用 |
| CN120424771B (zh) * | 2025-07-08 | 2025-10-17 | 华中农业大学 | 弓形虫mic19基因敲除虫株及其构建方法与应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5693325A (en) * | 1994-03-15 | 1997-12-02 | Molecumetics, Ltd. | Peptide vaccines and methods relating thereto |
| US8293224B2 (en) | 2000-02-07 | 2012-10-23 | Trustees Of Dartmouth College | Attenuated uracil auxotroph of an apicomplexan and use thereof |
| US20030096260A1 (en) * | 2001-10-09 | 2003-05-22 | Zhenhua Miao | Compositions useful as ligands for the formyl peptide receptor like 1 receptor and methods of use thereof |
| WO2004026903A2 (en) * | 2002-09-20 | 2004-04-01 | Akzo Nobel N.V. | Live antenuated parasite vaccine |
| US9757440B2 (en) | 2007-10-29 | 2017-09-12 | Trustees Of Dartmouth College | Method for treating cancer with Toxoplasma gondii vaccine |
| WO2016046321A1 (en) * | 2014-09-25 | 2016-03-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating cancer and infectious diseases |
| JP7148415B2 (ja) | 2016-06-29 | 2022-10-05 | ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド | タンパク質を中枢神経系（ｃｎｓ）に送達するための、組換え寄生虫 |
-
2017
- 2017-06-29 JP JP2018568203A patent/JP7148415B2/ja active Active
- 2017-06-29 CN CN201780053576.6A patent/CN109757100A/zh active Pending
- 2017-06-29 CA CA3028334A patent/CA3028334A1/en active Pending
- 2017-06-29 AU AU2017289886A patent/AU2017289886A1/en not_active Abandoned
- 2017-06-29 KR KR1020197001560A patent/KR102513120B1/ko active Active
- 2017-06-29 EP EP17819507.9A patent/EP3478301A4/en active Pending
- 2017-06-29 US US16/313,060 patent/US11260081B2/en active Active
- 2017-06-29 WO PCT/IL2017/050731 patent/WO2018002938A1/en not_active Ceased
-
2022
- 2022-01-26 US US17/584,508 patent/US12070476B2/en active Active
- 2022-09-22 JP JP2022151508A patent/JP7497397B2/ja active Active
-
2024
- 2024-05-29 JP JP2024087211A patent/JP7748681B2/ja active Active
- 2024-08-26 US US18/814,678 patent/US20250057892A1/en active Pending