JP2018524393A5 - - Google Patents

Info

Publication number

JP2018524393A5

JP2018524393A5 JP2018503747A JP2018503747A JP2018524393A5 JP 2018524393 A5 JP2018524393 A5 JP 2018524393A5 JP 2018503747 A JP2018503747 A JP 2018503747A JP 2018503747 A JP2018503747 A JP 2018503747A JP 2018524393 A5 JP2018524393 A5 JP 2018524393A5

Authority

JP

Japan

Prior art keywords

polypeptide

adenovirus

antigen

seq

related antigen

Prior art date

2016-07-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 108091007433 antigens Proteins 0.000 claims description 188
• 102000036639 antigens Human genes 0.000 claims description 188
• 239000000427 antigen Substances 0.000 claims description 187
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 150
• 229920001184 polypeptide Polymers 0.000 claims description 148
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 148
• 241000701161 unidentified adenovirus Species 0.000 claims description 99
• 241000990167 unclassified Simian adenoviruses Species 0.000 claims description 96
• 230000028993 immune response Effects 0.000 claims description 19
• 230000001939 inductive effect Effects 0.000 claims description 18
• 150000001413 amino acids Chemical class 0.000 claims description 14
• 239000000203 mixture Substances 0.000 claims description 13
• 239000012634 fragment Substances 0.000 claims description 11
• 108090000623 proteins and genes Proteins 0.000 claims description 9
• CXURGFRDGROIKG-UHFFFAOYSA-N 3,3-bis(chloromethyl)oxetane Chemical compound ClCC1(CCl)COC1 CXURGFRDGROIKG-UHFFFAOYSA-N 0.000 claims description 8
• NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims description 8
• 239000000835 fiber Substances 0.000 claims description 8
• 239000002671 adjuvant Substances 0.000 claims description 7
• 241000700605 Viruses Species 0.000 claims description 5
• 208000015181 infectious disease Diseases 0.000 claims description 5
• 102000004169 proteins and genes Human genes 0.000 claims description 5
• 241000187479 Mycobacterium tuberculosis Species 0.000 claims description 3
• 108700019146 Transgenes Proteins 0.000 claims description 3
• 230000002265 prevention Effects 0.000 claims description 3
• 241001217856 Chimpanzee adenovirus Species 0.000 claims description 2
• 238000009472 formulation Methods 0.000 claims description 2
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 238000000034 method Methods 0.000 description 60
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• 239000002157 polynucleotide Substances 0.000 description 6
• 230000010076 replication Effects 0.000 description 3
• 101150029662 E1 gene Proteins 0.000 description 2
• 101150005585 E3 gene Proteins 0.000 description 2
• 101150066038 E4 gene Proteins 0.000 description 2
• 125000000539 amino acid group Chemical group 0.000 description 2
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• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
• 102100037850 Interferon gamma Human genes 0.000 description 1
• 108010074328 Interferon-gamma Proteins 0.000 description 1
• 108010002350 Interleukin-2 Proteins 0.000 description 1
• 102000000588 Interleukin-2 Human genes 0.000 description 1
• 208000032420 Latent Infection Diseases 0.000 description 1
• 210000001744 T-lymphocyte Anatomy 0.000 description 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
• 239000000556 agonist Substances 0.000 description 1
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• 208000037771 disease arising from reactivation of latent virus Diseases 0.000 description 1
• 239000002245 particle Substances 0.000 description 1
• 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
• 229930182490 saponin Natural products 0.000 description 1
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• 201000008827 tuberculosis Diseases 0.000 description 1
• 230000003612 virological effect Effects 0.000 description 1