JP2015504675A5 - - Google Patents

Download PDF

Info

Publication number
JP2015504675A5
JP2015504675A5 JP2014552305A JP2014552305A JP2015504675A5 JP 2015504675 A5 JP2015504675 A5 JP 2015504675A5 JP 2014552305 A JP2014552305 A JP 2014552305A JP 2014552305 A JP2014552305 A JP 2014552305A JP 2015504675 A5 JP2015504675 A5 JP 2015504675A5
Authority
JP
Japan
Prior art keywords
fragment
subject
nucleic acid
aat
acid encoding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014552305A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015504675A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2013/021057 external-priority patent/WO2013106589A1/en
Publication of JP2015504675A publication Critical patent/JP2015504675A/ja
Publication of JP2015504675A5 publication Critical patent/JP2015504675A5/ja
Priority to JP2018018033A priority Critical patent/JP6920230B2/ja
Pending legal-status Critical Current

Links

JP2014552305A 2012-01-10 2013-01-10 アルファ−1アンチトリプシン融合分子の組成物、方法、及び使用 Pending JP2015504675A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2018018033A JP6920230B2 (ja) 2012-01-10 2018-02-05 アルファ−1アンチトリプシン融合ポリペプチド、それをコードする核酸構築体、及びそれらの組成物

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261585182P 2012-01-10 2012-01-10
US61/585,182 2012-01-10
US201261586038P 2012-01-12 2012-01-12
US61/586,038 2012-01-12
US201261614391P 2012-03-22 2012-03-22
US61/614,391 2012-03-22
PCT/US2013/021057 WO2013106589A1 (en) 2012-01-10 2013-01-10 Compositions, methods and uses for alpha-1 antitrypsin fusion molecules

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018018033A Division JP6920230B2 (ja) 2012-01-10 2018-02-05 アルファ−1アンチトリプシン融合ポリペプチド、それをコードする核酸構築体、及びそれらの組成物

Publications (2)

Publication Number Publication Date
JP2015504675A JP2015504675A (ja) 2015-02-16
JP2015504675A5 true JP2015504675A5 (enExample) 2016-03-03

Family

ID=48781909

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014552305A Pending JP2015504675A (ja) 2012-01-10 2013-01-10 アルファ−1アンチトリプシン融合分子の組成物、方法、及び使用
JP2018018033A Expired - Fee Related JP6920230B2 (ja) 2012-01-10 2018-02-05 アルファ−1アンチトリプシン融合ポリペプチド、それをコードする核酸構築体、及びそれらの組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018018033A Expired - Fee Related JP6920230B2 (ja) 2012-01-10 2018-02-05 アルファ−1アンチトリプシン融合ポリペプチド、それをコードする核酸構築体、及びそれらの組成物

Country Status (7)

Country Link
US (3) US10478508B2 (enExample)
EP (1) EP2802653A4 (enExample)
JP (2) JP2015504675A (enExample)
KR (2) KR102348985B1 (enExample)
AU (3) AU2013202648B2 (enExample)
CA (1) CA2896951A1 (enExample)
WO (1) WO2013106589A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1660094A4 (en) 2003-08-26 2009-09-16 Univ Colorado INHIBITORS OF SERINE PROTEASE ACTIVITY AND USES THEREOF IN METHODS AND PREPARATIONS FOR TREATING BACTERIAL INFECTIONS
CA2839917A1 (en) 2011-06-24 2012-12-27 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
US10400029B2 (en) 2011-06-28 2019-09-03 Inhibrx, Lp Serpin fusion polypeptides and methods of use thereof
IL312872A (en) 2011-06-28 2024-07-01 Inhibrx Inc Methods for purifying fusion proteins containing serphin
US9951104B2 (en) 2012-01-09 2018-04-24 Serpin Pharma, Llc Peptides and methods of using same
WO2014184794A1 (en) 2013-05-15 2014-11-20 Mor Research Applications Ltd. Compositions and methods for treating post-operative complications of cardiopulmonary surgery
EP3155117A4 (en) 2014-06-11 2017-11-22 Beth Israel Deaconess Medical Center, Inc. Alpha1-antitrypsin compositions and methods of treating autoimmune diseases
EP3193906B1 (en) * 2014-09-18 2020-11-11 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of Holy and Undiv. Trinity of Queen Elizabeth near Dublin Use of peptide inhibitors of il-36 proteolytic processing for the treatment and/or reduction of inflammation
JP6737781B2 (ja) * 2014-10-27 2020-08-12 インヒブルクス,インコーポレイティド セルピン融合ポリペプチド及びその使用方法
CA2996975C (en) 2015-08-28 2022-02-15 Serpin Pharma, Llc Methods for treatment of diseases
ES2975208T3 (es) 2017-12-01 2024-07-04 Csl Behring Llc A1AT para reducir el riesgo de aparición de la enfermedad aguda de injerto contra huésped tras el trasplante de células hematopoyéticas
US20210253671A1 (en) * 2018-06-07 2021-08-19 Prottech Inc. Pharmaceutical Composition Containing Fusion Protein and Use Thereof
WO2020026227A1 (en) * 2018-07-29 2020-02-06 Kamada Ltd- Methods and uses of alpha 1-antitrypsin for preservation of explanted organs
BR112021008200A2 (pt) * 2018-10-29 2021-12-14 Spin Therapeutics Llc Composições e métodos para distúrbios de alfa-1-antitripsina
US11779630B2 (en) 2020-07-06 2023-10-10 Serpin Pharma, Llc Peptides and methods of using the same
GB202102258D0 (en) * 2021-02-17 2021-03-31 Arecor Ltd Novel composition
KR20250076724A (ko) * 2023-11-22 2025-05-30 아주대학교산학협력단 지속형 재조합 알파-1 항트립신 및 이의 용도
WO2025083294A2 (en) * 2024-02-29 2025-04-24 Ageronix SA Aat-fc fusion protein

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874424A (en) 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
GB1472700A (en) 1974-11-01 1977-05-04 Ono Pharmaceutical Co Guanidinobehzoic acid derivatives and process for preparing the same
JPS5470241A (en) 1977-11-09 1979-06-05 Ono Pharmaceut Co Ltd Guanidinobenzoic acid derivative and its preparation
GB2044760B (en) 1979-03-01 1983-03-23 Ono Pharmaceutical Co Guanidinobenzoic acid derivatives
US4215051A (en) 1979-08-29 1980-07-29 Standard Oil Company (Indiana) Formation, purification and recovery of phthalic anhydride
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4711848A (en) 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin
EP0169114B1 (fr) 1984-06-19 1991-01-16 Transgene S.A. Dérivés de l'alpha 1-antitrypsine humaine et procédé pour leur préparation
US4629567A (en) 1986-03-07 1986-12-16 Smithkline-Rit Alpha-1-antiprotease purification
US5157019A (en) 1986-03-18 1992-10-20 Monsanto Company Serine protease inhibitors
US4829052A (en) 1986-06-11 1989-05-09 Monsanto Company Serine protease inhibitors
US5114917A (en) 1986-12-24 1992-05-19 John Lezdey Treatment of inflammation using alpha 1-antichymotrypsin
US5008242A (en) 1986-12-24 1991-04-16 John Lezdey Treatment of inflammation using 1-antichymotrypsin
US4829054A (en) 1987-04-13 1989-05-09 Miles Laboratories, Inc. Method of decreasing lung damage in a host following the onset of gram negative septicemia/endotoxemia
US4857538A (en) 1987-11-30 1989-08-15 The Research Foundation Of State University Of New York New compounds for the study and treatment of microfilament organization in cells
US4963654A (en) 1989-02-13 1990-10-16 Taisho Pharmaceutical Co., Ltd. Peptide serine protease inhibitor
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5116964A (en) 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US5612194A (en) 1989-06-23 1997-03-18 Trustees Of The University Of Pennsylvania Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors
JP2568281B2 (ja) 1989-11-17 1996-12-25 原田工業株式会社 自動車用三波共用アンテナ
US5714140A (en) 1989-12-13 1998-02-03 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting the production of bioactive IL-1 by administering M-CSF
EP0512090B2 (en) 1990-10-16 2006-11-22 Sonoran Desert Chemicals LLC Treatment of inflammation
US5134119A (en) 1990-10-16 1992-07-28 Lezdey John Treatment of inflammation using 358 substituted alpha-antitrypsin
US5470970A (en) 1991-02-28 1995-11-28 Dana-Farber Cancer Institute, Inc. Maspin, a serpin with tumor suppresing activity
EP0616614A1 (en) 1991-04-18 1994-09-28 The Uab Research Foundation Compositions and methods for inhibiting elastase
US5175253A (en) 1991-04-24 1992-12-29 Washington University Binding peptides
GB9115364D0 (en) 1991-07-16 1991-08-28 Wellcome Found Antibody
US5216022A (en) 1991-12-19 1993-06-01 Cortech, Inc. Aromatic esters of phenylenedialkanoates as inhibitors of human neutrophil elastase
WO1993018794A1 (en) 1992-03-26 1993-09-30 Gensia, Inc. In vivo peptide therapy
GB9209032D0 (en) 1992-04-25 1992-06-10 Ciba Geigy Ag New peptide derivatives
US5734014A (en) 1992-08-11 1998-03-31 Tsumura & Co. Elafin derivative
US5604201A (en) 1993-01-08 1997-02-18 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non-Profit Organization Methods and reagents for inhibiting furin endoprotease
US5346886A (en) 1993-11-15 1994-09-13 John Lezdey Topical α-1-antitrypsin, non-aqueous lipid miscible, benzalkonium chloride compositions for treating skin
JPH0827371A (ja) 1994-05-09 1996-01-30 Japan Carlit Co Ltd:The 紫外線及び赤外線吸収樹脂組成物
AU2790895A (en) 1994-06-10 1996-01-05 Universitaire Instelling Antwerpen Purification of serine protease and synthetic inhibitors thereof
US5610285A (en) 1994-08-24 1997-03-11 Bayer Corporation Purification of α-1 proteinase inhibitor using novel chromatographic separation conditions
US5514653A (en) 1994-09-09 1996-05-07 Washington University Method of blocking the SEC receptor
US5618792A (en) 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
US5712117A (en) 1995-02-08 1998-01-27 Zymogenetics, Inc. Cytoplasmic antiproteinase-2 and coding sequences
WO1997021690A1 (en) 1995-11-28 1997-06-19 Cephalon, Inc. D-amino acid derived inhibitors of cysteine and serine proteases
US6136834A (en) 1995-12-27 2000-10-24 Ono Pharmaceutical Co., Ltd. Tetrazole compounds and pharmaceutical agents containing such derivative
AU716923B2 (en) 1996-03-11 2000-03-09 Aerovance, Inc. Human bikunin
US6072041A (en) 1996-06-03 2000-06-06 Case Western Reserve University Fusion proteins for protein delivery
US5780440A (en) 1996-06-17 1998-07-14 Protease Sciences Inc. Treatment of pulmonary disease with protease inhibitors
US5616693A (en) 1996-07-01 1997-04-01 Alpha Therapeutic Corporation Process for seperating alpha-1-proteinase inhibitor from COHN IV1 +1V4 paste
US7147851B1 (en) * 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
DE69739673D1 (de) 1996-11-27 2009-12-31 Genentech Inc Affinitätsreinigung von Polypeptid-Proteinen auf einer Protein A Matrix
AU734615B2 (en) 1996-12-06 2001-06-21 Cortech, Inc. Serine protease inhibitors
US6150332A (en) 1997-01-09 2000-11-21 Virginia Commonwealth University Method and composition for lowering low density lipoprotein cholesterol
US6124257A (en) 1997-08-28 2000-09-26 Lezdey; John Method of treatment
US7279459B2 (en) 2001-01-04 2007-10-09 Vascular Biogenics Ltd. Methods employing and compositions containing plaque associated molecules for prevention and treatment of atherosclerosis
US6197294B1 (en) * 1998-10-26 2001-03-06 Neurotech S.A. Cell surface molecule-induced macrophage activation
WO2000044390A1 (en) 1999-02-01 2000-08-03 John Lezdey Treatment of bladder and gastrointestinal mastocytosis
GB9904421D0 (en) 1999-02-25 1999-04-21 Univ Edinburgh Telecommunications receiver
JP2002537810A (ja) 1999-03-01 2002-11-12 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド ヒトセルピンタンパク質
AU3731400A (en) 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Methods and compositions useful in inhibiting apoptosis
WO2000052034A2 (en) 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
US6849605B1 (en) 1999-03-05 2005-02-01 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
AU3864000A (en) 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses
AU3511500A (en) 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
US6174859B1 (en) 1999-04-06 2001-01-16 J & D Sciences, Inc. Method of treatment
AU782496B2 (en) 1999-07-13 2005-08-04 Bolder Biotechnology, Inc. Immunoglobulin fusion proteins
AU2050501A (en) 1999-12-01 2001-06-12 Human Genome Sciences, Inc. Four disulfide core domain-containing (fdcd) polynucleotides, polypeptides, and antibodies
US6955845B1 (en) 2000-06-30 2005-10-18 Owens Corning Fiberglas Technology, Inc. Acoustical and thermal insulator
PT1355919E (pt) 2000-12-12 2011-03-02 Medimmune Llc Moléculas com semivida longa, composições que as contêm e suas utilizações
US7247704B2 (en) 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
RU2316563C2 (ru) 2001-02-23 2008-02-10 Иммьюнекс Корпорейшн Способ промотирования активной конформации гликозилированного рекомбинантного белка, способ получения активного гликозилированного белка и способ получения композиции указанного белка для введения потребителю и/или пациенту или потребления потребителем и/или пациентом
CA2440582A1 (en) 2001-03-09 2002-10-03 Dyax Corp. Serum albumin binding moieties
US7074901B2 (en) 2001-05-25 2006-07-11 Serono Genetics Institute S.A. Isolated human vCOL16A1 polypeptide and fragments thereof
EP1401867A2 (en) 2001-06-22 2004-03-31 Health Protection Agency Mycobacterial antigens expressed under low oxygen tension
US7270960B2 (en) 2001-08-29 2007-09-18 Pacific Northwest Research Institute Diagnosis of ovarian carcinomas
US6924267B2 (en) 2001-09-18 2005-08-02 Suomen Punainen Risti Veripalvelu Methods and active substances for protecting organs
US6797493B2 (en) * 2001-10-01 2004-09-28 Lee-Hwei K. Sun Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities
US7138370B2 (en) * 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
MXPA04006053A (es) 2001-12-21 2005-03-31 Immunex Corp Metodos para purificacion de proteina.
CA2475388A1 (en) 2002-02-14 2003-08-21 William J. Rutter Chimeric molecules for cleavage in a treated host
DE60333937D1 (de) 2002-05-23 2010-10-07 Novartis Vaccines & Diagnostic Substituierte quinazolinone verbindungen
US20040019022A1 (en) 2002-07-25 2004-01-29 Karen Stec Use of 2,3 alkylcarbonyloxybenzoic acids, derivatives and analogues therefrom in the treatment of tissue and cellular dysfunction, damage and injury in mammals
US20040220242A1 (en) 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
EP1660094A4 (en) 2003-08-26 2009-09-16 Univ Colorado INHIBITORS OF SERINE PROTEASE ACTIVITY AND USES THEREOF IN METHODS AND PREPARATIONS FOR TREATING BACTERIAL INFECTIONS
CA2545718C (en) 2003-11-12 2016-05-10 The Trustees Of The University Of Pennsylvania Methods of using gelsolin to treat or prevent bacterial sepsis
JP2007531513A (ja) 2003-11-13 2007-11-08 ハンミ ファーム.インダストリー カンパニー リミテッド 薬物のキャリアとして有用なIgGFc断片およびその製造方法
PL1755661T3 (pl) 2004-05-12 2014-10-31 Brigham & Womens Hospital Inc Gelsolina do stosowania w leczeniu infekcji
WO2009005877A2 (en) 2007-04-20 2009-01-08 Regents Of The University Of Colorado Alpha-i antitrypsin having no significant serine protease inhibitor activity
US8715649B2 (en) * 2005-06-07 2014-05-06 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods of use for alpha-1 antitrypsin having no significant serine protease inhibitor activity
US20090227518A1 (en) 2005-12-02 2009-09-10 The Regents Of The University Of Colorado Compositions and methods for treating actin-mediated medical conditions
WO2008033890A2 (en) * 2006-09-12 2008-03-20 Beth Israel Deaconess Medical Center, Inc. Compositions containing alpha-1-antitrypsin and methods for use
PE20081250A1 (es) 2006-11-28 2008-10-07 Centelion FUSIONES Fc CON RECEPTOR PARA FGF SOLUBLE MODIFICADAS, CON ACTIVIDAD BIOLOGICA MEJORADA
WO2008100470A2 (en) * 2007-02-15 2008-08-21 Transtech Pharma, Inc. Rage - immunoglobulin fusion proteins
WO2008138017A2 (en) 2007-05-08 2008-11-13 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for modifying t cell immune responses and inflammation
WO2009006520A1 (en) 2007-07-03 2009-01-08 Medimmune, Llc Hinge domain engineering
WO2009015345A1 (en) 2007-07-25 2009-01-29 Amgen Inc. Pharmaceutical compositions comprising fc fusion proteins
EP2080812A1 (en) * 2008-01-18 2009-07-22 Transmedi SA Compositions and methods of detecting post-stop peptides
MX2011011130A (es) 2009-04-22 2011-11-18 Alteogen Inc Proteina o peptido de fusion con vida media in vivo incrementada mantenido por liberacion in vivo sostenida, y metodo para incrementar la vida media in vivo usando el mismo.
WO2011102845A1 (en) * 2010-02-18 2011-08-25 Transtech Pharma, Inc. Rage fusion protein compositions and methods of use
WO2011109768A2 (en) * 2010-03-04 2011-09-09 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for modulating cardiac conditions
US20120225813A1 (en) * 2010-06-11 2012-09-06 Lewis Eli C Compositions, methods and uses for treatment of type 1 diabetes
CA2839917A1 (en) * 2011-06-24 2012-12-27 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
US8986688B2 (en) * 2011-06-28 2015-03-24 Inhibrx, Llc WAP domain fusion polypeptides and methods of use thereof
IL312872A (en) * 2011-06-28 2024-07-01 Inhibrx Inc Methods for purifying fusion proteins containing serphin
KR101509020B1 (ko) * 2013-05-22 2015-04-14 (주)입디 알파 1 안티트립신 융합 분자에 대한 조성물, 방법 및 용도

Similar Documents

Publication Publication Date Title
JP2015504675A5 (enExample)
JP2014519852A5 (enExample)
JP6920230B2 (ja) アルファ−1アンチトリプシン融合ポリペプチド、それをコードする核酸構築体、及びそれらの組成物
TWI648401B (zh) 生長分化因子15(gdf-15)構築體
CN106573966B (zh) 用于治疗代谢异常的组合物和方法
JP2010516290A5 (enExample)
JP6938565B2 (ja) Uti融合タンパク質
JP2015503349A5 (enExample)
IL134602A (en) Conjugates that contain the homeodomain of antennapedia
JP2015500811A5 (enExample)
CN106632682A (zh) 融合蛋白ifn-elp及其应用
WO2014180288A1 (zh) 具有抑制肿瘤微环境血管再生和激活适应性免疫应答双功能的融合蛋白及其基因和应用
JP2015524413A5 (enExample)
JP2018517398A5 (enExample)
CN105073977B (zh) 重组酵母转化体和用其制备免疫球蛋白Fc片段的方法
JP2024178193A (ja) インスリン及びグルカゴンを含む薬学組成物
CN101463089B (zh) 人血清白蛋白-干扰素融合蛋白及其编码基因与应用
WO2021228052A1 (zh) 生物大分子靶向特异性补体抑制剂及其制备方法与应用
WO2012037771A1 (zh) 蝎毒肽及其制备方法与用途
JP2008502323A5 (enExample)
JP2008531463A5 (enExample)
CN105693864A (zh) 一种三聚体trail蛋白及其应用
JP4275065B2 (ja) キメラ拮抗物質anth1
CN105418767A (zh) 一种用于制备Aβ表位疫苗的融合蛋白及其制备方法和用途
CN103990110B (zh) 系列镇痛活性肽dkk及类似物的获得方法和应用