CN108265044A - 聚乙二醇定点修饰的精氨酸脱亚胺酶及其制备方法与应用 - Google Patents
聚乙二醇定点修饰的精氨酸脱亚胺酶及其制备方法与应用 Download PDFInfo
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- CN108265044A CN108265044A CN201711379689.3A CN201711379689A CN108265044A CN 108265044 A CN108265044 A CN 108265044A CN 201711379689 A CN201711379689 A CN 201711379689A CN 108265044 A CN108265044 A CN 108265044A
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- adi
- pegylation
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- polyethylene glycol
- peg
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
- C12Y305/03006—Arginine deiminase (3.5.3.6)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Description
Claims (10)
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CN201611267257 | 2016-12-31 | ||
CN2016112672579 | 2016-12-31 |
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CN108265044A true CN108265044A (zh) | 2018-07-10 |
CN108265044B CN108265044B (zh) | 2021-05-11 |
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CN201711379689.3A Active CN108265044B (zh) | 2016-12-31 | 2017-12-20 | 聚乙二醇定点修饰的精氨酸脱亚胺酶及其制备方法与应用 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112442496A (zh) * | 2019-08-28 | 2021-03-05 | 江苏众红生物工程创药研究院有限公司 | 精氨酸脱亚胺酶突变体及其应用 |
WO2022001818A1 (zh) * | 2020-06-28 | 2022-01-06 | 江苏中新医药有限公司 | 一种修饰的重组人神经生长因子及其制备方法 |
Citations (10)
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JPH04121187A (ja) * | 1990-09-10 | 1992-04-22 | Nikko Kyodo Co Ltd | ポリエチレングリコール修飾アルギニンデイミナーゼおよびその製造法 |
WO2001083774A3 (en) * | 2000-05-04 | 2002-05-23 | Phoenix Pharmacologics Inc | Novel mutated form of arginine deiminase |
CN1518595A (zh) * | 2000-11-28 | 2004-08-04 | 凤凰药理学公司 | 修饰的精氨酸脱亚胺酶 |
US20070100133A1 (en) * | 1998-11-30 | 2007-05-03 | Beals John M | Erythropoietic compounds |
CN101096664A (zh) * | 2006-07-13 | 2008-01-02 | 北京双鹭立生医药科技有限公司 | 一种精氨酸脱酰酶共价修饰物、其制造方法及应用 |
WO2010074082A1 (ja) * | 2008-12-24 | 2010-07-01 | 塩野義製薬株式会社 | バソヒビン修飾体 |
CN102481345A (zh) * | 2009-03-26 | 2012-05-30 | 香港理工大学 | 精氨酸酶的定向位点聚乙二醇化及其作为抗癌和抗病毒试剂的用途 |
CN103119055A (zh) * | 2010-05-17 | 2013-05-22 | 塞比克斯公司 | 聚乙二醇化c肽 |
TW201534727A (zh) * | 2014-03-14 | 2015-09-16 | Polaris Group | 用於癌症治療之對adi-peg20抗體交叉反應性降低之精胺酸去亞胺酶 |
CN105802948A (zh) * | 2014-12-29 | 2016-07-27 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇定点修饰的门冬酰胺酶及其制备方法与应用 |
-
2017
- 2017-12-20 CN CN201711379689.3A patent/CN108265044B/zh active Active
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04121187A (ja) * | 1990-09-10 | 1992-04-22 | Nikko Kyodo Co Ltd | ポリエチレングリコール修飾アルギニンデイミナーゼおよびその製造法 |
US20070100133A1 (en) * | 1998-11-30 | 2007-05-03 | Beals John M | Erythropoietic compounds |
WO2001083774A3 (en) * | 2000-05-04 | 2002-05-23 | Phoenix Pharmacologics Inc | Novel mutated form of arginine deiminase |
CN1518595A (zh) * | 2000-11-28 | 2004-08-04 | 凤凰药理学公司 | 修饰的精氨酸脱亚胺酶 |
CN101096664A (zh) * | 2006-07-13 | 2008-01-02 | 北京双鹭立生医药科技有限公司 | 一种精氨酸脱酰酶共价修饰物、其制造方法及应用 |
WO2010074082A1 (ja) * | 2008-12-24 | 2010-07-01 | 塩野義製薬株式会社 | バソヒビン修飾体 |
CN102481345A (zh) * | 2009-03-26 | 2012-05-30 | 香港理工大学 | 精氨酸酶的定向位点聚乙二醇化及其作为抗癌和抗病毒试剂的用途 |
CN103119055A (zh) * | 2010-05-17 | 2013-05-22 | 塞比克斯公司 | 聚乙二醇化c肽 |
TW201534727A (zh) * | 2014-03-14 | 2015-09-16 | Polaris Group | 用於癌症治療之對adi-peg20抗體交叉反應性降低之精胺酸去亞胺酶 |
CN105802948A (zh) * | 2014-12-29 | 2016-07-27 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇定点修饰的门冬酰胺酶及其制备方法与应用 |
Non-Patent Citations (6)
Title |
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FENG CHENG等: "Rational surface engineering of an arginine deiminase (an antitumor enzyme) for increased PEGylation efficiency", 《BIOTECHNOLOGY AND BIOENGINEERING》 * |
FREDERICK W.HOLTSBERG等: "Poly(ethylene glycol)(PEG) conjugated arginine deiminase: effects of PEG formulations on its pharmacological properties", 《JOURNAL OF CONTROLLED RELEASE》 * |
HARASAWA,R.,等: "Arginine deiminase (ADI) (Arginine dihydrolase) (AD)", 《GENBANK DATABASE》 * |
OLAF KINSTLER等: "Mono-N-terminal poly(ethylene glycol)-protein conjugates", 《ADVANCED DRUG DELIVERY REVIEWS》 * |
董红霞,等: "聚乙二醇化蛋白质多肽类药物定点修饰策略", 《药学与临床研究》 * |
蒋微琴: "新一代聚乙二醇修饰的精氨酸脱亚胺酶基础研究", 《中国优秀硕士学位论文全文数据库医药卫生科技辑》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112442496A (zh) * | 2019-08-28 | 2021-03-05 | 江苏众红生物工程创药研究院有限公司 | 精氨酸脱亚胺酶突变体及其应用 |
CN112442496B (zh) * | 2019-08-28 | 2023-05-12 | 江苏众红生物工程创药研究院有限公司 | 精氨酸脱亚胺酶突变体及其应用 |
WO2022001818A1 (zh) * | 2020-06-28 | 2022-01-06 | 江苏中新医药有限公司 | 一种修饰的重组人神经生长因子及其制备方法 |
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Address after: 213125 No. 518 Yunhe Road, Xinbei District, Changzhou City, Jiangsu Province Applicant after: ZonHon Biopharma Institute Inc. Applicant after: Jiangsu Jingsen Biomedical New Materials Technology Co., Ltd. Address before: 213125 No. 518 Yunhe Road, Xinbei District, Changzhou City, Jiangsu Province Applicant before: ZonHon Biopharma Institute Inc. Applicant before: Changzhou Gensun Institute of Biomedicine Co., Ltd. |
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