JP2018517398A5 - - Google Patents
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- JP2018517398A5 JP2018517398A5 JP2017552146A JP2017552146A JP2018517398A5 JP 2018517398 A5 JP2018517398 A5 JP 2018517398A5 JP 2017552146 A JP2017552146 A JP 2017552146A JP 2017552146 A JP2017552146 A JP 2017552146A JP 2018517398 A5 JP2018517398 A5 JP 2018517398A5
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- polypeptide
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 165
- 229920001184 polypeptide Polymers 0.000 claims description 164
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- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 239000004471 Glycine Substances 0.000 claims description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 2
- 235000004279 alanine Nutrition 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 238000012217 deletion Methods 0.000 claims description 2
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- 230000002496 gastric effect Effects 0.000 claims description 2
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- 210000004347 intestinal mucosa Anatomy 0.000 claims description 2
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- 101000632178 Homo sapiens Homeobox protein Nkx-2.1 Proteins 0.000 description 5
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- POIUWJQBRNEFGX-XAMSXPGMSA-N cathelicidin Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(C)C)C1=CC=CC=C1 POIUWJQBRNEFGX-XAMSXPGMSA-N 0.000 description 4
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- 239000003124 biologic agent Substances 0.000 description 2
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- SWISGLLTKITYOP-UHFFFAOYSA-N thuricin cd Chemical compound N1C(=O)CNC(=O)C(C(C)CC)NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)C(CO)NC(=O)C(C(C)CC)NC(=O)C(C(C)C)NC(=O)C(NC(=O)C(CO)NC(=O)CNC(=O)C(C(C)CC)NC2=O)CSC1(CO)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(C(NC(C)C(=O)N1)=O)(C(C)O)SCC2NC(=O)CNC(=O)C(C(C)CC)NC(=O)C(C(C)C)NC(=O)C(NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(N)=O)NC(=O)CN)CSC(C(=O)NC(CC(C)C)C(=O)NCC(O)=O)(C(C)O)NC(=O)C1CC1=CC=CC=C1 SWISGLLTKITYOP-UHFFFAOYSA-N 0.000 description 2
- 108010062877 Bacteriocins Proteins 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- LAWKVNVCUPIOMG-HWWYPGLISA-N gardimycin Chemical compound C1=CC=C2C(C[C@H](C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C)C(=O)NCC(=O)N[C@H](CC)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(O)=O)C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](CC)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](CC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)N)[C@@H](C)CC)C(C)C)=CNC2=C1 LAWKVNVCUPIOMG-HWWYPGLISA-N 0.000 description 1
- 108010070411 gardimycin Proteins 0.000 description 1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021030187A JP7156726B2 (ja) | 2015-04-06 | 2021-02-26 | 機能的タンパク質配列をディスプレイする生合成アミロイドに基づく材料 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562143560P | 2015-04-06 | 2015-04-06 | |
| US62/143,560 | 2015-04-06 | ||
| PCT/US2016/026161 WO2016164422A2 (en) | 2015-04-06 | 2016-04-06 | Biosynthetic amyloid-based materials displaying functional protein sequences |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021030187A Division JP7156726B2 (ja) | 2015-04-06 | 2021-02-26 | 機能的タンパク質配列をディスプレイする生合成アミロイドに基づく材料 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018517398A JP2018517398A (ja) | 2018-07-05 |
| JP2018517398A5 true JP2018517398A5 (enExample) | 2019-05-16 |
| JP6916524B2 JP6916524B2 (ja) | 2021-08-11 |
Family
ID=57072695
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017552146A Active JP6916524B2 (ja) | 2015-04-06 | 2016-04-06 | 機能的タンパク質配列をディスプレイする生合成アミロイドに基づく材料 |
| JP2021030187A Active JP7156726B2 (ja) | 2015-04-06 | 2021-02-26 | 機能的タンパク質配列をディスプレイする生合成アミロイドに基づく材料 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021030187A Active JP7156726B2 (ja) | 2015-04-06 | 2021-02-26 | 機能的タンパク質配列をディスプレイする生合成アミロイドに基づく材料 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20180258435A1 (enExample) |
| EP (1) | EP3280397A4 (enExample) |
| JP (2) | JP6916524B2 (enExample) |
| WO (1) | WO2016164422A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9815871B2 (en) | 2013-04-23 | 2017-11-14 | President And Fellows Of Harvard College | Genetic reprogramming of bacterial biofilms |
| JP6916524B2 (ja) | 2015-04-06 | 2021-08-11 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 機能的タンパク質配列をディスプレイする生合成アミロイドに基づく材料 |
| US11098133B2 (en) | 2016-05-19 | 2021-08-24 | President And Fellows Of Harvard College | Methods of making gels and films using curli nanofibers |
| FR3099648B1 (fr) * | 2019-07-30 | 2023-01-13 | Centre Nat Rech Scient | Membrane échangeuse d’ions |
| CN110585482B (zh) * | 2019-08-02 | 2022-03-01 | 大连理工大学 | 一种具有抗菌性能的杂萘联苯聚芳醚腈及其表面改性方法 |
| CN112608876B (zh) * | 2020-12-30 | 2024-02-09 | 江苏大学 | 一种生物素化Curli蛋白的活细胞标记方法及其应用 |
| GB202216905D0 (en) * | 2022-11-11 | 2022-12-28 | Oxford Nanopore Tech Plc | Novel pore monomers and pores |
| KR102855274B1 (ko) * | 2022-12-06 | 2025-09-08 | 충남대학교산학협력단 | strep-tag 결합물질에 대한 결합능을 가지는 융합단백질을 암호화하는 유전자 구조물 및 이를 함유하는 발현벡터, 재조합 균주 및 항암 조성물 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5762620A (en) | 1992-04-02 | 1998-06-09 | Ndm Acquisition Corp. | Wound dressing containing a partially dehydrated hydrogel |
| US6864365B1 (en) * | 1999-04-05 | 2005-03-08 | Innovation And Development Corporation, University Of Victoria | Bacterial fimbrial system for presentation of heterologous peptide sequences |
| DE60229867D1 (de) * | 2001-07-02 | 2008-12-24 | Merrion Res Iii Ltd | Zielgerichtete ligande gegen peyer's flecke- und/oder m-zellen |
| AU2003217415B2 (en) | 2002-02-14 | 2009-01-08 | William J Rutter | Chimeric molecules for cleavage in a treated host |
| PL1626799T3 (pl) | 2003-04-30 | 2010-09-30 | Univ Drexel | Mieszaniny polimerów żelujące w podwyższonej temperaturze, do stosowania w materiałach biokompatybilnych |
| EP1858546A4 (en) | 2005-03-04 | 2009-03-04 | Biorexis Pharmaceutical Corp | MODIFIED TRANSFERRINFUSION PROTEINS |
| EP3124614B1 (en) | 2007-01-12 | 2022-06-08 | Intrexon Actobiotics NV | Lactococcus promoters and uses thereof |
| JP2009073766A (ja) * | 2007-09-21 | 2009-04-09 | Otsuka Pharmaceut Co Ltd | 医薬 |
| WO2010111516A2 (en) | 2009-03-25 | 2010-09-30 | Whitehead Institute For Biomedical Research | Compositions and methods for inhibiting biofilms |
| US20110033389A1 (en) | 2009-04-29 | 2011-02-10 | Zhifeng Chen | Modified antibodies for passive immunotherapy |
| US20110108199A1 (en) | 2009-11-10 | 2011-05-12 | Tyco Healthcare Group Lp | Hemostatic Tapes and Dispensers Therefor |
| EP2536754A1 (en) * | 2010-02-16 | 2012-12-26 | Novo Nordisk A/S | Factor viii fusion protein |
| CA2830052C (en) | 2010-03-31 | 2018-10-09 | Wayne State University | Injectable dendrimer hydrogel nanoparticles |
| KR20110111594A (ko) | 2010-04-05 | 2011-10-12 | 서울대학교산학협력단 | 알파-시뉴클레인 유래 곱슬 아밀로이드 섬유의 제조방법, 이를 이용한 하이드로젤의 제조 방법 및 그 이용 방법 |
| US8741417B2 (en) | 2010-04-16 | 2014-06-03 | Korea University Research And Business Foundation | Films having switchable reflectivity |
| EP2624874A4 (en) | 2010-10-08 | 2014-04-02 | Univ Texas | Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications |
| BR112013008957A2 (pt) * | 2010-10-15 | 2019-09-24 | Univ Cornell | composições e métodos para tratamento de doenças endócrinas, gastrointestinais ou autoimunes |
| KR20120060442A (ko) | 2010-12-02 | 2012-06-12 | 가톨릭대학교 산학협력단 | 위암 진단용 마커로서 ｔｆｆ2의 용도 |
| US9140698B2 (en) * | 2011-04-06 | 2015-09-22 | The Board Of Regents Of The University Of Texas System | Modulating bacterial MAM polypeptides in pathogenic disease |
| US9580480B2 (en) * | 2011-05-31 | 2017-02-28 | Massachusetts Institute Of Technology | Cell-directed synthesis of multifunctional nanopatterns and nanomaterials |
| CN104271588B (zh) | 2011-07-08 | 2017-10-10 | 安米林药品有限责任公司 | 具有增强的作用持续时间和降低的免疫原性的工程改造的多肽 |
| EP2739312B1 (en) | 2011-08-03 | 2017-10-04 | Children's Medical Center Corporation | A broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin |
| WO2013188529A1 (en) | 2012-06-15 | 2013-12-19 | Temple University Of The Commonwealth System Of Higher Education | Use of isolated bacterial amyloids for treatment of inflammatory disorders or diseases of the epithelium |
| AU2013293092A1 (en) * | 2012-07-23 | 2015-02-26 | Zymeworks Inc. | Immunoglobulin constructs comprising selective pairing of the light and heavy chains |
| WO2014078489A1 (en) | 2012-11-16 | 2014-05-22 | President And Fellows Of Harvard College | Methods and compositions relating to amyloidogenic polypeptides |
| HRP20191865T1 (hr) * | 2013-01-14 | 2020-01-10 | Xencor, Inc. | Novi heterodimerni proteini |
| JP2014156428A (ja) * | 2013-02-15 | 2014-08-28 | Univ Of Tokyo | 抗体結合タンパク質 |
| WO2014139468A1 (en) * | 2013-03-15 | 2014-09-18 | Admark Healthcare, Llc | Fusion protein molecules and method of use |
| US9815871B2 (en) | 2013-04-23 | 2017-11-14 | President And Fellows Of Harvard College | Genetic reprogramming of bacterial biofilms |
| WO2015080671A1 (en) | 2013-11-30 | 2015-06-04 | Agency For Science, Technology And Research | Self-assembling peptides, peptidomimetics and peptidic conjugates as building blocks for biofabrication and printing |
| WO2015097289A1 (en) | 2013-12-24 | 2015-07-02 | Vib Vzw | Secretion and functional display of chimeric polypeptides |
| US20150342893A1 (en) | 2014-05-29 | 2015-12-03 | Sigmoid Pharma Limited | Celecoxib formulations useful for treating colorectal cancer |
| JP6916524B2 (ja) | 2015-04-06 | 2021-08-11 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 機能的タンパク質配列をディスプレイする生合成アミロイドに基づく材料 |
| US11098133B2 (en) | 2016-05-19 | 2021-08-24 | President And Fellows Of Harvard College | Methods of making gels and films using curli nanofibers |
-
2016
- 2016-04-06 JP JP2017552146A patent/JP6916524B2/ja active Active
- 2016-04-06 WO PCT/US2016/026161 patent/WO2016164422A2/en not_active Ceased
- 2016-04-06 EP EP16777174.0A patent/EP3280397A4/en active Pending
- 2016-04-06 US US15/564,619 patent/US20180258435A1/en not_active Abandoned
-
2020
- 2020-02-10 US US16/785,874 patent/US11286491B2/en active Active
-
2021
- 2021-02-26 JP JP2021030187A patent/JP7156726B2/ja active Active
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